Current Nutrition Reports, Год журнала: 2022, Номер 11(2), С. 102 - 116
Опубликована: Март 18, 2022
Язык: Английский
Journal of Endocrinological Investigation, Год журнала: 2024, Номер 47(3), С. 487 - 500
Опубликована: Янв. 18, 2024
Abstract Purpose The ketogenic nutritional therapy (KeNuT) is an effective dietary treatment for patients with obesity and obesity-related comorbidities, including type 2 diabetes, dyslipidaemia, hypertension, coronary artery disease, some of cancers. However, to date official document on the correct prescription diet, validated by authoritative societies in nutrition or endocrine sciences, missing. It important emphasize that requires proper medical supervision patient selection, due complex biochemical implications ketosis need a strict therapeutic compliance, experienced nutritionist personalization whole protocol. Methods This practical guide provides update main clinical indications contraindications meal replacements its mechanisms action. In addition, various phases protocol involving replacements, monitoring, management potential side effects, are also discussed. Conclusion will help healthcare provider acquire necessary skills provide comprehensive care overweight, diseases, using multistep treatment, recognized Club Italian Society Endocrinology (SIE)—Diet Therapies Metabolism.
Язык: Английский
Процитировано
24
Cell Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Фев. 13, 2024
Abstract Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which KD exerts its antiepileptic efficacy remain elusive. Herein, we report that KD-produced β-hydroxybutyric acid (BHB) augments brain gamma-aminobutyric (GABA) GABA/glutamate ratio to inhibit epilepsy. The ameliorated pentetrazol-induced mice. Mechanistically, BHB, but not other ketone bodies, inhibited HDAC1/HDAC2, increased H3K27 acetylation, transcriptionally upregulated SIRT4 glutamate decarboxylase 1 ( GAD1 ). BHB-induced de-carbamylated inactivated dehydrogenase preserve for GABA synthesis, upregulation mouse neuron excitation. BHB administration mice induced pentetrazol. BHB-mediated relief of required high level ratio. These results identified as major metabolite suggested may serve an alternative less toxic agent than KD.
Язык: Английский
Процитировано
23
Journal of Proteome Research, Год журнала: 2020, Номер 20(3), С. 1509 - 1521
Опубликована: Ноя. 9, 2020
Psoriasis is an inflammatory disease of the epidermis based on immunological mechanism involving Langerhans cells and T lymphocytes that produce pro-inflammatory cytokines. Genetic factors, environmental improper nutrition are considered triggers disease. Numerous studies have reported in a high number patients, psoriasis associated with obesity. Excess adipose tissue, typical obesity, causes systemic status coming from active tissue; therefore, weight reduction strategy to fight this state. This study aimed evaluate how nutritional regimen ketogenic diet influenced clinical parameters, metabolic profile, state patients. To end, 30 patients were subjected monitored for 4 weeks by evaluating data, biochemical NMR metabolomic IL-2, IL-1β, TNF-α, IFN-γ, IL-4 concentrations before after regimen. Our data show low-calorie can be successful therapeutic option gain improvement psoriasis-related dysmetabolism, significant correction full status.
Язык: Английский
Процитировано
82
Antioxidants, Год журнала: 2021, Номер 10(2), С. 157 - 157
Опубликована: Янв. 22, 2021
Chronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system may lead overproduction pro-inflammatory cytokines. Fatty acids as macronutrients key players for immunomodulation, with n-3 polyunsaturated fatty having most beneficial effect, while polyphenols carotenoids seem be promising antioxidants. Psoriasis is a chronic, immune-mediated inflammatory disease multifactorial etiology. Obesity major risk factor psoriasis, which leads worse clinical outcomes. Weight loss interventions and, generally, regimens such gluten-free Mediterranean diet or supplement use potentially improve psoriasis’ natural course response therapy. However, data about more sophisticated nutritional patterns, ketogenic, very low-carb specific macro- micro-nutrient substitution, scarce. This review aims present effect strictly structured nutrients, known affect glucose/lipid metabolism insulin responses, on chronic immunity, discuss utility possible therapeutic tools psoriasis psoriatic arthritis.
Язык: Английский
Процитировано
82
Nutrients, Год журнала: 2022, Номер 14(9), С. 1952 - 1952
Опубликована: Май 6, 2022
The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein that has gained popularity in recent years the context of neurological diseases (NDs). complexity pathogenesis these means effective forms treatment are still lacking. Conventional therapy often associated with increasing tolerance and/or drug resistance. Consequently, more therapeutic strategies being sought to increase effectiveness available improve quality life patients. For moment, it seems KD can provide benefits patients problems by effectively controlling balance between pro- antioxidant processes pro-excitatory inhibitory neurotransmitters, modulating inflammation or changing composition gut microbiome. In this review we evaluated potential efficacy epilepsy, depression, migraine, Alzheimer’s disease Parkinson’s disease. our opinion, should be considered as an adjuvant option for some diseases.
Язык: Английский
Процитировано
62
Nutrients, Год журнала: 2023, Номер 15(17), С. 3680 - 3680
Опубликована: Авг. 22, 2023
The ketogenic diet (KD) restricts carbohydrate consumption, leading to an increase in ketone bodies, such as acetoacetate, β-hydroxybutyrate, and acetone, which are utilized energy substrates. This dietary approach impacts several biochemical processes, resulting improved clinical management of various disorders, particularly childhood. However, the exact mechanisms underlying efficacy KD remain unclear. Interestingly, may also impact gut microbiota, plays a pivotal role metabolism, nutrition, development immune nervous systems. has gained popularity for its potential benefits weight loss, blood sugar control, certain neurological conditions. narrative review sums up KD-related studies published over 30 years. While short-term have provided valuable insights into effects on persistent uncertainties surround long-term inducing dysbiosis. significant influence epigenetic mechanisms, intracellular pathways, microbial composition underscores therapeutic choice. judicious consideration risks associated with strict adherence low-carbohydrate, high-fat, high-protein regimen prolonged periods is imperative. As KDs gain among adolescent young adult demographic management, it becomes imperative undertake additional research comprehensively assess their nutritional status ensuring holistic sustainable medical nutrition.
Язык: Английский
Процитировано
35
Frontiers in Pediatrics, Год журнала: 2024, Номер 12
Опубликована: Март 8, 2024
Obesity and depression represent major health problems due to their high prevalence morbidity rates. Numerous evidences elucidated the connections between dietary habits incidence or severity of depression. This overview aims investigate intricate relationship patterns with objective elaborating preventive strategies for childhood obesity. Literature data recognized that there is a link mood food choices, certain foods selected impact on brain's reward centers. behavior parallels one observed in substance addiction, suggesting specific neural mechanism addiction contributes overeating It important note significant correlation obesity depression, indicating shared biological pathway influencing these conditions. Stress substantially affects also eating behaviors, often leading increased consumption pleasurable rewarding foods. can trigger cycle overeating, weight gain, psychological distress, exacerbating disorders In addition, types foods, especially “comfort foods” fat calories, may provide temporary relief from symptoms but lead long-term further mental problems. Understanding complex interactions critical developing focusing dietary, emotional, environmental factors, thereby reducing risk disorders.
Язык: Английский
Процитировано
10
Nutrients, Год журнала: 2020, Номер 12(9), С. 2645 - 2645
Опубликована: Авг. 30, 2020
Epilepsy is a chronic and debilitating neurological disorder, with worldwide prevalence of 0.5-1% lifetime incidence 1-3%. An estimated 30% epileptic patients continue to experience seizures throughout life, despite adequate drug therapy or surgery, major impact on society global health. In recent decades, dietary regimens have been used effectively in the treatment drug-resistant epilepsy, following path non-pharmacological approach. The ketogenic diet its variants (e.g., modified Atkins diet) an established role contrasting epileptogenesis through production series cascading events induced by physiological ketosis. Other regimens, such as caloric restriction gluten free diet, can also exert beneficial effects neuroprotection and, therefore, refractory epilepsy. purpose this review was analyze evidence from literature about possible efficacy different focusing underlying pathophysiological mechanisms, safety, tolerability both pediatric adult population. We believe that better knowledge cellular molecular biochemical processes behind anticonvulsant alimentary therapies may lead development personalized intervention protocols.
Язык: Английский
Процитировано
61
Brain Sciences, Год журнала: 2021, Номер 11(5), С. 663 - 663
Опубликована: Май 19, 2021
Epilepsy is a chronic neurological disorder characterized by recurring spontaneous seizures. Drug resistance appears in 30% of patients and it can lead to premature death, brain damage or reduced quality life. The purpose the study was analyze drug mechanisms, especially neuroinflammation, epileptogenesis. information bases biomedical literature Scopus, PubMed, Google Scholar SciVerse were used. To obtain full-text documents, electronic resources PubMed Central Research Gate article examines recent research mechanisms epilepsy discusses hypotheses development (genetic, epigenetic, target hypothesis, etc.). Drug-resistant associated with neuroinflammatory, autoimmune neurodegenerative processes. Neuroinflammation causes immune, pathophysiological, biochemical psychological consequences. Focal systemic unregulated inflammatory processes formation aberrant neural connections hyperexcitable networks. Inflammatory mediators affect endothelium cerebral vessels, destroy contacts between endothelial cells induce abnormal angiogenesis (the “leaky” vessels), thereby affecting blood–brain barrier permeability. Thus, analysis pro-inflammatory other components epileptogenesis contribute further therapeutic treatment drug-resistant epilepsy.
Язык: Английский
Процитировано
56
Nutrients, Год журнала: 2023, Номер 15(4), С. 1058 - 1058
Опубликована: Фев. 20, 2023
(1) Background: The aim of our study was to evaluate parental stress after 6 and 12 months a ketogenic diet, considering demographic clinical variables (epilepsy type, epilepsy duration, seizure number, antiseizure medications, comorbidities, efficacy, adverse events). (2) Methods: We consecutively enrolled 36 children aged between 3 10 years who had been diagnosed with various types drug-resistant were in therapy diet for better control. A standardized neuropsychological questionnaire (Parenting Stress Index-PSI) administered the parents evaluating at baseline (T0), (T1) months, (T2). (3) Results: After dietary treatment, Parental Distress Total mean scores statistically significantly increased. Post hoc analysis showed no significant changes T0 T1, although there increase T1 T2. did not find relationships other considered. (4) Conclusions: can be challenging affect perception stress, especially long term. Parents may feel inadequate their role; therefore, they should helped encouraged through additional supports order maximize adherence therapy.
Язык: Английский
Процитировано
22