International Journal of Advanced Research in Science Communication and Technology,
Год журнала:
2024,
Номер
unknown, С. 388 - 397
Опубликована: Дек. 25, 2024
Even
though
oncology
has
advanced
throughout
time,
cancer
remains
the
largest
cause
of
mortality,
a
global
burden
that
negatively
affects
patients’
quality
life
and
economy.
The
present
traditional
treatments,
which
include
lengthy
treatment
periods
systemic
drug
exposure,
early
deterioration,
excruciating
pain,
adverse
effects,
recurrence.
In
order
to
prevent
further
delays
in
patient
diagnosis
or
are
crucial
lowering
worldwide
mortality
rate
personalized
precision-based
care
also
desperately
needed,
particularly
light
current
pandemic.
Recently,
microneedles
patch
with
tiny,
micron-sized
needles
attached
have
gained
lot
attention
as
cutting-edge
transdermal
application
technique
for
variety
diseases.
Since
microneedle
patches
provide
better
approach
through
self-administration,
discomfort-free
treatment,
an
economical
environmentally
friendly
compared
other
conventional
methods,
use
therapies
is
being
thoroughly
researched.
several
kinds
microneedles,
their
materials
manufacturing
processes,
well
most
developments
prospects,
highlighted
this
overview.
Furthermore,
review
discusses
difficulties
constraints
associated
using
offers
solutions
based
on
ongoing
research
upcoming
projects
support
clinical
treatment...
Abstract
With
the
aging
and
obesity
era,
increasing
incidence
of
diabetes
diabetic
complications,
especially
non‐healing
wounds,
imposes
a
serious
economic
burden
on
both
patients
society.
The
complex
microenvironments,
including
hyperglycemia,
bacterial
infection,
ischemia,
nerve
damage,
lead
to
prolonged
inflammation
proliferation
phase
wounds.
Mesenchymal
stem
cell‐derived
small
extracellular
vesicles
(MSC‐sEVs),
which
contain
rich
variety
therapeutic
molecules,
have
been
chased
for
decades
because
their
potential
roles
in
cellular
communication,
tissue
regeneration,
drug
delivery.
As
powerful
tools
controlled‐sustained
release
sEVs,
biocompatible
hydrogels
applied
wide
range
biomedical
applications.
Herein,
we
first
summarize
pathological
features
such
as
angiopathy,
neuropathy,
immune
cell
dysfunction.
Then,
discuss
biological
properties,
performance,
stability
pure
MSC‐sEVs.
After
that,
components,
application
patterns,
responsiveness
hydrogels.
Next,
loading
avenues
MSC‐sEVs
into
hydrogel,
behaviors
sEVs
from
hydrogels,
influence
crosslinking
method
hydrogel‐sEV
composites.
Finally,
provide
an
overview
current
applications
loaded
with
novel
cell‐free
engineering
system
managing
wounds
propose
critical
unsolved
issues.
This
review
is
expected
meaningful
guidance
developing
wound
management.
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 512 - 512
Опубликована: Янв. 23, 2025
The
rise
of
antibiotic-resistant
Staphylococcus
aureus
strains,
particularly
MRSA,
complicates
the
management
skin
and
soft
tissue
infections.
This
review
highlights
ultrasonic
methodologies
as
adjunctive
therapies
to
combat
S.
aureus-driven
infections
prevent
progression
biofilm
formation
chronic
wounds.
Low-
high-frequency
ultrasound
(LFU
HFU)
demonstrate
potential
in
disrupting
biofilms,
enhancing
drug
delivery,
promoting
repair
through
cavitation
microbubble
activity.
These
approaches
integrate
frequencies
with
microbubbles
therapeutics,
such
antibiotics
affimers,
minimize
resistance
improve
healing.
Tailoring
bioeffects
on
structures
localized
delivery
technologies,
including
microneedle
patches
piezoelectric
systems,
presents
promising
solutions
for
early
intervention
structure
(SSSIs).
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Abstract
The
skin
microenvironment
is
a
highly
intricate
and
dynamic
system,
characterized
by
an
acidic
pH,
diverse
microbiota,
various
metabolites,
numerous
enzymes,
creating
both
challenges
opportunities
for
the
development
of
innovative
drug
delivery
systems.
Dissolving
Microneedles
(MNs)
have
emerged
as
promising,
pain‐free
alternative
to
conventional
invasive
injections,
offering
ability
deliver
therapeutics
through
gradual
degradation
within
skin's
interstitial
fluids.
Building
upon
unique
properties
dissolving
MNs,
novel
concept
introduced
wherein
MNs
serve
in
situ
chemical
reaction
chambers.
In
this
framework,
can
reactants
or
catalysts
skin,
enabling
initiation
specific
reactions,
such
prodrug
activation
targeted
therapy,
harmful
enhanced
synthesis
beneficial
molecules.
Moreover,
review
systematically
explores
potential
chambers,
discussing
key
aspects
their
sustained
release
mechanisms,
design
strategies,
range
therapeutic
applications.
Finally,
forward‐looking
perspective
provided
on
future
addressing
broader
clinical
translation
application
personalized
medicine.
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
290, С. 117535 - 117535
Опубликована: Март 20, 2025
Cancer
drug
delivery
remains
a
critical
challenge
with
systemic
toxicity,
poor
bioavailability,
and
lack
of
effective
targeting.
Overcoming
these
barriers
is
essential
for
improving
treatment
efficacy
patient
outcomes.
This
review
discusses
current
techniques
that
reshape
cancer
therapy
by
offering
precise,
controlled-release
tailored
to
tumor-specific
features.
Innovations
in
nanotechnology,
immunotherapy,
gene
enable
interventions
at
molecular
cellular
levels.
Radiomics
pathomics
integrate
high-dimensional
data
optimize
diagnostics
planning.
Combination
addresses
the
complexities
tumor
heterogeneity
synergizing
multiple
agents
within
single
therapeutic
framework,
while
peptide-drug
conjugates
enhance
specificity
potency.
Hydrogel-based
systems
microneedle
arrays
offer
localized,
sustained
release,
significantly
However,
clinical
translation
advancements
faces
significant
such
as
resistance,
off-target
effects,
scalability,
cost,
ethical
concerns.
Moreover,
regulatory
economic
feasibility
therapies
highlight
need
innovative
frameworks
make
them
accessible
globally.
Therefore,
there
innovation
cell
therapy,
next-generation
platforms,
personalized
medicine.
focuses
on
recent
over
past
decade,
evaluating
their
limitations
exploring
potential
future
directions
transforming
treatment.
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Сен. 10, 2024
Pain
is
a
subjective
concept
which
ever-present
in
the
medical
field.
Health
professionals
are
confronted
with
variety
of
pain
types
and
sources,
as
well
challenge
managing
patient
acute
or
chronic
suffering.
An
even
bigger
presented
pediatric
population,
often
cannot
quantify
numerical
scale
like
adults.
Infants
small
children
especially
show
their
discomfort
through
behavioral
physiological
indicators,
leaving
health
provider
task
rating
pain.
Depending
on
pathophysiology
it,
can
be
classified
neuropathic
nociceptive,
first
being
defined
by
an
irregular
signal
processing
nervous
system
second
appearing
cases
direct
tissue
damage
prolonged
contact
certain
stimulant.
The
approach
generally
either
pharmacological
non-pharmacological
it
vary
from
using
NSAIDs,
local
anesthetics,
opiates
to
physical
psychological
routes.
Unfortunately,
some
pathologies
involve
intense
that
managed
traditional
methods.
Recent
studies
have
involved
nanoparticles
special
characteristics
such
dimension
large
surface
area
facilitate
carrying
treatments
tissues
offer
intrinsic
analgesic
properties.
Pediatrics
has
benefited
significantly
application
nanotechnology,
enabled
development
novel
strategies
for
drug
delivery,
disease
diagnosis,
engineering.
This
narrative
review
aims
evaluate
role
nanotechnology
current
therapy,
emphasis
children.
