Lactiplantibacillus (Lactobacillus) plantarum as a Complementary Treatment to Improve Symptomatology in Neurodegenerative Disease: A Systematic Review of Open Access Literature

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 3010 - 3010

Опубликована: Март 5, 2024

This systematic review addresses the use of Lactiplantibacillus (Lactobacillus) plantarum in symptomatological intervention neurodegenerative disease. The existence gut microbiota dysbiosis has been associated with systemic inflammatory processes present disease, creating opportunity for new treatment strategies. involves modifying strains that constitute to enhance synaptic function through gut–brain axis. Recent studies have evaluated beneficial effects on motor and cognitive symptomatology, alone or combination. includes 20 research articles (n = 3 human n 17 animal models). main result this was combination produced improvements symptomatology related However, one included reported negative after administration plantarum. provides current relevant information about probiotic pathologies such as Alzheimer’s Parkinson’s disease Multiple Sclerosis.

Язык: Английский

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Gram-negative bacteria and their lipopolysaccharides in Alzheimer’s disease: pathologic roles and therapeutic implications

Translational Neurodegeneration, Год журнала: 2021, Номер 10(1)

Опубликована: Дек. 1, 2021

Abstract Alzheimer’s disease (AD) is the most serious age-related neurodegenerative and causes destructive irreversible cognitive decline. Failures in development of therapeutics targeting amyloid-β (Aβ) tau, principal proteins inducing pathology AD, suggest a paradigm shift towards new therapeutic targets. The gram-negative bacteria lipopolysaccharides (LPS) are attractive targets for AD treatment. Surprisingly, an altered distribution their LPS has been reported patients. Moreover, have shown to affect variety AD-related pathologies, such as Aβ homeostasis, tau pathology, neuroinflammation, neurodegeneration. approaches or bacterial molecules significantly alleviated dysfunction. Despite multiple evidence showing that play crucial role pathogenesis, pathogenic mechanisms not clarified. Here, we summarize roles pathomechanisms AD. Furthermore, discuss possibility using novel pathological characteristics

Язык: Английский

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Treadmill Exercise Modulates Intestinal Microbes and Suppresses LPS Displacement to Alleviate Neuroinflammation in the Brains of APP/PS1 Mice

Nutrients, Год журнала: 2022, Номер 14(19), С. 4134 - 4134

Опубликована: Окт. 5, 2022

Neuroinflammation occurs throughout the pathogenesis of Alzheimer's disease (AD). Here, we investigated effects treadmill exercise on neuroinflammation in APP/PS1 transgenic AD mice and potential involvement microbe-gut-brain axis (MGB) mechanisms based growing evidence that AD's is correlated with a deterioration function gut microbiota. were subjected to 12 weeks exercise, followed by spatial memory tests. After behavioral study, amyloid (Aβ) pathology, microbes metabolites, bacterial lipopolysaccharide (LPS) displacement, degree analyzed. We found this strategy enriched microbial diversity alleviated brain. Notably, led reductions pathogenic bacteria such as intestinal Allobaculum, increases probiotic Akkermansia, increased levels intestine-brain barrier proteins, attenuated LPS displacement. These results suggest prolonged can effectively modulate thereby reduce displacement ultimately alleviate AD-related neuroinflammation.

Язык: Английский

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Food, gut barrier dysfunction, and related diseases: A new target for future individualized disease prevention and management

Food Science & Nutrition, Год журнала: 2023, Номер 11(4), С. 1671 - 1704

Опубликована: Март 7, 2023

Dysfunction of gut barrier is known as "leaky gut" or increased intestinal permeability. Numerous recent scientific evidences showed the association between dysfunction and multiple gastrointestinal tract (GI) non-GI diseases. Research also demonstrated that food plays a crucial role to cause remedy related We reviewed articles from electronic databases, mainly PubMed. The data were based on animal models, cell human research in vivo vitro models. In this comprehensive review, our aim focused relationship dietary factors, permeability dysfunction, This review synthesizes currently available literature discussed three parts: (a) mechanism function, (b) supplements may promote health, medication alter (c) table organizes synthesized information by general mechanisms for diseases leaky gut/intestinal associated influences. With future research, intervention could be new target individualized disease prevention management.

Язык: Английский

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Gut-brain axis through the lens of gut microbiota and their relationships with Alzheimer's disease pathology: Review and recommendations

Mechanisms of Ageing and Development, Год журнала: 2023, Номер 211, С. 111787 - 111787

Опубликована: Фев. 1, 2023

Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Growing evidence suggests the gut microbiome (GM) plays pivotal role in pathogenesis AD through microbiota-gut-brain axis (MGB). Alterations GM composition and diversity have been observed both animal models human patients with AD. dysbiosis has implicated increased intestinal permeability, blood-brain barrier (BBB) impairment, neuroinflammation development hallmarks Further elucidation could pave way for holistic predictive methods determining risk progression disease. Furthermore, accumulating modulation alleviate adverse symptoms or serve as preventive measure. In addition, increasing shows Type 2 Diabetes Mellitus (T2DM) often comorbid AD, common alterations inflammatory response, which chart GM-related treatment interventions diseases. We conclude by exploring therapeutic potential alleviating reducing risk. we also propose future directions research, namely fecal microbiota transplantation (FMT) precision medicine.

Язык: Английский

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Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

Neural Regeneration Research, Год журнала: 2023, Номер 19(4), С. 833 - 845

Опубликована: Авг. 14, 2023

A growing body of evidence suggests that the gut microbiota contributes to development neurodegenerative diseases via microbiota-gut-brain axis. As a contributing factor, dysbiosis always occurs in pathological changes diseases, such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped reveal bidirectional communication between central nervous system enteric is facilitated by microbiota's diverse microorganisms, for both neuroimmune neuroendocrine systems. Here, we summarize bioinformatics analysis wet-biology validation metagenomics with an emphasis on multi-omics studies virome. The pathogen-associated signaling biomarkers identifying brain disorders potential therapeutic targets are also elucidated. Finally, discuss role diet, prebiotics, probiotics, postbiotics exercise interventions remodeling microbiome reducing symptoms diseases.

Язык: Английский

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Polygonatum sibiricum polysaccharides improve cognitive function in D-galactose-induced aging mice by regulating the microbiota-gut-brain axis

Journal of Functional Foods, Год журнала: 2023, Номер 103, С. 105476 - 105476

Опубликована: Март 3, 2023

Anti-aging has attracted worldwide attention. Polygonatum sibiricum polysaccharide (PSP), as the main component of sibiricum, shown good anti-aging activity by regulating gut microbes and relevant metabolites. In this study, we investigated effects PSP based on D-galactose-induced aging model explained its mechanism forming "microbiota-gut-brain" axis. The results showed that could effectively reduce pathological changes oxidative stress in hippocampus, improve cognitive functions. At same time, increased abundance Bacteroidota a reduced Firmicutes, Patescibacteria, Actinobacteriota Campilobacterota were observed. addition, Metabolomic analysis was associated with 12 significantly differential metabolites, mainly enriched purine metabolism, taurine hypotaurine, glycerophospholipids, alanine, aspartate glutamate glycerophospholipid riboflavin metabolism. Our suggested function mice regulate through

Язык: Английский

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Gut Microbiota and Alzheimer’s Disease: How to Study and Apply Their Relationship

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 4047 - 4047

Опубликована: Фев. 17, 2023

Gut microbiota (GM), the microorganisms in gastrointestinal tract, contribute to regulation of brain homeostasis through bidirectional communication between gut and brain. GM disturbance has been discovered be related various neurological disorders, including Alzheimer's disease (AD). Recently, microbiota-gut-brain axis (MGBA) emerged as an enticing subject not only understand AD pathology but also provide novel therapeutic strategies for AD. In this review, general concept MGBA its impacts on development progression are described. Then, diverse experimental approaches studying roles pathogenesis presented. Finally, MGBA-based discussed. This review provides concise guidance those who wish obtain a conceptual methodological understanding relationship with emphasis practical application.

Язык: Английский

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Gut microbiota and intestinal barrier function in subjects with cognitive impairments: a cross-sectional study

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 15

Опубликована: Июнь 7, 2023

Gut-brain axis might play an important role in cognitive impairments by various diseases including Alzheimer's disease (AD).To investigate the differences gut microbial composition, intestinal barrier function, and systemic inflammation patients with AD or mild impairment (MCI), normal control (NC) cases.A total of 118 subjects (45 AD, 38 MCI, 35 NC) were recruited. Cognitive function was assessed using Mini-Mental State Examination (MMSE), Montreal Assessment Scale (MoCA). Functional ability Activity Daily Living (ADL). The composition microbiome examined 16S rRNA high-throughput sequencing. Phylogenetic Investigation Communities Reconstruction Unobserved States (PICRUSt) used to predict functional transfer microbiota. Gut dysfunction evaluated measuring levels diamine oxidase (DAO), D-lactic acid (DA), endotoxin (ET). serum high-sensitivity C-reactive protein (hs-CRP) level indicate inflammation.Compared controls, (AD MCI) had lower abundance Dorea higher DAO, DA, ET. Kyoto Encyclopedia Genes Genomes (KEGG) results showed that pathways related glycan biosynthesis metabolism increased MCI patients, while ones membrane transport decreased. Bacteroides Faecalibacterium negatively correlated content ET, positively scores MMSE MoCA. hs-CRP similar among three groups. A significant negative correlation observed between severity function.Cognitive be associated dysbiosis dysfunction.

Язык: Английский

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Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management

Archives of Pharmacal Research, Год журнала: 2024, Номер 47(2), С. 146 - 164

Опубликована: Янв. 15, 2024

Abstract The gut microbiota that exists in the human gastrointestinal tract is incredibly important for maintenance of general health as it contributes to multiple aspects host physiology. Recent research has revealed a dynamic connection between and central nervous system, can influence neurodegenerative diseases (NDs). Indeed, imbalances microbiota, or dysbiosis, play vital role pathogenesis progression diseases, particularly NDs. Herbal medicine been used centuries treat including These compounds help relieve symptoms delay NDs by improving intestinal barrier function, reducing neuroinflammation, modulating neurotransmitter production. Notably, herbal mitigate regulating microbiota. Therefore, an in-depth understanding potential mechanisms which regulates treatment explain from novel perspective propose therapeutic strategies In this review, we investigate neuroprotective effects medicine, focusing on its ability regulate restore homeostasis. We also highlight challenges future priorities integration modern medicine. As global population ages, access information becoming increasingly developing effective treatments these diseases.

Язык: Английский

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