Dietary Polyphenols as Natural Inhibitors of α-Amylase and α-Glucosidase

Life, Год журнала: 2022, Номер 12(11), С. 1692 - 1692

Опубликована: Окт. 25, 2022

It is well known that carbohydrates are the main source of calories in most diets. However, by inhibiting carbohydrases, intake reduced and weight loss improved. α-amylase an enzyme hydrolyses α-1,4 glycosidic linkages α-linked polysaccharides, resulting low-molecular-weight products such as glucose, maltose maltotriose, while α-glucosidase catalyzes hydrolysis nonreducing α-1,4-linked glucose moieties from disaccharides or oligosaccharides. Currently, one common nutritional disorders world hyperglycemia. One new therapeutic approaches to treat this disease application natural inhibitors, polyphenols, control starch digestion regulate blood level. Dietary polyphenols showed potential inhibitory activity against review summarizes recently published literature studied inhibition mechanisms structure–activity relationship between individual dietary mentioned digestive enzymes. higher binding interactions cause activities; thus, different can affect steps polysaccharides. The aim clarify these introduce polyphenol-rich functional foods tools for α-glucosidase.

Язык: Английский

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Anti-Inflammatory, Antioxidant, and Other Health Effects of Dragon Fruit and Potential Delivery Systems for Its Bioactive Compounds

Pharmaceutics, Год журнала: 2023, Номер 15(1), С. 159 - 159

Опубликована: Янв. 3, 2023

Dragon fruit (

Язык: Английский

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Current Understanding of Polyphenols to Enhance Bioavailability for Better Therapies

Biomedicines, Год журнала: 2023, Номер 11(7), С. 2078 - 2078

Опубликована: Июль 24, 2023

In recent years, plant polyphenols have become a popular focus for the development of novel functional foods. Polyphenols, class bioactive compounds, including flavonoids, phenolic acids, and lignans, are commonly found in plant-based diets with variety biological actions, antioxidant, anti-inflammatory, anticancer effects. Unfortunately, not widely used nutraceuticals since many chemicals possess poor oral bioavailability. Thankfully, can be encapsulated transported using bio-based nanocarriers, thereby increasing their Polyphenols' limited water solubility low bioavailability limiting factors practical usage, but this issue resolved if suitable delivery vehicles developed encapsulating delivering polyphenolic compounds. This paper provides an overview study nanocarriers enhancement polyphenol bioavailability, as well summary health advantages prevention treatment several diseases.

Язык: Английский

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Anthocyanins: What do we know until now?

Journal of Berry Research, Год журнала: 2023, Номер 13(1), С. 1 - 6

Опубликована: Янв. 17, 2023

Diets enriched in plant-based foods are associated with the maintenance of a good well-being and prevention many non-communicable diseases. The health effects fruits vegetables consumption mainly due to presence micronutrients, including vitamins minerals, polyphenols, plant secondary metabolites. One most important classes phenolic compounds anthocyanins, that confer typical purple-red color foods, such as berries, peaches, plums, red onions, purple corn, eggplants, well carrots, sweet potatoes cabbages, among others. This commentary aims briefly highlight progress made by science last years, focusing on some unexpected aspects related their bioavailability, relationship gut microbiota.

Язык: Английский

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Potential Role of Quercetin Glycosides as Anti-Atherosclerotic Food-Derived Factors for Human Health

Antioxidants, Год журнала: 2023, Номер 12(2), С. 258 - 258

Опубликована: Янв. 23, 2023

Quercetin is a monomeric polyphenol of plant origin that belongs to the flavonol-type flavonoid subclass. Extensive studies using cultured cells and experimental model animals have demonstrated anti-atherosclerotic effects dietary quercetin in relation prevention cardiovascular disease (CVD). As exclusively present plant-based foods form glycosides, this review focuses on bioavailability bioefficacy glycosides vascular health effects. Some glucose-bound are absorbed from small intestine after glucuronide/sulfate conjugation. Both conjugated metabolites deconjugated aglycones formed by plasma β-glucuronidase activity act as food-derived anti-atherogenic factors exerting antioxidant, anti-inflammatory, low-density lipoprotein cholesterol-lowering However, most reach large intestine, where they subject gut microbiota-dependent catabolism resulting deglycosylated aglycone chain-scission products. These catabolites also affect transfer into circulation. Furthermore, may improve microbiota profiles. A variety human cohort intervention support idea intake glycoside-rich such onion helps prevent CVD. Thus, offer potential benefits terms possible clinical applications.

Язык: Английский

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Chemistry, bioavailability, bioactivity, nutritional aspects and human health benefits of polyphenols: A comprehensive review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 277, С. 134223 - 134223

Опубликована: Июль 29, 2024

Язык: Английский

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Sensory Nutrition and Bitterness and Astringency of Polyphenols

Biomolecules, Год журнала: 2024, Номер 14(2), С. 234 - 234

Опубликована: Фев. 17, 2024

Recent studies have demonstrated that the interaction of dietary constituents with taste and olfactory receptors nociceptors expressed in oral cavity, nasal cavity gastrointestinal tract regulate homeostasis through activation neuroendocrine system. Polyphenols, which 8000 been identified to date, represent greatest diversity secondary metabolites plants, most are bitter some them astringent. Epidemiological shown polyphenol intake contributes maintaining improving cardiovascular, cognitive sensory health. However, because polyphenols very low bioavailability, mechanisms their beneficial effects unknown. In this review, we focused on from perspective nutrition, summarized results previous relationship bioregulation discussed future potential.

Язык: Английский

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Flavonoids: Potential therapeutic agents for cardiovascular disease

Heliyon, Год журнала: 2024, Номер 10(12), С. e32563 - e32563

Опубликована: Июнь 1, 2024

Flavonoids are found in the roots, stems, leaves, and fruits of many plant taxa. They related to growth development, pigment formation, protection against environmental stress. function as antioxidants exert anti-inflammatory effects cardiovascular system by modulating classical inflammatory response pathways, such TLR4-NF-ĸB, PI3K-AKT, Nrf2/HO-1 signalling pathways. There is increasing evidence for therapeutic flavonoids on hypertension, atherosclerosis, other diseases. The potential clinical value diseases has been widely explored. For example, studies have evaluated roles regulation blood pressure via endothelium-dependent non-endothelium-dependent pathways myocardial systolic diastolic functions influencing calcium homeostasis smooth muscle-related protein expression. also hypoglycaemic, hypolipidemic, anti-platelet, autophagy, antibacterial effects. In this paper, role mechanism were reviewed order provide reference application future.

Язык: Английский

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Global burden of cardiovascular diseases attributable to diet low in vegetables from 1990 to 2021 and forecasting the future trends: a population-based study

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 15, 2025

This investigation examines the worldwide impact of cardiovascular diseases (CVD) resulting from inadequate vegetable consumption, based on 2021 Global Burden Disease Study data. The study assessed global, regional, and national repercussions low intake CVD, with a focus variations among different age gender demographics. It further analyzed correlation between disease burden Socio-Demographic Index (SDI), employed an ARIMA model to predict future trends in CVD associated insufficient consumption up 2050. In 2021, diet lacking vegetables was responsible for roughly 682,400 deaths 16 million disability-adjusted life years (DALYs) attributed indicating declining pattern over recent year. Individuals aged 75 older were predominantly affected. Future projections indicate expected rise incidence lower-middle SDI regions, African nations potentially experiencing increased challenges related by 2030 findings underscore critical necessity preventive measures against emphasize significance improving dietary habits, particularly intake.

Язык: Английский

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Strawberry and Drupe Fruit Wines Antioxidant Activity and Protective Effect Against Induced Oxidative Stress in Rat Synaptosomes

Antioxidants, Год журнала: 2025, Номер 14(2), С. 155 - 155

Опубликована: Янв. 28, 2025

The aim of this study was to investigate the antioxidant capacity fruit wines and their protective effects against hydrogen peroxide-induced oxidative stress in rat synaptosomes vitro. were produced from strawberries drupe fruits (i.e., plum, sweet cherry, peach, apricot) through microvinification with a pure S. cerevisiae yeast culture. Fruit without added sugar before start fermentation, whereas subvariants pits only applied wines. First, treated wines, while induced H2O2. Subsequently, activities enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)) content malondialdehyde (MDA), an indicator membrane injury, determined. In addition, Briggs–Rauscher reaction (BR) used evaluate inhibition free radicals. All investigated increased activity studied decreased MDA compared corresponding controls (synaptosomes H2O2). After synaptosomal treatment plum wine, highest observed for SOD (5.57 U/mg protein) GPx (0.015 protein). Strawberry wine CAT (0.047 showed best ability reduce lipid peroxidation, yielding lowest level (2.68 nmol/mg). Strawberry, cherry identified as samples higher both principal component analysis (PCA) hierarchical cluster (HCA). Finally, exhibited inhibitory BR (397 s). results suggest that could be considered potential functional food due stress.

Язык: Английский

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