Cells, Год журнала: 2024, Номер 13(19), С. 1658 - 1658
Опубликована: Окт. 7, 2024
Umbilical cord mesenchymal stem cell-derived extracellular vesicles (UC-EVs) are valuable in nanomedicine as natural nanocarriers, carrying information molecules from their parent cells and fusing with targeted cells. miRNA-126, specific to endothelial derived these vesicles, supports vascular integrity angiogenesis has protective effects kidney diseases.
Язык: Английский
Bioengineering, Год журнала: 2025, Номер 12(1), С. 92 - 92
Опубликована: Янв. 20, 2025
Critical limb ischemia (CLI) poses a substantial and intricate challenge in vascular medicine, necessitating the development of innovative therapeutic strategies to address its multifaceted pathophysiology. Conventional revascularization approaches often fail adequately complexity CLI, identification alternative methodologies. This review explores uncharted territory beyond traditional therapies, focusing on potential two distinct yet interrelated entities: cell-derived extracellular vesicles (EVs) artificial nanovesicles. Cell-derived EVs are small membranous structures naturally released by cells, nanovesicles artificially engineered nanosized vesicles. Both these represent promising avenues for intervention. They act as carriers bioactive cargo, including proteins, nucleic acids, lipids, that can modulate cellular responses associated with ischemic tissue repair angiogenesis. also assesses evolving landscape CLI through unique perspective The spans spectrum from early preclinical investigations latest translational advancements, providing comprehensive overview current state research this emerging field. These groundbreaking vesicle therapies hold immense revolutionizing treatment paradigms.
Язык: Английский
Процитировано
2
Life Sciences, Год журнала: 2025, Номер 368, С. 123499 - 123499
Опубликована: Фев. 22, 2025
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Авг. 1, 2024
Exosomes play a crucial role in various biological processes, such as human development, immune responses, and disease occurrence. The membrane proteins on exosomes are pivotal factors for their functionality. Currently, numerous have been identified exosome membranes, participating intercellular communication, mediating target cell recognition, regulating processes. Furthermore, from derived cancer cells can serve relevant biomarkers early diagnosis. This article provides comprehensive review of the composition diverse functions organism's Through in-depth exploration proteins, it is expected to offer essential foundations future development novel biomedical diagnostics therapies.
Язык: Английский
Процитировано
5
Biomedicines, Год журнала: 2024, Номер 12(8), С. 1822 - 1822
Опубликована: Авг. 11, 2024
The increase in the variety of nano-based tools offers new possibilities to approach therapy poorly treatable tumors, which includes glioblastoma multiforme (GBM; a primary brain tumor). available nanocomplexes exhibit great potential as vehicles for targeted delivery anti-GBM compounds, including chemotherapeutics, nucleic acids, and inhibitors. main advantages nanoparticles (NPs) include improved drug stability, increased penetration blood-brain barrier, better precision tumor targeting. Importantly, alongside their drug-delivery ability, NPs may also present theranostic properties, applications imaging or photothermal malignant cells. can be classified into two categories according core, metal non-metal based. Among NPs, most studied regard GBM treatment are exosomes, liposomes, cubosomes, polymeric micelles, dendrimers, nanogels, carbon nanotubes, silica- selenium-based NPs. They characterized by satisfactory stability biocompatibility, limited toxicity, high accumulation tissue. Moreover, they easily functionalized cargo Therefore, discussed here, offer promising improving outcomes aggressive tumors.
Язык: Английский
Процитировано
5
Exploration of Targeted Anti-tumor Therapy, Год журнала: 2025, Номер unknown
Опубликована: Март 28, 2025
Glioblastoma (GBM), the most aggressive and lethal primary brain tumor, poses a significant therapeutic challenge due to its highly invasive nature resistance conventional therapies, including surgery, chemotherapy, radiotherapy. Despite advances in standard treatments, patient survival remains limited, requiring exploration of innovative strategies. Photodynamic therapy (PDT) has emerged as promising approach, leveraging light-sensitive photosensitizers (PSs), molecular oxygen, specific light wavelengths generate reactive oxygen species (ROS) that selectively induce tumor cell death. Originally developed for skin cancer, PDT evolved target more complex malignancies, GBM. The refinement second- third-generation PS, coupled with advancements nanotechnology, significantly improved PDT's selectivity, bioavailability, efficacy. Moreover, combination targeted therapy, immunotherapy, among other modalities, shown potential enhancing outcomes. This review provides comprehensive analysis preclinical clinical applications GBM, detailing mechanisms action, evolution novel combinatory strategies optimize treatment However, several challenges remain, overcoming GBM-associated hypoxia, PS delivery across blood-brain barrier, mitigating mechanisms. integration genetic insight, alongside cutting-edge nanotechnology-based systems, may revolutionize GBM treatment, offering new prospects quality life.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101650 - 101650
Опубликована: Март 12, 2025
Prostate cancer remains a leading cause of cancer-related mortality, with conventional therapies limited by systemic toxicity and poor tumor targeting. Developing innovative drug delivery systems that enhance therapeutic specificity while minimizing off-target effects is critical. We engineered cryo-trojan human umbilical cord mesenchymal stem cells (CT-MSCs) as non-living, tumor-homing carriers for mitoxantrone (MTX), termed CT-MTX. Cryo-treatment preserved structural integrity chemokine receptors (CXCR4/CCR2) targeting eliminating proliferative risks. Comprehensive evaluations included loading/release kinetics, in vitro suppression, immunogenic cell death (ICD) induction, vivo efficacy/safety prostate models. CT-MTX demonstrated superior loading (116.38 μg/106 cells) pH-sensitive release (74.10 % at pH 5.5), outperforming exosomes, liposomes, living MSCs stability tumor-specific delivery. Compared to liposomes (low targeting) nanomaterials (biocompatibility concerns), leveraged MSC-derived tropism without tumorigenic In vitro, inhibited proliferation (84.83 MTX uptake), migration (4.42 residual migration), induced apoptosis (43.23 late apoptosis). Mechanistically, triggered ICD via PAMPs release, activating CD8+ T suppressing immunosuppressive Treg. vivo, selectively accumulated tumors, reducing growth 87.88 extending survival (93.30 vs. 66.70 controls) negligible toxicity. Proteomics revealed enriched immune pathways like NK cytotoxicity, validating its dual role direct killing activation. represents novel, non-proliferative platform combines the capacity enhanced safety controlled inducing ICDs other immunologically "cold" tumors improve infiltration.
Язык: Английский
Процитировано
0
World Journal of Gastrointestinal Oncology, Год журнала: 2025, Номер 17(4)
Опубликована: Март 24, 2025
Recently, numerous studies have reported the application of nanomedicines in colorectal cancer treatment. However, no systematic bibliometric analysis has been conducted to examine potential and mechanisms action nanomedicine this context. Such an may provide a comprehensive overview current research landscape, identify emerging trends, highlight key areas for future investigation. To describe global landscape on The Web Science Core Collection database was searched literature published from January 1, 2010, August 7, 2024, focusing Bibliometric visualization mapping countries, institutions, authors, keywords, references relevant were using CiteSpace (6.2R6), VOSviewer (1.6.20), bibliometrix (based R 4.3.2). A total 3598 articles included, with rapid increase publication volume starting 2010. China most papers topic, followed by United States India. emerged as central country field, Egyptian Knowledge Bank Chinese Academy Sciences institutions highest number publications. exhibited centrality. prolific author Zhang Y, whereas Siegel RL cited author, Li Y had H-index. International Journal Nanomedicine publications Biomaterials received citations. Keyword co-occurrence identified 11837 keywords grouped into 13 clusters 15 high-frequency highlighted keywords. top three keyword "0 cancer", "1 drug delivery", "2 being "nanoparticles", "colorectal "drug delivery". Research surged since "nanoparticles" Future should investigate nanomaterial stability target-specific release.
Язык: Английский
Процитировано
0
Cancer Cell International, Год журнала: 2024, Номер 24(1)
Опубликована: Окт. 5, 2024
Язык: Английский
Процитировано
2
Cells, Год журнала: 2024, Номер 13(19), С. 1658 - 1658
Опубликована: Окт. 7, 2024
Umbilical cord mesenchymal stem cell-derived extracellular vesicles (UC-EVs) are valuable in nanomedicine as natural nanocarriers, carrying information molecules from their parent cells and fusing with targeted cells. miRNA-126, specific to endothelial derived these vesicles, supports vascular integrity angiogenesis has protective effects kidney diseases.
Язык: Английский
Процитировано
1