Опубликована: Янв. 1, 2024
Язык: Английский
Metabolites, Год журнала: 2025, Номер 15(2), С. 124 - 124
Опубликована: Фев. 13, 2025
Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood
Язык: Английский
Процитировано
5
Advanced Science, Год журнала: 2024, Номер 11(16)
Опубликована: Фев. 28, 2024
Abstract Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related central nervous system (CNS) damage. However, the blood‐brain barrier (BBB) constitutes a significant impediment effective delivery of TCM, thus substantially diminishing its efficacy. Advances nanotechnology and applications TCM (also known as nano‐TCM) can deliver active ingredients or components across BBB targeted brain region. This review provides an overview physiological pathological mechanisms systematically classifies common CNS types nanocarriers that effectively brain. Additionally, drug strategies for nano‐TCMs utilize vivo properties vitro devices bypass cross are discussed. further focuses on application treatment various diseases. Finally, this article anticipates design strategy with higher efficiency probes their potential treating wider range
Язык: Английский
Процитировано
12
Current Osteoporosis Reports, Год журнала: 2024, Номер 22(3), С. 353 - 365
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 297, С. 139468 - 139468
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
0
Separations, Год журнала: 2025, Номер 12(2), С. 34 - 34
Опубликована: Янв. 28, 2025
Quercetin in Taraxacum mongolicum was extracted by ultrasound-assisted extraction synergy with an ionic liquid–enzyme complex system, and the antioxidant function of quercetin investigated based on network pharmacology. From 1-butyl-3-methylimidazolium chloride, acetate, tetrafluoroborate, bromide, first step to choose appropriate liquid. Subsequently, a response surface methodology single-factor experiment were used optimize process. The key targets for antioxidants obtained from public database. Antioxidant activity assessed measuring scavenging rate 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals hydroxyl radicals(•OH). approach revealed that optimal process liquid–solid ratio 31.62:1 mL/g, enzymatic temperature 55 °C, amount cellulase added 14.79% dry weight dandelion. Under this condition, yield 0.24 ± 0.011 mg/g, which 1.3 times higher than conventional reflux method 0.185 0.015 mg/g. Pharmacological findings showed 57 cross-targets antioxidants. Gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis indicated may be related chemical carcinogenesis-reactive oxygen species, Phosphoinositide 3-kinase/protein kinase B signaling pathway. has strong DPPH •OH radical activity. development use industrial dandelion are supported sustainable effective extracting
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(5), С. 1169 - 1169
Опубликована: Март 5, 2025
Donepezil (DH), a selective acetylcholinesterase inhibitor, is widely used to manage symptoms of mild moderate Alzheimer's disease by enhancing cholinergic neurotransmission and preventing acetylcholine breakdown. Despite the effectiveness oral formulations, extensive hepatic metabolism low systemic bioavailability have driven search for alternative delivery systems. This study focuses on nasal as non-parenteral substitute, utilizing hydroxypropyl methylcellulose (HPMC) its mucoadhesive properties methyl-β-cyclodextrin (Me-β-CD) ability enhance permeability form inclusion complexes with drugs. Prior studies demonstrated potential HPMC-based films nose-to-brain donepezil highlighted Me-β-CD's role in improving drug solubility. Building this, transparent gel formulations containing DH, HPMC, 2,6 Me-β-CD were developed investigate molecular interactions within two- three-component utilized combination nuclear magnetic resonance (NMR) spectroscopy density functional theory (DFT) provide detailed insights into between 2,6-Me-β-CD, HPMC. The findings critical drug-excipient interactions, aiding optimization stability, solubility, controlled release. advances rational design nanotechnology-based systems enhanced therapeutic efficacy.
Язык: Английский
Процитировано
0
Journal of Traditional Chinese Medical Sciences, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Авг. 7, 2024
Psoriasis is one of the most common autoimmune skin diseases. Increasing evidence shows that alterations in diversity and function microbiota can participate pathogenesis psoriasis through various pathways mechanisms.
Язык: Английский
Процитировано
4
The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
The naturally occurring 3″-O-acylquercitrin family exhibits a range of biological activities with significant potential health and medical benefits. Herein, we present unified strategy for concise total syntheses all six known natural products─namely, 3″-O-galloylquercitrin, 3″-O-(E)-cinnamoylquercitrin, 3″-O-(E)-coumaroylquercitrin, 3″-O-(E)-feruloylquercitrin, 3″-O-acetylquercitrin, 3″-O-tigloylquercitrin─based on regioselective acylation carbohydrates catalyzed by N-methylimidazole-containing boronic acid. core advancement in this approach is late-stage catalytic functionalization common synthetic intermediate, enabling efficient access to the products.
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2025, Номер 343, С. 119450 - 119450
Опубликована: Фев. 9, 2025
Язык: Английский
Процитировано
0