Brazilian Archives of Biology and Technology, Год журнала: 2024, Номер 67
Опубликована: Янв. 1, 2024
Язык: Английский
Antioxidants, Год журнала: 2024, Номер 13(12), С. 1462 - 1462
Опубликована: Ноя. 28, 2024
Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s (AD). In these diseases, oxidative stress can disrupt blood–brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, pathogens to enter brain, leading increased ROS production, mitochondrial dysfunction, inflammation. Collectively, factors result protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. this review article, we present mechanisms by which damage leads BBB breakdown brain diseases. Additionally, summarize potential therapeutic approaches aimed at reducing that contributes
Язык: Английский
Процитировано
10
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Июнь 27, 2024
Ferroptosis, a new type of programmed cell death proposed in recent years, is characterized mainly by reactive oxygen species and iron-mediated lipid peroxidation differs from death, such as apoptosis, necrosis, autophagy. Ferroptosis associated with variety physiological pathophysiological processes. Recent studies have shown that ferroptosis can aggravate or reduce the occurrence development diseases targeting metabolic pathways signaling tumors, ischemic organ damage, other degenerative related to peroxidation. Increasing evidence suggests closely linked onset progression various ophthalmic conditions, including corneal injury, glaucoma, age-related macular degeneration, diabetic retinopathy, retinal detachment, retinoblastoma. Our review current research on reveals significant advancements our understanding pathogenesis, aetiology, treatment these conditions.
Язык: Английский
Процитировано
5
Redox Biology, Год журнала: 2025, Номер unknown, С. 103504 - 103504
Опубликована: Янв. 1, 2025
During its catalytic cycle, the homodimeric ATPase topoisomerase II alpha (TOP2A) cleaves double stranded DNA and remains covalently bound to 5' ends via tyrosine phosphodiester bonds. After passing a second, intact duplex through, TOP2A rejoins break releases from DNA. Thereby, can relieve strain accumulated during transcription, replication chromatin remodeling disentangle sister chromatids for mitosis. Chemotherapy agents such as etoposide are poisons that trap mid-cycle, cleaved DNA, leaving behind strand breaks activating damage response. While has been proposed stabilize TOP2A-DNA cleavage complex (TOP2Acc) interfacial inhibition, we have elucidated complementary mechanism mediated by ability of other induce oxidative stress. Consequently, lipid peroxidation accumulation lipid-derived electrophiles 4-hydroxynonenal (HNE) results in covalent modification TOP2A, both blocking activity trapping TOP2Acc. HNE modifies multiple sites on human vitro, including alkylating Cys216 domain DNA-dependent fashion. Taken together, our data suggest an underappreciated role redox sensor tumor cells, connecting stress signaling thereby creating target redox-active drugs.
Язык: Английский
Процитировано
0
Organic Letters, Год журнала: 2025, Номер unknown
Опубликована: Фев. 7, 2025
We report a novel photocatalyzed selective functionalization of terminal olefins for the synthesis Z-olefins and cyclobutanes under mild conditions in excellent yields. A series Z-cinnamic acid derivatives, enamines, amide-containing were efficiently synthesized using this method. Mechanistic studies indicated that success reaction is based on triple radical relay strategy, anion-π interaction aryl halide activation generation, palladium controlling chemoselectivity radical, photocatalyst stereoselectivity via diradical species, respectively.
Язык: Английский
Процитировано
0
Food Chemistry, Год журнала: 2025, Номер 479, С. 143752 - 143752
Опубликована: Март 7, 2025
Язык: Английский
Процитировано
0
Life Sciences in Space Research, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Communications Biology, Год журнала: 2025, Номер 8(1)
Опубликована: Апрель 11, 2025
Abstract Hypersaline environments, including brines and brine inclusions of evaporite crystals, are currently great interest due to their unique preservation properties for the search terrestrial potentially extraterrestrial biosignatures ancient life. However, much is still unclear about specific effects that dictate brines. Here we present first insights into cell envelope fragments in brines, characterizing relative contributions composition, UV photochemistry, cellular macromolecules on biosignature preservation. Cell envelopes from model halophile Halobacterium salinarum were used simulate dead microbial remains hypersaline environments based life as know it. Using different Early Earth Mars analogue show acidic NaCl-dominated compositions more predisposed preserving complex degradation, but composition biological material also influences this Furthermore, a combinatory effect between chaotropicity photochemistry occurs, with importance each being brine-specific. These results provide an experimental framework detection emphasizing need laboratory simulations evaluate potential environment, elsewhere solar system.
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2024, Номер 17(11), С. 1535 - 1535
Опубликована: Ноя. 15, 2024
:
Процитировано
1
Brazilian Archives of Biology and Technology, Год журнала: 2024, Номер 67
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0