Time-restricted Eating for the Prevention and Management of Metabolic Diseases

Endocrine Reviews, Год журнала: 2021, Номер 43(2), С. 405 - 436

Опубликована: Сен. 22, 2021

Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE, humans) are an emerging behavioral intervention approach based on the understanding of role circadian rhythms in physiology metabolism. In this approach, all calorie intake is restricted within a consistent interval less than 12 hours without overtly attempting to reduce calories. This article will summarize origin TRF/TRE starting with concept chronic rhythm disruption increasing risk for metabolic diseases. Circadian usually perceived as sleep-wake cycle dependent arising from central nervous system. However, recent discovery peripheral organs plasticity these response changes nutrition availability raised possibility that adopting daily short window can sustain robust rhythm. Preclinical animal studies have demonstrated proof identified potential mechanisms driving TRF-related benefits. Pilot human reported promising results reducing obesity, diabetes, cardiovascular Epidemiological indicated maintaining long overnight fast, which similar TRE, significantly risks Despite early successes, more clinical mechanistic needed implement TRE alone or adjuvant lifestyle prevention management

Язык: Английский

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Food Timing, Circadian Rhythm and Chrononutrition: A Systematic Review of Time-Restricted Eating’s Effects on Human Health

Nutrients, Год журнала: 2020, Номер 12(12), С. 3770 - 3770

Опубликована: Дек. 8, 2020

Introduction: Recent observations have shown that lengthening the daily eating period may contribute to onset of chronic diseases. Time-restricted (TRE) is a diet especially limits this food window. It could represent dietary approach likely improve health markers. The aim study was review how time-restricted affects human health. Method: Five general databases and six nutrition journals were screened identify all studies published between January 2014 September 2020 evaluating effects TRE on populations. Results: Among 494 articles collected, 23 finally included for analysis. overall adherence rate 80%, with 20% unintentional reduction in caloric intake. induced an average weight loss 3% fat mass. This also observed without any restriction. Interestingly, produced beneficial metabolic independently loss, suggesting intrinsic effect based realignment feeding circadian clock. Conclusions: simple well-tolerated generates many chrononutrition principles. More rigorous are needed, however, confirm those effects, understand their mechanisms assess applicability

Язык: Английский

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Effects of Diet, Lifestyle, Chrononutrition and Alternative Dietary Interventions on Postprandial Glycemia and Insulin Resistance

Nutrients, Год журнала: 2022, Номер 14(4), С. 823 - 823

Опубликована: Фев. 16, 2022

As years progress, we are found more often in a postprandial than postabsorptive state. Chrononutrition is an integral part of metabolism, pancreatic function, and hormone secretion. Eating most calories carbohydrates at lunch time early afternoon, avoiding late evening dinner, keeping consistent number daily meals relative times eating occasions seem to play pivotal role for glycemia insulin sensitivity. Sequence nutrients also significant role, as foods low density such vegetables, salads, or soups consumed first, followed by protein then starchy lead ameliorated glycemic responses. There several dietary schemes available, intermittent fasting regimes, which may improve Weight loss important the treatment resistance, it can be achieved many approaches, low-fat, low-carbohydrate, Mediterranean-style diets, etc. Lifestyle interventions with small weight (7-10%), 150 min weekly moderate intensity exercise behavioral therapy approach highly effective preventing treating type 2 diabetes. Similarly, decreasing improves significantly responses, but extent this reduction should individualized, patient-centered, monitored. Alternative ingredients, vinegar, yogurt, whey protein, peanuts tree nuts considered ameliorating hyperglycemia resistance. This review aims describe available evidence about effects diet, chrononutrition, alternative on

Язык: Английский

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Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial

Diabetologia, Год журнала: 2022, Номер 65(10), С. 1710 - 1720

Опубликована: Июль 24, 2022

Time-restricted eating (TRE) is suggested to improve metabolic health by limiting food intake a defined time window, thereby prolonging the overnight fast. This prolonged fast expected lead more pronounced depletion of hepatic glycogen stores and might insulin sensitivity due an increased need replenish nutrient storage. Previous studies showed beneficial effects 6-8 h TRE regimens in healthy, overweight adults under controlled conditions. However, on glucose homeostasis individuals with type 2 diabetes are unclear. Here, we extensively investigated levels diabetes.Fourteen (BMI 30.5±4.2 kg/m2, HbA1c 46.1±7.2 mmol/mol [6.4±0.7%]) participated 3 week (daily within 10 h) vs control (spreading over ≥14 regimen randomised, crossover trial design. The study was performed at Maastricht University, Netherlands. Eligibility criteria included diagnosis diabetes, intermediate chronotype absence medical conditions that could interfere execution and/or outcome. Randomisation study-independent investigator, ensuring equal amount participants started CON. Due nature study, neither volunteers nor investigators were blinded interventions. quality data checked without knowledge intervention allocation. Hepatic assessed 13C-MRS using hyperinsulinaemic-euglycaemic two-step clamp. Furthermore, 24 continuous monitoring devices. Secondary outcomes energy expenditure substrate oxidation, lipid content skeletal muscle mitochondrial capacity.Results depicted as mean ± SEM. similar between condition (0.15±0.01 0.15±0.01 AU, p=0.88). M value not significantly affected (19.6±1.8 17.7±1.8 μmol kg-1 min-1 control, respectively, p=0.10). peripheral also remained unaffected (p=0.67 p=0.25, respectively). Yet, insulin-induced non-oxidative disposal (non-oxidative 4.3±1.1 1.5±1.7 min-1, p=0.04). spent normoglycaemic range (15.1±0.8 12.2±1.1 per day, p=0.01), decreased fasting (7.6±0.4 8.6±0.4 mmol/l, p=0.03) (6.8±0.2 7.6±0.3 p<0.01). Energy unaffected; nevertheless, oxidation (260.2±7.6 277.8±10.7 g/day, No adverse events reported related interventions.We show feasible, safe effective means free-living diabetes. these changes accompanied or glycogen.ClinicalTrials.gov NCT03992248 FUNDING: ZonMW, 459001013.

Язык: Английский

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Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock

Nutrients, Год журнала: 2021, Номер 13(5), С. 1405 - 1405

Опубликована: Апрель 22, 2021

The importance of metabolic health is a major societal concern due to the increasing prevalence diseases such as obesity, diabetes, and various cardiovascular diseases. circadian clock clearly implicated in development these Indeed, it regulates physiological processes by hormone modulation, thus helping body perform them at ideal time day. Since industrial revolution, actions rhythms everyday life have been modified are characterized changes sleep pattern, work schedules, eating habits. These modifications turn lead night shift, social jetlag, late-night eating, meal skipping, group customs that causes rhythm disruption leads an increase risks. Intermittent fasting, especially time-restricted proposes solution: restraining feeding window from 6 10 h per day match with clock. This approach seems improve markers could be therapeutic solution fight against review summarizes matching habits for assesses advantages limits application fasting objective treating preventing

Язык: Английский

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Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease

Acta Pharmaceutica Sinica B, Год журнала: 2021, Номер 12(2), С. 511 - 531

Опубликована: Июнь 30, 2021

Aging is by far the most prominent risk factor for Alzheimer's disease (AD), and both aging AD are associated with apparent metabolic alterations. As developing effective therapeutic interventions to treat clearly in urgent need, impact of modulating whole-body intracellular metabolism preclinical models human patients, on pathogenesis, have been explored. There also an increasing awareness differential potential targeting strategies related biological sex, microbiome, circadian regulation. a major part metabolism, mitochondrial bioenergetics, quality-control mechanisms, mitochondria-linked inflammatory responses considered interventions. This review summarizes highlights these efforts.

Язык: Английский

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Complex physiology and clinical implications of time-restricted eating

Physiological Reviews, Год журнала: 2022, Номер 102(4), С. 1991 - 2034

Опубликована: Июль 14, 2022

Time-restricted eating (TRE) is a dietary intervention that limits food consumption to specific time window each day. The effect of TRE on body weight and physiological functions has been extensively studied in rodent models, which have shown considerable therapeutic effects important interactions among eating, circadian biology, metabolic homeostasis. In contrast, it difficult make firm conclusions regarding the people because heterogeneity results, regimens, study populations. this review, we 1) provide background history meal normal physiology fasting; 2) discuss interaction between molecular metabolism TRE; 3) integrate results preclinical clinical studies evaluated functions; 4) summarize other time-related interventions people; identify current gaps knowledge framework for future research directions.

Язык: Английский

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Advances in the management of type 2 diabetes in adults

BMJ Medicine, Год журнала: 2023, Номер 2(1), С. e000372 - e000372

Опубликована: Сен. 1, 2023

Type 2 diabetes is a chronic and progressive cardiometabolic disorder that affects more than 10% of adults worldwide major cause morbidity, mortality, disability, high costs. Over the past decade, pattern management has shifted from predominantly glucose centric approach, focused on lowering levels haemoglobin A

Язык: Английский

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Dietary circadian rhythms and cardiovascular disease risk in the prospective NutriNet-Santé cohort

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Дек. 14, 2023

Daily eating/fasting cycles synchronise circadian peripheral clocks, involved in the regulation of cardiovascular system. However, associations daily meal and fasting timing with disease (CVD) incidence remain unclear. We used data from 103,389 adults NutriNet-Santé study. Meal number eating occasions were estimated repeated 24 h dietary records. built multivariable Cox proportional-hazards models to examine their association risk CVD, coronary heart cerebrovascular disease. In this study, having a later first (later than 9AM compared earlier 8AM) last day 9PM 8PM) was associated higher outcomes, especially among women. Our results suggest potential benefit adopting patterns, coupling longer nighttime period an early meal, rather breakfast skipping, CVD prevention.

Язык: Английский

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Time Restricted Eating: A Dietary Strategy to Prevent and Treat Metabolic Disturbances

Frontiers in Endocrinology, Год журнала: 2021, Номер 12

Опубликована: Авг. 12, 2021

Time-restricted eating (TRE), a dietary approach limiting the daily window, has attracted increasing attention in media and research. The behavior our modern society is often characterized by prolonged erratic patterns, which might be associated with increased risk of obesity, diabetes, cardiovascular diseases. In contrast, recent evidence suggests that TRE support weight loss, improve cardiometabolic health, overall wellbeing, but data are controversial. present work reviews how affects glucose lipid metabolism based on clinical trials published until June 2021. A range demonstrated intervention lowered fasting postprandial levels response to standard meal or oral tolerance test, as well mean 24-h glycemic excursions assessed using continuous monitoring. addition, insulin decreases improvement sensitivity were demonstrated. These changes accompanied decrease blood triglyceride cholesterol levels. However, number studies found had either adverse no effects traits, explained different study designs (i.e., fasting/eating duration, daytime eating, calorie intake, duration intervention) subject cohorts (metabolic status, age, gender, chronotype, etc.). To summarize, represents an attractive easy-to-adapt strategy for prevention therapy metabolic disturbances. carefully controlled future needed confirm these understand underlying mechanisms assess applicability personalized interventions.

Язык: Английский

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