Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
Traditional
Chinese
medicine
(TCM)
has
been
employed
for
centuries
in
treating
and
managing
Alzheimer's
disease
(AD).
However,
their
effective
delivery
to
target
sites
can
be
a
major
challenge.
This
is
due
poor
water
solubility,
low
bioavailability,
potential
toxicity.
Furthermore,
the
blood-brain
barrier
(BBB)
obstacle
TCM
delivery,
significantly
reducing
efficacy.
Advancements
nanotechnology
its
applications
(nano-TCM)
deliver
active
ingredients
or
components
of
across
BBB
targeted
brain
area.
review
summarizes
recent
advances
nanocarrier-based
systems
different
types
constituents
AD,
including
terpenoids,
polyphenols,
alkaloids,
flavonoids,
quinones.
Besides,
main
challenges
opportunities
future
development
these
advanced
nanocarriers
are
emphasized.
In
conclusion,
this
provides
valuable
insights
guidance
utilizing
shape
drug
delivery.
Abstract
Traditional
Chinese
Medicine
(TCM)
is
widely
used
in
clinical
practice
to
treat
diseases
related
central
nervous
system
(CNS)
damage.
However,
the
blood‐brain
barrier
(BBB)
constitutes
a
significant
impediment
effective
delivery
of
TCM,
thus
substantially
diminishing
its
efficacy.
Advances
nanotechnology
and
applications
TCM
(also
known
as
nano‐TCM)
can
deliver
active
ingredients
or
components
across
BBB
targeted
brain
region.
This
review
provides
an
overview
physiological
pathological
mechanisms
systematically
classifies
common
CNS
types
nanocarriers
that
effectively
brain.
Additionally,
drug
strategies
for
nano‐TCMs
utilize
vivo
properties
vitro
devices
bypass
cross
are
discussed.
further
focuses
on
application
treatment
various
diseases.
Finally,
this
article
anticipates
design
strategy
with
higher
efficiency
probes
their
potential
treating
wider
range
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 19, 2025
Abstract
The
complex
composition
of
traditional
Chinese
medicines
(TCMs)
has
posed
challenges
for
in‐depth
study
and
global
application,
despite
their
abundance
bioactive
compounds
that
make
them
valuable
resources
disease
treatment.
To
overcome
these
obstacles,
it
is
essential
to
modernize
TCMs
by
focusing
on
precise
This
involves
elucidating
the
structure‐activity
relationships
within
compositions,
ensuring
accurate
in
vivo
delivery,
monitoring
delivery
process.
review
discusses
research
progress
precision
treatment
from
three
perspectives:
spatial
multi‐omics
technology
therapeutic
activity,
carrier
systems
medical
imaging
visualizing
aim
establish
a
novel
paradigm
advances
therapy
TCMs.
Acta Pharmacologica Sinica,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Abstract
Demyelination
is
a
common
feature
of
numerous
neurological
disorders
including
multiple
sclerosis
and
leukodystrophies.
Although
myelin
can
be
regenerated
spontaneously
following
injury,
this
process
often
inadequate,
potentially
resulting
in
neurodegeneration
exacerbating
dysfunction.
Several
drugs
aimed
at
promoting
the
differentiation
oligodendrocyte
precursor
cells
(OPCs)
have
yielded
unsatisfactory
clinical
effects.
A
recent
study
has
shifted
strategy
pro-OPC
towards
enhancing
myelinogenesis.
In
we
identified
pro-myelinating
drug
using
zebrafish
model.
Five
traditional
Chinese
medicine
monomers
gastrodin,
paeoniflorin,
puerarin,
salidroside
scutellarin
were
assessed
by
bath-application
Tg
(MBP:eGFP-CAAX)
transgenic
line
1–5
dpf.
Among
5
monomers,
only
gastrodin
exhibited
significant
pro-myelination
activity.
We
showed
that
(10
µM)
enhanced
sheath
formation
(OL)
maturation
without
affecting
number
OLs.
Gastrodin
markedly
increased
phosphorylation
levels
PI3K,
AKT,
mTOR
primary
cultured
OLs
via
direct
interaction
with
PI3K.
Co-treatment
PI3K
inhibitor
LY294002
(5
mitigated
gastrodin-induced
OL
maturation.
Furthermore,
injection
(100
mg·kg
−1
·d
,
i.p.)
effectively
facilitated
remyelination
lysophosphatidylcholine-induced
demyelinating
mouse
model
alleviated
demyelination
experimental
autoimmune
encephalomyelitis
mice.
These
results
identify
as
promising
therapeutic
agent
for
diseases
highlight
potential
screening
pro-myelinogenic
pharmacotherapy.
Journal of Drug Delivery and Therapeutics,
Год журнала:
2025,
Номер
15(3), С. 133 - 141
Опубликована: Март 15, 2025
Nanotechnology
has
revolutionized
the
field
of
herbal
medicine
by
enhancing
bioavailability
and
efficacy
phytoconstituents.
This
review
article
discusses
application
nanotechnology
in
medicine,
including
use
nanoparticles,
liposomes,
nanoemulsions
for
targeted
drug
delivery.
The
advantages
nanotechnology-based
formulations,
such
as
improved
solubility,
stability,
bioavailability,
are
highlighted.
Additionally,
potential
therapeutic
medicines,
their
anti-inflammatory,
antioxidant,
anticancer
properties.
also
explores
various
types
nanocarriers
used
polymeric
solid
lipid
nanostructured
carriers.
role
permeability
retention
medicines
body
is
discussed.
Overall,
provides
a
comprehensive
overview
highlighting
its
Keywords:
Nanotechnology,
Herbal
Liposomes,
Nanosuspension,
Nano
emulsion.
Plant-derived
extracellular
vesicles
(EVs)
are
promising
therapeutic
agents
owing
to
their
natural
abundance,
accessibility,
and
unique
biological
properties.
This
review
provides
a
comprehensive
exploration
of
the
potential
plant-derived
EVs
emphasizes
anti-inflammatory,
antimicrobial,
tumor-inhibitory
effects.
Here,
we
discussed
advancements
in
isolation
purification
techniques,
such
as
ultracentrifugation
size-exclusion
chromatography,
which
critical
for
maintaining
functional
integrity
these
nanovesicles.
Next,
investigated
diverse
administration
routes
carefully
weighed
respective
advantages
challenges
related
bioavailability
patient
compliance.
Moreover,
elucidated
multifaceted
mechanisms
action
EVs,
including
roles
anti-inflammation,
antioxidation,
antitumor
activity,
modulation
gut
microbiota.
We
also
impact
on
specific
diseases
cancer
inflammatory
bowel
disease,
highlighting
importance
addressing
current
production
scalability,
regulatory
compliance,
immunogenicity.
Finally,
proposed
future
research
directions
optimizing
EV
extraction
developing
targeted
delivery
systems.
Through
efforts,
envision
seamless
integration
into
mainstream
medicine,
offering
safe
potent
alternatives
across
various
medical
disciplines.
Nanotechnology Reviews,
Год журнала:
2024,
Номер
13(1)
Опубликована: Янв. 1, 2024
Abstract
Childhood
rhinitis
is
an
inflammatory
condition
affecting
the
nasal
mucosa
of
children
worldwide.
The
physical,
social,
and
cognitive
performance
affected
by
chronic
symptoms
childhood
rhinitis.
Effective
treatment
essential
to
avoid
long-term
effects
on
children’s
lifestyles
well-being.
Traditional
Chinese
medicine
(TCM)
has
been
used
treat
prevent
several
illnesses,
it
plays
a
crucial
role
in
healthcare
rehabilitation.
TCM
traditionally
holistically
However,
drawbacks
TCMs,
such
as
their
poor
water
solubility,
low
bioavailability,
single-use,
targeting
ability,
severely
restrict
use.
In
recent
years,
nanotechnology
for
various
drugs
improve
therapeutic
effectiveness
reduce
associated
adverse
effects.
Nanomaterials
formulations
are
synthesized
be
compatible
with
herbal
extracts
sustain
active
component
qualities.
Nanocarrier-based
drug
delivery
improves
circulation
time,
targeted
distribution,
resolving
administration
issues.
This
review
assesses
innovative
combination
developments
rhinitis,
providing
insights
into
novel
approaches.
also
provides
significant
potential
this
multidisciplinary
approach
transform
techniques
offers
road
map
future
research
initiatives
promising
sector.
Abstract
The
treatment
of
brain
diseases
has
always
been
the
focus
attention.
Due
to
presence
blood‐brain
barrier
(BBB),
most
small
molecule
drugs
are
difficult
reach
brain,
leading
undesirable
therapeutic
outcomes.
Recently,
nanomedicines
that
can
cross
BBB
and
precisely
target
lesion
sites
have
emerged
as
thrilling
tools
enhance
early
diagnosis
treat
various
intractable
disorders.
Extensive
research
shown
reactive
oxygen
species
(ROS)
play
a
crucial
role
in
occurrence
progression
diseases,
including
tumors
neurodegenerative
(NDDs)
such
Alzheimer's
disease,
Parkinson's
stroke,
or
traumatic
injury,
making
ROS
potential
target.
In
this
review,
on
structure
function
well
mechanisms
first
elaborated
through
which
nanomedicine
traverses
it.
Then,
recent
studies
production
summarized
photodynamic
therapy
(PDT),
chemodynamic
(CDT),
sonodynamic
(SDT)
for
treating
tumors,
depletion
NDDs.
This
provides
valuable
guidance
future
design
ROS‐targeted
disease
treatment.
ongoing
challenges
perspectives
developing
nanomedicine‐based
management
also
discussed
outlined.
