Celiac Disease: Beyond Diet and Food Awareness

Foods, Год журнала: 2025, Номер 14(3), С. 377 - 377

Опубликована: Янв. 24, 2025

Celiac disease is attributable to a combination of genetic predisposition and exposure dietary gluten, with immune system involvement. The incidence increasing globally, the societal economic burden celiac stretches beyond cost gluten-free food. This enteropathy that affects small intestine has been related different disorders comorbidities. Thus, implications suffering from this are multidimensional need further consideration. serious condition remains under-recognized, resulting in an increased for programs better management. review aims summarize current evidence regarding diseases, special emphasis on clinical implications, diagnosis, management, socioeconomical aspects, future perspectives.

Язык: Английский

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Role of gastrointestinal health in managing children with autism spectrum disorder

World Journal of Clinical Pediatrics, Год журнала: 2023, Номер 12(4), С. 171 - 196

Опубликована: Сен. 5, 2023

Children with autism spectrum disorders (ASD) or are more prone to gastrointestinal (GI) than the general population. These can significantly affect their health, learning, and development due various factors such as genetics, environment, behavior. The causes of GI in children ASD include gut dysbiosis, immune dysfunction, food sensitivities, digestive enzyme deficiencies, sensory processing differences. Many studies suggest that numerous experience problems, effective management is crucial. Diagnosing typically done through genetic, neurological, functional, behavioral assessments observations, while tests not consistently reliable. Some may increase risk developing exacerbating symptoms. Addressing issues individuals improve overall well-being, leading better behavior, cognitive function, educational abilities. Proper digestion, nutrient absorption, appetite by relieving physical discomfort pain. Alleviating symptoms sleep patterns, energy levels, contribute a sense ultimately quality life for individual improved family dynamics. primary goal interventions nutritional status, reduce symptom severity, promote balanced mood, patient independence.

Язык: Английский

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Bridging the Gap: Awareness, Knowledge, and Challenges of Living with Celiac Disease in Bulgaria

Nutrients, Год журнала: 2025, Номер 17(7), С. 1267 - 1267

Опубликована: Апрель 4, 2025

Background: Celiac disease (CD) is a chronic immune-mediated systemic disorder induced by gluten in genetically predisposed individuals, requiring lifelong management through strict gluten-free diet (GFD). Although its global prevalence around 1%, awareness and diagnosis remain suboptimal, contributing to challenges management. Objectives: To assess the awareness, knowledge, experiences of Bulgarian CD patients caregivers regarding CD, diagnosis, dietary adherence. Methods: A structured survey was conducted evaluate patient caregiver with focusing on diagnostic process practices. Data were collected from sample their caregivers. Results: The majority 191 respondents (94%) recognized as condition, but only 26.7% correctly identified autoimmune, nature. average delay 8.1 months, over 50% relying serological tests alone, consistent recent non-biopsy guidelines. Dietary adherence significantly hindered misconceptions about gluten-containing grains societal barriers. Notably, 83.6% participants reported bringing own food when eating outside. Conclusions: findings underscore need for targeted public health initiatives, enhanced healthcare provider training, improved education address knowledge gaps, expedite improve Such interventions could help reduce psychosocial burden enhance quality life affected individuals.

Язык: Английский

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Effects of CB2 Receptor Modulation on Macrophage Polarization in Pediatric Celiac Disease

Biomedicines, Год журнала: 2022, Номер 10(4), С. 874 - 874

Опубликована: Апрель 9, 2022

Celiac Disease (CD) represents an autoimmune disorder triggered by the exposure to gluten in genetically susceptible individuals. Recent studies suggest involvement of macrophages CD pathogenesis. Macrophages are immune cells, present as pro-inflammatory classically activated (M1) or anti-inflammatory alternatively (M2). The Cannabinoid Receptor 2 (CB2) has important and immunoregulatory properties. We previously demonstrated that a common CB2 functional variant, Q63R, causing reduced function, is associated with several inflammatory diseases first aim this study was investigate phenotype isolated from peripheral blood patients expression. second evaluate effects pharmacological modulation on macrophage polarization. Moreover, vitro model "immunocompetent gut" we investigated role inducing intestinal barrier damage possibility restore its functionality modulating their found increased expression M1 also typical mucosal CD. stimulation switches polarization towards M2 thus reducing inflammation but limiting epithelial dysfunction. Therefore, receptor possible novel therapeutic target for regulating preventing damage.

Язык: Английский

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Nutrition, Physical Activity and Supplementation in Irritable Bowel Syndrome

Nutrients, Год журнала: 2023, Номер 15(16), С. 3662 - 3662

Опубликована: Авг. 21, 2023

Irritable Bowel Syndrome (IBS) is a chronic, recurrent functional disorder of the intestine diagnosed based on Rome IV criteria. Individuals suffering from IBS often associate severity their symptoms with food they consume, leading them to limit variety foods eat and seek information that could help determine appropriate selection dietary items. Clear nutritional recommendations have not been established thus far. NICE recommends rational approach nutrition and, if necessary, short-term implementation low FODMAP diet. Currently, diet holds greatest significance among patients, although it does yield positive results for everyone affected. Other unconventional diets adopted by individuals lack supporting research effectiveness may additionally lead deterioration in status, as eliminate high value. The role physical activity also raises questions, previous studies shown its beneficial effects mental well-being every individual, can further alleviate people IBS. Supplementation be supportive element therapy. Attention drawn use probiotics, vitamin D, psyllium husk/ispaghula. This review aims analyze existing scientific impact various items, activity, supplementation specific components through supplements course

Язык: Английский

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Celiac disease - a pluripathological model in pediatric practice

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 23, 2024

Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially pediatrics, celiac disease (also called gluten enteropathy), is gaining more and ground terms of diagnosis, also interest research. The data from the literature last decades attest chameleonic way its presentation, there may be both classic onset symptoms atypical symptoms. Given impact played by disease, optimal growth development children, current narrative review aims to highlight presentation methods, intended guide clinician towards inclusion pathology differential diagnosis scheme. To these we add summary general therapeutic lines regarding underlying condition existing comorbidities. In order place related information up date, performed a recent articles published international databases. We bring forward theories approaches manifestations. Among note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, disorders biological constants association with multiple autoimmunities. Knowing correlating them key management patients, thus reducing subsequent burden disease.

Язык: Английский

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Vitamin D: An Essential Nutrient in the Dual Relationship between Autoimmune Thyroid Diseases and Celiac Disease—A Comprehensive Review

Nutrients, Год журнала: 2024, Номер 16(11), С. 1762 - 1762

Опубликована: Июнь 4, 2024

Autoimmune thyroid diseases (AITD) are among the most frequent autoimmune disorders, with a multifactorial etiology in which both genetic and environmental determinants probably involved. Celiac disease (CeD) also represents public concern, given its increasing prevalence due to recent improvement of screening programs, leading detection silent subtypes. The two conditions may be closely associated common risk factors, including setting, changes composition diversity gut microbiota, deficiency nutrients like vitamin D. This comprehensive review discussed current evidence on pivotal role D modulating microbiota dysbiosis immune system dysfunction, shedding light possible relevance an adequate intake this nutrient primary prevention AITD CeD. While future technology-based strategies for proper supplementation could attractive context personalized medicine, several issues remain defined, standardized assays determination, timely recommendations functioning, longitudinal studies randomized controlled trials definitely establish causal relationship between serum levels onset

Язык: Английский

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Perceptions towards gluten free products among consumers: A narrative review

Applied Food Research, Год журнала: 2024, Номер 4(2), С. 100441 - 100441

Опубликована: Июнь 24, 2024

Язык: Английский

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Systematic Review and Dose-Response Meta-Analysis on the Relationship between Different Gluten Doses and Risk of Coeliac Disease Relapse

Nutrients, Год журнала: 2023, Номер 15(6), С. 1390 - 1390

Опубликована: Март 14, 2023

Gluten proteins are known as immunological triggers for inflammation resulting in mucosal lesions patients with coeliac disease (CD). Adherence to a strict gluten-free diet (GFD) is currently the only effective treatment CD. In this study, we performed systematic review and dose-response meta-analysis on data from previous studies investigate association between different gluten doses administered risk of CD relapse. Electronic databases were systematically searched retrieve that investigated response amounts intake evaluated clinical, serologic, and/or histologic evidence recognize Study-specific relative risks (RRs) combined using random effects model. A total 440 identified published papers screened, which 7 records selected following full-text reviewing eligibility assessment meta-analysis. According our analysis, relapse estimated be 0.2% (RR: 1.002; 95% CI: 1.001 1.004) consumption 6 mg gluten/day, was increased 7% 1.07; 1.03 1.10), 50% 1.50; 1.23 1.82), 80% 1.80; 1.36 2.38), 100% 2.00; 1.43 2.78) by daily 150, 881, 1276, 1505 gluten, respectively. Although good adherence GFD can adequately control CD-related symptoms, might happen even very low dose duration exposure also an important matter. The current literature has substantial limitations, such relying just few countries terms amount administered, challenge, etc. Therefore, more randomized clinical trials standardized challenge protocol needed confirm findings present study.

Язык: Английский

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The Role of Artificial Intelligence in Deciphering Diet–Disease Relationships: Case Studies

Annual Review of Nutrition, Год журнала: 2023, Номер 43(1), С. 225 - 250

Опубликована: Май 19, 2023

Modernization of society from a rural, hunter-gatherer setting into an urban and industrial habitat, with the associated dietary changes, has led to increased prevalence cardiometabolic additional noncommunicable diseases, such as cancer, inflammatory bowel disease, neurodegenerative autoimmune disorders. However, while sciences have been rapidly evolving meet these challenges, validation translation experimental results clinical practice remain limited for multiple reasons, including inherent ethnic, gender, cultural interindividual variability, among other methodological, reporting-related, analytical issues. Recently, large cohorts artificial intelligence analytics introduced new precision personalized nutrition concepts that enable one successfully bridge gaps in real-life setting. In this review, we highlight selected examples case studies at intersection between diet-disease research intelligence. We discuss their potential challenges offer outlook toward transformation individualized translation.

Язык: Английский

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