Опубликована: Янв. 1, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 6987 - 6987
Опубликована: Июнь 26, 2024
The number of people diagnosed with type 2 diabetes is on the increase worldwide. Of growing concern, prevalence in children and youths increasing rapidly mirrors burden childhood obesity. There are many risk factors associated condition; some due to lifestyle, but beyond our control, such as genetics. an urgent need develop better therapeutics for prevention management this complex condition since current medications often cause unwanted side effects, poorly managed can result onset related comorbidities. Naturally derived compounds have gained momentum preventing managing several conditions, including diabetes. Here, we provide update benefits limitations fenugreek its components a therapeutic diabetes, bioavailability interaction microbiome.
Язык: Английский
Процитировано
6
Current Diabetes Reports, Год журнала: 2024, Номер 24(5), С. 85 - 95
Опубликована: Фев. 29, 2024
Язык: Английский
Процитировано
5
Journal of Diabetes Investigation, Год журнала: 2024, Номер 15(10), С. 1410 - 1421
Опубликована: Июль 24, 2024
Efficacy of long-term low-carbohydrate diets (LCD) to improve glycemic management for type 2 diabetes remains controversial. Thus, we investigated the association between LCD and control in individuals with diabetes.
Язык: Английский
Процитировано
5
Ophthalmology Retina, Год журнала: 2024, Номер 8(10), С. 943 - 952
Опубликована: Май 11, 2024
Язык: Английский
Процитировано
4
Results in Chemistry, Год журнала: 2025, Номер 14, С. 102139 - 102139
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
0
Australian Journal of Primary Health, Год журнала: 2025, Номер 31(2)
Опубликована: Март 3, 2025
Background Approximately 500 million people worldwide live with type 2 diabetes mellitus. The UK's 'Diabetes Remission Clinical Trial' (DiRECT) is a potential novel method for care. An Australian trial of DiRECT (DiRECT-Aus) showed that 56% participants achieved remission at 12months. We explored the experiences patients, clinicians and partners involved in DiRECT-Aus to ascertain acceptability feasibility DiRECT-Aus, as well factors influencing implementation, inform recommendations sustainable scale up into mainstream primary Methods This qualitative implementation research conducted within constructivist paradigm semi-structured interviews key stakeholders. Data analysis followed an inductive thematic approach, informed by Consolidated Framework Implementation Research. Results Patients (n =14), general practitioners =3), practice nurses =6), dietitians =7) =5) were interviewed. identified four core components are essential up. They were: (1) access very low-energy diet products; (2) high frequency contact dietitian; (3) dietitian's clinical knowledge patient-centred practice; (4) absence financial costs patients. Several additional could support suggested funding models described. Conclusions study concludes was acceptable feasible patients clinicians.
Язык: Английский
Процитировано
0
Tissue and Cell, Год журнала: 2025, Номер 95, С. 102852 - 102852
Опубликована: Март 8, 2025
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(3), С. 399 - 399
Опубликована: Март 11, 2025
GABA (γ-Aminobutyric Acid), a well-established inhibitory neurotransmitter in the central nervous system, has garnered considerable interest for its potential role diabetes management, particularly due to presence pancreatic islets. This review aims explore therapeutic of management and mechanisms antidiabetic effects. Relevant studies were searched across databases such as PubMed ScienceDirect, applying strict eligibility criteria focused on administration methods diabetic models. The collective results showed that models resulted remarkable enhancements glucose insulin homeostasis, favorable modifications lipid profiles, amelioration dysfunctions neural, hepatic, renal, cardiac systems. findings from literature demonstrated GABAergic signaling within tissues can significantly contribute stimulation β cell proliferation through facilitation sustained trans-differentiation process, wherein glucagon-secreting α cells are converted into insulin-secreting β-like cells. In addition, activated trigger initiation PI3K/AKT pathway tissues, leading improved maintained homeostasis. further function hepatic promoting effects expression genes related gluconeogenesis lipogenesis. Moreover, may enhance gut microbiota diversity by attenuating inflammation, attributable anti-inflammatory immunomodulatory properties. Furthermore, neuroprotective play significant ameliorating neural disorders associated with facilitating substantial reduction neuronal apoptosis. conclusion, emerges promising candidate an agent; however, research is highly encouraged develop rigorously designed framework comprehensively identifies optimizes appropriate dosages intervention effectively managing combating diabetes.
Язык: Английский
Процитировано
0
Le Praticien en Anesthésie Réanimation, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Процитировано
0
International Journal of Environmental Research and Public Health, Год журнала: 2025, Номер 22(3), С. 414 - 414
Опубликована: Март 12, 2025
This study investigates the impact of Health Belief Model (HBM) constructs on self-care behaviors among Black/African American men with Type 2 Diabetes (T2D). A cross-sectional survey was conducted from February to June 2024, involving 1225 aged 21 years or older who self-reported a T2D diagnosis. The included HBM constructs, and measured using established scales. Statistical analyses, including multiple linear regression, were performed assess relationships between components practices, adjusted by demographic factors such as age, education, income. found that self-efficacy strongest predictor across all domains (β = 0.055, p < 0.001). Perceived susceptibility positively associated healthful eating 0.042, 0.038), glucose monitoring 0.117, 0.001), foot care 0.140, severity linked diet adherence 0.015, 0.001) 0.028, barriers negatively -0.047, However, perceived benefits did not significantly overall 0.001, 0.893). Self-efficacy, susceptibility, significant predictors T2D. In particular, interventions aimed at enhancing self-efficacy, addressing barriers, promoting awareness diabetes risks may improve management in this population.
Язык: Английский
Процитировано
0