Bioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3813 - 3813

Опубликована: Фев. 14, 2023

It is generally accepted that diet-derived polyphenols are bioactive compounds with several potentially beneficial effects on human health. In general, have chemical structures, and the most representative flavonoids, phenolic acids, stilbenes. should be noted of closely related to their bioavailability bioaccessibility, as many them rapidly metabolized after administration. Polyphenols—with a protective effect gastrointestinal tract—promote maintenance eubiosis intestinal microbiota against gastric colon cancers. Thus, benefits obtained from dietary supplementation would seem mediated by gut microbiota. Taken at certain concentrations, been shown positively modulate bacterial component, increasing Lactiplantibacillus spp. Bifidobacterium involved in protection barrier decreasing Clostridium Fusobacterium, which negatively associated well-being. Based diet–microbiota–health axis, this review aims describe latest knowledge action health through activity discusses micro-encapsulation strategy improve

Язык: Английский

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Small Intestinal Bacterial Overgrowth—Pathophysiology and Its Implications for Definition and Management

Gastroenterology, Год журнала: 2022, Номер 163(3), С. 593 - 607

Опубликована: Апрель 7, 2022

Язык: Английский

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Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications

Nutrients, Год журнала: 2021, Номер 13(11), С. 3839 - 3839

Опубликована: Окт. 28, 2021

The gut microbiota is a crucial factor in maintaining homeostasis. presence of commensal microorganisms leads to the stimulation immune system and its maturation. In turn, dysbiosis with an impaired intestinal barrier accelerated contact host’s cells. Microbial structural parts, i.e., pathogen-associated molecular patterns (PAMPs), such as flagellin (FLG), peptidoglycan (PGN), lipoteichoic acid (LTA), lipopolysaccharide (LPS), induce inflammation via activation pattern recognition receptors. metabolites can also develop chronic low-grade inflammation, which cause many metabolic diseases. This article aims systematize information on influence benefits modification through dietary changes, prebiotics, probiotic intake. Scientific research indicates that various disease states reduce improve profile. However, since there no for healthy microbiota, optimal way modify it. methods influencing should be adapted type dysbiosis. Although are studies effects this subject still relatively unknown, more needed area.

Язык: Английский

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Diet and gut microbiome in gastrointestinal disease

Journal of Gastroenterology and Hepatology, Год журнала: 2021, Номер 37(2), С. 237 - 245

Опубликована: Окт. 30, 2021

The composition and function of the dynamic microbial community that constitutes gut microbiome is continuously shaped by host genome, mode birth delivery, geography, life stage, antibiotic consumption, diet. Diet one most potent factors in determining integrity. Dietary early appear to substantially determine risk later health or disease; for example, exposure ultra-processed foods childhood adolescence may increase development inflammatory bowel disease colorectal cancer, thought be mediated modulation microbiota. when diseases are established influence symptoms activity, can form a factor ongoing disease, used as therapy decrease activity. characterization dietary content currently complex imperfect, but tools emerging define precisely nature composition. Similarly, revolution analysis allows greater understanding how diet influences function. Defining interaction between diet, microbiome, gastrointestinal leading radical changes our clinical approach these disorders.

Язык: Английский

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The Relationships between Gut Microbiota and Diabetes Mellitus, and Treatments for Diabetes Mellitus

Biomedicines, Год журнала: 2022, Номер 10(2), С. 308 - 308

Опубликована: Янв. 28, 2022

Diabetes mellitus is considered to be a global epidemic. The combination of genetic susceptibility and an unhealthy lifestyle the main trigger this metabolic disorder. Recently, there has been increased interest in roles gut microbiota as new potential contributor Research, recent years, contributed in-depth characterization human microbiome its associations with various diseases, including diseases diabetes mellitus. It known that diet can change composition microbiota, but it unclear how this, turn, may influence metabolism. objective review evaluate pathogenetic association between explore any therapeutic agents, nutraceuticals modulate microbiota. We also look at several mechanisms involved process. There clear, bidirectional relationship diabetes. Current treatments for ways, some beneficial, others still effects. Microbiota-aimed have seen no real-world significant effects on progression complications, more studies needed order find really beneficial agent.

Язык: Английский

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Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation

Nutrients, Год журнала: 2022, Номер 14(9), С. 1918 - 1918

Опубликована: Май 3, 2022

Increasing evidence on the significance of nutrition in reproduction is emerging from both animal and human studies, suggesting a mutual association between female fertility. Different “fertile” dietary patterns have been studied; however, humans, conflicting results or weak correlations are often reported, probably because individual variations genome, proteome, metabolome, microbiome extent exposure to different environmental conditions. In this scenario, “precision nutrition”, namely personalized based deep phenotyping metabolomics, microbiome, nutrigenetics each case, might be more efficient for infertile patients than applying generic nutritional approach. review, we report new insights into management patients, discussing main nutrigenetic, nutrigenomic, microbiomic aspects that should investigated achieve effective interventions. Specifically, will focus low-grade chronic inflammation, which associated with several infertility-related diseases.

Язык: Английский

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Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management

Food Science & Nutrition, Год журнала: 2023, Номер 11(4), С. 1671 - 1704

Опубликована: Март 7, 2023

Dysfunction of gut barrier is known as "leaky gut" or increased intestinal permeability. Numerous recent scientific evidences showed the association between dysfunction and multiple gastrointestinal tract (GI) non-GI diseases. Research also demonstrated that food plays a crucial role to cause remedy related We reviewed articles from electronic databases, mainly PubMed. The data were based on animal models, cell human research in vivo vitro models. In this comprehensive review, our aim focused relationship dietary factors, permeability dysfunction, This review synthesizes currently available literature discussed three parts: (a) mechanism function, (b) supplements may promote health, medication alter (c) table organizes synthesized information by general mechanisms for diseases leaky gut/intestinal associated influences. With future research, intervention could be new target individualized disease prevention management.

Язык: Английский

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Advances in understanding wheat-related disorders: A comprehensive review on gluten-free products with emphasis on wheat allergy, celiac and non-celiac gluten sensitivity

Food Chemistry Advances, Год журнала: 2024, Номер 4, С. 100627 - 100627

Опубликована: Фев. 15, 2024

Globally, population consume energy dense wheat-based foods and highly processed products due to their superior propensities like viscoelastic approach, minimal cost nutritional characteristics. This leads the suffering of people with various gluten related disorders, like, wheat allergy, celiac disease non-celiac sensitivity. However, in this contemporary world, majority inhabitants relies on free (GF) by exploring understanding health benefits from variety GF grains recent decades. Despite being advantageous, diet also faces multifarious outbreaks functional, rheological aspects. Therefore, overcome it, novel technologies proteolysis peptides, modified CRISPER/Cas9 technology, microbial transglutaminase proteins have been developed. The present review layouts comprehensive impression disorders that lead promote approaches for curative measures along hazard associated those risk factors. Recent advances purpose seeking reduction characterizing clinical entities, looking forward at future advancement, more so, researchers should shed chronicled mindsets must make broader vision towards approach.

Язык: Английский

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Food Intolerances, Food Allergies and IBS: Lights and Shadows

Nutrients, Год журнала: 2024, Номер 16(2), С. 265 - 265

Опубликована: Янв. 16, 2024

This narrative review delves into the intricate relationship between irritable bowel syndrome (IBS) and food intolerances. IBS, a chronic functional gastrointestinal disorder, is characterized by symptoms like abdominal pain altered habits. The prevalence of IBS has increased globally, especially among young adults. Food dietary habits play crucial role in management. About 85-90% patients report symptom exacerbation linked to specific consumption, highlighting strong connection intolerances IBS. often exhibit dose-dependent pattern, posing challenge identifying trigger foods. issue further complicated complex nature physiology varying compositions. discusses various patterns their impact on including low-FODMAP diet, gluten-free Mediterranean diet. It highlights importance personalized approach management, considering individual variability history. In conclusion, this emphasizes need for accurate diagnosis holistic management interplay factors pathophysiology. underlines patient education adherence treatment plans, acknowledging challenges posed triggers psychological restrictions.

Язык: Английский

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Probiotics, Prebiotics and Other Dietary Supplements for Gut Microbiota Modulation in Celiac Disease Patients

Nutrients, Год журнала: 2020, Номер 12(9), С. 2674 - 2674

Опубликована: Сен. 2, 2020

To date, the only available treatment for celiac disease (CD) patients is a life-lasting gluten-free diet (GFD). Lack of adherence to GFD leads significant risk adverse health consequences. Food cross-contamination, nutritional imbalances, and persistent gastrointestinal symptoms are main concerns related GFD. Moreover, despite rigid compliance GFD, struggle in achieving full restoring gut microbiota, which plays role nutritive compounds processing, absorption. Pivotal studies on supplementation with probiotics, such as Bifidobacterium Lactobacilli, reported potential restore microbiota composition pre-digest gluten intestinal lumen, reducing inflammation associated intake, permeability, cytokine antibody production. These findings could explain an improvement quality life treated probiotics. On other hand, inclusion prebiotics also be easy administer cost-effective adjunctive CD, having power stimulate growth potentially health-promoting bacteria strains. However, evidence regarding use probiotics CD still insufficient justify their clinical practice.

Язык: Английский

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