Evidence Update on the Relationship between Diet and the Most Common Cancers from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study: A Systematic Review

Nutrients, Год журнала: 2021, Номер 13(10), С. 3582 - 3582

Опубликована: Окт. 13, 2021

The European Prospective Investigation into Cancer and Nutrition (EPIC) is a multicentre prospective study conducted in 23 centres 10 countries. Here we review the findings from EPIC on relationship between diet-related exposures incidence or mortality four most frequent cancers population: colorectal, breast, lung, prostate cancer. We systematic following PRISMA guidelines identified 110 high-quality studies based cohort. Fruit vegetable consumption had protective effect against lung cancer, whereas only fruit A higher of fish lower red processed meat were related with risk colorectal cancer; fatty breast Calcium yogurt intake found to protect Alcohol increased for Finally, adherence Mediterranean diet emerged as factor results are agreement latest evidence leading authorities cancer prevention help inform public policies strategies.

Язык: Английский

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Healthy Lifestyle and Cancer Risk: Modifiable Risk Factors to Prevent Cancer

Nutrients, Год журнала: 2024, Номер 16(6), С. 800 - 800

Опубликована: Март 11, 2024

Cancer has become a serious problem worldwide, as it represents the main cause of death, and its incidence increased over years. A potential strategy to counter growing spread various forms cancer is adoption prevention strategies, in particular, use healthy lifestyles, such maintaining weight, following diet; being physically active; avoiding smoking, alcohol consumption, sun exposure; vitamin D supplementation. These modifiable risk factors are associated with this disease, contributing development, progression, severity. This review evaluates relationship between potentially overall specifically breast, colorectal, prostate cancer, highlights updated recommendations on prevention. The results numerous clinical epidemiological studies clearly show influence lifestyles development cancer. An incorrect diet, composed mainly saturated fats processed products, resulting body combined physical inactivity, induced an increase all three types under study. Given importance adopting correct prevent global institutions should develop strategies environments that encourage individuals adopt regular behaviors.

Язык: Английский

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Underlying Features of Prostate Cancer—Statistics, Risk Factors, and Emerging Methods for Its Diagnosis

Current Oncology, Год журнала: 2023, Номер 30(2), С. 2300 - 2321

Опубликована: Фев. 15, 2023

Prostate cancer (PCa) is the most frequently occurring type of malignant tumor and a leading cause oncological death in men. PCa very heterogeneous terms grade, phenotypes, genetics, displaying complex features. This often has indolent growth, not compromising patient’s quality life, while its more aggressive forms can manifest rapid growth with progression to adjacent organs spread lymph nodes bones. Nevertheless, overtreatment patients leads important physical, mental, economic burdens, which be avoided careful monitoring. Early detection, even cases locally advanced metastatic tumors, provides higher chance cure, thus go through less treatments fewer side effects. Furthermore, it offer knowledge about how modifiable risk factors an effective method for reducing risk. Innovations diagnostics therapy are still required overcome some limitations current screening techniques, specificity sensitivity. In this context, review brief overview statistics, reporting incidence mortality rates worldwide, factors, emerging strategies.

Язык: Английский

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Role of Natural and Synthetic Compounds in Modulating NRF2/KEAP1 Signaling Pathway in Prostate Cancer

Cancers, Год журнала: 2023, Номер 15(11), С. 3037 - 3037

Опубликована: Июнь 2, 2023

Prostate cancer is the second most common in men worldwide. can be treated by surgery or active surveillance when early diagnosed but, at an advanced metastatic stage, radiation therapy androgen-deprivation needed to reduce progression. However, both of these therapies cause prostate resistance treatment. Several studies demonstrated that oxidative stress involved occurrence, development, progression and treatment resistance. The nuclear factor erythroid 2-related 2 (NRF2)/KEAP1 (Kelch-Like ECH-Associated Protein 1) pathway plays important role protecting cells against damage. Reactive oxygen species (ROS) levels NRF2 activation determine cell fate. In particular, toxic ROS lead physiological death tumor suppression, while lower are associated with carcinogenesis On contrary, a high level promotes survival related activating adaptive antioxidant response. this review, we analyzed current literature regarding natural synthetic compounds modulating NRF2/KEAP1 signaling cancer.

Язык: Английский

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Metabolic changes during prostate cancer development and progression

Journal of Cancer Research and Clinical Oncology, Год журнала: 2022, Номер 149(5), С. 2259 - 2270

Опубликована: Сен. 23, 2022

Abstract Metabolic reprogramming has been recognised as a hallmark in solid tumours. Malignant modification of the tumour’s bioenergetics provides energy for tumour growth and progression. Otto Warburg first reported these metabolic biochemical changes 1927. In prostate cancer (PCa) epithelial cells, metabolism also during development progress. These alterations are partly driven by androgen receptor, key regulator PCa development, progress, survival. contrast to other cells different entities, glycolytic sustains physiological citrate secretion normal prostatic epithelium. early stages PCa, is utilised power oxidative phosphorylation fuel lipogenesis, enabling advanced incurable castration-resistant shift towards choline, amino acid, fueling progression described. Therefore, even if not fully understood, altered may provide opportunities novel therapeutic strategies, especially stages. This review focuses on main differences PCa’s tumourigenesis highlighting glutamine’s role PCa.

Язык: Английский

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Targeting lipid metabolism in metastatic prostate cancer

Therapeutic Advances in Medical Oncology, Год журнала: 2023, Номер 15

Опубликована: Янв. 1, 2023

Despite key advances in the treatment of prostate cancer (PCa), a proportion men have de novo resistance, and all will develop resistance to current therapeutics over time. Aberrant lipid metabolism has long been associated with carcinogenesis progression, but more recently there an explosion preclinical clinical data which is informing new trials. This review explores epidemiological links between obesity metabolic syndrome PCa, evidence for altered circulating lipids PCa their potential role as biomarkers, well novel therapeutic strategies targeting including therapies widely used cardiovascular disease such statins, metformin lifestyle modification, targeted agents sphingosine kinase inhibitors, DES1 inhibitors FASN beta oxidation.

Язык: Английский

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Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer

Nutrients, Год журнала: 2022, Номер 14(4), С. 851 - 851

Опубликована: Фев. 18, 2022

Prostate cancer (PCa) is the most commonly diagnosed malignant neoplasm in men Western world. Localized low-risk PCa has an excellent prognosis thanks to effective local treatments; however, despite incorporation of new therapeutic strategies, metastatic remains incurable mainly due disease heterogeneity and development resistance therapy. The mechanisms underlying progression therapy are multiple include metabolic reprogramming, especially relation lipid metabolism, as well epigenetic remodelling, both which enable cells adapt dynamic changes tumour. Interestingly, metabolism epigenetics interconnected. Metabolism can regulate through direct influence metabolites on processes, while control by directly or indirectly regulating expression genes. Moreover, epidemiological studies suggest association between a high-fat diet, alter availability metabolites, progression. Here, we review alterations PCa, before focusing that connect them. We also discuss diet this scenario. This information may help identify prognostic predictive biomarkers targetable vulnerabilities.

Язык: Английский

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Associations of Dietary Intakes with Gynecological Cancers: Findings from a Cross-Sectional Study

Nutrients, Год журнала: 2022, Номер 14(23), С. 5026 - 5026

Опубликована: Ноя. 25, 2022

Background: Gynecological cancers, including cervical cancer, ovarian cancer and endometrial are leading causes of cancer-related death in women worldwide. Diet plays an important role development, which is widely accepted. However, the associations between dietary intakes gynecological cancers remain unclear. Methods: A total 12,437 aged over 20 years from National Health Nutrition Examination Survey (NHANES), conducted 2007−2016, were included this study. The relationships 30 factors (4 macronutrients, 15 vitamins, 9 minerals, caffeine alcohol) assessed. Results: We observed negative correlations phosphorus (odds ratio (OR), 95% confidence interval (CI); 0.998 (0.996, 0.999), p = 0.002) with vitamin B12 (0.812 (0.714, 0.925), 0.002), (0.997 < 0.001) alcohol (0.971 (0.950, 0.992), 0.009) cancer. data showed positive intake (1.002 (1.001, 1.003), 0.003) copper (2.754 (1.313, 5.778), In addition, we found potential B1 (p 0.025) cancer; zinc 0.048) potassium 0.032) Potential calcium 0.026) 0.034), sodium 0.042) Intakes protein, sugars, fat, cholesterol, A, alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, B2, niacin, B6, food folate, C, D, E, K, magnesium, iron selenium no relationship > 0.05). Conclusions: Specific associated cancers. More epidemiological studies needed to validate our results.

Язык: Английский

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Trends of Prostate Cancer Morbidity in Low-Incidence Countries from 1990–2019

Cancer Epidemiology Biomarkers & Prevention, Год журнала: 2024, Номер 33(2), С. 186 - 195

Опубликована: Фев. 6, 2024

Abstract Background: Our study was designed to elucidate the morbidity trends of prostate cancer in low-incidence countries. Methods: Data on were extracted from 2019 Global Burden Disease study. A cluster analysis growth rates stratified by age conducted, and correlation analyses performed between age-standardized incidence (ASIR), estimated annual percent change (EAPC), socio-demographic index (SDI). Results: Among 35 countries for cancer, predominantly located Asia North Africa, SDI ranged low high-middle levels. Higher regions exhibited considerably higher ASIR. With exception Kyrgyzstan, Kiribati, Samoa that experienced a decrease ASIR, remaining 32 displayed an upward trend since 1990, with all their EAPCs exceeding global average. In addition, men ages 90 years above consistently highest ASIR cancer. The most notable rate observed individuals 20 44 years. Conclusions: Overall, generally witnessed increase morbidity, albeit at levels lower than those seen Western Individuals maintained 1990. Notably, more substantial younger also Impact: This offers comprehensive overview worldwide 1990 2019. Future research should delve into associations incidence, clinical stages, PSA screening, environmental factors, lifestyle, genetic risk these

Язык: Английский

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Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis

Frontiers in Nutrition, Год журнала: 2022, Номер 9

Опубликована: Фев. 7, 2022

Debate on the potential carcinogenic effects of meat intake is open and relationship between consumption risk prostate cancer remains uncertain. This meta-analysis was conducted to summarize earlier prospective studies association with cancer.Relevant were identified by exploring PubMed/Medline, Scopus, Web Science, EMBASE, Google Scholar databases up December 2020. Fixed-effects random-effects meta-analyses used for pooling relative risks (RRs). Heterogeneity across evaluated using Q-statistic I-square (I2). A funnel plot Egger's test detect publication bias. Linear non-linear dose-response analyses performed estimate relations cancer.Twenty-five included in this meta-analysis. Totally, 1,900,910 participants 35,326 incident cases investigated. Pooling eligible effect sizes, we observed that high processed might be associated an increased "total cancer" (RR: 1.06; 95% CI: 1.01, 1.10; I2 = 1.5%, P 0.43) "advanced (1.17; 1.09, 1.26; 58.8%, 0.01). However, not significant model: 1.12 (95% 0.98, 1.29). linear analysis indicated increment 50 grams per day related a 4% greater (1.04; 1.00, 1.08; 0.0%, 0.51). "Total intake" marginally all outcomes 1.07; 58.4%, < 0.001).This systematic review meat" "processed higher cancer.https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=230824, identifier: CRD42021230824.

Язык: Английский

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