Journal of Herbmed Pharmacology,
Год журнала:
2024,
Номер
14(1), С. 112 - 119
Опубликована: Дек. 25, 2024
Introduction:
Natural
products
are
a
rich
source
of
antioxidants,
effective
on
immunological
disorders.
The
present
study
was
planned
to
evaluate
the
antioxidant
activity
ethanolic
extract
root
bark
an
Indian
medicinal
plant,
Eugenia
jambolana,
by
in
vitro
methods
and
immunomodulatory
vivo
methods.
Methods:
collected
E.
jambolana
(EJE)
prepared
tested
for
using
concentrations
10-50
µg/mL
through
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
free
radical
superoxide
anion
scavenging
assays.
Further,
effects
EJE
were
assessed
animal
studies
against
experimental
antigen,
sheep
RBC,
oral
administration
at
doses
100,
200,
400
mg/kg,
measuring
its
impact
antibody
titer
values
antigen-antibody
reaction
paw
thickness
mice
(delayed-type
hypersensitivity
[DTH]
study)
humoral
cell-mediated
immune
responses,
respectively.
Results:
exhibited
properties
DPPH
radicals
with
IC50
43.79
±
0.24
47.64
0.18
respective
studies.
mg/kg
dose
demonstrated
significant
(P<0.05)
value
DTH
response
These
showed
that
produced
29.36%
39.06%
immunity
studies,
Conclusion:
experiments
this
potential
bark.
Heliyon,
Год журнала:
2025,
Номер
11(4), С. e42739 - e42739
Опубликована: Фев. 1, 2025
This
review
explores
the
synergistic
potential
of
natural
products
and
nanotechnology
for
viral
infections,
highlighting
key
antiviral,
immunomodulatory,
antioxidant
properties
to
combat
pandemics
caused
by
highly
infectious
viruses.
These
often
result
in
severe
public
health
crises,
particularly
affecting
vulnerable
populations
due
respiratory
complications
increased
mortality
rates.
A
cytokine
storm
is
initiated
when
an
overload
pro-inflammatory
cytokines
chemokines
released,
leading
a
systemic
inflammatory
response.
Viral
mutations
limited
availability
effective
drugs,
vaccines,
therapies
contribute
continuous
transmission
virus.
The
coronavirus
disease-19
(COVID-19)
pandemic
has
sparked
renewed
interest
product-derived
antivirals.
efficacy
traditional
medicines
against
infections
examined.
Their
anti-inflammatory,
are
highlighted.
discusses
how
enhances
herbal
combating
infections.
Journal of Toxicology and Environmental Health,
Год журнала:
2025,
Номер
unknown, С. 1 - 16
Опубликована: Янв. 23, 2025
This
study
aimed
to
identify
chemical
compounds
derived
from
Vassobia
breviflora
methanolic
extract
using
ESI-ToF-MS
and
their
antioxidant
potential
activity
utilizing
the
following
methods:
total
phenols,
DPPH,
ABTS•+.
The
MTT
assay
measured
cytotoxic
activity,
while
DCFH-DA
nitric
oxide
assays
were
employed
determine
reactive
oxygen
species
(ROS)
nitrogen
(RNS)
levels
African
green
monkey
kidney
(VERO)
human
keratinocyte
(HaCat)
cell
lines.
minimal
inhibitory
concentration
(MIC)
bactericidal
(MBC)
assessed
in
seven
clinical
isolates
nine
ATCC
strains.
Biofilm
inhibition
was
tested
against
four
biofilm-forming
properties
of
identified
as
follows:
35.74
mg
GAE/g
(gallic
acid
equivalents)/g
for
10.5
µg/ml
50.68
µmol
trolox/µg
mean
(IC50)
values
622.86
784.33
(HaCat).
These
concentrations
did
not
markedly
alter
ROS
RNS.
Conversely,
Bacillus
cereus
β-hemolytic
displayed
higher
sensitivity
extract,
with
MIC
64
MBC
128
µg/ml.
Enterococcus
faecium
exhibited
lowest
biofilm
formation
among
bacteria.
studied
plant
all
bacterial
strains
at
lower
than
IC50
VERO
HaCat
cells,
suggesting
future
studies.
Data
present
a
comprehensive
molecular
docking
analysis
HlyIIR
protein
(PDB
ID:
2FX0)
determined
antimicrobial
endocrine-modulating
potentials.
Notably,
lancifodilactone
I
nicandrin
B
demonstrated
strongest
binding
affinities,
energies
-9.8
kcal/mol
-8.3
kcal/mol,
respectively,
significant
effects
B.
cereus.
In
addition,
several
showed
interactions
nuclear
receptors,
indicating
effects.
findings
provide
insights
into
developing
target-specific
therapies
agents.
Plants,
Год журнала:
2025,
Номер
14(6), С. 897 - 897
Опубликована: Март 13, 2025
The
rising
prevalence
of
infectious
diseases
and
immune-related
disorders
underscores
the
need
for
effective
accessible
therapeutic
solutions.
Herbal
immunostimulants
derived
from
medicinal
plants
offer
promising
alternatives,
enhancing
immune
responses
with
lower
toxicity
fewer
side
effects
than
synthetic
drugs.
This
review
explores
immunostimulatory
potential
Morinda
citrifolia,
Echinacea
purpurea,
Phyllanthus
niruri,
focusing
on
their
bioactive
compounds,
mechanisms
action,
relevance.
These
modulate
innate
adaptive
by
activating
macrophages,
dendritic
cells,
lymphocytes
while
regulating
cytokine
production
to
maintain
homeostasis.
Their
immunomodulatory
are
linked
key
signaling
pathways,
including
NF-κB,
MAPK,
JAK/STAT.
In
vitro
in
vivo
studies
highlight
strengthen
control
inflammation,
making
them
candidates
managing
diseases.
However,
further
research
is
needed
standardize
formulations,
determine
optimal
dosages,
validate
safety
efficacy
clinical
settings.
Addressing
these
gaps
will
support
integration
herbal
into
evidence-based
healthcare
as
sustainable
immune-enhancing
strategies.
JMIR Formative Research,
Год журнала:
2024,
Номер
8, С. e63281 - e63281
Опубликована: Ноя. 5, 2024
Background
Legacy
media
are
publications
that
existed
before
the
internet.
Many
of
these
have
migrated
to
a
web
format,
either
replacing
or
in
parallel
their
print
issues.
Readers
place
an
economic
value
on
access
information
presented
as
they
pay
for
subscriptions
and
higher
degree
trust
content.
Much
has
been
written
about
inaccurate
misleading
health
social
media;
however,
content
accuracy
contained
legacy
not
examined
detail.
Discussion
herbs,
spices,
other
botanicals
absent
from
this
context.
Objective
The
objectives
study
were
(1)
identify
associations
botanical
products
mentioned
targeted
range
demographic
groups
(2)
evaluate
against
published
scientific
studies.
Methods
In
total,
10
popular
magazines
targeting
gender,
race/ethnicity,
sexual
orientation
selected
analysis.
Relevant
was
extracted
coded
over
1
year.
Associations
between
specific
factors
identified.
For
most
frequent
botanical–health
application
associations,
PubMed
search
conducted
reviews
corresponding
each
item’s
indicated
applications.
Where
no
systematic
available,
single
research
studies
sought.
Results
A
total
237
unique
There
128
mentions
issues
1215
websites.
18
applications
identified
used
categorize
uses
various
individually
general
categories.
frequently
skin
care,
with
913
mentions,
immunity
enhancement,
705
gastrointestinal
probiotics,
184
cognitive
function
(stress
mental
health),
106
mentions.
Comparison
literature
evaluating
efficacy
functions
positive
support
aloe
vera,
argan
oil,
chamomile,
jojoba
lavender,
rosemary,
tea
tree
oil
care.
Berries,
ginger,
turmeric,
green
had
strongest
evidence
role
enhancement.
Ginger
oats
supported
having
health.
Finally,
berries,
ashwagandha,
cannabidiol
managing
stress.
Other
items
such
mushrooms
less
strongly
supported.
Conclusions
prevalent
indicates
that,
overall,
consistent
current
reports
products.
While
some
greater
than
others,
truly
egregious
falsehoods
absent.
Therefore,
may
be
considered
credible
source
readers
topics.
