Curcumin: Overview of Extraction Methods, Health Benefits, and Encapsulation and Delivery Using Microemulsions and Nanoemulsions

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(10), С. 8874 - 8874

Опубликована: Май 17, 2023

Curcumin is the principal curcuminoid found in rhizomes of turmeric. Due to its therapeutic action against cancer, depression, diabetes, some bacteria, and oxidative stress, it has been used widely medicine since ancient times. low solubility, human organism cannot completely absorb it. Advanced extraction technologies, followed by encapsulation microemulsion nanoemulsion systems, are currently being improve bioavailability. This review discusses different methods available for curcumin from plant material, identification resulting extracts, beneficial effects on health, techniques into small colloidal systems that have over past decade deliver this compound.

Язык: Английский

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Potential of Curcumin in the Management of Skin Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3617 - 3617

Опубликована: Март 23, 2024

Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal preventing treating skin inflammation, premature ageing, psoriasis, acne. Additionally, exhibits antiviral, antimutagenic, antifungal effects. provides protection against damage caused by prolonged exposure UVB radiation. It reduces wound healing times improves collagen deposition. Moreover, increases fibroblast vascular density in wounds. review summarizes available information on therapeutic effect curcumin diseases. The results suggest that may be an inexpensive, well-tolerated, effective agent However, larger clinical trials are needed confirm these observations limitations vivo use, such as low bioavailability after oral administration metabolism.

Язык: Английский

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Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential

Molecules, Год журнала: 2022, Номер 27(10), С. 3291 - 3291

Опубликована: Май 20, 2022

(1) Background: Dyes play an important role in food, medicine, textile, and other industries, which make human life more colorful. With the increasing demand for food safety, development of natural dyes becomes attractive. (2) Methods: The literature was searched using electronic databases PubMed, Web Science, SciFinder this scoping review carried out following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA). (3) Results: 248 articles were included review. This summarizes research progress on last ten years. According to structural features, mainly include carotenoids, polyphenols, porphyrins, alkaloids, some newest are summarized. Some pharmacological activities anthocyanin, curcumin, betalains 10 years summarized, biological effects regarding illumination conditions. disadvantages dyes, including sources, cost, stability, poor bioavailability, limit their application. Here, feasible strategies (potential resources, biotechnology, new extraction separation strategies, improving stability) described, will contribute utilization dyes. (4) Conclusion: Natural show health benefits potential additives. However, it is necessary pass toxicity tests quality receive many regulatory approvals before final entry into market as colorants or drugs.

Язык: Английский

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Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Май 31, 2023

The aim of this study is to evaluate the effectiveness and safety curcumin in rheumatoid arthritis patients.

Язык: Английский

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Role of dietary polyphenols in non-communicable chronic disease prevention, and interactions in food systems: An overview

Nutrition, Год журнала: 2023, Номер 112, С. 112034 - 112034

Опубликована: Март 15, 2023

Язык: Английский

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Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Опубликована: Июль 12, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin's effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2,256 documents, leading selection 15 clinical trials synthesis. Here we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Язык: Английский

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Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence

Nutrients, Год журнала: 2024, Номер 16(16), С. 2721 - 2721

Опубликована: Авг. 15, 2024

Aging-related disorders pose significant challenges due to their complex interplay of physiological and metabolic factors, including inflammation, oxidative stress, mitochondrial dysfunction. Curcumin, a natural compound with potent antioxidant anti-inflammatory properties, has emerged as promising candidate for mitigating these age-related processes. However, gaps in understanding the precise mechanisms curcumin’s effects optimal dosages different conditions necessitate further investigation. This systematic review synthesizes current evidence on potential addressing disorders, emphasizing its impact cognitive function, neurodegeneration, muscle health older adults. By evaluating safety, efficacy, action curcumin supplementation, this aims provide insights into therapeutic promoting healthy aging. A search across three databases using specific keywords yielded 2256 documents, leading selection 15 clinical trials synthesis. Here, we highlight multifaceted agent combating disorders. The findings suggest that could offer effective approach enhancing quality life aging individuals. Further research well-designed are essential validate optimize use personalized medicine approaches conditions.

Язык: Английский

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The Influence of Polyphenols on Atherosclerosis Development

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7146 - 7146

Опубликована: Апрель 12, 2023

Polyphenols have attracted tremendous attention due to their pro-health properties, including antioxidant, anti-inflammatory, antibacterial and neuroprotective activities. Atherosclerosis is a vascular disorder underlying several CVDs. One of the main risk factors causing atherosclerosis type quality food consumed. Therefore, polyphenols represent promising agents in prevention treatment atherosclerosis, as demonstrated by vitro, animal, preclinical clinical studies. However, most cannot be absorbed directly small intestine. Gut microbiota play crucial role converting dietary into absorbable bioactive substances. An increasing understanding field has confirmed that specific GM taxa strains mediate gut microbiota–atherosclerosis axis. The present study explores anti-atherosclerotic properties associated mechanisms polyphenols. Moreover, it provides basis for better relationship between polyphenols, microbiota, cardiovascular benefits.

Язык: Английский

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The effect of curcumin supplementation on weight loss and anthropometric indices: an umbrella review and updated meta-analyses of randomized controlled trials

American Journal of Clinical Nutrition, Год журнала: 2023, Номер 117(5), С. 1005 - 1016

Опубликована: Март 9, 2023

Curcumin supplementation may promote weight loss and ameliorate obesity-related complications through its antioxidative anti-inflammatory properties.

Язык: Английский

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Therapeutic Effects of Curcumin Derivatives against Obesity and Associated Metabolic Complications: A Review of In Vitro and In Vivo Studies

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(18), С. 14366 - 14366

Опубликована: Сен. 21, 2023

Obesity is a major cause of morbidity and mortality globally, increasing the risk for chronic diseases. Thus, need to identify more effective anti-obesity agents has spurred significant interest in health-promoting properties natural compounds. Of these, curcumin, most abundant bioactive constituent turmeric, possesses variety health benefits including effects. However, despite its potential, curcumin demonstrated poor bioavailability, which limits clinical applicability. Synthesizing derivatives, are structurally modified analogs been postulated improve bioavailability while maintaining therapeutic efficacy. This review summarizes vitro vivo studies that assessed effects derivatives against obesity associated metabolic complications. We identified eight synthetic were shown ameliorate dysfunction diet-induced obese animal models, five these also attenuated complications cell culture models. These modulated adipogenesis, lipid metabolism, insulin resistance, steatosis, lipotoxicity, inflammation, oxidative stress, endoplasmic reticulum apoptosis, autophagy, fibrosis, dyslipidemia greater extent than curcumin. In conclusion, findings from this show compared present potential candidates further development as modulate obesity-associated

Язык: Английский

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