Food Bioscience, Год журнала: 2024, Номер unknown, С. 105096 - 105096
Опубликована: Сен. 1, 2024
Язык: Английский
Medicine, Год журнала: 2024, Номер 103(5), С. e37114 - e37114
Опубликована: Фев. 2, 2024
The gastrointestinal tract is embedded with microorganisms of numerous genera, referred to as gut microbiota. Gut microbiota has multiple effects on many body organs, including the brain. There a bidirectional connection between and brain called gut-brain-axis, these connections are formed through immunological, neuronal, neuroendocrine pathways. In addition, modulates synthesis functioning neurotransmitters. Therefore, disruption in composition or function, which known dysbiosis, associated pathogenesis mental disorders, such schizophrenia, depression, other psychiatric disorders. This review aims summarize modulation role 4 prominent neurotransmitters (tryptophan serotonergic system, dopamine, gamma-aminobutyric acid, glutamate), well its association disorders (schizophrenia, anxiety autism spectrum disorder). More future research required develop efficient gut-microbiota-based therapies for illnesses.
Язык: Английский
Процитировано
34
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 614 - 614
Опубликована: Янв. 13, 2025
The complex relationship between diet, the gut microbiota, and mental health, particularly depression, has become a focal point of contemporary research. This critical review examines how specific dietary components, such as fiber, proteins, fats, vitamins, minerals, bioactive compounds, shape microbiome influence microbial metabolism in order to regulate depressive outcomes. These dietary-induced changes microbiota can modulate production metabolites, which play vital roles gut–brain communication. axis facilitates this communication through neural, immune, endocrine pathways. Alterations metabolites central nervous system (CNS) functions by impacting neuroplasticity, inflammatory responses, neurotransmitter levels—all are linked onset course depression. highlights recent findings linking components with beneficial composition reduced symptoms. We also explore challenges individual variability responses interventions long-term sustainability these strategies. underscores necessity for further longitudinal mechanistic studies elucidate precise mechanisms diet interactions be leveraged mitigate paving way personalized nutritional therapies.
Язык: Английский
Процитировано
3
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Фев. 8, 2024
Depression is a prevalent mental disorder. However, clinical treatment options primarily based on chemical drugs have demonstrated varying degrees of adverse reactions and drug resistance, including somnolence, nausea, cognitive impairment. Therefore, the development novel antidepressant medications that effectively reduce suffering side effects has become prominent area research. Polysaccharides are bioactive compounds extracted from natural plants possess diverse pharmacological activities medicinal values. It been discovered polysaccharides can mitigate depression symptoms. This paper provides an overview action mechanisms, intervention approaches, experimental models regarding derived various sources. Additionally, we summarize roles potential mechanisms through which these prevent by regulating neurotransmitters, HPA axis, neurotrophic factors, neuroinflammation, oxidative stress, tryptophan metabolism, gut microbiota. Natural plant hold promise as adjunctive antidepressants for prevention, reduction, exerting their therapeutic multiple pathways targets. this review aims to provide scientific evidence developing polysaccharide resources effective drugs.
Язык: Английский
Процитировано
8
International Immunopharmacology, Год журнала: 2024, Номер 135, С. 112308 - 112308
Опубликована: Май 23, 2024
Язык: Английский
Процитировано
8
Molecular Cancer, Год журнала: 2024, Номер 23(1)
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 814 - 814
Опубликована: Янв. 9, 2024
Current pharmacological treatments for depression fail to produce adequate remission in a significant proportion of patients. Increasingly, other systems, such as the microbiome-gut-brain axis, are being looked at putative novel avenues treatment. Dysbiosis and dysregulation along this axis highly comorbid with severity symptoms. The endogenous extracellular matrix protein reelin is present all intestinal layers well myenteric submucosal ganglia, its receptors also gut. Reelin secretion from subepithelial myofibroblasts regulates cellular migration crypt-villus small intestine colon. brain expression downregulated mood psychotic disorders, injections have fast antidepressant-like effects animal models depression. This review seeks discuss roles gastrointestinal system propose role actions microbiota-gut-brain pathogenesis treatment depression, primarily reflecting on alterations gut epithelial cell renewal clustering serotonin transporters.
Язык: Английский
Процитировано
6
Current Developments in Nutrition, Год журнала: 2024, Номер 8(6), С. 103785 - 103785
Опубликована: Май 22, 2024
Язык: Английский
Процитировано
5
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 235 - 264
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Март 31, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(23), С. 14968 - 14968
Опубликована: Ноя. 29, 2022
Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in microbiota–gut–brain axis contributes to pathogenesis This extensive review aimed elucidate antidepressive effects brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products their derivatives gut–brain axis. information could facilitate development novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, synaptic transmission. Signaling via its receptor tropomyosin kinase B (TrkB) plays a vital role etiopathogenesis depression mechanism antidepressants. comprehensive provides researchers scientists identification neuropsychiatric disorders, especially stress. Future research should aim determine possible causative BDNF-TrkB depression, which will require further animal clinical as well analytical approaches.
Язык: Английский
Процитировано
20