Heliyon,
Год журнала:
2022,
Номер
9(1), С. e12698 - e12698
Опубликована: Дек. 31, 2022
Healthy
diet
is
vital
to
cellular
health.
The
human
body
succumbs
numerous
diseases
which
afflict
severe
economic
and
psychological
burdens
on
the
patient
family.
Oxidative
stress
a
possible
crucial
regulator
of
various
pathologies,
including
type
2
diabetes
neurodegenerative
diseases.
It
generates
reactive
oxygen
species
(ROS)
that
trigger
dysregulation
essential
functions,
ultimately
affecting
health
homeostasis.
However,
lower
levels
ROS
can
be
advantageous
are
implicated
in
variety
signaling
pathways.
Due
this
dichotomy,
terms
oxidative
"eustress,"
refers
good
event,
"distress,"
hazardous,
have
developed.
affects
multiple
pathways,
leading
compromised
insulin
secretion,
resistance,
β-cell
dysfunction
diabetes.
also
associated
with
increased
mitochondrial
neuroinflammation,
aggravating
conditions
body,
particularly
age.
Treatment
includes
drugs/therapies
often
dependence,
side
effects
non-selectivity,
toxicity,
long
run.
imperative
explore
alternative
medicines
as
an
adjunct
therapy,
utilizing
natural
remedies/resources
avoid
all
harms.
Antioxidants
components
our
fight
disease
by
reducing
or
nullifying
excess
toxic
free
radicals
produced
under
pathological
conditions.
In
review,
we
focus
antioxidant
dietary
foods
such
tea,
coffee,
wine,
oils,
honey
role
mechanism
action
these
antioxidants
alleviating
disorders.
We
aim
provide
information
about
alternatives
drug
treatments
used
alone
combined
reduce
intake
encourage
consumption
ingredients
at
doses
adequate
promote
combat
pathologies
while
unwanted
risks
effects.
Phytotherapy Research,
Год журнала:
2021,
Номер
36(4), С. 1442 - 1458
Опубликована: Дек. 14, 2021
Abstract
This
systematic
review
was
designed
to
determine
the
clinical
efficacy
and
safety
of
curcumin
supplementation
for
pediatric
patients
based
on
trials
in
children.
We
systematically
searched
electronic
databases
including
PubMed,
EMBASE,
Web
Science,
Scopus
all
studies
that
investigated
administration
population
without
any
time
frame
limitation.
Finally,
we
identified
16
this
review.
Clinical
were
assessed
children
with
inflammatory
immune
disorders
(including
asthma,
bowel
disease
(IBD),
juvenile
idiopathic
arthritis
(JIA)),
metabolic
disorders,
autosomal
dominant
polycystic
kidney
(ADPKD),
cystic
fibrosis
(CF),
tetralogy
Fallot
(TOF),
infectious
diseases.
Curcumin
administered
a
wide
range
doses
(45
mg–4,000
mg
daily)
durations
(2–48
weeks).
Overall,
well
tolerated
improved
severity
However,
more
are
needed
clarify
role
among
ADPKD,
CF,
TOF,
Because
substantial
heterogeneity
methodological
quality,
design,
outcomes,
dose,
duration
intake,
formulations,
study
populations
across
studies,
no
quantitative
analysis
performed.
Additional
large‐scale,
randomized,
placebo‐controlled
confirm
results
conducted
studies.
Nutrients,
Год журнала:
2022,
Номер
14(1), С. 231 - 231
Опубликована: Янв. 5, 2022
Chronic
kidney
disease
(CKD)
subjects
suffer
from
high
risk
of
cardiovascular
mortality,
and
any
intervention
preventing
the
progression
CKD
may
have
an
enormous
impact
on
public
health.
In
last
decade,
there
has
been
growing
awareness
that
gut
microbiota
(GM)
can
play
a
pivotal
role
in
controlling
pathogenesis
systemic
inflammatory
state
progression.
To
ameliorate
quality
life
subjects,
use
dietary
supplements
increased
over
time.
Among
those,
curcumin
demonstrated
significant
vitro
anti-inflammatory
properties.
this
pilot
study,
24
patients
20
healthy
volunteers
were
recruited.
followed
nutritional
counselling
supplemented
with
(Meriva®)
for
six
months.
Different
parameters
evaluated
at
baseline
after
3–6
months:
uremic
toxins,
metagenomic
GM,
nutritional,
inflammatory,
oxidative
status.
Curcumin
significantly
reduced
plasma
pro-inflammatory
mediators
(CCL-2,
IFN-γ,
IL-4)
lipid
peroxidation.
Regarding
6
months
supplementation,
Escherichia-Shigella
was
lower,
while
Lachnoclostridium
higher.
Notably,
family
level,
Lactobacillaceae
spp.
found
higher
3
supplementation.
No
adverse
events
observed
group,
confirming
good
safety
profile
phytosome
long-term
administration.
BioMed Research International,
Год журнала:
2022,
Номер
2022, С. 1 - 14
Опубликована: Фев. 2, 2022
Diabetes
is
a
metabolic
disease
with
multifactorial
causes
which
requires
lifelong
drug
therapy
as
well
lifestyle
changes.
There
now
growing
scientific
evidence
to
support
the
effectiveness
of
use
herbal
supplements
in
prevention
and
control
diabetes.
Curcumin
one
most
studied
bioactive
components
traditional
medicine,
but
its
physicochemical
characteristics
are
represented
by
low
solubility,
poor
absorption,
efficacy.
Nanotechnology-based
pharmaceutical
formulations
can
help
overcome
problems
reduced
bioavailability
curcumin
increase
antidiabetic
effects.
The
objectives
this
review
were
effects
nanocurcumin
on
DM
search
for
databases
such
PubMed/MEDLINE
ScienceDirect.
results
showed
that
activity
due
complex
pharmacological
mechanisms
reducing
characteristic
hyperglycemia
DM.
In
light
these
results,
may
be
considered
potential
agent
pharmacotherapeutic
management
patients
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(2), С. 639 - 639
Опубликована: Янв. 7, 2022
Obesity
is
a
global
health
problem
needing
urgent
research.
Synthetic
anti-obesity
drugs
show
side
effects
and
variable
effectiveness.
Thus,
there
tendency
to
use
natural
compounds
for
the
management
of
obesity.
There
considerable
body
knowledge,
supported
by
rigorous
experimental
data,
that
polyphenols,
including
curcumin,
can
be
an
effective
safer
alternative
managing
Curcumin
important
compound
present
in
Curcuma
longa
L.
rhizome.
It
lipophilic
molecule
rapidly
permeates
cell
membrane.
has
been
used
as
pharmacological
traditional
medicinal
agent
Ayurvedic
medicine
∼6000
years.
This
plant
metabolite
doubtless
effectiveness
reported
through
increasingly
detailed
vitro,
vivo
clinical
trials.
Regarding
its
biological
effects,
multiple
health-promoting,
disease-preventing
even
treatment
attributes
have
remarkably
highlighted.
review
documents
status
research
on
mechanisms
evaluates
curcumin
summarizes
different
action,
associated
with
enzymes,
energy
expenditure,
adipocyte
differentiation,
lipid
metabolism,
gut
microbiota
anti-inflammatory
potential
curcumin.
However,
still
need
systematic
targeted
studies
before
mainstream
therapy
Heliyon,
Год журнала:
2022,
Номер
9(1), С. e12698 - e12698
Опубликована: Дек. 31, 2022
Healthy
diet
is
vital
to
cellular
health.
The
human
body
succumbs
numerous
diseases
which
afflict
severe
economic
and
psychological
burdens
on
the
patient
family.
Oxidative
stress
a
possible
crucial
regulator
of
various
pathologies,
including
type
2
diabetes
neurodegenerative
diseases.
It
generates
reactive
oxygen
species
(ROS)
that
trigger
dysregulation
essential
functions,
ultimately
affecting
health
homeostasis.
However,
lower
levels
ROS
can
be
advantageous
are
implicated
in
variety
signaling
pathways.
Due
this
dichotomy,
terms
oxidative
"eustress,"
refers
good
event,
"distress,"
hazardous,
have
developed.
affects
multiple
pathways,
leading
compromised
insulin
secretion,
resistance,
β-cell
dysfunction
diabetes.
also
associated
with
increased
mitochondrial
neuroinflammation,
aggravating
conditions
body,
particularly
age.
Treatment
includes
drugs/therapies
often
dependence,
side
effects
non-selectivity,
toxicity,
long
run.
imperative
explore
alternative
medicines
as
an
adjunct
therapy,
utilizing
natural
remedies/resources
avoid
all
harms.
Antioxidants
components
our
fight
disease
by
reducing
or
nullifying
excess
toxic
free
radicals
produced
under
pathological
conditions.
In
review,
we
focus
antioxidant
dietary
foods
such
tea,
coffee,
wine,
oils,
honey
role
mechanism
action
these
antioxidants
alleviating
disorders.
We
aim
provide
information
about
alternatives
drug
treatments
used
alone
combined
reduce
intake
encourage
consumption
ingredients
at
doses
adequate
promote
combat
pathologies
while
unwanted
risks
effects.
