Molecules,
Год журнала:
2024,
Номер
30(1), С. 71 - 71
Опубликована: Дек. 28, 2024
The
gut–brain
axis
(GBA)
is
a
complex
communication
network
connecting
the
gastrointestinal
tract
(GIT)
and
central
nervous
system
(CNS)
through
neuronal,
endocrine,
metabolic,
immune
pathways.
Omega-3
(n-3)
fatty
acids,
particularly
eicosapentaenoic
acid
(EPA)
docosahexaenoic
(DHA),
are
crucial
food
components
that
may
modulate
function
of
this
molecular
mechanisms.
Derived
mainly
from
marine
sources,
these
long-chain
polyunsaturated
acids
integral
to
cell
membrane
structure,
enhancing
fluidity
influencing
neurotransmitter
signal
transduction.
Additionally,
n-3
inflammation
by
altering
eicosanoid
production,
reducing
proinflammatory
cytokines,
promoting
anti-inflammatory
mediators.
These
actions
help
preserve
integrity
cellular
barriers
like
intestinal
blood–brain
barriers.
In
CNS,
EPA
DHA
support
neurogenesis,
synaptic
plasticity,
neurotransmission,
improving
cognitive
functions.
They
also
regulate
hypothalamic–pituitary–adrenal
(HPA)
excessive
cortisol
associated
with
stress
responses
mental
health
disorders.
Furthermore,
influence
composition
gut
microbiota,
beneficial
bacterial
populations
abundance
contribute
improve
systemic
immunity.
Their
multifaceted
roles
within
GBA
underscore
their
significance
in
maintaining
homeostasis
supporting
well-being.
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 270 - 270
Опубликована: Фев. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Designed Monomers & Polymers,
Год журнала:
2024,
Номер
28(1), С. 1 - 34
Опубликована: Дек. 31, 2024
This
review
paper
analyzes
recent
advancements
in
bio-polymer
coatings
for
probiotic
microencapsulation,
with
a
particular
emphasis
on
chitosan
and
its
synergistic
combinations
other
materials.
Probiotic
microencapsulation
is
essential
protecting
probiotics
from
environmental
stresses,
enhancing
their
stability,
ensuring
effective
delivery
to
the
gut.
The
begins
an
overview
of
highlighting
significance
safeguarding
through
processing,
storage,
gastrointestinal
transit.
Advances
chitosan-based
encapsulation
are
explored,
including
integration
bio-polymers
such
as
alginate,
gelatin,
pectin,
well
application
nanotechnology
innovative
techniques
like
spray
drying
layer-by-layer
assembly.
Detailed
mechanistic
insights
integrated,
illustrating
how
influences
gut
microbiota
by
promoting
beneficial
bacteria
suppressing
pathogens,
thus
role
prebiotic
or
synbiotic.
Furthermore,
delves
into
chitosan's
immunomodulatory
effects,
particularly
context
inflammatory
bowel
disease
(IBD)
autoimmune
diseases,
describing
immune
signaling
pathways
influenced
linking
changes
improvements
systemic
immunity.
Recent
clinical
trials
human
studies
assessing
efficacy
chitosan-coated
presented,
alongside
discussion
practical
applications
comparison
vitro
vivo
findings
highlight
real-world
relevance.
sustainability
sources
impact
addressed,
along
novel
concept
gut-brain
axis.
Finally,
emphasizes
future
research
needs,
development
personalized
therapies
exploration
techniques.
OBM Neurobiology,
Год журнала:
2025,
Номер
09(01), С. 1 - 12
Опубликована: Фев. 28, 2025
Interactions
in
the
gut-brain
crosstalk
have
led
to
development
of
an
entirely
new
concept:
"microbiota-gut-brain
axis".
Microbiota
has
gained
considerable
attention
relation
disorders
a
more
neurological
nature,
such
as
neurodevelopmental
and
neuropsychiatric
illnesses
like
autism
spectrum
disorder,
anxiety,
mood
disorders.
This
review
aims
summarize
recent
trends
insights
into
role
consequences
gut
microbiota
brain
health
pediatric
Dysbiosis
may
be
associated
with
increased
risk
diseases
that
lead
different
disruptions
conditions,
including
mental
issues.
During
dysbiosis,
neuropsychological
stress
hormones
usually
affect
oxytocin
GABA
neurons
are
significantly
reduced.
Current
studies
report
major
depression,
cognitive
dysfunction
closely
dysbiosis.
In
last
few
years,
handful
clinical
emerged,
illustrating
potential
for
bidirectional
relationship
interactions
humans.
Perhaps
some
most
crucial
investigations
demonstrating
overlapping
relationships
human
axis
come
from
trials
focusing
on
modulating
noting
significant
correlates.
A
field
is
emerging
gene-editing
technology
could
represent
tool
improve
microbial
characteristics.
approach
particularly
relevant
neurodegenerative
brain-gut
linked
loss
species
and/or
high
pathobiont
load.
Neurodevelopmental
disorders
(NDDs)
encompass
a
range
of
disruptive
conditions
with
varying
prevalence
rates
and
multiple
contributing
factors.
Recent
studies
have
suggested
potential
connection
between
NDDs
the
gut-brain
axis.
Furthermore,
there
is
evidence
indicating
that
nutritional
supplements
might
an
impact
on
gastrointestinal
(GI)
behavioral
symptoms.
This
study
aimed
to
explore
effects
gut
microbiota
symptoms
in
individuals
NDDs.
A
systematic
search
databases
such
as
PubMed,
Scopus,
Web
Science,
Embase,
APA
PsycINFO
was
conducted,
utilizing
relevant
keywords
until
February
2025.
In
addition,
for
gray
literature
carried
out
Google
Scholar
ProQuest.
The
risk
bias
assessed
using
ROBINS-I
tool
non-randomized
RoB-1
randomized
controlled
trials.
Due
heterogeneity
studies,
Synthesis
without
Meta-analysis
(SWiM)
approach
employed.
overall
findings
from
indicated
positive
supplementation
reducing
Gastrointestinal
Severity
Index
(GIS)
score
alleviating
GI
Supplementation
probiotics
vitamins
increased
good
microbiomes
(GM)
decrease
bad
(BM)
among
autism
spectrum
disorder
(ASD).
Moreover,
Firmicutes
Bacteroidetes
ratio
(F/R
ratio)
exhibited
significant
changes
after
supplementation.
Additionally,
improvements
were
observed
various
assessment
scores,
including
ATEC,
ABC,
CARS,
PGI-2.
Nutritional
can
influence
by
modulating
microbiome,
dysbiosis,
enhancing
barrier
integrity.
Shifting
F/R
be
considered
reason
improving
influencing
neurotransmitter
activity
neuroinflammation.
Targeting
axis
interventions
focus
offers
promising
adjunct
therapy
management
NDD.
Registration
review
protocol.
PROSPERO
registration
no.
CRD42023460449.
Journal of Food Science,
Год журнала:
2025,
Номер
90(3)
Опубликована: Март 1, 2025
Abstract
Intermittent
fasting
(IF)
is
an
eating
pattern
that
promotes
health
and
cognitive
improvement
through
periodic
eating.
It
has
been
shown
to
enhance
neuroplasticity
reduce
oxidative
stress
inflammation.
Recent
studies
have
demonstrated
probiotic
supplementation
enhances
performance
by
modulating
gut
microbiota
composition
increasing
short‐chain
fatty
acid
production,
which
in
turn
neurogenesis
synaptic
plasticity.
The
microbiota‐gut‐brain
axis
(MGBA)
the
communication
bridge
between
brain,
influencing
function
immune,
endocrine,
nervous
systems.
combination
of
probiotics
IF
may
exert
complementary
effects
on
function,
with
enhancing
microbial
diversity
metabolic
efficiency,
while
further
modulate
barrier
integrity
neurotransmitter
synthesis.
This
review
critically
examines
interplay
via
MGBA,
identifying
key
mechanisms
potential
therapeutic
strategies
remain
underexplored
current
research.
