Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 728 - 728
Опубликована: Март 17, 2025
Atherosclerosis
is
a
closely
related
complication
of
diabetes
mellitus
(DM),
driven
by
endothelial
dysfunction,
inflammation,
and
oxidative
stress.
The
progression
atherosclerosis
accelerated
hyperglycemia,
insulin
resistance,
hyperlipidemia.
Novel
antidiabetic
agents,
SGLT2
inhibitors,
GLP-1
agonists
improve
glycemic
control
offer
cardiovascular
protection,
reducing
the
risk
major
adverse
events
(MACEs)
heart
failure
hospitalization.
These
along
with
nonsteroidal
mineralocorticoid
receptor
antagonists
(nsMRAs),
promise
to
mitigate
metabolic
disorders
their
impact
on
function,
stress,
inflammation.
This
review
explores
potential
molecular
mechanisms
through
which
these
drugs
may
prevent
development
disease
(CVD),
supported
summary
preclinical
clinical
evidence.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Фев. 9, 2023
The
global
pandemic
of
coronavirus
disease
2019
(COVID-19)
continues
to
affect
people
around
the
world,
with
one
most
frequent
comorbidities
being
Type
2
Diabetes
(T2D).
Studies
have
suggested
a
link
between
disbalances
in
gut
microbiota
and
these
diseases,
as
well
COVID-19,
potentially
due
inflammatory
dysfunction.
This
study
aims
analyze
changes
COVID-19
patients
T2D
using
culture-based
method.The
stool
samples
were
taken
from
128
confirmed
COVID-19.
Changes
composition
analyzed
by
method.
used
chi-squared
t-test
find
significant
differences
bacteria
non-parametric
correlation
analysis
examine
relationship
abundance,
C-reactive
protein
(CRP)
levels
length
stay
(LoS)
without
T2D.The
showed
increased
Clostridium
spp.,
Candida
decreased
Bifidobacterium
Lactobacillus
spp.
Metformin-treated
antibiotic
treatment
Bacteroides
Enterococcus,
compared
same
group
treatment.
also
found
positive
abundance
certain
genera,
such
Klebsiella
Enterococcus
CRP
LoS
T2D,
while
other
was
negative
correlation.In
conclusion,
this
provides
important
insights
into
SARS-CoV-2-infected
individuals
its
potential
impact
on
course
disease.
findings
suggest
that
genera
may
be
associated
longer
hospital
stays.
significance
lies
fact
it
highlights
role
progression
inform
future
research
strategies
for
patient
population.
could
include
development
targeted
interventions
modulate
order
improve
outcomes
T2D.
Journal of Advanced Research,
Год журнала:
2023,
Номер
52, С. 151 - 170
Опубликована: Июнь 2, 2023
The
relationship
between
gut
microbiota
and
human
health
has
gradually
been
recognized.
Increasing
studies
show
that
the
disorder
of
is
related
to
occurrence
development
many
diseases.
Metabolites
produced
by
are
responsible
for
their
extensive
regulatory
roles.
In
addition,
naturally
derived
medicine
food
homology
species
with
low
toxicity
high
efficiency
have
clearly
defined
owing
outstanding
physiological
pharmacological
properties
in
disease
prevention
treatment.Based
on
supporting
evidence,
current
review
summarizes
representative
work
targeting
regulate
host
pathophysiology
discusses
challenges
prospects
this
field.
It
aims
facilitate
understanding
among
species,
microbiota,
further
stimulate
advancement
more
relevant
research.As
reveals,
from
initial
practical
application
mechanism
studies,
evolved
into
an
irrefutable
interaction.
On
one
hand,
through
affecting
population
structure,
metabolism,
function
maintain
homeostasis
intestinal
microenvironment
microbiota.
other
also
involved
bioconversion
active
ingredients
thus
influences
properties.
Adult
humans
harbor
at
least
as
many
microbial
cells
eukaryotic
ones.
The
largest
compartment
of
this
diverse
population,
the
gut
microbiota,
encompasses
collection
bacteria,
archaea,
viruses,
and
organisms
that
populate
gastrointestinal
tract,
represents
a
complex
dynamic
ecosystem
has
been
increasingly
implicated
in
health
disease.
microbiota
carries
∼100-to-150-times
more
genes
than
human
genome
is
intimately
involved
development,
homeostasis,
Of
several
metabolites
have
studied,
short-chain
fatty
acids
emerge
group
molecules
shape
gene
expression
types
by
multiple
mechanisms,
which
include
DNA
methylation
changes,
histone
post-translational
modifications,
microRNA-mediated
silencing.
Butyric
acid,
one
most
extensively
studied
acids,
reaches
higher
concentrations
colonic
lumen,
where
it
provides
source
energy
for
healthy
colonocytes,
its
decrease
towards
bottom
crypts,
stem
reside.
lower
butyric
acid
concentration
crypts
allows
undifferentiated
cells,
such
to
progress
through
cell
cycle,
pointing
importance
providing
them
with
protective
niche.
In
cancerous
metabolize
relatively
little
mostly
rely
on
glycolysis,
preferentially
acts
deacetylase
inhibitor,
leading
decreased
proliferation
increased
apoptosis.
A
better
understanding
interface
between
epigenetic
changes
promises
unravel
detail
processes
occur
physiologically
part
disease,
help
develop
novel
biomarkers,
identify
new
therapeutic
modalities.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Март 16, 2023
Introduction
Type
2
diabetes
mellitus
(T2DM)
has
a
high
incidence
rate
globally,
increasing
the
burden
of
death,
disability,
and
economy
worldwide.
Previous
studies
have
found
that
compositions
oral
intestinal
microbiota
changed
respectively
in
T2DM;
whether
changes
were
associated
or
interacted
between
two
sites
there
some
associations
T2DM
ectopic
colonization
gut
still
need
to
be
identified.
Research
design
methods
We
performed
cross-sectional
observational
study;
183
74
controls
enrolled.
used
high-throughput
sequencing
technology
detect
V3-V4
region
16S
rRNA
stool
samples.
The
Source
Tracker
method
was
identify
proportion
colonized
from
cavity.
Results
marker
bacteria
found,
such
as
Actinobacteria,
Streptococcus,
Rothia
,
Bifidobacterium,
Streptococcus
Blautia
at
genus
level.
Among
them,
Actinobacteria
played
vital
role
different
symbiotic
relationships
microbiota.
commonly
distributed
bacteria,
Firmicutes,
Bacteroidetes,
both
intestine.
Moreover,
relative
abundance
composition
sites.
glycine
betaine
degradation
I
pathway
significantly
up-regulated
flora
T2DM.
main
serum
indexes
related
inflammatory.
Proteobacteria
intestine
Spirochete
positively
correlated,
correlation
coefficient
highest,
0.240
(P<0.01).
2.36%.
Conclusion
dysbacteriosis
exited
simultaneously,
differences
connections
Ectopic
might
relate
Further,
clarifying
oral-gut-transmitting
can
provide
an
essential
reference
for
diagnosing
treating
future.
Biomedicines,
Год журнала:
2024,
Номер
12(1), С. 221 - 221
Опубликована: Янв. 18, 2024
This
comprehensive
review
article
delves
into
the
critical
role
of
human
microbiota
in
development
and
management
endocrine-related
diseases.
We
explore
complex
interactions
between
endocrine
system,
emphasizing
implications
dysbiosis
for
onset
progression
various
disorders.
The
aims
to
synthesize
current
knowledge,
highlighting
recent
advancements
potential
novel
therapeutic
approaches
targeting
microbiota-endocrine
interactions.
Key
topics
include
impact
on
hormone
regulation,
its
pathologies,
promising
avenues
modulation
through
diet,
probiotics,
prebiotics,
fecal
transplantation.
underscore
importance
this
research
advancing
personalized
medicine,
offering
insights
more
tailored
effective
treatments
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 1321 - 1321
Опубликована: Янв. 22, 2024
There
is
a
growing
need
to
develop
new
approaches
prevent
and
treat
diseases
related
metabolic
syndromes,
including
obesity
or
type
2
diabetes,
that
focus
on
the
different
factors
involved
in
pathogenesis
of
these
diseases.
Due
role
gut
microbiota
regulation
glucose
insulin
homeostasis,
probiotics
with
beneficial
properties
have
emerged
as
an
alternative
therapeutic
tool
ameliorate
diseases-related
disturbances,
fat
excess
inflammation.
In
last
few
years,
strains
bacteria,
mainly
lactic
acid
bacteria
(LAB)
species
from
genus
Bifidobacterium,
potential
due
their
anti-obesogenic
and/or
anti-diabetic
properties.
However,
vivo
studies
are
needed
demonstrate
mechanisms
probiotic
features.
this
context,
Caenorhabditis
elegans
has
very
powerful
simple
model
study
physiological
molecular
effects
applications
regarding
pathologies
syndrome.
This
review
aims
summarize
main
describing
anti-obesogenic,
anti-diabetic,
anti-inflammatory
using
C.
research
model,
well
providing
description
activities.
Objective
Sirt6,
reactive
oxygen
species
and
ferroptosis
may
participate
in
the
pathogenesis
of
Diabetic
Nephropathy
(DN).
Exploring
relationship
between
oxidative
stress,
provides
new
scientific
ideas
to
DN.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 8, 2024
Objective
Emerging
evidence
has
provided
compelling
linking
gut
microbiota
(GM)
and
diabetic
nephropathy
(DN)
via
the
“gut-kidney”
axis.
But
causal
relationship
between
them
hasn’t
been
clarified
yet.
We
perform
a
Two-Sample
Mendelian
randomization
(MR)
analysis
to
reveal
connection
with
GM
development
of
DN,
type
1
diabetes
(T1DN),
2
(T2DN),
mellitus
(T1DM),
(T2DM).
Methods
used
summary
data
from
MiBioGen
on
211
taxa
in
18340
participants.
Generalized
MR
methods
were
conducted
estimate
their
causality
risk
T1DN,
T2DN,
T1DM
T2DM
FinnGen.
To
ensure
reliability
findings,
comprehensive
set
sensitivity
analyses
confirm
resilience
consistency
results.
Results
It
was
showed
that
Class
Verrucomicrobiae
[odds
ratio
(OR)
=1.5651,
95%CI:1.1810-2.0742,
P
FDR=0.0018],
Order
Verrucomicrobiales
(OR=1.5651,
95%CI:
1.1810-2.0742,
FDR=0.0018)
Family
Verrucomicrobiaceae
(OR=1.3956,
95%CI:1.0336-1.8844,
FDR=0.0296)
had
significant
DN.
Our
found
associations
including
Verrucomimicrobiae
(OR=1.8227,
95%
CI:
1.2414-2.6763,
PFDR=0.0139),
1.8227-2.6764,
PFDR=0.0024),
Rhodospirillales
(OR=1.8226,
1.2412-2.6763,
PFDR=0.0026),
Verrucomicroniaceae
PFDR=0.0083).
The
Eubacteriumprotogenes
(OR=0.4076,
0.2415-0.6882,
PFDR=0.0021)
exhibited
protection
against
T1DN.
Sensitivity
confirmed
there
no
heterogeneity
pleiotropy.
Conclusions
At
gene
prediction
level,
we
identified
specific
is
causally
linked
DN
both
patients.
Moreover,
distinct
microbial
changes
T1DN
differed
those
seen
offering
valuable
insights
into
signatures
associated
subtype
nephropathy.
