Toxicology in Vitro, Год журнала: 2024, Номер 98, С. 105814 - 105814
Опубликована: Апрель 4, 2024
Язык: Английский
RSC Advances, Год журнала: 2023, Номер 13(13), С. 8606 - 8629
Опубликована: Янв. 1, 2023
Cancer is known as the most dangerous disease in world terms of mortality and lack effective treatment. Research on cancer treatment still active great social importance. Since 1930, chemotherapeutics have been used to treat cancer. However, such conventional treatments are associated with pain, side effects, a targeting. Nanomedicines an emerging alternative due their targeting, bioavailability, low toxicity. Nanoparticles target cells via passive mechanisms. FDA approval for Doxil®, several nano-therapeutics developed, few received use Along liposomes, solid lipid nanoparticles, polymeric nanoemulsions, even newer techniques involving extracellular vesicles (EVs) thermal nanomaterials now being researched implemented practice. This review highlights evolution current status therapy, focus clinical/pre-clinical nanomedicine studies. Insight also provided into prospects this regard.
Язык: Английский
Процитировано
104
Cancers, Год журнала: 2022, Номер 14(19), С. 4652 - 4652
Опубликована: Сен. 24, 2022
Melanoma is the deadliest skin cancer, whose morbidity and mortality indicators show an increasing trend worldwide. In addition to its great heterogeneity, melanoma has a high metastatic potential, resulting in very limited response therapies currently available, which were restricted surgery, radiotherapy chemotherapy for many years. Advances knowledge about pathophysiological mechanisms of disease have allowed development new therapeutic classes, such as immune checkpoint small molecule kinase inhibitors. However, despite incontestable progress quality life survival rates patients, effectiveness still far from desired. Some adverse side effects resistance are main barriers. Thus, search better options resulted clinical trials that now investigating drugs and/or combinations. The low water solubility drugs, stability rapid metabolism limit potential use some compounds. research nanotechnology-based strategies being explored basis broad application different types nanosystems treatment melanoma. Future focus on challenges understanding make these more effective.
Язык: Английский
Процитировано
92
Biomolecules, Год журнала: 2022, Номер 12(9), С. 1254 - 1254
Опубликована: Сен. 7, 2022
Oral ulcers affect oral and systemic health have high prevalence in the population. There are significant individual differences etiology extent of disease among patients. In treatment ulcers, nanofiber films can control drug-release rate enable long-term local administration. Compared to other drug-delivery methods, avoid disadvantages frequent administration certain side effects. Electrospinning is a simple effective method for preparing films. Currently, electrospinning technology has made breakthroughs energy-saving large-scale production. This paper summarizes polymers that mucosal adhesion active pharmaceutical ingredients used ulcers. Moreover, therapeutic effects currently available electrospun on animal experiments clinical trials investigated. addition, solvent casting cross-linking methods be conjunction with techniques. Based literature, more systems different loading components inspired. These expected synergistic achieve better not only provides new possibilities drug-loaded nanofibers but also brings hope
Язык: Английский
Процитировано
70
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3643 - 3643
Опубликована: Фев. 11, 2023
Breast cancer (BC) is one of the most widely diagnosed cancers and a leading cause death among women worldwide. Globally, BC second frequent first gynecological one, affecting with relatively low case-mortality rate. Surgery, radiotherapy, chemotherapy are main treatments for BC, even though latter often not aways successful because common side effects damage caused to healthy tissues organs. Aggressive metastatic BCs difficult treat, thus new studies needed in order find therapies strategies managing these diseases. In this review, we intend give an overview field, presenting data from literature concerning classification drugs used therapy treatment BCs, along clinical studies.
Язык: Английский
Процитировано
45
Biomarker Research, Год журнала: 2024, Номер 12(1)
Опубликована: Янв. 7, 2024
Abstract The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune responses, playing crucial role in improving antitumor immunity through effector responses. Targeting the holds promise for overcoming immunosuppressive tumor microenvironments (TME) and promoting effective elimination. However, systemic administration current STING agonists faces challenges related to low bioavailability potential adverse effects, thus limiting their clinical applicability. Recently, nanotechnology-based strategies have been developed modulate TMEs robust immunotherapeutic encapsulation delivery within nanoparticles (STING-NPs) present an attractive avenue immunotherapy. This review explores range designed encapsulate agonists, highlighting benefits, including favorable biocompatibility, improved penetration, efficient intracellular agonists. also summarizes immunomodulatory impacts STING-NPs on TME, enhanced secretion pro-inflammatory cytokines chemokines, dendritic cell activation, cytotoxic T priming, macrophage re-education, vasculature normalization. Furthermore, offers insights into co-delivered nanoplatforms involving alongside agents such chemotherapeutic compounds, checkpoint inhibitors, antigen peptides, other adjuvants. These platforms demonstrate remarkable versatility inducing immunogenic responses ultimately amplifying
Язык: Английский
Процитировано
22
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5842 - 5842
Опубликована: Май 27, 2024
This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.
Язык: Английский
Процитировано
22
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 18, 2025
Clinically, multimodal therapies are adopted worldwide for the management of cancer, which continues to be a leading cause death. In recent years, immunotherapy has firmly established itself as new paradigm in cancer care that activates body's immune defense cope with cancer. Immunotherapy resulted significant breakthroughs treatment stubborn tumors, dramatically improving clinical outcome patients. Multiple forms immunotherapy, including checkpoint inhibitors (ICIs), adoptive cell therapy and vaccines, have become widely available. However, effectiveness these immunotherapies is not much satisfying. Many patients do respond disease recurrence appears unavoidable because rapidly evolving resistance. Moreover, can give rise severe off-target immune-related adverse events. Strategies remove hindrances mainly focus on development combinatorial or exploitation novel immunotherapeutic mediations. Nanomaterials carrying anticancer agents target site considered practical approaches treatment. Nanomedicine combined offers possibility potentiate systemic antitumor immunity facilitate selective cytotoxicity against cells an effective safe manner. A myriad nano-enabled currently under investigation. Owing gaps between preclinical studies, nano-immunotherapy faces multiple challenges, biosafety nanomaterials trial design. this review, we provide overview summarize evidence indicating how nanomedicine-based increase efficacy immunotherapies. We also discuss key challenges emerged era nanotechnology-based immunotherapy. Taken together, combination drawing increasing attention, it anticipated will achieve desired success therapy.
Язык: Английский
Процитировано
5
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Янв. 17, 2025
Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.
Язык: Английский
Процитировано
2
Bioconjugate Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
Brain tumors, particularly glioblastomas, represent the most complicated cancers to treat and manage due their highly invasive nature protective barriers of brain, including blood-brain barrier (BBB). The efficacy currently available treatments, viz., radiotherapy, chemotherapy, immunotherapy, are frequently limited by major side effects, drug resistance, restricted penetration into brain. Lipid nanoparticles (LNPs) have emerged as a promising targeted delivery system for brain tumors. nanocarriers gained tremendous attention tumor therapeutics multiple encapsulation abilities, controlled release, better biocompatibility, ability cross BBB. Herein, detailed analysis design, mechanisms, therapeutic benefits LNPs in treatment is discussed. Moreover, we also discuss safety issues clinical developments current future challenges. Further, focused on transformation therapy eliminating effects engineering overcome related biological barriers, which provide personalized, affordable, low-risk options.
Язык: Английский
Процитировано
2
Nanomaterials, Год журнала: 2022, Номер 12(15), С. 2672 - 2672
Опубликована: Авг. 4, 2022
Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder success of different cancer therapeutics. The traditional therapeutic approach has been proven insufficient and lacking in suppression tumor growth. simultaneous delivery small-molecule chemotherapeutic drugs genes improves effectiveness each treatment, thus optimizing efficacy improving synergistic effects. Nanomedicines integrating inorganic, lipid, polymeric-based nanoparticles designed to regulate spatiotemporal release encapsulated drugs. Multidrug-loaded nanocarriers are a potential strategy fight incorporation co-delivery systems as feasible treatment method projected benefits limited undesirable Moreover, development for maximum impact necessitates better knowledge appropriate agent ratio well inherent heterogeneity cells. Co-delivery can simplify clinical processes increase patient quality life, even though such more difficult prepare than single drug systems. This review highlights progress attained design nano carrier-based discusses limitations, challenges, future perspectives fabrication
Язык: Английский
Процитировано
54