Coordination Chemistry Reviews, Год журнала: 2025, Номер 530, С. 216489 - 216489
Опубликована: Фев. 3, 2025
Язык: Английский
ACS Nano, Год журнала: 2023, Номер 17(15), С. 14347 - 14405
Опубликована: Июль 24, 2023
Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.
Язык: Английский
Процитировано
187
Molecules, Год журнала: 2023, Номер 28(18), С. 6687 - 6687
Опубликована: Сен. 18, 2023
Nanotechnology has ushered in a new era of medical innovation, offering unique solutions to longstanding healthcare challenges. Among nanomaterials, copper and oxide nanoparticles stand out as promising candidates for multitude applications. This article aims provide contemporary insights into the perspectives challenges regarding use medicine. It summarises biomedical potential copper-based nanoformulations, including progress early-stage research, evaluate mitigate toxicity nanomaterials. The discussion covers prospects nanomaterials context their successful clinical translation. also addresses safety concerns, emphasizing need assessments nanomedicines. However, attention is needed solve current such biocompatibility controlled release. Ongoing research collaborative efforts overcome these obstacles are discussed. analysis guidance safe effective integration practice, thereby advancing recent literature highlighted multifaceted associated with translation from laboratory clinic. In particular, remains formidable hurdle, requiring innovative ensure seamless human body. Additionally, achieving release therapeutic agents poses complex challenge that requires meticulous engineering precise design.
Язык: Английский
Процитировано
67
Life Sciences, Год журнала: 2024, Номер 352, С. 122899 - 122899
Опубликована: Июль 9, 2024
This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.
Язык: Английский
Процитировано
60
Photodiagnosis and Photodynamic Therapy, Год журнала: 2024, Номер 45, С. 103959 - 103959
Опубликована: Янв. 21, 2024
Breast cancer (BC) remains an enigmatic fatal modality ubiquitously prevalent in different parts of the world. Contemporary medicines face severe challenges remediating and healing breast cancer. Due to its spatial specificity nominal invasive therapeutic regime, photothermal therapy (PTT) has attracted much scientific attention down lane. PTT utilizes a near-infrared (NIR) light source irradiate tumor target intravenously or non-invasively, which is converted into heat energy over optical fibre. Dynamic progress nanomaterial synthesis was achieved with specialized visual, physicochemical, biological, pharmacological features make up for inadequacies expand horizon PTT. Numerous nanomaterials have substantial NIR absorption can function as efficient transducers. It achievable limit wavelength range absorbance peak specific by manipulating their synthesis, enhancing precision quality Along same lines, various are conjugated wide surface-modifying chemicals, including polymers antibodies, may modify persistence diminish toxicity concerns. In this article, we tend put forth insights fundamental conceptualizations on pre-existing advances upon conjugation biocompatible working synergy combat cancer, encompassing several strategies like immunotherapy, chemotherapy, photodynamic therapy, radiotherapy coupled Additionally, role mechanisms nanoparticles, well possible alternatives PTT, summarized distinctive integral aspect article.
Язык: Английский
Процитировано
54
European Polymer Journal, Год журнала: 2024, Номер 210, С. 112983 - 112983
Опубликована: Март 26, 2024
Язык: Английский
Процитировано
47
Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)
Опубликована: Янв. 19, 2024
Abstract Humanity is suffering from cancer which has become a root cause of untimely deaths individuals around the globe in recent past. Nanotheranostics integrates therapeutics and diagnostics to monitor treatment response enhance drug efficacy safety. We hereby propose discuss all imaging diagnostic tools, mechanism targeting tumor cells, current nanotheranostic platforms available for cancer. This review discusses various agents novel molecular tools like MRI, CT, PET, SPEC, PAT used diagnostics. Emphasis given gold nanoparticles, silica, liposomes, dendrimers, metal-based agents. also highlight limitations different field research treatment. Due complexity this area, multifunctional hybrid nanoparticles functionalized with targeted moieties or anti-cancer drugs show best feature theranostics that enables them work on carrying delivering active materials desired area requirement early detection diagnosis. Non-invasive techniques have specificity receptor binding internalization processes nanosystems within cells. may provide appropriate medicine at dose patient time. Graphical abstract
Язык: Английский
Процитировано
37
Heliyon, Год журнала: 2024, Номер 10(3), С. e25521 - e25521
Опубликована: Фев. 1, 2024
Nanomaterials (NMs) have garnered significant attention in recent decades due to their versatile applications a wide range of fields. Thanks tiny size, enhanced surface modifications, impressive volume-to-surface area ratio, magnetic properties, and customized optical dispersion. NMs experienced an incredible upsurge biomedical including diagnostics, therapeutics, drug delivery. This minireview will focus on notable examples that tackle important issues, demonstrating various aspects such as design, synthesis, morphology, classification, use cutting-edge applications. Furthermore, we classified outlined the distinctive characteristics advanced nanoscale particles hybrid NMs. Meanwhile, emphasize potential metal-organic frameworks (MOFs), highly group These MOFs gained recognition promising candidates for bio-applications, bioimaging, biosensing, antiviral therapy, anticancer nanomedicines, theranostics, immunotherapy, photodynamic photothermal gene Although shown great field, clinical is still limited by issues stability, cytotoxicity, biocompatibility, health concerns. review article provides thorough analysis offering valuable insights researchers investigating explore new development, expansion opportunities. Remarkably, ponder prospects nanocomposites conjunction with current technology.
Язык: Английский
Процитировано
25
Plasmonics, Год журнала: 2024, Номер unknown
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
25
ACS Omega, Год журнала: 2024, Номер 9(9), С. 9849 - 9864
Опубликована: Фев. 22, 2024
Antimicrobial and anticancer drugs are widely used due to increasing widespread infectious diseases caused by microorganisms such as bacterial, fungal, viral agents, or cancer cells, which one of the major causes mortality globally. Nevertheless, several developed resistance antibiotics a result genetic changes that have occurred over an extended period. Carbon-based materials, particularly carbon dots (C-dots), potential candidates for antibacterial nanomaterials their low toxicity, ease synthesis functionalization, high dispersibility in aqueous conditions, promising biocompatibility. In this Review, content is divided into four sections. The first section concentrates on C-dot structures, surface morphology. Following that, we summarize classifications preparation methods arc discharge, laser ablation, electrochemical oxidation, so on. antimicrobial applications C-dots antibacterial, antifungal, antiviral agents both vivo vitro discussed. Finally, thoroughly examined activity displayed C-dots.
Язык: Английский
Процитировано
22
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5842 - 5842
Опубликована: Май 27, 2024
This study provides a brief discussion of the major nanopharmaceuticals formulations as well impact nanotechnology on future pharmaceuticals. Effective and eco-friendly strategies biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) outlined. paper discusses need use natural resources for “green” design new with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, preparation nanomaterials must be carefully considered. Therefore, safety long-term effects not overlooked. The testing represents an essential point their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent valuable, bioinspired model nanopharmaceutical that avoids using animals. Nanoformulations critical various fields, especially pharmacy, medicine, agriculture, material science, due unique properties advantages over conventional allows improved solubility, bioavailability, targeted drug delivery, controlled release, reduced toxicity. have transitioned from experimental stages being vital component clinical practice, significantly improving outcomes medical fields cancer treatment, infectious diseases, neurological disorders, personalized advanced diagnostics. Here key points highlighting importance. significant challenges, opportunities, directions mentioned final section.
Язык: Английский
Процитировано
22