Tissue Engineering Part B Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Epicatechin
(EC)-based
derivatives
have
garnered
significant
attention
for
their
powerful
antioxidant,
anti-inflammatory,
anticancer,
and
antibacterial
properties,
all
of
which
are
attributed
to
the
phenolic
hydroxyl
groups
in
structure.
These
compounds
promising
regenerative
medicine,
particularly
as
bioactive
components
scaffolds.
This
review
provides
an
in-depth
analysis
mechanisms
by
EC-based
materials
enhance
tissue
repair,
examining
application
various
scaffold
forms,
such
hydrogels,
nanoparticles,
nanofibers.
study
also
addresses
challenges
stability
bioavailability
associated
with
ECs
proposes
encapsulation
techniques
overcome
these
barriers.
The
potential
clinical
benefits
medicine
role
fostering
advancements
engineering
discussed,
making
this
a
valuable
resource
guiding
future
studies
on
integration
into
practice.
Molecules,
Год журнала:
2024,
Номер
29(5), С. 1082 - 1082
Опубликована: Фев. 29, 2024
Enhalus
arcoides
is
a
highly
beneficial
type
of
seagrass.
Prior
studies
have
presented
proof
the
bioactivity
E.
acoroides,
suggesting
its
potential
to
combat
cancer.
Therefore,
this
study
aims
delve
deeper
into
acoroides
bioactive
molecule
profiles
and
their
direct
biological
anticancer
activities
potentials
through
combination
in-silico
in-vitro
studies.
This
conducted
metabolite
profile
analysis
on
utilizing
HPLC-ESI-HRMS/MS
analysis.
Two
extraction
techniques,
ethanol
hexane,
were
employed
for
process.
Furthermore,
was
using
molecular
docking
simulations
HER2,
EGFR
tyrosine
kinase
HIF-1α
protein
receptor.
Afterward,
antioxidant
activity
metabolites
examined
ABTS,
antiproliferative
tested
an
MTT
assay.
An
revealed
ability
breast
cancer
by
inhibiting
HER2/EGFR/HIF-1α
pathway
docking.
In
addition,
assay
demonstrated
that
higher
dosages
from
increased
effectiveness
toxicity
against
cell
lines.
Additionally,
possess
function
as
potent
antioxidants,
effectively
series
carcinogenic
mechanisms.
Ultimately,
showed
new
approach
unveiling
metabolites’
receptors,
with
great
cytotoxicity
property
prevent
cascade.
Future Foods,
Год журнала:
2024,
Номер
9, С. 100354 - 100354
Опубликована: Апрель 23, 2024
Novel
dietary
strategies
are
urgently
needed
to
address
the
limitations
of
current
management
and
treatment
options
Type-2
Diabetes
(T2D).
Marine
algae-derived
peptides
(MAP)
represent
a
promising
avenue,
although,
their
potential
remains
mostly
underexplored.
This
study
employs
pharmacoinformatics
in
vitro
methods
evaluate
antidiabetic
properties
MAP
provide
new
insights
mechanisms
mitigate
prevalence
T2D.
Through
systematic
search
predictive
modeling,
were
identified
assessed
for
bioactivity,
toxicity,
drug-likeness.
Furthermore,
molecular
docking
simulations
with
protein
targets
related
T2D
binding
sites
that
be
used
optimize
activity
MAP.
The
structure-activity
relationship
profile
reveals
13
candidates
probable
(Pa)
scores
>0.4,
indicative
insulin
promoter.
peptide
FDGIP
(P13;Phe-Asp-Gly-Ile-Pro)
from
Caulerpa
lentillifera
had
best
silico
assessment
value
compared
50
other
its
was
confirmed
by
data
(e.g.EC50
60.4
57.9
α-amylase
α-glucosidase
inhibitions).
Interestingly,
3T3-L1
cells,
P13
exhibited
inhibitory
activities
against
transcription
factors
hormones
(MAPK8-JNK1/PPARGC1A/Ghrelin/GLP-1/CPT-1)
can
regulate
blood
sugar
decrease
as
anti-diabetes.
then
appears
action
may
formulation
foods
manage
Food Research International,
Год журнала:
2025,
Номер
208, С. 116173 - 116173
Опубликована: Март 14, 2025
Diet
is
one
of
the
main
drivers
non-communicable
chronic
diseases
(NCD).
Modifying
food
supply
may
be
an
attractive
strategy
for
promoting
health
and
reducing
NCD
risk.
The
intentional
modification,
processing,
enrichment,
or
fortification
foods
to
produce
"functional
foods"
currently
varies
according
legal
definitions
existing
regulatory
frameworks,
initially
intended
function,
production
methods.
This
review
critically
appraises
concepts
applied
functional
foods,
proposing
a
new
concept
"functionalized
foods".
conceptual
difference
between
two
categories
that
term
used
products
validated
human
through
controlled
trials,
while
obtained
enrichment
(bio)fortification
lack
such
validation,
yet.
Consequently,
aims
establish
framework
better
understanding
range
products,
enhancing
communication,
more
accurate
interpretation
landscape.
Journal of Agriculture and Food Research,
Год журнала:
2024,
Номер
18, С. 101362 - 101362
Опубликована: Авг. 23, 2024
The
discovery
of
new
molecules
from
natural
sources
for
the
treatment
tumors
such
as
breast
cancers
is
importance
development
functional
foods
and
to
pharmaceutical
industry.
A
resource
with
potential
activity
against
cancer
forest
onion,
Eleutherine
bulbosa
(Mill.)
Urb.,
but
identity
its
active
constituents
their
mechanisms
action
remain
unexplored.
Therefore,
this
study
focuses
on
metabolite
profiling,
in
silico
or
pharmacoinformatic
mechanisms,
well
advanced
validation
vitro
cell
lines.
Ten
compounds
identified
E.
bulb
ethanolic
extract
(EBE)
showed
receptor
radical
inhibitory
via
network
pharmacology
molecular
docking
simulation.
most
promising
compound
was
avenasterol
binding
PARP-1,
HER2,
iNOS
receptors
values
−11.26,
−8.34,
−9.17
μg/mL,
respectively.
EBE
had
a
smaller
EC50
value,
higher
potency,
than
control
antioxidant
Trolox
scavenging
tests
ABTS
DPPH.
In
line
study,
antiproliferative
human
MCF-7
LD50
217.8
relatively
low
cytotoxicity
normal
MCF-10A
cells
(LD50
>
1000
μg/mL).
mechanism
associated
downregulation
TGF-β,
PI3K,
AKT
which
are
known
tumor
activators.
Significant
(p
<
0.05)
upregulation
suppressor
gene
miR-29a-3p
observed
after
dose-dependent
manner.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 11, 2024
Human
melanoma
is
linked
with
aging-related
disorders,
prompting
interest
in
the
development
of
functional
foods
derived
from
natural
ingredients
to
mitigate
its
incidence.
Molecules
green
seaweeds
such
as
Caulerpa
racemosa
can
serve
this
purpose
due
their
anti-tumor
and
anti-inflammatory
properties.
A
previous
work
study
compounds
profiling
has
been
carried
out,
research
molecular
docking
studies
targeting
receptors
associated
(GRP78,
IRE1,
BRAF)
aging
(mTOR,
AMPK,
SIRT1)
identified
four
promising
compound
an
extract
C.
racemosa.
The
current
aims
mechanism
those
at
a
cellular
level
using
human
A375
(BRAF-V600E
mutation)
B16-F10
cell
lines.
MTT
assay
was
used
evaluate
potential
GSCRE
against
lines,
comparisons
made
normal
HDFa
Results
indicated
that
C2,
also
known
Caulersin,
demonstrated
significantly
different
∆G
affinity
binding
score
compared
control
drug
Dabrafenib.
crude
extract,
particularly
showed
modulating
mTOR,
SIRT1
pathways
downregulating
GRP78,
BRAF
signaling
(p
<
0.05).
Interestingly,
C2
less
effective
suppressing
lines
(LD
Foods,
Год журнала:
2024,
Номер
13(23), С. 3935 - 3935
Опубликована: Дек. 5, 2024
Coffee
silverskin
(CS)
is
a
by-product
of
the
coffee
roasting
process
that
known
for
its
potential
as
fiber
source
with
antioxidant
properties.
Therefore,
this
study
aimed
to
provide
an
overview
latest
research
on
CS
ingredient
functional
foods
and
evaluate
effect
adding
different
amounts
sensory
attributes
chocolate
cakes.
The
addition
increased
total
dietary
content,
capacity
contents
extractable
non-extractable
phenolics
in
evaluated
were
color,
smell,
taste,
texture
overall
impression,
they
according
9-point
hedonic
scale.
Internal
preference
maps
obtained
based
results
from
acceptance
"intention
buy"
tests.
In
general,
cakes
lower
content
(2.6%
3.6%)
had
similar
level
cake
4.6%
was
least
accepted.
most
important
taste
corresponding
"like
slightly"
moderately"
better
acceptance.
Nonetheless,
even
lowest
amount
added
(2.6%),
produced
could
be
regarded
sources
(with
above
3
g/100
g),
thus
confirming
food
additive.
