Springer eBooks, Год журнала: 2023, Номер unknown, С. 469 - 541
Опубликована: Янв. 1, 2023
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3866 - 3866
Опубликована: Фев. 15, 2023
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), multiple sclerosis (MS), spinal cord injury (SCI), and amyotrophic lateral (ALS), are characterized by acute or chronic progressive loss of one several neuronal subtypes. However, despite their increasing prevalence, little progress has been made in successfully treating these diseases. Research recently focused on neurotrophic factors (NTFs) as potential regenerative therapy for neurodegenerative Here, we discuss the current state knowledge, challenges, future perspectives NTFs with a direct effect inflammatory degenerative disorders. Various systems delivery NTFs, such stem immune cells, viral vectors, biomaterials, have applied to deliver exogenous central nervous system, promising results. The challenges that currently need be overcome include amount delivered, invasiveness route, blood-brain barrier permeability, occurrence side effects. Nevertheless, it is important continue research develop standards clinical applications. In addition use single complexity diseases may require combination therapies targeting pathways other possibilities using smaller molecules, NTF mimetics, effective treatment.
Язык: Английский
Процитировано
52
Biology, Год журнала: 2024, Номер 13(9), С. 719 - 719
Опубликована: Сен. 12, 2024
Neurodegenerative diseases (NDs), like amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's (PD), primarily affect the central nervous system, leading to progressive neuronal loss motor cognitive dysfunction. However, recent studies have revealed that muscle tissue also plays a significant role in these diseases. ALS is characterized by severe wasting as result of neuron degeneration, well alterations gene expression, protein aggregation, oxidative stress. Muscle atrophy mitochondrial dysfunction are observed AD, which may exacerbate decline due systemic metabolic dysregulation. PD patients exhibit fiber atrophy, altered composition, α-synuclein aggregation within cells, contributing symptoms progression. Systemic inflammation impaired degradation pathways common among disorders, highlighting key player Understanding muscle-related changes offers potential therapeutic avenues, such targeting function, reducing inflammation, promoting regeneration with exercise pharmacological interventions. This review emphasizes importance considering an integrative approach neurodegenerative research, both peripheral pathological mechanisms, order develop more effective treatments improve patient outcomes.
Язык: Английский
Процитировано
8
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 96, С. 105699 - 105699
Опубликована: Апрель 22, 2024
Microfluidic-based nanoscale drug delivery systems have risen to prominence in the field of precision nanomedicine recent years. This intriguing innovation could provide unique therapeutic prospects treatment serious disorders as traumatic brain injury, a potentially fatal condition that is widespread during childhood. According current scientific study, neurotrophins are vital for healing injured parenchyma, and brain-derived neurotrophic factor (BDNF) particular may significant regenerative effects. To address BDNF-related pharmacokinetic constraints, microfluidic-assisted manufacturing BDNF-loaded solid lipid nanoparticles (BDNF-SLNs) was carried out, following evaluation, formulation demonstrated optimum characteristics terms size (190.3 ± 10.1 nm), PDI (0.180 0.023), ζ-potential (– 39.2 1.30 mV). Short-term stability studies haemolysis assay verified formulation's biocompatibility, while an vitro permeability analysis revealed increase Papp encapsulated BDNF (1.27x10-5 cm/sec) compared plain (9.31x10-6 cm/sec). The mimicked neuroinflammatory model enhanced decrease nitrite production Nos mRNA levels using BDNF-SLNs control, validating proficiency microfluidic-based pioneering valuable approaches biologicals.
Язык: Английский
Процитировано
6
Biomolecules, Год журнала: 2023, Номер 13(11), С. 1582 - 1582
Опубликована: Окт. 26, 2023
Amyotrophic lateral sclerosis (ALS) is a fatal condition characterized by the selective loss of motor neurons in cortex, brainstem, and spinal cord. Muscle involvement, muscle atrophy, subsequent paralysis are among main features this disease, which defined as neuromuscular disorder. ALS persistently progressive continue to degenerate, individuals with experience gradual decline their ability perform daily activities. Ultimately, function may result paralysis, presenting significant challenges mobility, communication, self-care. While majority research has traditionally focused on pathogenic pathways central nervous system, there been great interest research. These studies were carried out patients animal models order better understand molecular mechanisms involved develop therapies aimed at improving function. This review summarizes discusses role muscle, well examines recent development treatments.
Язык: Английский
Процитировано
15
Nanotechnology in the life sciences, Год журнала: 2025, Номер unknown, С. 131 - 181
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(8), С. 3599 - 3619
Опубликована: Фев. 18, 2023
The prevalence of neurodegenerative, cerebrovascular, and psychiatric diseases other neurological disorders has increased dramatically worldwide. Fucoxanthin is an algal pigment with many biological functions, there rising evidence that fucoxanthin plays a preventive therapeutic role in disorders. This review focuses on the metabolism, bioavailability, blood–brain barrier penetration fucoxanthin. Furthermore, neuroprotective potential neurodegenerative diseases, cerebrovascular as well such epilepsy, neuropathic pain, brain tumors by acting multiple targets will be summarized. include regulating apoptosis, reducing oxidative stress, activating autophagy pathway, inhibiting Aβ aggregation, improving dopamine secretion, α-synuclein attenuating neuroinflammation, modulating gut microbiota, brain-derived neurotrophic factor, etc. Additionally, we look forward to brain-targeted oral transport systems due low bioavailability permeability We also propose exploring systemic mechanisms metabolism through gut–brain process envision new for act central nervous system. Finally, dietary delivery interventions achieve effects provides reference application neural field.
Язык: Английский
Процитировано
8
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(17), С. 21400 - 21414
Опубликована: Апрель 19, 2024
Morin, a naturally occurring bioactive compound shows great potential as an antioxidant, anti-inflammatory agent, and regulator of blood glucose levels. However, its low water solubility, poor lipid limited bioavailability, rapid clearance in vivo hinder application regulation. To address these limitations, we report enzymatically synthesized nanosized morin particle (MNs) encapsulated sodium alginate microgels (M@SA). This approach significantly enhances morin's delivery efficiency therapeutic efficacy Utilizing horseradish peroxidase, MNs averaging 305.7 ± 88.7 nm size. These were then via electrohydrodynamic microdroplet spraying to form M@SA microgels. In studies revealed that demonstrated prolonged intestinal retention superior compared with unmodified alone. Moreover, notably improved uptake HepG2 cells. Furthermore, effectively regulated glucose, profiles, oxidative stress diabetic mice while mitigating liver, kidney, pancreatic damage enhancing responses. Our findings propose promising strategy for the oral administration natural compounds regulation, implications broader applications.
Язык: Английский
Процитировано
2
Gene Expression, Год журнала: 2024, Номер 23(2), С. 127 - 138
Опубликована: Май 8, 2024
A key element in the pathogenesis of metabolic syndrome (MetS) is reprogramming hypothalamic cells at genetic level (in prenatal phase), which leads to neuroinflammation. We hypothesize that alterations structure neurons mediated by (epi)genetic are directly related impaired expression/production neurotrophins and neurotransmitters control metabolism substances brain periphery, including brain-derived neurotrophic factor (BDNF). The aim this review describe molecular epigenetic role BDNF development MetS. Articles entered into National Library Medicine Medline database via PubMed interface were used create review. attempted include as much literature possible, reviews, animal studies, cell culture clinical trials. Studies on point its processes, glucose, insulin, cholesterol homeostasis. Evidence-based studies show multiple genes close proximity involved aimed analyzing diseases using different biological samples will reveal clear pathophysiological links between processes periphery.
Язык: Английский
Процитировано
2
Pharmaceuticals, Год журнала: 2023, Номер 16(6), С. 816 - 816
Опубликована: Май 30, 2023
Cationic and hydrophilic coatings based on casting drying water dispersions of two different nanoparticles (NPs) onto glass are here described evaluated for antimicrobial activity. Discoid cationic bilayer fragments (BF) surrounded by carboxy-methylcellulose (CMC) poly (diallyl dimethyl ammonium) chloride (PDDA) NPs spherical gramicidin D (Gr) dispersed in solution were cast coverslips dried, forming a coating quantitatively against Pseudomonas aeruginosa, Staphylococcus aureus Candida albicans. From plating colony units (CFU) counting, all strains interacting 1 h with the lost viability from 105 to 106, zero CFU, at sets Gr PDDA doses: 4.6 25 μg, respectively, or, 0.94 5 respectively. Combinations produced broad spectrum, coatings; electrostatically attached microbes damaging cell walls, allowing interaction membrane. This concerted action promoted optimal activity low doses. Further washing deposited dried showed that they washed out so was no longer present surface. Significant applications biomedical materials can be foreseen these transient coatings.
Язык: Английский
Процитировано
3
Journal of Bioactive and Compatible Polymers, Год журнала: 2024, Номер 39(4), С. 217 - 235
Опубликована: Июнь 22, 2024
In the current research, nanofibrous neural channels were produced by electrospinning of PCL/Gelatin solution loaded with Calendula officinalis extract. The scaffolds properties studied using various in vitro characterization methods. Then, conduits’ healing potential was investigated a rat model PNS injury. results showed that not toxic and quenched DPPH free radicals. addition, extract-loaded conduits exhibited significant anti-inflammatory activity. vivo study regular treadmill exercise significantly improved efficacy officinalis-delivering upregulating BDNF GFAP proteins.
Язык: Английский
Процитировано
0