Cyclodextrins: Enhancing Drug Delivery, Solubility and Bioavailability for Modern Therapeutics
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 288 - 288
Опубликована: Фев. 22, 2025
Cyclodextrins
(CDs)
have
revolutionized
the
pharmaceutical
industry
with
their
ability
to
enhance
stability,
solubility,
and
bioavailability
of
a
wide
range
active
substances.
These
cyclic
oligosaccharides,
unique
hydrophilic
exterior
hydrophobic
cavity,
form
inclusion
complexes
poorly
soluble
drugs,
improving
pharmacokinetic
profiles
therapeutic
efficacy.
This
review
explores
multifaceted
roles
cyclodextrins
in
formulations,
ranging
from
oral,
ophthalmic,
parenteral,
topical
applications
emerging
use
targeted
therapies,
gene
delivery,
treatment
neurodegenerative,
cardiovascular,
infectious
diseases.
not
only
improve
drug
solubility
controlled
release
but
also
reduce
toxicity
side
effects,
leading
safer
more
effective
treatments.
Recent
advancements,
such
as
cyclodextrin-based
nanoparticles,
offer
promising
pathways
for
cancer
therapy,
chronic
disease
management,
personalized
medicine.
As
research
continues,
remain
at
forefront
innovation
delivery
systems,
ensuring
better
patient
outcomes
expanding
possibilities
modern
therapeutics.
Язык: Английский
Ashwagandha: Optimizing the Extraction and Electrospun Nanofiber Production
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 61 - 61
Опубликована: Янв. 5, 2025
Background/Objectives:
This
study
explores
the
development
of
electrospun
nanofibers
incorporating
bioactive
compounds
from
Withania
somnifera
(Ashwagandha)
root
extract,
focusing
on
optimizing
extraction
conditions
and
nanofiber
composition
to
maximize
biological
activity
application
potential.
Methods:
Using
Design
Experiment
(DoE)
approach,
optimal
parameters
were
identified
as
80%
methanol,
70
°C,
60
min,
yielding
high
levels
phenolic
antioxidant
activity.
Methanol
concentration
emerged
critical
factor
influencing
phytochemical
properties.
Electrospinning
technology
was
employed
produce
using
polyvinylpyrrolidone
(PVP)
hydroxypropyl-β-cyclodextrin
(HPβCD)
carriers,
ensuring
encapsulation,
stabilization,
an
enhanced
bioavailability
active
compounds.
Results:
Nanofibers
demonstrated
a
surface-to-volume
ratio,
rapid
dissolution,
significant
mucoadhesive
properties,
making
them
suitable
for
oral
mucosal
applications.
The
determined
be
2.5
mL
25%
PVP,
extract-to-HPβCD
ratio
1:0.6.
Statistical
modeling
confirmed
that
electrospinning
process
did
not
compromise
or
anti-inflammatory
properties
with
extract
content
being
primary
determinant
Conclusions:
These
findings
highlight
potential
integrating
advanced
techniques
nanotechnology
develop
innovative
delivery
systems
traditional
herbal
remedies.
developed
offer
promising
applications
in
pharmaceuticals,
cosmetics,
functional
foods,
paving
way
scalable
efficient
utilization
Ashwagandha
bioactives.
Язык: Английский
Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile Acid Levels
Molecules,
Год журнала:
2025,
Номер
30(2), С. 281 - 281
Опубликована: Янв. 13, 2025
Our
previous
study
demonstrated
that
γ-cyclodextrin
(γ-CD)–perilla
oil
inclusion
complexes
increase
plasma
α-linolenic
acid
and
eicosapentaenoic
levels
in
healthy
rats
without
adverse
effects.
The
present
examined
the
effects
of
perilla
oil,
γ-CD,
their
on
fed
cholic
(CA)
to
mimic
elevated
gastrointestinal
12-hydroxylated
(12OH)
bile
high-fat
diet-fed
rats.
Rats
CA
(CA
group)
tended
have
higher
AST,
ALT,
total
cholesterol
(T-CHO),
triglyceride
(TG)
compared
controls
a
standard
diet
CA.
(CA+LP
showed
tendency
for
lower
AST
TG
than
those
group.
γ-CD
(CA+CD
had
significantly
T-CHO,
controls,
indicating
severe
liver
injury
dyslipidemia.
γ-CD–perilla
complex
(CA+IC
ALT
CA+CD
rats,
with
trend
towards
T-CHO
levels.
Plasma
were
CA+LP
CA+IC
groups
groups.
However,
group
This
suggests
an
accelerated
conversion
group,
which
may
contribute
attenuation
These
findings
suggest
exacerbate
dyslipidemia
caused
by
12OH
levels,
whereas
ameliorate
these
altering
fatty
metabolism.
Furthermore,
we
recommend
evaluating
safety
both
pathological
models
carefully
selecting
compounds
co-ingested
γ-CD.
Язык: Английский
Approaches for Inclusion Complexes of Ezetimibe with Cyclodextrins: Strategies for Solubility Enhancement and Interaction Analysis via Molecular Docking
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1686 - 1686
Опубликована: Фев. 16, 2025
This
study
aimed
to
improve
the
solubility
of
ezetimibe
(EZT),
which
has
low
aqueous
solubility,
by
preparing
complexes
using
β-cyclodextrin
(β-CD)
derivatives.
Phase
studies
and
Job's
plot
confirmed
a
high
apparent
stability
constant
for
EZT
with
β-CD
even
higher
constants
its
derivatives,
establishing
1:1
stoichiometric
ratio.
The
composites
were
prepared
spray
drying
over
range
molar
ratios,
their
physicochemical
properties
evaluated
techniques
such
as
scanning
electron
microscopy
(SEM),
powder
X-ray
diffraction
(PXRD),
Fourier
transform
infrared
spectroscopy
(FT-IR).
Saturation
in
vitro
dissolution
tests
revealed
that
increased
CD
ratios.
EZT/RM-β-CD
inclusion
(ICs)
EZT/DM-β-CD
ICs
exhibited
similar
was
greater
than
EZT/HP-β-CD
EZT/SBE-β-CD
(where
RM,
DM,
HP,
SEB
represent
H,
CH3,
-CH2-CHOH-CH3
-(CH2)4-SO3Na
synthetic
respectively).
Most
complexes,
except
at
1:2
or
showed
superior
compared
commercial
products.
Molecular
docking
simulations
within
CD,
revealing
hydrogen
bonds
binding
energies
aligned
trends.
These
findings
suggest
derivatives
significantly
highlighting
potential
developing
more
effective
oral
solid
formulations
hyperlipidemia
treatment.
Язык: Английский
Enhancing the Solubility of Isoconazole Nitrate Using Methyl-β-Cyclodextrin: Formulation and Characterization of Inclusion Complexes
Molecules,
Год журнала:
2025,
Номер
30(8), С. 1654 - 1654
Опубликована: Апрель 8, 2025
Isoconazole
nitrate
(ISN)
is
a
broad-spectrum
antifungal
agent
whose
therapeutic
potential
limited
by
poor
aqueous
solubility
and
low
bioavailability.
This
study
aimed
to
enhance
the
physicochemical
properties
of
ISN
through
formation
inclusion
complexes
with
methyl-β-cyclodextrin
(M-β-CD)
using
freeze-drying
(FD)
spray-drying
(SD)
methods.
The
prepared
were
comprehensively
characterized
high-performance
liquid
chromatography
(HPLC),
phase
analysis,
scanning
electron
microscopy
(SEM),
differential
calorimetry
(DSC),
Fourier-transform
infrared
spectroscopy
(FT-IR),
proton
nuclear
magnetic
resonance
(1H-NMR).
Phase
studies
revealed
an
AL-type
diagram
1:1
molar
ratio
apparent
stability
constant
(KS)
2711
M−1.
Structural
thermal
analyses
confirmed
successful
complex
reduced
crystallinity.
assessment
showed
that
ISN/M-β-CD
SD
exhibited
approximately
seven-fold
higher
than
performed
better
those
FD.
Moreover,
demonstrated
drug
content.
These
findings
highlight
M-β-CD-based
complexation,
particularly
via
spray-drying,
as
effective
strategy
bioavailability
poorly
water-soluble
drugs,
such
ISN.
Язык: Английский
Fabrication and Characterization of Co-Sensitized Dye Solar Cells Incorporating Cyclodextrin Functional Layers with Energy Transfer from Spiropyran Derivatives to Sq2-Dye
Опубликована: Янв. 1, 2025
Язык: Английский
Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 506 - 506
Опубликована: Апрель 11, 2025
Cyclodextrins
(CDs)
have
largely
been
investigated
during
the
last
decades
for
their
outstanding
properties,
such
as
biocompatibility
and
biodegradability,
with
wide
applications
in
pharmaceutical
field,
among
which
formation
of
inclusion
complexes
(ICs)
natural
or
synthetic
lipophilic
compounds.
This
review
prioritizes
research
recent
years
(2022–2025),
being
focused
on
(1)
systematization
ICs
based
structure
secondary
metabolite,
namely
(i)
polyphenols
(PPs),
(ii)
terpenes
terpenoids
(TTs),
(iii)
alkaloids
(Alks);
(2)
each
type
complex,
following
aspects
discussed:
benefits
complexation,
composite
materials,
vitro/in
vivo
theoretical
studies;
(3)
pharmacokinetics
pharmacodynamics,
risks,
limitations,
perspectives
cyclodextrin
metabolites.
Язык: Английский