European Polymer Journal, Год журнала: 2024, Номер 219, С. 113400 - 113400
Опубликована: Авг. 30, 2024
Язык: Английский
Polymers, Год журнала: 2022, Номер 14(15), С. 3023 - 3023
Опубликована: Июль 26, 2022
Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced solved. Hydrogels have been proposed excellent candidates these they promising properties the mentioned including biocompatibility, biodegradability, great absorption capacity tunable mechanical properties. However, depending on material or manufacturing method, resulting hydrogel may not up to specific task it is designed, thus different approaches enhance performance requirements of application in question. The main purpose this review article was summarize most recent trends technology, going through used polymeric materials popular synthesis methods years, strategies enhancing hydrogels' properties, cross-linking manufacture composite hydrogels. In addition, secondary objective briefly discuss other novel applications hydrogels that past few years drawn a lot attention.
Язык: Английский
Процитировано
209
Chemistry - An Asian Journal, Год журнала: 2022, Номер 17(21)
Опубликована: Сен. 6, 2022
The development of ideal wound dressing with excellent properties, such as exudate absorption capacity, drug release control ability, and increased healing, is currently a major requirement for healing. Polyvinyl alcohol (PVA) biodegradable semi-crystalline synthetic polymer that has been used in the field biotechnology tissue regeneration, dressing, delivery systems. In recent years, PVA-based materials have received considerable attention due to their properties biodegradability, biocompatibility, non-toxicity low cost. PVA can be material create necessary moist environment, improve physical increase healing rates. addition, also mixed other organic inorganic This review article addresses role biomaterials based on ingredients dressing. It focuses its use dressings carriers active substances.
Язык: Английский
Процитировано
102
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15397 - 15397
Опубликована: Окт. 20, 2023
In recent years, interest in nanotechnology has increased exponentially due to enhanced progress and technological innovation. tissue engineering, the development of metallic nanoparticles been amplified, especially their antibacterial properties. Another important characteristic metal NPs is that they enable high control over features developed scaffolds (optimizing mechanical strength offering controlled release bioactive agents). Currently, main concern related method synthesis oxide environmental impact. The physical chemical uses toxic agents could generate hazards or exert carcinogenicity/environmental toxicity. Therefore, a greener, cleaner, more reliable approach needed. Green synthetic come as solution counter aforementioned limitations. Nowadays, green preferred because it leads prevention/minimization waste, reduction derivatives/pollution, use non-toxic (safer) solvents. This not only biomass sources reducing for salts. biomolecules also cover synthesized act situ capping agents. Further, involvement formation process reduces toxicity, prevents nanoparticle agglomeration, improves antimicrobial activity nanomaterial, leading possible synergistic effect. study aims provide comprehensive review nanoparticles, from routes, selected solvents, parameters latest application biomedical field.
Язык: Английский
Процитировано
91
Marine Drugs, Год журнала: 2023, Номер 21(3), С. 177 - 177
Опубликована: Март 13, 2023
Alginate is a natural polymer of marine origin and, due to its exceptional properties, has great importance as an essential component for the preparation hydrogels and scaffolds biomedical applications. The design biologically interactive with advanced, expected required properties are one key issues successful outcomes in healing injured tissues. This review paper presents multifunctional applications alginate-based selected areas, highlighting effect alginate influence on first part covers scientific achievements dermal tissue regeneration, drug delivery systems, cancer treatment, antimicrobials. second dedicated our results obtained research opus hydrogel materials based synergy different (polymers bioactive agents). proved be combining other naturally occurring synthetic polymers, well loading therapeutic agents achieve dermal, controlled delivery, antimicrobial purposes. Our was combinations gelatin, 2-hydroxyethyl methacrylate, apatite, graphene oxide iron(III) oxide, curcumin resveratrol agents. Important features prepared scaffolds, such morphology, porosity, absorption capacity, hydrophilicity, mechanical vitro degradation, vivo biocompatibility, have shown favorable aforementioned applications, been important link achieving these properties. Alginate, indispensable factor played excellent "role" optimal adjustment tested study provides valuable data information researchers demonstrates role biomaterial that powerful medical "tools"
Язык: Английский
Процитировано
69
Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(9), С. 455 - 455
Опубликована: Сен. 3, 2023
Biomaterials are at the forefront of future, finding a variety applications in biomedical field, especially wound healing, thanks to their biocompatible and biodegradable properties. Wounds spontaneously try heal through series interconnected processes involving several initiators mediators such as cytokines, macrophages, fibroblasts. The combination biopolymers with healing properties may provide opportunities synthesize matrices that stimulate trigger target cell responses crucial process. This review outlines optimal management care required for treatment special focus on biopolymers, drug-delivery systems, nanotechnologies used enhanced applications. Researchers have utilized range techniques produce dressings, leading products different characteristics. Each method comes its unique strengths limitations, which important consider. future trajectory dressing advancement should prioritize economical eco-friendly methodologies, along improving efficacy constituent materials. aim this work is give researchers possibility evaluate proper materials preparation better understand synthesis conditions well most effective bioactive molecules load.
Язык: Английский
Процитировано
67
Macromolecules, Год журнала: 2023, Номер 56(21), С. 8377 - 8392
Опубликована: Окт. 18, 2023
In the past decade, stimuli-responsive hydrogels are increasingly studied as biomaterials for tissue engineering and regenerative medicine purposes. Smart can not only replicate physicochemical properties of extracellular matrix but also mimic dynamic processes that crucial regulation cell behavior. Dynamic changes be influenced by hydrogel itself (isotropic vs anisotropic) or guided applying localized triggers. The resulting swelling–shrinking, shape-morphing, well patterns have been shown to influence function in a spatiotemporally controlled manner. Furthermore, use bioinks 4D bioprinting is very promising they allow biofabrication complex microstructures. This perspective discusses recent cutting-edge advances current challenges field smart engineering. Additionally, emerging trends potential future directions addressed.
Язык: Английский
Процитировано
58
Biomaterials, Год журнала: 2024, Номер 312, С. 122718 - 122718
Опубликована: Июль 27, 2024
Functional hydrogels are used for numerous biomedical applications such as tissue engineering, wound dressings, lubricants, contact lenses and advanced drug delivery systems. Most of them based on synthetic or natural polymers forming a three-dimensional network that contains aqueous media. Among polymers, poly(meth)acrylates, polyethyleneglycols, poly(vinylalcohols), poly(vinylpyrrolidones), PLGA poly(urethanes) high relevance, whereas mainly polysaccharides hyaluronic acid, alginate chitosan proteins albumin, collagen elastin. In contrast to most biodegradable. Both often chemically modified in order improve induce favorable properties functions like mechanical strength, stiffness, elasticity, porosity, adhesive properties, situ gelling water binding capacity release controlling properties. Within this review we provide an overview about the broad spectrum functional hydrogels, summarize innovative approaches, discuss concept relevant clinical trials highlight products examples successful developments.
Язык: Английский
Процитировано
48
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Март 27, 2024
Skin, the largest biological organ, consists of three main parts: epidermis, dermis, and subcutaneous tissue. Wounds are abnormal wounds in various forms, such as lacerations, burns, chronic wounds, diabetic acute fractures. The wound healing process is dynamic, complex, lengthy four stages involving cells, macrophages, growth factors. Wound dressing refers to a substance that covers surface prevent infection secondary damage. Biomaterials applied management have advanced significantly. Natural biomaterials increasingly used due their advantages including biomimicry ECM, convenient accessibility, involvement native healing. However, there still limitations low mechanical properties expensive extraction methods. Therefore, combination with synthetic and/or adding bioactive agents has become an option for researchers this field. In present study, natural effect on its direction, type, level will be investigated. Then, different types polysaccharides proteins were selected desirable biomaterials, polymers variable suitable properties, effective additives. following, structure production methods, participation healing, quality control techniques biomaterials-based dressings discussed.
Язык: Английский
Процитировано
23
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 270, С. 132123 - 132123
Опубликована: Май 17, 2024
Язык: Английский
Процитировано
19
Discover Materials, Год журнала: 2025, Номер 5(1)
Опубликована: Янв. 9, 2025
Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.
Язык: Английский
Процитировано
12