The Ketogenic Diet and Cardiovascular Diseases

Nutrients, Год журнала: 2023, Номер 15(15), С. 3368 - 3368

Опубликована: Июль 28, 2023

The most common and increasing causes of death worldwide are cardiovascular diseases (CVD). Taking into account the fact that diet is a key factor, it worth exploring this aspect CVD prevention therapy. aim article to assess potential ketogenic in treatment CVD. comprehensive, meticulous analysis literature area, taking recent studies currently available. has been shown have multifaceted effect on Among other aspects, beneficial blood lipid profile, even compared diets. It shows strong anti-inflammatory cardioprotective potential, which due, among factors, properties state ketosis, elimination simple sugars, restriction total carbohydrates supply omega-3 fatty acids. In addition, ketone bodies provide "rescue fuel" for diseased heart by affecting its metabolism. They also function vascular endothelium, including improving inhibiting premature ageing. pressure risk factors through, weight loss. evidence cited often superior standard diets, making likely advantages over dietary models diseases. There legitimate need further research area.

Язык: Английский

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Personalizing Nutrition Strategies: Bridging Research and Public Health

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(3), С. 305 - 305

Опубликована: Март 13, 2024

In recent years, although life expectancy has increased significantly, non-communicable diseases (NCDs) continue to pose a significant threat the health of global population. Therefore, eating habits have been recognized as key modifiable factors that influence people’s and well-being. For this reason, it is interesting study dietary patterns, since human diet complex mixture macronutrients, micronutrients, bioactive compounds, can modulate multiple physiological processes, including immune function, metabolism, inflammation. To ensure data we acquired were current relevant, searched primary secondary sources, scientific journals, bibliographic indexes, databases in last 15 years with most relevant articles. After search, observed all research on NCDs suggests critical factor shaping an individual’s outcomes. Thus, cardiovascular, metabolic, mental, dental, visual depends largely intake, nutritional behaviors. A high processed refined foods, added sugars, saturated fats increase risk developing chronic diseases. On other hand, rich whole, nutrient-dense such vegetables, fruits, nuts, legumes, adherence Mediterranean improve health’s people.

Язык: Английский

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Cancer Metabolism as a Therapeutic Target and Review of Interventions

Nutrients, Год журнала: 2023, Номер 15(19), С. 4245 - 4245

Опубликована: Окт. 1, 2023

Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this reprogramming in cells, possible target cancers metabolically by depriving them of glucose. In addition dietary modifications work on tumors metabolically, there are panoply nutritional supplements repurposed drugs associated with prevention better treatment outcomes. These interventions their evidentiary basis covered the latter half review guide future treatment.

Язык: Английский

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Polyphenol consumption and Nonalcoholic fatty liver disease risk in adults

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 21, 2024

In this cross-sectional investigation, the primary objective was to explore correlation between consumption of polyphenols and likelihood non-alcoholic fatty liver disease (NAFLD) in adult population participating Hoveyzeh cohort. Data from cohort study, part Persian Cohort Study, involving 10,009 adults aged 35-70, were analyzed. Exclusions made for missing data, extreme energy intake, cancer patients. Dietary habits assessed using a food frequency questionnaire, polyphenol intake calculated Phenol Explorer database. Logistic regression analyses, adjusted confounders, performed assess relationship subclasses (total polyphenols, total flavonoids, phenolic acid, lignin) NAFLD. Among 9894 participants, those highest quintile (OR 0.65, CI 0.5-0.84; P = 0.007), acid 0.67, 0.52-0.86; < 0.001), lignin 0.69, 0.52-0.87; 0.001) demonstrated lower odds NAFLD compared lowest quintile, even after adjusting confounding factors. However, no significant association found flavonoid 1.26, 0.96-1.67; 0.47). Subgroup analysis indicated inverse women 0.64, 0.42-0.93; 0.001). Higher associated with reduced among This suggests that dietary patterns rich these may play role mitigating risk Further interventional longitudinal studies are needed validate findings potential preventive strategies polyphenol-rich diets.

Язык: Английский

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A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients

Virology Journal, Год журнала: 2024, Номер 21(1)

Опубликована: Апрель 23, 2024

Abstract Background This study sought to examine the impact of magnesium supplementation on clinical outcomes and biochemical factors among hospitalized patients with COVID-19. Methods double-blind, randomized trial was conducted at Razi Hospital, Ahvaz, Iran, between September 2021 March 2022. Participants aged 18–70 years moderate disease severity were enrolled. Magnesium (300 mg daily) administered intervention group, while control group received a placebo. Clinical outcomes, including need for oxygen therapy, saturation, respiratory rate, fever, hs-CRP TNF-α levels, as well quality life mental health, assessed. Blood samples collected measure variables. Results The main result count individuals requiring therapy. Additional comprised health. Out 64 participants, 60 completed study. results showed that significantly reduced number therapy (9 vs. 14; P < 0.001). Moreover, demonstrated improved saturation compared (4.55 ± 2.35 1.8 1.67; Furthermore, we observed noteworthy enhancement in depression score group. No significant differences hs-CRP, levels ( > 0.05). Conclusion findings suggest may have beneficial effects arterial COVID-19 patients. More investigation is necessary delve into its potential mechanisms long-term patient outcomes. Trial registration registered Iranian Registry Trials (IRCT) under identifier IRCT20210413050957N1. (The date: May 1, 2021).

Язык: Английский

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The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases

Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(4), С. 143 - 143

Опубликована: Апрель 9, 2024

Coenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing fundamental role in regulating transfer reactions and participating cellular metabolic processes. As the principal substrate cofactor engaged diverse reactions, CoA its derivatives exert central influence over various physiological processes, primarily modulating lipid ketone metabolism, well protein modification. This paper presents comprehensive review molecular mechanisms by which influences onset progression cancer, cardiovascular disease (CVD), neurodegenerative disorders, other illnesses. The main focal points include following. (1) In enzymes such acetyl-CoA synthetase 2, ATP citrate lyase, carboxylase regulate synthesis energy metabolism levels. (2) CVD, effects stearoyl-CoA desaturase-1, 3-hydroxy-3-methylglutaryl-CoA (HMGC) synthase HMGC reductase on formation advancement these diseases are elucidated their regulation across multiple organs. (3) significance maintaining cholesterol homeostasis brain implications development disorders thoroughly discussed. processes involving span all aspects critical diseases. Elucidating conditions yields important insights that can serve valuable references guidance for diagnosis, treatment, drug development.

Язык: Английский

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Ketone Bodies as Metabolites and Signalling Molecules at the Crossroad between Inflammation and Epigenetic Control of Cardiometabolic Disorders

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(23), С. 14564 - 14564

Опубликована: Ноя. 23, 2022

For many years, it has been clear that a Western diet rich in saturated fats and sugars promotes an inflammatory environment predisposing person to chronic cardiometabolic diseases. In parallel, the emergence of ketogenic diets, deprived carbohydrates promoting synthesis ketone bodies imitating metabolic effects fasting, shown provide possible nutritional solution alleviating diseases triggered by environment. The main body, β-hydroxybutyrate (BHB), acts as alternative fuel, also substrate for novel histone post-translational modification, β-hydroxybutyrylation. β-hydroxybutyrylation influences state chromatin architecture transcription multiple genes. BHB modulate inflammation this review, we discuss, pathological context cardiovascular risks, current understanding how bodies, or diet, are able modulate, trigger, inhibit epigenome remodeling may be key contributor.

Язык: Английский

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Ketogenic diet in children and adolescents: The effects on growth and nutritional status

Pharmacological Research, Год журнала: 2023, Номер 191, С. 106780 - 106780

Опубликована: Апрель 23, 2023

The ketogenic diet is known to be a possible adjuvant treatment in several medical conditions, such as patients with severe or drug-resistant forms of epilepsy. Its use has recently been increasing among adolescents and young adults due its supposed weight-loss effect, mediated by lipolysis lowered insulin levels. However, there are still no precise indications on the diets pediatric age for weight loss. This approach also proposed other types disorder inherited metabolic disorders, Prader-Willi syndrome, some specific cancers. Due unbalanced ratio lipids, carbohydrates proteins, clinical evaluation side effects strict growth nutritional status essential all following long-term restrictive one. prophylactic micronutrients supplementation should considered before starting any diet. Lastly, while sufficient literature short-term diets, their impact not yet fully understood, especially when started age.

Язык: Английский

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Influence of the Mediterranean diet on seminal quality—a systematic review

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Фев. 15, 2024

Currently, there is a growing interest in the study of fertility because fertility-related problems affect up to 15% world’s population. The aim this was determine influence Mediterranean diet on seminal quality men reproductive age. For purpose, systematic review literature carried out following PRISMA method. Electronic searches were international databases PubMed, Scopus, Cochrane Library, and Web Science. In total, 10 articles with 2032 included. As inclusion criteria, published between 2012 2022 selected, including those that included aged 18 55 years. Nutritional status assessed through weight, height, BMI. Dietary habits evaluated different indexes food frequency questionnaires, finally, semen by measuring sperm concentration motility (progressive non-progressive). six (60%) articles, positive relationship adherence demonstrated; two (20%) no association found; dietary patterns typical DM evaluated. quality. Adherence can improve male health, as it antioxidant anti-inflammatory effects. This first about quality, results are positive. These findings may allow us provide better advice our patients establish interventions improving assisted reproduction techniques.

Язык: Английский

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Ketogenesis attenuated KLF5 disrupts iron homeostasis via LIF to confer oxaliplatin vulnerability in colorectal cancer

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(6), С. 167210 - 167210

Опубликована: Май 3, 2024

Язык: Английский

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