Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products DOI Creative Commons
Guo Chen, Ya Zhang,

Y.‐H. Zhou

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 10421 - 10440

Published: Dec. 1, 2024

Despite advancements in cancer treatment through surgery and drugs, hepatocellular carcinoma (HCC) remains a significant challenge, as reflected by its low survival rates. The mammalian target of rapamycin (mTOR) signaling pathway plays crucial role regulating the cell cycle, proliferation, apoptosis, metabolism. Notably, dysregulation leading to activation mTOR is common HCC, making it key focus for in-depth research current therapeutic strategies. This review focuses on downstream effectors HCC autophagy, metabolic reprogramming. Moreover, emphasizes potential natural products modulators pathway. When incorporated into combination therapies, these have been demonstrated augment efficacy surmount drug resistance. These pathways such pathways. Examples include 11-epi-sinulariolide acetate, matrine, asparagus polysaccharide. Their inhibitory effects processes suggest valuable directions development more effective Various ability inhibit suppress progression. phytochemicals, functioning inhibitors, hold great promise anti-HCC agents, especially context overcoming chemoresistance enhancing outcomes therapies.

Language: Английский

Protective Effects of Oleanolic Acid on Human Keratinocytes: A Defense Against Exogenous Damage DOI Creative Commons
Marzia Vasarri, Maria Camilla Bergonzi, Manuela Leri

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 238 - 238

Published: Feb. 11, 2025

Background/objectives: Aging leads to increased oxidative stress and chronic inflammation in the skin, which contribute various disorders such as dermatitis cancer. This study explores cytoprotective effects of oleanolic acid (OA), a natural triterpenoid compound known for its potential mitigating damage, on human keratinocyte (HaCaT) cells exposed from tert-butyl hydroperoxide (tBHP). Methods: Using vitro experiments, we assessed cell viability, reactive oxygen species (ROS) levels, nitric oxide (NO) production, protein expression following OA pre-treatment. Advanced imaging techniques were employed visualize localization. Results: Results demonstrated that significantly improved viability reduced intracellular ROS levels compared with those controls. Additionally, inhibited inducible synthase (iNOS) subsequent release, indicating modulation inflammatory responses. Notably, while tBHP activated Nrf2/HO-1 signaling pathway, did not enhance this response, suggesting exerts through mechanisms independent Nrf2 activation. Conclusion: shows promise protecting HaCaT tBHP-induced stress, highlighting role promoting skin health addressing aging-related damage. The proposes operates pathways distinct MAPKs, paving way new therapeutic strategies aimed at improving against stress.

Language: Английский

Citations

1
In-Silico Investigation of Eleusine coracana Phytocompounds as Prostate Cancer Therapeutics Targeting Heat Shock Protein 90 Alpha Family Protein DOI
Saba Parveen, Praveen Kumar,

Akshat H. Rathi

et al.

Journal of Computational Biophysics and Chemistry, Journal Year: 2025, Volume and Issue: 24(07), P. 933 - 948

Published: Jan. 9, 2025

The major cause of death among men comes from prostate cancer which contributes a significant portion to the rate mortality. therapeutics including surgery, radiation, and chemotherapy, are often effective but can have an adverse side effect on patient’s body. Numerous medicinal plants available that contain therapeutic values combat against cancer. compounds Eleusine coracana known possess numerous properties. Moreover, plant is also promising anticancer effects. This work involved screening phytocompounds E. Indian database, IMPAAT, investigate their ability as activators HSP90AA1. in silico tools, such PASS Online server pkCSM software were used anticipate anticancerous activity ADMET properties, respectively. Molecular docking was determine binding energies validate interaction between ligands All active substances, isovitexin, vitexin, triglochinin, caffeic acid stigmasterol, affinity for HSP90AA1 pocket demonstrate suitable array drug-like characteristics. Furthermore, MD simulation confirmed protein-ligand complex’s stability, dynamic behavior conformational changes. Taken together, stigmasterol might be designing potential drug molecules targeting Nonetheless, hold great development novel, less toxic agents management.

Language: Английский

Citations

0
New Derivatives of Oleanolic Acid: Semi-Synthesis and Evaluation of Their Anti-15-LOX, Anti-α-Glucosidase and Anticancer Activities and Molecular Docking Studies DOI Creative Commons

Nahla Triaa,

Salma Jlizi,

Mansour Znati

et al.

Chemistry, Journal Year: 2025, Volume and Issue: 7(2), P. 36 - 36

Published: March 7, 2025

A novel series of oleanolic acid (OA, 1) derivatives incorporating phenolic and coumarin moieties were synthesized. This was extracted from olive pomace (Olea europaea L.) using an ultrasound-assisted method. The structures these OA characterized through the utilization 1H-NMR, 13C-NMR ESI-HRMS analyses. An evaluation some biological activities prepared conducted. focused principally on capacity to inhibit 15-lipoxygenase α-glucosidase, as well their anticancer properties when tested against tumour cell lines (HCT-116 LS-174T) a non-tumour line (HEK-293). In terms cytotoxic activity, majority compounds exhibited notable inhibitory effects compared starting molecule, OA. Derivatives 4d, 4k 4m particularly strong HCT-116 line, with IC₅₀ values 38.5, 39.3, 40.0 µM, respectively. 4l, 4e 5d demonstrated most effective inhibition LS-174T IC50 44.0, 44.3, 38.0 However, compound 2a effective, exhibiting potent 52.4 59.5 Furthermore, molecular docking studies supported in vitro revealing that low binding energies interacted effectively within EGFR enzyme’s active pocket (PDB: 1M17). These findings highlight potential agents enzymatic inhibitors, warranting further investigation.

Language: Английский

Citations

0
Synthesis of novel bioactive amides derived from carbazole moiety with deep-blue and single-component white photoluminescence DOI
Mostafa Ahmed, Mostafa Sayed, Ahmed F. Al‐Hossainy

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 116394 - 116394

Published: March 1, 2025

Language: Английский

Citations

0
Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products DOI Creative Commons
Guo Chen, Ya Zhang,

Y.‐H. Zhou

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 10421 - 10440

Published: Dec. 1, 2024

Despite advancements in cancer treatment through surgery and drugs, hepatocellular carcinoma (HCC) remains a significant challenge, as reflected by its low survival rates. The mammalian target of rapamycin (mTOR) signaling pathway plays crucial role regulating the cell cycle, proliferation, apoptosis, metabolism. Notably, dysregulation leading to activation mTOR is common HCC, making it key focus for in-depth research current therapeutic strategies. This review focuses on downstream effectors HCC autophagy, metabolic reprogramming. Moreover, emphasizes potential natural products modulators pathway. When incorporated into combination therapies, these have been demonstrated augment efficacy surmount drug resistance. These pathways such pathways. Examples include 11-epi-sinulariolide acetate, matrine, asparagus polysaccharide. Their inhibitory effects processes suggest valuable directions development more effective Various ability inhibit suppress progression. phytochemicals, functioning inhibitors, hold great promise anti-HCC agents, especially context overcoming chemoresistance enhancing outcomes therapies.

Language: Английский

Citations

2