Recent Advancements in Materials and Coatings for Biomedical Implants

Gels, Год журнала: 2022, Номер 8(5), С. 323 - 323

Опубликована: Май 21, 2022

Metallic materials such as stainless steel (SS), titanium (Ti), magnesium (Mg) alloys, and cobalt-chromium (Co-Cr) alloys are widely used biomaterials for implant applications. implants sometimes fail in surgeries due to inadequate biocompatibility, faster degradation rate (Mg-based alloys), inflammatory response, infections, inertness (SS, Ti, Co-Cr lower corrosion resistance, elastic modulus mismatch, excessive wear, shielding stress. Therefore, address this problem, it is necessary develop a method improve the biofunctionalization of metallic surfaces by changing materials’ surface morphology without altering mechanical properties implants. Among various methods, modification on applying coatings an effective way material performance. In review, we discuss recent developments ceramics, polymers, Their biocompatibility also discussed. The trends biomedical implants, applications, their future directions were discussed detail.

Язык: Английский

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Bone/cartilage targeted hydrogel: Strategies and applications

Bioactive Materials, Год журнала: 2022, Номер 23, С. 156 - 169

Опубликована: Ноя. 11, 2022

The skeletal system is responsible for weight-bearing, organ protection, and movement. Bone diseases caused by trauma, infection, aging can seriously affect a patient's quality of life. targeted biomaterials are suitable the treatment bone diseases. Biomaterials with bone-targeted properties improve drug utilization reduce side effects. A large number micro-nano materials have been developed. However, only few studies addressed hydrogel. size hydrogel makes it difficult to achieve systematic targeting. local still has significant prospects. Molecules in bone/cartilage extracellular matrix cells provide binding sites Drug delivery systems featuring microgels targeting key construction strategy Besides, injectable depot carrying drugs another strategy. In this review, we summarize through application environment, strategies disease applications. We hope article will reference development hydrogels. also could increase awareness materials.

Язык: Английский

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Osteosarcoma mechanobiology and therapeutic targets

British Journal of Pharmacology, Год журнала: 2021, Номер 179(2), С. 201 - 217

Опубликована: Окт. 22, 2021

Osteosarcoma is one of the most common primary tumours bone, with a 5-year survival rate less than 20% after development metastases. highly predisposed in Paget's disease and both have characteristic skeletal features due to rapid bone remodelling. prognosis location dependent, which further emphasizes likely contribution microenvironment its pathogenesis. Mechanobiology describes processes involved when mechanical cues from changing physical are transduced biological pathways through mechanosensitive cellular components. Mechanobiology-driven therapies been used curb tumour progression by direct alteration or inhibition metastasis-associated proteins. This review mechanobiology osteosarcoma sheds light on current mechanobiology-based potential new targets for improving management. Additionally, many different 3D models currently study summarized.

Язык: Английский

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New Insights of Scaffolds Based on Hydrogels in Tissue Engineering

Polymers, Год журнала: 2022, Номер 14(4), С. 799 - 799

Опубликована: Фев. 18, 2022

In recent years, biomaterials development and characterization for new applications in regenerative medicine or controlled release represent one of the biggest challenges. Tissue engineering is most intensively studied domain where hydrogels are considered optimum biomedical field. The delicate nature their low mechanical strength limit exploitation tissue engineering. Hence, developing new, stronger, more stable with increased biocompatibility, essential. However, both natural synthetic polymers possess many limitations. Hydrogels based on offer particularly high biocompatibility biodegradability, immunogenicity, excellent cytocompatibility, variable, controllable solubility. At same time, they have poor properties, production costs, reproducibility. Synthetic come to aid through superior strength, reproducibility, reduced ability regulate composition improve processes such as hydrolysis biodegradation over variable periods. mixtures can lead optimization properties obtain ideal scaffolds. Also, incorporating different nanoparticles hydrogel's stability several biological effects. this regard, essential oils drug molecules facilitate desired effect even produce a synergistic effect. This study's main purpose establish needed develop sustainable polymeric These scaffolds be applied regeneration process without producing other side effects environment.

Язык: Английский

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Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Язык: Английский

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3D-printed alginate-hydroxyapatite aerogel scaffolds for bone tissue engineering

Materials Science and Engineering C, Год журнала: 2021, Номер 131, С. 112525 - 112525

Опубликована: Окт. 28, 2021

3D-printing technology allows the automated and reproducible manufacturing of functional structures for tissue engineering with customized geometries compositions by depositing materials layer-by-layer high precision. For these purposes, production bioactive gel-based 3D-scaffolds made biocompatible well-defined internal structure comprising a dual (mesoporous macroporous) highly interconnected porosity is essential. In this work, aerogel scaffolds bone regeneration purposes were obtained an innovative strategy that combines alginate-hydroxyapatite (HA) hydrogels supercritical CO2 drying gels. BET SEM analyses performed to assess textural parameters dimensional accuracy original computer-aided design (CAD) was also evaluated. The biological characterization carried out regarding cell viability, adhesion migration capacity. alginate-HA porous, biocompatible, fidelity CAD-pattern allowed attachment proliferation mesenchymal stem cells (MSCs). An enhancement fibroblast toward damaged area observed in presence formulations tested, which positive terms regeneration.

Язык: Английский

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Stimuli-responsive dynamic hydrogels: design, properties and tissue engineering applications

Materials Horizons, Год журнала: 2023, Номер 10(9), С. 3325 - 3350

Опубликована: Янв. 1, 2023

This review provides a brief overview of the recent developments in hydrogel systems that respond dynamically to various stimuli, including some interesting fabrication strategies, and their application cardiac, bone, neural tissue regeneration.

Язык: Английский

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Printability of hybridized composite from maleic acid-treated bacterial cellulose with gelatin for bone tissue regeneration

Advanced Composites and Hybrid Materials, Год журнала: 2023, Номер 6(4)

Опубликована: Июль 5, 2023

Язык: Английский

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Potential use of propolis-loaded quaternized chitosan/pectin hydrogel films as wound dressings: Preparation, characterization, antibacterial evaluation, and in vitro healing assay

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 241, С. 124633 - 124633

Опубликована: Апрель 28, 2023

Язык: Английский

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Hydrogel-integrated graphene superstructures for tissue engineering: From periodontal to neural regeneration

Carbon, Год журнала: 2024, Номер 223, С. 118970 - 118970

Опубликована: Фев. 26, 2024

Hydrogel-integrated graphene superstructures (GSSs) represent a promising platform for applications in tissue engineering and regenerative medicine. Graphene, two-dimensional carbon-based material, possesses remarkable mechanical, thermal, electrical characteristics, making it strong candidate application biomedicine. Researchers have pursued the integration of with hydrogels, known their biocompatibility ability to provide conducive environment cellular growth, craft sophisticated scaffolds tailored needs. The hydrogels enables construction 3D frameworks that closely mimic natural extracellular matrix (ECM) found biological tissues. Hydrogels furnish biocompatible, well-hydrated environment, while component bolsters scaffold's mechanical integrity conductivity. This amalgamation enhances adhesion, differentiation, proliferation, thereby facilitating regeneration. A notable advantage hydrogel-integrated GSSs lies capacity support growth differentiation variety cell types such as PC12, MG-63, U-87, MC3T3-E1 lines. Overall, exhibit great potential advancing biomimetic combination unique properties development advanced scaffold systems Further research this domain will play crucial role medicine treatment various diseases injuries.

Язык: Английский

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