Gut Microbiota and Obesity: A Role for Probiotics

Nutrients, Год журнала: 2019, Номер 11(11), С. 2690 - 2690

Опубликована: Ноя. 7, 2019

Nowadays, obesity is one of the most prevalent human health problems. Research from last 30 years has clarified role imbalance between energy intake and expenditure, unhealthy lifestyle, genetic variability in development obesity. More recently, composition metabolic functions gut microbiota have been proposed as being able to affect development. Here, we will report current knowledge on definition, composition, intestinal microbiota. We performed an extensive review literature, searching for following keywords: metabolism, microbiota, dysbiosis, There evidence association bacteria both infancy adults. are several genetic, metabolic, inflammatory pathophysiological mechanisms involved interplay microbes Microbial changes can be considered a factor humans. The modulation bacterial strains digestive tract help reshape profile obese host suggested by data animal studies. Thus, deep revision pertaining use probiotics, prebiotics, antibiotics patients conceivable

Язык: Английский

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The links between gut microbiota and obesity and obesity related diseases

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 147, С. 112678 - 112678

Опубликована: Фев. 5, 2022

The obesity epidemic has become a global public health crisis in recent years and is continuing to worsen at an alarming rate. However, the pathophysiological mechanisms involved development of obesity-related diseases are still being unraveled. In past ten years, gut microbiota been identified as crucial player affecting onset progression diseases, especially with respect changes its composition metabolites during progression. Herein, we summarize roles microbiota’s metabolite play related diseases. Furthermore, discuss potential therapeutic treatments that can be used modulate microbiome target relevant metabolic pathways

Язык: Английский

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The Influence of the Gut Microbiome on Obesity in Adults and the Role of Probiotics, Prebiotics, and Synbiotics for Weight Loss

Preventive Nutrition and Food Science, Год журнала: 2020, Номер 25(2), С. 113 - 123

Опубликована: Июнь 30, 2020

The link between the gut microbiome and obesity is not well defined. Understanding of role in weight health management may lead to future revolutionary changes for treating obesity. This review examined relationship microbiome, probiotics, prebiotics, synbiotics preventing We used PubMed Google Scholar collect appropriate articles review. showed that has an impact on nutrient metabolism energy expenditure. Moreover, different modalities treatment have been shown change diversity composition microbiome; this raises questions about these play loss. In addition, studies supplementation with alter secretion hormones, neurotransmitters, inflammatory factors, thus food intake triggers gain. Further clinical are needed better understand how species bacteria affect gain, determine most doses, compositions, regimens long-term control.

Язык: Английский

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Microbial Medicine: Prebiotic and Probiotic Functional Foods to Target Obesity and Metabolic Syndrome

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(8), С. 2890 - 2890

Опубликована: Апрель 21, 2020

Obesity has become a global epidemic and public health crisis in the Western World, experiencing threefold increase prevalence since 1975. High-caloric diets sedentary lifestyles have been identified as significant contributors to this widespread issue, although role of genetic, social, environmental factors obesity’s pathogenesis remain incompletely understood. In recent years, much attention drawn contribution gut microbiota development obesity. Indeed, research shown that contrast their healthier counterparts microbiomes obese individuals are structurally functionally distinct, strongly suggesting microbiome potential target for obesity therapeutics. particular, pre probiotics emerged effective integrative means modulating microbiome, order reverse microbial dysbiosis associated with an phenotype. The following review brings forth animal human supporting myriad mechanisms by which affects obesity, well strengths limitations probiotic or prebiotic supplementation prevention treatment Finally, we set roadmap comprehensive functional food solutions combatting capitalize on pre/probiotic therapies optimizing host health.

Язык: Английский

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Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients

Gut, Год журнала: 2020, Номер 69(11), С. 1975 - 1987

Опубликована: Фев. 10, 2020

Objective The gut microbiota has been proposed as an interesting therapeutic target for metabolic disorders. Inulin a prebiotic shown to lessen obesity and related diseases. aim of the current study was investigate whether preintervention characteristics determine physiological response inulin. Design stools from four obese donors differing by microbial diversity composition were sampled before dietary intervention inoculated antibiotic-pretreated mice ( hum-ob mice; humanised mice). Hum-ob fed with high-fat diet treated Metabolic changes on inulin treatment in compared those obtained cohort individuals supplemented 3 months. Results We show that colonised faecal different differentially respond supplementation diet. Among several bacterial genera, Barnesiella, Bilophila, Butyricimonas, Victivallis, Clostridium XIVa, Akkermansi a, Raoultella Blautia correlated observed outcomes (decrease adiposity hepatic steatosis) mice. In addition, individuals, levels Anaerostipes, Akkermansia Butyricicoccus drive decrease body mass index Conclusion These findings support characterising prior nutritional prebiotics is important increase positive outcome context

Язык: Английский

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Depolymerized RG-I-enriched pectin from citrus segment membranes modulates gut microbiota, increases SCFA production, and promotes the growth ofBifidobacteriumspp.,Lactobacillusspp. andFaecalibaculumspp.

Food & Function, Год журнала: 2019, Номер 10(12), С. 7828 - 7843

Опубликована: Янв. 1, 2019

Rhamnogalacturonan-I (RG-I)-enriched pectin (WRP) was recovered from citrus processing water by sequential acid and alkaline treatments in a previous study. RG-I-enriched proposed as potential supplement for functional food pharmaceutical development. However, studies illustrated that favorable modulations of gut microbiota were based on vitro changes the overall microbial structure question whether there is structure-dependent modulation remains largely enigmatic. In present study, commercial (CP), WRP its depolymerized fraction (DWRP) with different RG-I contents Mw compared vivo. It revealed 16s rRNA high-throughput sequencing DWRP mainly composed modulated positive way. significantly increased abundance prebiotic such Bifidobacterium spp., Lactobacillus while SCFAs producers including species Ruminococcaceae family. By maintaining more balanced composition enriching some SCFA producers, dietary also elevated content colon. Collectively, our findings offer new insights into structure-activity correlation provide impetus towards development small molecular weight specific use health-promoting ingredients therapeutic products.

Язык: Английский

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The influence of the gut microbiota on the bioavailability of oral drugs

Acta Pharmaceutica Sinica B, Год журнала: 2020, Номер 11(7), С. 1789 - 1812

Опубликована: Сен. 28, 2020

Due to its safety, convenience, low cost and good compliance, oral administration attracts lots of attention. However, the efficacy many drugs is limited their unsatisfactory bioavailability in gastrointestinal tract. One critical most overlooked factors symbiotic gut microbiota that can modulate by participating biotransformation drugs, influencing drug transport process altering some properties. In this review, we summarized existing research investigating possible relationship between which may provide great ideas useful instructions for design novel delivery systems or achievement personalized medicine.

Язык: Английский

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Plant Prebiotics and Their Role in the Amelioration of Diseases

Biomolecules, Год журнала: 2021, Номер 11(3), С. 440 - 440

Опубликована: Март 16, 2021

Prebiotics are either natural or synthetic non-digestible (non-)carbohydrate substances that boost the proliferation of gut microbes. Undigested fructooligosaccharides in large intestine utilised by beneficial microorganisms for synthesis short-chain fatty acids their own growth. Although various food products now recognized as having prebiotic properties, several others, such almonds, artichoke, barley, chia seeds, chicory, dandelion greens, flaxseeds, garlic, and oats, being explored used functional foods. Considering benefits these prebiotics mineral absorption, metabolite production, microbiota modulation, diseases diabetes, allergy, metabolic disorders, necrotising enterocolitis, increasing attention has been focused on applications both pharmaceutical industries, although some actually supplements. This review aims to highlight potential need diet also discusses data related distinct types, sources, modes action, health benefits.

Язык: Английский

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Maintaining homeostatic control of periodontal bone tissue

Periodontology 2000, Год журнала: 2021, Номер 86(1), С. 157 - 187

Опубликована: Март 10, 2021

Abstract Alveolar bone is a unique osseous tissue due to the proximity of dental plaque biofilms. Periodontal health and homeostasis are mediated by balanced host immune response these polymicrobial Dysbiotic shifts within biofilms can drive proinflammatory state in periodontal epithelial gingival connective tissues, which leads paracrine signaling subjacent cells. Sustained chronic inflammation disrupts “coupled” osteoclast‐osteoblast actions, ultimately result alveolar destruction. This chapter will provide an overview physiology highlight why oral microbiota critical regulator remodeling. The ecology be discussed context that periodontitis disruption homeostasis. pathogenesis loss explained from both historical current perspective, providing opportunity revisit role fibrosis cell interactions with cells reviewed based on our understanding osteoimmunological mechanisms influencing Lastly, probiotic prebiotic interventions evaluated as potential noninvasive therapies support prevent loss.

Язык: Английский

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The promise of the gut microbiome as part of individualized treatment strategies

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2021, Номер 19(1), С. 7 - 25

Опубликована: Авг. 27, 2021

Язык: Английский

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