Future Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
10(1)
Опубликована: Фев. 22, 2024
Abstract
Background
Cancer
is
a
significant
global
health
issue,
resulting
from
uncontrolled
cell
division
leading
to
abnormal
or
tissue
growth.
Traditional
chemotherapeutic
techniques
have
investigated
wide
variety
of
pharmaceutically
active
molecules
despite
their
poor
bioavailability,
quick
renal
clearance,
inconsistent
distribution,
and
unavoidable
side
effects.
Green
synthesis,
unlike
chemical
methods,
prioritizes
eco-friendliness
cost-effectiveness.
Using
natural
sources
like
plant
extracts,
it
minimizes
environmental
impact,
reduces
costs,
aligns
with
sustainability
goals.
Operating
under
milder
conditions,
consumes
less
energy
compared
traditional
approaches.
synthesis
highly
promising
efficient
method
for
producing
nanoparticles
due
its
versatility
scalability.
Main
body
Nanotechnology
making
progress
in
cancer
treatment
because
nanoparticles'
tiny
size,
large
surface
area,
adaptability,
functionality,
as
well
potential
induce
apoptotic
pathways
fast
penetration
internalization
into
cells.
Biosynthesis
metallic
using
microbe
extracts
attracting
attention
replace
toxic
chemicals
phytochemicals
that
can
act
reducing,
capping,
stabilizing
agents
improve
biocompatibility,
antitumor,
antioxidant
properties.
This
review
focuses
on
biosynthesized
anticancer
effects
breast,
prostate,
skin,
cervical,
colorectal,
lung,
liver
cancer.
Conclusion
therapy
stands
at
the
forefront
innovative
sustainable
Despite
challenges,
ongoing
research
demonstrates
biosynthesis
revolutionize
nanomedicine,
emphasizing
need
continued
exploration
collaboration
this
rapidly
advancing
field.
Overall,
offers
comprehensive
understanding
most
recent
developments
future
applications
medicine.
ACS Omega,
Год журнала:
2023,
Номер
8(16), С. 14290 - 14320
Опубликована: Апрель 10, 2023
Cancer
is
ranked
as
the
second
leading
cause
of
death
globally.
Traditional
cancer
therapies
including
chemotherapy
are
flawed,
with
off-target
and
on-target
toxicities
on
normal
cells,
requiring
newer
strategies
to
improve
cell
selective
targeting.
The
application
nanomaterial
has
been
extensively
studied
explored
chemical
biology
tools
in
theranostics.
It
shows
greater
applications
toward
stability,
biocompatibility,
increased
permeability,
resulting
precise
targeting,
mitigating
shortcomings
traditional
therapies.
nanoplatform
offers
an
exciting
opportunity
gain
targeting
multifunctionality.
advent
nanotechnology,
particular
development
smart
nanomaterials,
transformed
diagnosis
treatment.
large
surface
area
nanoparticles
enough
encapsulate
many
molecules
ability
functionalize
various
biosubstrates
such
DNA,
RNA,
aptamers,
antibodies,
which
helps
theranostic
action.
Comparatively,
biologically
derived
nanomaterials
perceive
advantages
over
produced
by
conventional
methods
terms
economy,
ease
production,
reduced
toxicity.
present
review
summarizes
techniques
theranostics
emphasizes
(such
organic
(NPs),
inorganic
NPs,
carbon-based
NPs).
We
also
critically
discussed
challenges
impeding
their
translation
treatment
diagnostic
applications.
This
concludes
that
use
could
significantly
will
facilitate
new
dimensions
for
tumor
detection
therapy.
International Journal of Nanomedicine,
Год журнала:
2022,
Номер
Volume 17, С. 3735 - 3749
Опубликована: Авг. 1, 2022
Abstract:
Cancer
remains
the
most
devastating
disease
and
major
cause
of
mortality
worldwide.
Although
early
diagnosis
treatment
are
key
approach
in
fighting
against
cancer,
available
conventional
diagnostic
therapeutic
methods
not
efficient.
Besides,
ineffective
cancer
cell
selectivity
toxicity
traditional
chemotherapy
remain
significant
challenge.
These
limitations
entail
need
for
development
both
safe
effective
options.
Due
to
its
robust
application,
nanotechnology
could
be
a
promising
method
in-vivo
imaging
detection
cells
biomarkers.
Nanotechnology
provide
quick,
safe,
cost-effective,
efficient
management.
It
also
provides
simultaneous
using
nano-theragnostic
particles
that
facilitate
selective
destruction
cells.
Updated
recent
discussions
important
selecting
best
diagnosis,
treatment,
management
options,
new
insights
on
designing
protocols
utmost
important.
This
review
discusses
application
therapeutics,
theragnosis
future
perspectives
field.
Keywords:
nanotechnology,
theragnostics
Cancers,
Год журнала:
2023,
Номер
15(14), С. 3608 - 3608
Опубликована: Июль 13, 2023
(1)
Background:
The
application
of
deep
learning
technology
to
realize
cancer
diagnosis
based
on
medical
images
is
one
the
research
hotspots
in
field
artificial
intelligence
and
computer
vision.
Due
rapid
development
methods,
requires
very
high
accuracy
timeliness
as
well
inherent
particularity
complexity
imaging.
A
comprehensive
review
relevant
studies
necessary
help
readers
better
understand
current
status
ideas.
(2)
Methods:
Five
radiological
images,
including
X-ray,
ultrasound
(US),
computed
tomography
(CT),
magnetic
resonance
imaging
(MRI),
positron
emission
(PET),
histopathological
are
reviewed
this
paper.
basic
architecture
classical
pretrained
models
comprehensively
reviewed.
In
particular,
advanced
neural
networks
emerging
recent
years,
transfer
learning,
ensemble
(EL),
graph
network,
vision
transformer
(ViT),
introduced.
overfitting
prevention
methods
summarized:
batch
normalization,
dropout,
weight
initialization,
data
augmentation.
image-based
analysis
sorted
out.
(3)
Results:
Deep
has
achieved
great
success
diagnosis,
showing
good
results
image
classification,
reconstruction,
detection,
segmentation,
registration,
synthesis.
However,
lack
high-quality
labeled
datasets
limits
role
faces
challenges
rare
multi-modal
fusion,
model
explainability,
generalization.
(4)
Conclusions:
There
a
need
for
more
public
standard
databases
cancer.
pre-training
potential
be
improved,
special
attention
should
paid
multimodal
fusion
supervised
paradigm.
Technologies
such
ViT,
few-shot
will
bring
surprises
images.
Crystals,
Год журнала:
2023,
Номер
13(11), С. 1576 - 1576
Опубликована: Ноя. 8, 2023
Green
synthesis
offers
a
superior
alternative
to
traditional
methods
for
producing
metal
and
oxide
nanoparticles.
This
approach
is
not
only
benign
safe
but
also
cost-effective,
scalable,
straightforward,
operating
under
ambient
conditions.
Notable
metals
nanoparticles,
such
as
manganese
oxides,
iron
silver,
gold,
have
been
produced
using
various
bio-reductants
derived
from
plant
extracts.
These
biological
agents
expedite
the
reduction
process
stabilize
serving
dual
roles
reducing
capping
agents.
review
presents
green
of
nanoparticles
(NPs)
obtained
biogenic
wastes
The
green-synthesized
nanostructured
MnO2
are
evaluated
potential
photocatalyst
water
treatment
an
electrode
material
in
lithium-ion
batteries
supercapacitors.
green-derived
examined
promising
antioxidant,
anti-inflammatory,
anti-diabetic
Additionally,
this
discusses
precious
specifically
silver
(Ag
NPs)
gold
(Au
NPs),
highlighting
their
medical
applications
areas
like
antiviral
treatments
cancer
therapy.
Polymers,
Год журнала:
2023,
Номер
15(2), С. 440 - 440
Опубликована: Янв. 13, 2023
The
increase
in
the
population
rate
has
increased
demand
for
safe
and
quality
food
products.
However,
current
agricultural
system
faces
many
challenges
producing
vegetables
fruits.
Indiscriminate
use
of
pesticides
fertilizers,
deficiency
water
resources,
short
shelf
life
products
postharvest,
nontargeted
delivery
agrochemicals
are
main
challenges.
In
this
regard,
carboxymethyl
cellulose
(CMC)
is
one
most
promising
materials
agriculture
sector
minimizing
these
due
to
its
mechanical
strength,
viscosity,
wide
availability,
edibility
properties.
CMC
also
high
absorbency;
therefore,
it
can
be
used
(as
superabsorbent
hydrogels).
Due
hydroxyl
groups
on
surface,
substance
efficacy
removing
pollutants,
such
as
heavy
metals.
Enriching
coatings
with
additional
substances,
antimicrobial,
antibrowning,
antioxidant,
antisoftening
materials,
provide
further
novel
formulations
unique
advantages.
addition,
encapsulation
bioactive
or
provides
a
targeted
system.
This
review
presents
comprehensive
overview
applications
preserving
fruit
vegetable
quality,
remediating
pollution,
sources,
encapsulating
molecules
delivery.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 4057 - 4057
Опубликована: Апрель 5, 2024
In
recent
years,
the
extensive
exploration
of
Gold
Nanoparticles
(AuNPs)
has
captivated
scientific
community
due
to
their
versatile
applications
across
various
industries.
With
sizes
typically
ranging
from
1
100
nm,
AuNPs
have
emerged
as
promising
entities
for
innovative
technologies.
This
article
comprehensively
reviews
advancements
in
research,
encompassing
synthesis
methodologies,
diverse
applications,
and
crucial
insights
into
toxicological
profiles.
Synthesis
techniques
span
physical,
chemical,
biological
routes,
focusing
on
eco-friendly
“green
synthesis”
approaches.
A
critical
examination
physical
chemical
methods
reveals
limitations,
including
high
costs
potential
toxicity
associated
with
using
chemicals.
Moreover,
this
investigates
biosafety
implications
AuNPs,
shedding
light
toxic
effects
cellular,
tissue,
organ
levels.
By
synthesizing
key
findings,
review
underscores
pressing
need
a
thorough
understanding
toxicities,
providing
essential
safety
assessment
advancing
green
toxicology
principles.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 5842 - 5842
Опубликована: Май 27, 2024
This
study
provides
a
brief
discussion
of
the
major
nanopharmaceuticals
formulations
as
well
impact
nanotechnology
on
future
pharmaceuticals.
Effective
and
eco-friendly
strategies
biofabrication
are
also
highlighted.
Modern
approaches
to
designing
pharmaceutical
nanoformulations
(e.g.,
3D
printing,
Phyto-Nanotechnology,
Biomimetics/Bioinspiration,
etc.)
outlined.
paper
discusses
need
use
natural
resources
for
“green”
design
new
with
therapeutic
efficiency.
Nanopharmaceuticals
research
is
still
in
its
early
stages,
preparation
nanomaterials
must
be
carefully
considered.
Therefore,
safety
long-term
effects
not
overlooked.
The
testing
represents
an
essential
point
their
further
applications.
Vegetal
scaffolds
obtained
by
decellularizing
plant
leaves
represent
valuable,
bioinspired
model
nanopharmaceutical
that
avoids
using
animals.
Nanoformulations
critical
various
fields,
especially
pharmacy,
medicine,
agriculture,
material
science,
due
unique
properties
advantages
over
conventional
allows
improved
solubility,
bioavailability,
targeted
drug
delivery,
controlled
release,
reduced
toxicity.
have
transitioned
from
experimental
stages
being
vital
component
clinical
practice,
significantly
improving
outcomes
medical
fields
cancer
treatment,
infectious
diseases,
neurological
disorders,
personalized
advanced
diagnostics.
Here
key
points
highlighting
importance.
significant
challenges,
opportunities,
directions
mentioned
final
section.
