Mediterranean diet in the management and prevention of obesity

Experimental Gerontology, Год журнала: 2023, Номер 174, С. 112121 - 112121

Опубликована: Фев. 17, 2023

The current pandemic of obesity represents a major global public health problem, mainly due to its association with chronic non-communicable disabling conditions and increased mortality. Population aging increases the chances diseases allowing longer exposure risk factors for these conditions. Obesity is factor contributing pathological aging. Numerous epidemiological studies have shown that death cardiovascular disease cancer progressively as overweight rise. Nutrition research now focused on effects combinations foods in dietary patterns instead those single nutrients or foods. model largest body evidence benefit traditionally followed by inhabitants some Mediterranean countries. There confirming inverse adhering diet obesity. Four meta-analyses randomized controlled trials, including up 16 greater reduction weight BMI MedDiet compared other diets, while meta-analysis 7 prospective cohort studies, found reduced becoming obese gaining over time associated higher adherence MedDiet. This narrative review examines reporting associations overweight/obesity age-associated related

Язык: Английский

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A Heart-Healthy and Stroke-Free World

Journal of the American College of Cardiology, Год журнала: 2023, Номер 82(25), С. 2343 - 2349

Опубликована: Дек. 1, 2023

Язык: Английский

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Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review

Critical Reviews in Food Science and Nutrition, Год журнала: 2022, Номер 63(31), С. 10709 - 10774

Опубликована: Июнь 16, 2022

Age-related diseases are associated with increased morbidity in the past few decades and cost treatment of these age-related exerts a substantial impact on social health care expenditure. Anti-aging strategies aim to mitigate, delay reverse aging-associated diseases, thereby improving quality life reducing burden pathologies. The natural dietary antioxidant supplementation offers pharmacological therapeutic effects against various disease conditions. Astaxanthin is one such carotenoid superior activity than other carotenoids, as well vitamins C E, additionally, it known exhibit plethora effects. present review summarizes protective molecular mechanisms actions astaxanthin multiple organs Neurodegenerative [Alzheimer's (AD), Parkinson's (PD), Stroke, Multiple Sclerosis (MS), Amyotrophic lateral sclerosis (ALS), Status Epilepticus (SE)], Bone Related Diseases [Osteoarthritis (OA) Osteoporosis], Cancers [Colon cancer, Prostate Breast Lung Cancer], Cardiovascular disorders [Hypertension, Atherosclerosis Myocardial infarction (MI)], Diabetes complications [Diabetic nephropathy (DN), Diabetic neuropathy, retinopathy (DR)], Eye [Age related macular degeneration (AMD), Dry eye (DED), Cataract Uveitis], Gastric Disorders [Gastritis, Colitis, Functional dyspepsia], Kidney [Nephrolithiasis, Renal fibrosis, Ischemia reperfusion (RIR), Acute kidney injury (AKI), hyperuricemia], Liver [Nonalcoholic fatty liver (NAFLD), Alcoholic Disease (AFLD), Hepatic Ischemia-Reperfusion (IR) Injury], Pulmonary [Pulmonary Fibrosis, (ALI), Chronic obstructive pulmonary (COPD)], Muscle (skeletal muscle atrophy), Skin [Atopic dermatitis (ATD), Photoaging, Wound healing]. We have also briefly discussed astaxanthin's reproductive health.

Язык: Английский

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Dietary patterns and cardiometabolic health: Clinical evidence and mechanism

MedComm, Год журнала: 2023, Номер 4(1)

Опубликована: Фев. 1, 2023

Abstract For centuries, the search for nutritional interventions to underpin cardiovascular treatment and prevention guidelines has contributed rapid development of field dietary patterns cardiometabolic disease (CMD). Numerous studies have demonstrated that healthy with emphasis on food‐based recommendations are gold standard extending lifespan reducing risks CMD mortality. Healthy include various permutations energy restriction, macronutrients, food intake such as calorie intermittent fasting, Mediterranean diet, plant‐based diets, etc. Early implementation in patients is encouraged, but an understanding mechanisms by which these trigger benefits remains incomplete. Hence, this review examined several may improve health, including restrictive patterns, regional diets based controlled macronutrients groups, summarizing cutting‐edge evidence potential treatment. Particularly, considering individual differences responses composition changes organ tissue diversity, we highlighted critical role gut microbiota crosstalk between diet recommend a more precise dynamic strategy developing profiles.

Язык: Английский

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Diet, Nutrition, and Oral Health in Older Adults: A Review of the Literature

Dentistry Journal, Год журнала: 2023, Номер 11(9), С. 222 - 222

Опубликована: Сен. 19, 2023

Diet, nutrition, and oral health are closely linked. Malnutrition is a challenging concern in older adults that associated with physical decline affecting their daily activities quality of life. The aim this review to provide an evidence-based summary the relationship between diet nutrition its implications. World Health Organization has declared healthy ageing priority work on ageing. American Dental Association confirmed bidirectional health. literature shows related diseases, including dental caries, periodontal tooth wear, even cancer. Insufficient nutritional intake poor dietary habits increase risk such as adults. On other hand, adults, conditions disease may induce pain, infection, loss, intake. Surveys have shown particular, those disadvantaged communities, suffered from deficiencies or imbalances In addition, current malnutrition frailty, hospitalization, mortality, morbidity. Good functional dentition essential maintain sufficient among reduce malnutrition. Therefore, integrating into general care service imperative improve status achieve

Язык: Английский

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The Integral Role of Magnesium in Muscle Integrity and Aging: A Comprehensive Review

Nutrients, Год журнала: 2023, Номер 15(24), С. 5127 - 5127

Опубликована: Дек. 16, 2023

Aging is characterized by significant physiological changes, with the degree of decline varying significantly among individuals. The preservation intrinsic capacity over course an individual's lifespan fundamental for healthy aging. Locomotion, which entails independent movement, intricately connected various dimensions human life, including cognition, vitality, sensory perception, and psychological well-being. Notably, skeletal muscle functions as a pivotal nexus within this intricate framework. Any perturbation in its functionality can manifest compromised physical performance elevated susceptibility to frailty. Magnesium essential mineral that plays central role approximately 800 biochemical reactions body. Its distinctive chemical attributes render it indispensable stabilizing factor orchestration diverse cellular organelle functions, thereby rendering irreplaceable processes directly impacting health. This narrative review offers comprehensive exploration played magnesium maintaining integrity, emphasizing critical importance optimal levels promoting

Язык: Английский

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Molecular Mechanisms of Healthy Aging: The Role of Caloric Restriction, Intermittent Fasting, Mediterranean Diet, and Ketogenic Diet—A Scoping Review

Nutrients, Год журнала: 2024, Номер 16(17), С. 2878 - 2878

Опубликована: Авг. 28, 2024

As the population ages, promoting healthy aging through targeted interventions becomes increasingly crucial. Growing evidence suggests that dietary can significantly impact this process by modulating fundamental molecular pathways. This review focuses on potential of strategies in and mechanisms which specific nutrients patterns influence key pathways involved cellular repair, inflammation, metabolic regulation. Caloric restriction, intermittent fasting, Mediterranean diet, as well ketogenic diet showed promising effects aging, possibly mTORC1 AMPK, an insulin signaling pathway. By understanding intricate interplay between pathways, we develop personalized not only prevent age-related diseases, but also promote overall health well-being throughout process.

Язык: Английский

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Supplementation With Carotenoids, Omega-3 Fatty Acids, and Vitamin E Has a Positive Effect on the Symptoms and Progression of Alzheimer’s Disease

Journal of Alzheimer s Disease, Год журнала: 2022, Номер 90(1), С. 233 - 249

Опубликована: Сен. 9, 2022

Background: Preliminary work by our center has reported behavior and functional benefits in patients with Alzheimer’s disease (AD) following targeted micronutritional supplementation. Objective: To build on the existing exploratory research investigate impact of these micronutrients natural progression AD a randomized controlled trial. Methods: Patients mild-moderate consumed daily 1 g fish oil (of which 500 mg DHA, 150 EPA), 22 carotenoids (10 lutein, 10 meso-zeaxanthin, 2 zeaxanthin), 15 vitamin E or placebo for 12 months double-blind, placebo-controlled, clinical Carotenoids, ω-3FAs, were quantified blood. Carotenoids also measured skin. severity was using mini-mental state examination dementia rating scale tools. Behavior, mood, memory an informant-based questionnaire. Results: Following supplementation, active group (n = 50) compared to 27), demonstrated statistically significant improvements skin carotenoid measurements, blood carotenoids, concentrations (p < 0.05, all). The performed better objective measures (i.e., mood), difference collateral 0.001). Conclusion: Exponential increases prevalence its relentless progressive nature is driving need interventions that help ameliorate symptoms improve quality life patients. Given positive outcomes this trial, combined micronutrient dietary supplement should be considered overall management AD.

Язык: Английский

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Influence of Oxidative Stress and Inflammation on Nutritional Status and Neural Plasticity: New Perspectives on Post-Stroke Neurorehabilitative Outcome

Nutrients, Год журнала: 2022, Номер 15(1), С. 108 - 108

Опубликована: Дек. 26, 2022

Beyond brain deficits caused by strokes, the effectiveness of neurorehabilitation is strongly influenced baseline clinical features stroke patients, including a patient’s current nutritional status. Malnutrition, either as pre-stroke existing condition or occurring because ischemic injury, predisposes patients to poor rehabilitation outcomes. On other hand, proper status compliant with specific needs required process recovery plays key role in post-stroke rehabilitative outcome favoring neuroplasticity mechanisms. Oxidative stress and inflammation play stroke-associated malnutrition, well cascade events area, where damage leads neuronal death infarction, and, via cell-to-cell signaling, alteration processes underlying functional induced multidisciplinary treatment. Nutrition strategies based on food components oxidative anti-inflammatory properties may help reverse stop malnutrition be prerequisite for supporting ability plasticity result satisfactory patients. To expand recommendations recovery, studies considering evolution changes over time are required. The assessment must included routine tool settings integrated care stroke-patients.

Язык: Английский

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Healthy dietary patterns and the risk of individual chronic diseases in community-dwelling adults

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Окт. 23, 2023

It is unclear regarding associations of dietary patterns with a wide range chronic diseases and which score more predictive major diseases. Using the UK Biobank, we examine four individual healthy scores risk 48 Higher Alternate Mediterranean Diet associated lower 32 (all 8 cardiometabolic disorders, 3 out 10 types cancers, 7 psychological/neurological 5 6 digestive 9 14 other diseases). Healthy Eating Index-2010 Healthful Plant-based Index are inversely 29 23 diseases, respectively. A higher Anti-Empirical Dietary Inflammatory incidence two Our findings support guidelines for prevention most

Язык: Английский

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