Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
161, С. 114424 - 114424
Опубликована: Фев. 22, 2023
Melanoma
is
one
of
the
most
aggressive
forms
skin
cancer
and
characterized
by
high
metastatic
potential.
Despite
improvements
in
early
diagnosis
treatment,
mortality
rate
among
melanoma
patients
continues
to
represent
a
significant
clinical
challenge.
Therefore,
it
imperative
that
we
search
for
new
treatment.
Trametes
versicolor
mushroom
commonly
used
Chinese
traditional
medicine
due
its
numerous
beneficial
properties.
In
present
work,
demonstrate
T.
fruiting
body
mycelium
ethanol
extracts
exhibit
potent
cytotoxic
activity
towards
A375
(IC50
=
663.3
114.5
µg/mL
respectively)
SK-MEL-5
358.4
88.6
human
cell
lines.
Further
studies
revealed
extract
induced
apoptotic
death
poly
(ADP-ribose)
polymerase
cleavage,
upregulated
expression
autophagy-associated
marker
LC3-II,
increased
presentation
major
histocompatibility
complex
II
programmed
death-ligand
receptor,
inhibited
migration
cells.
our
findings
highlight
therapeutic
potential
treatment
merit
further
study.
Biotechnology and Bioengineering,
Год журнала:
2022,
Номер
120(4), С. 917 - 931
Опубликована: Дек. 16, 2022
Odd-chain
fatty
acids
(OcFAs)
and
their
derivatives
have
attracted
much
attention
due
to
beneficial
physiological
effects
potential
be
alternatives
advanced
fuels.
However,
cells
naturally
produce
even-chain
(EcFAs)
with
negligible
OcFAs.
In
the
process
of
biosynthesis
(FAs),
acetyl-CoA
serves
as
starter
unit
for
EcFAs,
propionyl-CoA
works
The
lack
sufficient
propionyl-CoA,
precursor,
is
usually
regarded
main
restriction
large-scale
bioproduction
recent
years,
synthetic
biology
strategies
been
used
modify
several
microorganisms
more
that
would
enable
an
efficient
This
review
discusses
reported
metabolic
pathways
biosynthesis,
followed
by
advances
in
engineering
cell
factories
OcFAs
production.
Finally,
trends
challenges
driven
production
are
discussed.
Food Science & Nutrition,
Год журнала:
2022,
Номер
10(3), С. 740 - 750
Опубликована: Янв. 26, 2022
Bananas,
one
of
the
most
widely
consumed
fruits
worldwide,
are
a
rich
source
valuable
phytochemicals.
In
this
study,
antioxidant
and
anticancer
potential
banana
flesh
was
investigated.
Of
four
kinds
extracts,
hexane
extract
(HE)
had
highest
total
polyphenol
content
(2.54
±
0.60
mg
GAE/g)
flavonoid
(1.69
0.34
RE/g),
followed
by
chloroform
fraction,
ethanol
extract,
fraction.
HE
found
to
exert
strong
radical
scavenging
activity
on
2,2-diphenyl-1-picrylhydrazyl
(DPPH•)
2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonicacid)
(ABTS•)
free
radicals.
According
IC
Fermentation,
Год журнала:
2023,
Номер
9(2), С. 110 - 110
Опубликована: Янв. 24, 2023
Traditional
fermented
foods
harbor
microbes
that
transform
raw
food
components,
improving
their
nutritional,
shelf
life,
organoleptic,
and
health-promoting
characteristics.
Fermented
are
an
important
conduit
of
contact
between
bioactive
components
act
like
antigens
the
human
body
system.
Versatile
in
traditional
associated
with
many
end-products,
including
dietary
fatty
acids
inherent
fermenting
microbial
cells.
Evidence
shows
acid
regulate
genes
a
hormonally
dependent
manner,
either
directly
via
specific
binding
to
nuclear
receptors
or
indirectly
by
changing
regulatory
transcription
factors.
Fatty
implicated
anti-inflammatory,
anti-obesogenic,
immunoregulatory,
cardioprotective,
etc.,
activities.
Challenges
scaling
production
stem
from
losing
effective
consortiums
groups
differential
end-products.
Industrialists
must
overcome
safety
consistency
challenges.
They
need
combine
processes
lessen
advent
public
health
issues
introduce
omics
technologies
identify
maintain
consortium
groups,
prune
code
for
toxic
products,
inculcate
additional
beneficial
Incorporating
will
avail
benefits
larger
population
craves
them
outside
native
areas.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
161, С. 114424 - 114424
Опубликована: Фев. 22, 2023
Melanoma
is
one
of
the
most
aggressive
forms
skin
cancer
and
characterized
by
high
metastatic
potential.
Despite
improvements
in
early
diagnosis
treatment,
mortality
rate
among
melanoma
patients
continues
to
represent
a
significant
clinical
challenge.
Therefore,
it
imperative
that
we
search
for
new
treatment.
Trametes
versicolor
mushroom
commonly
used
Chinese
traditional
medicine
due
its
numerous
beneficial
properties.
In
present
work,
demonstrate
T.
fruiting
body
mycelium
ethanol
extracts
exhibit
potent
cytotoxic
activity
towards
A375
(IC50
=
663.3
114.5
µg/mL
respectively)
SK-MEL-5
358.4
88.6
human
cell
lines.
Further
studies
revealed
extract
induced
apoptotic
death
poly
(ADP-ribose)
polymerase
cleavage,
upregulated
expression
autophagy-associated
marker
LC3-II,
increased
presentation
major
histocompatibility
complex
II
programmed
death-ligand
receptor,
inhibited
migration
cells.
our
findings
highlight
therapeutic
potential
treatment
merit
further
study.
