Separations,
Год журнала:
2024,
Номер
11(12), С. 349 - 349
Опубликована: Дек. 11, 2024
Flavonoids
are
the
most
abundant
functional
compounds
distributed
in
higher
plants,
and
used
as
important
dietary
components
for
human
health
protection.
The
development
of
natural
flavonoids,
such
food
or
medicinal
food,
has
received
extensive
attention
recent
years.
extraction,
separation,
quantitation
flavonoids
key
techniques
utilization
flavonoid
resources.
traditional
methods
extraction
separation
always
toxic
solvents,
which
produce
residues
pollute
environment.
Based
on
an
analysis
literature
resources,
utilization,
quantitation,
green
were
summarized.
First,
by
hot
water
ethanol,
assisted
pressurization
microwave-ultrasonication,
then
concentration
precipitation
cool
ethanol
ethanol/water
specific
ratios.
This
method
could
obtain
over
85%
purity
first
cycle
95%
after
three
cycles
commonly
dihydromyricetin,
rutin,
quercetin.
In
conclusion,
showed
great
prospects
protection
disease
treatment.
Chemical
structure-based
using
water–ethanol
with
pressurization,
temperature
regulation
proved
to
be
efficient
environmentally
friendly,
showing
potential
industry.
These
“green”
processing
mechanisms
deserve
further
research.
Antioxidants,
Год журнала:
2025,
Номер
14(2), С. 200 - 200
Опубликована: Фев. 10, 2025
Polyphenols
(PPs)
are
recognized
as
bioactive
compounds
and
antimicrobial
agents,
playing
a
critical
role
in
enhancing
food
safety,
preservation,
extending
shelf
life.
The
effectiveness
of
PPs
has
different
molecular
biological
reasons,
predominantly
linked
to
their
hydroxyl
groups
electron
delocalization,
which
interact
with
microbial
cell
membranes,
proteins,
organelles.
These
interactions
may
reduce
the
efficiency
metabolic
pathways,
cause
destructive
damage
membrane,
or
they
harm
proteins
nucleic
acids
foodborne
bacteria.
Moreover,
exhibit
distinctive
ability
form
complexes
metal
ions,
further
amplifying
activity.
This
narrative
review
explores
complex
multifaceted
between
pathogens,
underlying
correlation
chemical
structures
mechanisms
action.
Such
insights
shed
light
on
potential
innovative
natural
preservatives
within
systems,
presenting
an
eco-friendly
sustainable
alternative
synthetic
additives.
Molecules,
Год журнала:
2025,
Номер
30(2), С. 257 - 257
Опубликована: Янв. 10, 2025
Vascular
endothelial
growth
factor
(VEGF),
also
known
as
VEGF-A,
has
been
linked
to
various
diseases,
such
wet
age-related
macular
degeneration
(wAMD)
and
cancer.
Even
though
there
are
VEGF
inhibitors
that
currently
commercially
available
in
clinical
applications,
severe
adverse
effects
have
associated
with
these
treatments.
There
is
still
a
need
develop
novel
VEGF-based
therapeutics
against
VEGF-related
diseases.
Here,
we
established
series
of
computational
docking
analyses
cell
models,
wound
healing
assay
HaCaT
cells
an
evaluation
NF-κB
performance
macrophages,
screen
large
library
flavonoid-type
phytochemicals.
Three
flavonoids,
namely,
farrerol,
ononin
(-)-epicatechin,
were
shown
express
binding
affinities
protein
inhibit
VEGF-mediated
biological
activities.
The
investigation
evidently
suggested
the
three
flavonoids
above
could
be
considered
potential
anti-VEGF
agents
for
following
drug
development
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2678 - 2678
Опубликована: Март 16, 2025
Despite
the
substantial
advances
in
cancer
therapies,
developing
safe
and
effective
treatment
methodologies
is
critical.
Natural
(plant-derived
compounds),
such
as
flavonoids,
might
be
crucial
a
methodology
without
toxicity
toward
healthy
tissues.
Prunin
flavonoid
with
potential
to
used
biomedical
applications.
has
yet
undergo
thorough
scientific
research,
its
precise
molecular
mechanisms
of
action
remain
largely
unexplored.
This
review
summarizes
therapeutic
prunin
for
first
time,
focusing
on
underlying
an
anticancer
compound.
gained
significant
attention
due
antioxidant,
anti-inflammatory,
effects.
aims
unlock
how
functions
at
level
exert
effects,
primarily
modulating
key
cellular
pathways.
Furthermore,
we
have
discussed
prunin’s
adjunctive
therapy
conventional
treatments,
highlighting
ability
strengthen
responses
while
decreasing
drug
resistance.
Moreover,
discussion
probes
into
innovative
delivery
methods,
particularly
nanoformulations,
that
address
bioavailability,
solubility,
stability
limitations
optimize
application.
By
providing
comprehensive
analysis
properties,
this
stimulate
further
exploration
using
agent,
thereby
progressing
development
targeted,
selective,
safe,
methods.
Current Topics in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(24), С. 2093 - 2116
Опубликована: Авг. 7, 2024
Flavonoids
are
biologically
active
chemicals
in
various
fruits,
plants,
vegetables,
and
leaves,
which
have
promising
uses
medicinal
science.
The
health
properties
of
these
natural
widely
accepted,
efforts
underway
to
extract
the
specific
components
referred
as
flavonoids.
demonstrate
a
diverse
range
bio-activities,
anticancer,
antioxidant
activity,
anti-cholinesterase
antiinflammatory
antimalarial
antidiabetic
neurodegenerative
disease,
cardiovascular
effect,
hepatoprotective
effects,
antiviral
antimicrobial
activity.
This
study
aims
examine
prevailing
trends
flavonoid
investigation
studies,
elucidate
activity
flavonoids,
their
functions
uses,
assess
potential
flavonoids
preventive
medications
for
chronic
diseases,
outline
future
research
opportunities
this
field.
review
explores
preventing
managing
diseases.
Pathophysiology,
Год журнала:
2024,
Номер
31(4), С. 596 - 607
Опубликована: Окт. 12, 2024
Angiogenesis
is
a
process
involved
in
the
formation
of
new
blood
capillaries
from
pre-existing
ones.
It
regulated
by
several
anti-angiogenic
molecules
tumor
growth
and
metastasis.
The
endothelial
angiopoietin
Ang-Tie/PI3K/AKT
receptor
pathway
necessary
for
healthy
vascular
development.
activation
AKT
controlled
multistep
involving
phosphoinositide
3-kinase
(PI3K).
This
article
aims
to
provide
an
overview
role
mechanism
signaling
pathways
potential
flavonoids
as
drugs.
Flavonoids
have
shown
great
preventing
angiogenesis
targeting
exhibit
additional
anti-cancer
properties.
Research
studies
revealed
that
currently
available
drugs
do
not
meet
safety
efficacy
standards
treating
growth.
Phytocompounds
long
been
valuable
resource
development
novel
therapeutic
explores
recent
findings
explaining
pathways,
well
interaction
with
angiogenic
approach.
Several
investigations
synergistic
natural
phytocompounds
target
these
inhibit
Therefore,
flavonoid-based
medications
may
offer
more
effective
strategy
treat
cancer.
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2405 - 2405
Опубликована: Окт. 21, 2024
Apigenin
is
an
organic
flavonoid
abundant
in
some
plants
such
as
parsley,
chamomile,
or
celery.
Recently,
it
has
been
investigated
for
several
of
its
pharmacological
characteristics,
ability
to
act
antioxidant,
reduce
inflammation,
and
inhibit
the
growth
cancer
cells.
The
purpose
this
review
provide
a
summary
existing
knowledge
regarding
effects
apigenin
on
female
reproductive
systems
dysfunctions.
can
influence
processes
by
regulating
multiple
biological
events,
including
oxidative
processes,
cell
proliferation,
apoptosis,
renewal
viability,
ovarian
blood
supply,
release
hormones.
It
could
stimulate
folliculogenesis,
well
embryonal
proliferation
which
lead
increase
fertility
hormones,
may
exert
health.
Furthermore,
activities
cells
alleviate
pathological
changes
system
caused
environmental
pollutants,
harmful
medications,
cancer,
polycystic
syndrome,
ischemia,
endometriosis.
Therefore,
have
potential
biostimulator
therapeutic
agent
certain
diseases.
Ovarian
cancer
is
a
leading
cause
of
mortality
among
women
with
gynecological
malignancies,
largely
due
to
its
asymptomatic
nature
in
early
stages
and
frequent
late
diagnosis.
Targeted
therapies,
such
as
angiogenesis
inhibitors
poly(ADP-ribose)
polymerase
(PARPi),
have
emerged
promising
treatments
by
disrupting
tumor
vasculature
impairing
DNA
repair
mechanisms,
particularly
patients
BRCA
mutations.
The
objective
the
present
study
was
comprehensively
evaluate
combined
use
different
PARPi
ovarian
treatment
meta-analysis.
This
included
assessing
their
impact
on
response
rate
(ORR)
progression-free
survival
(PFS),
understanding
role
mutation
status,
comparing
effects
various
when
used
combination
PARPi.
PubMed,
Embase
Cochrane
databases
were
searched
from
inception
February
2024.
Only
studies
included.
Duplicate
studies,
incomplete
data,
animal
literature
reviews
systematic
excluded.
results
underscored
noteworthy
improvement
ORR
median
PFS
(mPFS)
receiving
therapy
compared
those
monotherapy.
Specifically,
pooled
for
significantly
higher
than
that
monotherapy,
indicating
substantial
benefit
terms
response.
Furthermore,
found
prolong
PFS,
offering
longer
duration
without
disease
progression.
Subgroup
analyses
treated
provided
deeper
insights,
revealing
mutations
exhibited
an
90%
61%
Additionally,
compared,
anti-VEGF
agents
showed
mPFS
(15.53
months)
TKIs
(7.49
months).
In
conclusion,
demonstrates
combinations
show
great
potential
improving
outcomes
cancer,
observed
differences
efficacy
between
highlight
importance
personalized
approaches.
Further
research
warranted
explore
long-term
benefits
these
strategies
refine
them
obtain
optimal
patient
outcomes.
