Inorganic Chemistry Communications, Год журнала: 2023, Номер 150, С. 110457 - 110457
Опубликована: Фев. 1, 2023
Язык: Английский
Biomolecules, Год журнала: 2022, Номер 12(6), С. 784 - 784
Опубликована: Июнь 4, 2022
Cancer is one of the main causes death worldwide. To date, and despite advances in conventional treatment options, therapy cancer still far from optimal due to non-specific systemic biodistribution antitumor agents. The inadequate drug concentrations at tumor site led an increased incidence multiple resistance appearance many severe undesirable side effects. Nanotechnology, through development nanoscale-based pharmaceuticals, has emerged provide new innovative drugs overcome these limitations. In this review, we overview approved nanomedicine for rationale behind their designs applications. We also highlight approaches that are currently under investigation perspectives challenges nanopharmaceuticals, focusing on microenvironment disseminate cells as most attractive effective strategies treatments.
Язык: Английский
Процитировано
164
Journal of Personalized Medicine, Год журнала: 2022, Номер 12(5), С. 673 - 673
Опубликована: Апрель 22, 2022
Both personalized medicine and nanomedicine are new to medical practice. Nanomedicine is an application of the advances nanotechnology in being integrated into diagnostic therapeutic tools manage array conditions. On other hand, medicine, which also referred as precision a novel concept that aims individualize/customize management based on personal attributes patient overcome blanket treatment only efficient subset patients, leaving others with either ineffective or results significant toxicity. Novel nanomedicines have been employed several diseases, can be adapted each patient-specific case according their genetic profiles. In this review, we discuss both areas intersection between two emerging scientific domains. The review focuses current situation advantages offered by nanoconstructs diagnosis variability identify right drug for patient. Finally, touch upon challenges fields towards translation nano-personalized medicine.
Язык: Английский
Процитировано
138
Bioengineering & Translational Medicine, Год журнала: 2022, Номер 8(2)
Опубликована: Ноя. 2, 2022
Abstract Poly(lactic‐ co ‐glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability sustained controlled release. To prolong NP circulation time, enable target‐specific overcome physiological barriers, NPs camouflaged in cell membranes have been developed evaluated to improve delivery. Here, we discuss recent advances membrane‐coated PLGA NPs, preparation methods, application cancer therapy, management inflammation, treatment cardiovascular disease control infection. We address the current challenges highlight future research directions needed effective use membrane‐camouflaged NPs.
Язык: Английский
Процитировано
87
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(9), С. 5253 - 5253
Опубликована: Май 8, 2022
Being one of the leading causes death and disability worldwide, cancer represents an ongoing interdisciplinary challenge for scientific community. As currently used treatments may face limitations in terms both efficiency adverse effects, continuous research has been directed towards overcoming existing challenges finding safer specific alternatives. In particular, increasing interest gathered around integrating nanotechnology management subsequentially developing various tumor-targeting nanoparticles applications. this respect, present paper briefly describes most clinical practice to set a reference framework recent findings, further focusing on novel developments field. More specifically, review elaborates top studies concerning nanomaterials (i.e., carbon-based, metal-based, liposomes, cubosomes, lipid-based, polymer-based, micelles, virus-based, exosomes, cell membrane-coated nanomaterials) that show promising potential different
Язык: Английский
Процитировано
75
Photodiagnosis and Photodynamic Therapy, Год журнала: 2024, Номер 45, С. 103959 - 103959
Опубликована: Янв. 21, 2024
Breast cancer (BC) remains an enigmatic fatal modality ubiquitously prevalent in different parts of the world. Contemporary medicines face severe challenges remediating and healing breast cancer. Due to its spatial specificity nominal invasive therapeutic regime, photothermal therapy (PTT) has attracted much scientific attention down lane. PTT utilizes a near-infrared (NIR) light source irradiate tumor target intravenously or non-invasively, which is converted into heat energy over optical fibre. Dynamic progress nanomaterial synthesis was achieved with specialized visual, physicochemical, biological, pharmacological features make up for inadequacies expand horizon PTT. Numerous nanomaterials have substantial NIR absorption can function as efficient transducers. It achievable limit wavelength range absorbance peak specific by manipulating their synthesis, enhancing precision quality Along same lines, various are conjugated wide surface-modifying chemicals, including polymers antibodies, may modify persistence diminish toxicity concerns. In this article, we tend put forth insights fundamental conceptualizations on pre-existing advances upon conjugation biocompatible working synergy combat cancer, encompassing several strategies like immunotherapy, chemotherapy, photodynamic therapy, radiotherapy coupled Additionally, role mechanisms nanoparticles, well possible alternatives PTT, summarized distinctive integral aspect article.
Язык: Английский
Процитировано
62
Journal of Controlled Release, Год журнала: 2023, Номер 354, С. 503 - 522
Опубликована: Янв. 20, 2023
Язык: Английский
Процитировано
59
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 132579 - 132579
Опубликована: Май 23, 2024
Язык: Английский
Процитировано
38
Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 101036 - 101036
Опубликована: Фев. 1, 2025
Процитировано
3
Environmental Research, Год журнала: 2023, Номер 227, С. 115722 - 115722
Опубликована: Март 21, 2023
Язык: Английский
Процитировано
42
Journal of Controlled Release, Год журнала: 2023, Номер 363, С. 57 - 83
Опубликована: Сен. 23, 2023
There is increasing evidence that malignant tumors are initiated and maintained by a sub-population of tumor cells have similar biological properties to normal adult stem cells. This very small population Cancer Stem Cells (CSC) comprises initiating responsible for cancer recurrence, drug resistance metastasis. Conventional treatments such as chemotherapy, radiotherapy surgery, in addition being potentially toxic non-specific, may paradoxically increase the population, spread survival CSCs. Next-generation sequencing omics technologies our understanding pathways factors involved development CSCs, can help discover new therapeutic targets against In addition, recent advances nanomedicine provided hope optimal specific therapies eradicate Moreover, use artificial intelligence nano-informatics elucidate targets, design drugs nanoparticles (NPs) deal with this review, we first summarize CSCs describe signaling molecular characteristics emergence Also, location within effect host on creation maintenance discussed. Newly discovered stemness some novel compounds combat highlighted. The optimum anti-CSC NPs, including blood circulation stability, accumulation penetration, cellular internalization, release, endosomal escape, aptamers designed targeting covered. Finally, smart NPs theranostic purposes overcome
Язык: Английский
Процитировано
39