Fiber-Type Shifting in Sarcopenia of Old Age: Proteomic Profiling of the Contractile Apparatus of Skeletal Muscles

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2415 - 2415

Опубликована: Янв. 26, 2023

The progressive loss of skeletal muscle mass and concomitant reduction in contractile strength plays a central role frailty syndrome. Age-related neuronal impairments are closely associated with sarcopenia the elderly, which is characterized by severe muscular atrophy that can considerably lessen overall quality life at old age. Mass-spectrometry-based proteomic surveys senescent human muscles, as well animal models sarcopenia, have decisively improved our understanding molecular cellular consequences fiber-type shifting during aging. This review outlines spectrometric identification proteome-wide changes atrophying focus on proteins potential markers distribution patterns. observed trend fast-to-slow transitions individual muscles aging process most likely linked to preferential susceptibility fast-twitching fibers atrophy. Studies models, including mostly aged rodent confirmed shifting. analysis fast versus slow isoforms key proteins, such myosin heavy chains, light actins, troponins tropomyosins, suggests them suitable bioanalytical tools

Язык: Английский

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Optimal dietary patterns for healthy aging

Nature Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

As the global population ages, it is critical to identify diets that, beyond preventing noncommunicable diseases, optimally promote healthy aging. Here, using longitudinal questionnaire data from Nurses' Health Study (1986–2016) and Professionals Follow-Up (1986–2016), we examined association of long-term adherence eight dietary patterns ultraprocessed food consumption with aging, as assessed according measures cognitive, physical mental health, well living 70 years age free chronic diseases. After up 30 follow-up, 9,771 (9.3%) 105,015 participants (66% women, mean = 53 (s.d. 8)) achieved For each pattern, higher was associated greater odds aging its domains. The ratios for highest quintile versus lowest ranged 1.45 (95% confidence interval (CI) 1.35–1.57; healthful plant-based diet) 1.86 CI 1.71–2.01; Alternative Healthy Eating Index). When threshold shifted 75 years, Index diet showed strongest an ratio 2.24 2.01–2.50). Higher intakes fruits, vegetables, whole grains, unsaturated fats, nuts, legumes low-fat dairy products were linked whereas trans sodium, sugary beverages red or processed meats (or both) inversely associated. Our findings suggest that rich in foods, moderate inclusion animal-based may enhance overall guiding future guidelines. In two cohorts followed associations different aging—encompassing health—were studied, identifying constituents lesser

Язык: Английский

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Nutrition and Healthy Aging: A Review

Current Nutrition Reports, Год журнала: 2023, Номер 12(3), С. 369 - 375

Опубликована: Май 16, 2023

Язык: Английский

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Association between plant-based dietary pattern and biological aging trajectory in a large prospective cohort

BMC Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Авг. 17, 2023

Abstract Background Aging is a dynamic and heterogeneous process that may better be captured by trajectories of aging biomarkers. Biological age has been advocated as biomarker than chronological age, plant-based dietary patterns have found to linked aging. However, the associations biological with mortality remained unclear. Methods Using group-based trajectory modeling approach, we identified distinctive groups among 12,784 participants based on recently developed measure acquired at four-time points within an 8-year period. We then examined between quintiles assessed overall diet index (PDI), healthful PDI (hPDI), unhealthful (uPDI) 10,191 who had complete data intake, using multivariable multinomial logistics regression adjusting for sociodemographic lifestyles factors. Cox proportional hazards models were applied investigate association all-cause mortality. Results three latent classes accelerated trajectories: slow aging, medium-degree, high-degree trajectories. Participants higher or hPDI lower odds being in medium-degree (OR = 0.75, 95% CI: 0.65, 0.86 PDI; OR 0.73, 0.62, 0.85 hPDI) 0.63, 0.46, 0.44, 0.88 highest quintile uPDI more likely 1.72, 1.48, 1.99) 1.70, 1.21, 2.38) With mean follow-up time 8.40 years 803 (6.28%) died end follow-up, (HR 1.56, 1.29, 1.89) 3.72, 2.73, 5.08) risks death those trajectory. Conclusions large Asian cohort adopting pattern, especially when rich plant foods, was associated substantially lowered pace

Язык: Английский

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The Postbiotic Properties of Butyrate in the Modulation of the Gut Microbiota: The Potential of Its Combination with Polyphenols and Dietary Fibers

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 6971 - 6971

Опубликована: Июнь 26, 2024

The gut microbiota is a diverse bacterial community consisting of approximately 2000 species, predominantly from five phyla: Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, and Verrucomicrobia. microbiota's species create distinct compounds that impact the host's health, including well-known short-chain fatty acids. These are produced through breakdown dietary fibers fermentation undigested carbohydrates by intestinal microbiota. main acids consist acetate, propionate, butyrate. concentration butyrate in mammalian intestines varies depending on diet. Its functions use as an energy source, cell differentiation, reduction inflammatory process intestine, defense against oxidative stress. It also plays epigenetic role histone deacetylases, thus helping to reduce risk colon cancer. Finally, affects gut-brain axis crossing brain-blood barrier, making it crucial determine right concentrations for both local peripheral effects. In recent years, there has been significant amount attention given polyphenols promoting human health. Polyphenols play roles protecting health can produce fermentation. This paper aims summarize information key summits related negative correlation between diversity chronic diseases guide future research determining specific activity carry out these vital functions.

Язык: Английский

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Molecular Mechanisms of Healthy Aging: The Role of Caloric Restriction, Intermittent Fasting, Mediterranean Diet, and Ketogenic Diet—A Scoping Review

Nutrients, Год журнала: 2024, Номер 16(17), С. 2878 - 2878

Опубликована: Авг. 28, 2024

As the population ages, promoting healthy aging through targeted interventions becomes increasingly crucial. Growing evidence suggests that dietary can significantly impact this process by modulating fundamental molecular pathways. This review focuses on potential of strategies in and mechanisms which specific nutrients patterns influence key pathways involved cellular repair, inflammation, metabolic regulation. Caloric restriction, intermittent fasting, Mediterranean diet, as well ketogenic diet showed promising effects aging, possibly mTORC1 AMPK, an insulin signaling pathway. By understanding intricate interplay between pathways, we develop personalized not only prevent age-related diseases, but also promote overall health well-being throughout process.

Язык: Английский

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Easy Nitrite Analysis of Processed Meat with Colorimetric Polymer Sensors and a Smartphone App

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(32), С. 37051 - 37058

Опубликована: Авг. 3, 2022

We have developed an in situ methodology for determining nitrite concentration processed meats that can also be used by unskilled personnel. It is based on a colorimetric film-shaped sensory polymer changes its color upon contacting the meat and mobile app automatically calculates manufacturing residual only taking digital photographs of films analyzing parameters. The sensor detects anions azo-coupling reaction, since they activate this reaction between two four monomers copolymer on. complemented with app, which analyzes different spaces (RGB HSV) performs set 32 data fittings representing versus eight variables, finally providing test samples using best fitting curve. calculated correlates validated method (ISO 2918: 1975) usually to determine nitrite, no statistically significant difference these methods our proposed one has been found study (26 samples, 8 prepared, 18 commercial). Our represents great advance terms analysis time, simplicity, orientation use average citizens.

Язык: Английский

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Deciphering the mechanisms, biochemistry, physiology, and social habits in the process of aging

Archives of Gerontology and Geriatrics Plus, Год журнала: 2023, Номер 1(1), С. 100003 - 100003

Опубликована: Дек. 25, 2023

Aging is a complex journey shaped by interactions among mechanisms, biochemistry, physiology, and social habits. This review explores aging's core facets uncovering the mechanisms driving cellular senescence, oxidative stress, telomere shortening, mitochondrial dysfunction. The also delves into biochemistry physiology of aging, shedding light on hormonal shifts, genetic influences, immune system modifications that contribute to aging process. It navigates terrain habits linked considering profound impact dietary choices, physical activity, engagement, stress management. These elements intricately intertwine, emphasizing holistic nature aging. interplay between underscores need for comprehensive understanding transcends single disciplines. Deciphering these factors significance personalized approaches healthy Tailoring interventions individual genetics, lifestyles, health needs emerges as critical strategy optimizing well-being in later life. In conclusion, this illuminates multifaceted urging embrace complexity interdependence. By fostering holistic, approach, individuals can navigate with grace, vitality, resilience.

Язык: Английский

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Interactive association of the dietary oxidative balance score and cardiovascular disease with mortality in older adults: evidence from NHANES

Food & Function, Год журнала: 2024, Номер 15(11), С. 6164 - 6173

Опубликована: Янв. 1, 2024

: We conducted an assessment to explore potential associations of the dietary oxidative balance score (DOBS), cardiovascular disease (CVD), with all-cause mortality among older adults, while also exploring moderating effect DOBS on relationship between CVD and mortality.

Язык: Английский

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Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7411 - 7411

Опубликована: Июль 5, 2024

Advancing age is associated with several age-related diseases (ARDs), musculoskeletal conditions impacting millions of elderly people worldwide. With orthopedic contributing towards considerable number patients, a deeper understanding bone aging the need hour. One underlying factors cellular senescence and its secretory phenotype (SASP). SASP comprises pro-inflammatory markers, cytokines chemokines that arrest cell growth development. The accumulation over years leads to chronic low-grade inflammation advancing age, also known as inflammaging. pathways molecular mechanisms focused on inflammaging are currently limited but increasingly being explored. Most genes, involved in coincide those cancer other ARDs like osteoarthritis (OA). Thus, exploring these using techniques sequencing, identifying combatting them most suitable approach crucial for healthy early detection ARDs. Several approaches can be used aid regeneration reduce bone. These may pharmacological, non-pharmacological lifestyle interventions. increasing evidence intricate relationship between aging, senescence, ARDs, anti-aging strategies marrow (BM).

Язык: Английский

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