Nutrients,
Год журнала:
2023,
Номер
15(20), С. 4479 - 4479
Опубликована: Окт. 23, 2023
In
this
Editorial,
we
comment
on
a
series
of
recent
articles
featured
in
the
Special
Issue
“Emerging
Benefits
Vitamin
B3
Derivatives
Aging,
Health
and
Disease:
From
Basic
Research
to
Translational
Applications”
Nutrients
[...]
Antioxidants,
Год журнала:
2023,
Номер
12(2), С. 376 - 376
Опубликована: Фев. 4, 2023
Nicotinamide
adenine
dinucleotide
(NAD+)
is
a
ubiquitous
metabolite
that
takes
part
in
many
key
redox
reactions.
NAD+
biosynthesis
and
NAD+-consuming
enzymes
have
been
attracting
markedly
increasing
interest
since
they
demonstrated
to
be
involved
several
crucial
biological
pathways,
impacting
genes
transcription,
cellular
signaling,
cell
cycle
regulation.
As
consequence,
pathological
conditions
are
associated
with
an
impairment
of
intracellular
levels,
directly
or
indirectly,
which
include
cardiovascular
diseases,
obesity,
neurodegenerative
cancer,
aging.
In
this
review,
we
describe
the
general
pathways
starting
from
different
precursors,
analyzing
actual
state-of-art
administration
precursors
blocking
NAD+-dependent
as
strategies
increase
levels
counteract
decline
ageing.
Subsequently,
focus
on
disease-related
age-related
alterations
homeostasis
endothelium
consequent
vascular
dysfunction,
significantly
contributes
wide
group
disorders.
Advances in Nutrition,
Год журнала:
2023,
Номер
14(6), С. 1416 - 1435
Опубликована: Авг. 23, 2023
The
importance
of
nicotinamide
adenine
dinucleotide
(NAD+)
in
human
physiology
is
well
recognized.
As
the
NAD+
concentration
skin,
blood,
liver,
muscle
and
brain
are
thought
to
decrease
with
age,
finding
ways
increase
status
could
possibly
influence
ageing
process
associated
metabolic
sequelae.
Nicotinamide
mononucleotide
(NMN)
a
precursor
for
biosynthesis,
vitro/in
vivo
studies
have
demonstrated
that
NMN
supplementation
increases
mitigate
ageing-related
disorders
such
as
oxidative
stress,
DNA
damage,
neurodegeneration
inflammatory
responses.
promotion
an
anti-ageing
health
supplement
has
gained
popularity
due
findings;
however,
since
most
evaluating
effects
been
conducted
cell
or
animal
models,
concern
remains
regarding
safety
physiological
population.
Nonetheless,
dozen
clinical
trials
currently
underway.
This
review
summarizes
current
progress
these
NMN/NAD+
biology
clarify
potential
shed
light
on
future
study
directions.
Nicotinamide
riboside
alleviated
cognitive
impairment
induced
by
sucrose/aspartame,
which
might
be
related
to
neuroinflammation,
pyroptosis,
oxidative
stress,
apoptosis
and
autophagy.
Next-generation
live
biotherapeutics
are
promising
to
aid
the
treatment
of
obesity
and
metabolic
diseases.
Here,
we
reported
a
novel
anti-obesity
probiotic
candidate,
Roseburia
hominis,
that
was
depleted
in
stool
samples
obese
subjects
compared
with
lean
controls,
its
abundance
negatively
correlated
body
mass
index
serum
triglycerides.
Supplementation
R.
hominis
prevented
weight
gain
disorders
glucose
lipid
metabolism,
fatty
liver,
inhibited
white
adipose
tissue
expansion
brown
whitening
mice
fed
high-fat
diet,
boosted
lean-related
species.
The
effects
could
be
partially
attributed
production
nicotinamide
riboside
upregulation
Sirtuin1/mTOR
signaling
pathway.
These
results
indicated
is
candidate
for
development
next-generation
prevention
Molecules,
Год журнала:
2023,
Номер
28(16), С. 6078 - 6078
Опубликована: Авг. 15, 2023
Many
studies
have
suggested
that
the
oxidized
form
of
nicotinamide
adenine
dinucleotide
(NAD+)
is
involved
in
an
extensive
spectrum
human
pathologies,
including
neurodegenerative
disorders,
cardiomyopathy,
obesity,
and
diabetes.
Further,
healthy
aging
longevity
appear
to
be
closely
related
NAD+
its
metabolites,
riboside
(NR)
mononucleotide
(NMN).
As
a
dietary
supplement,
NR
appears
well
tolerated,
having
better
pharmacodynamics
greater
potency.
Unfortunately,
reactive
molecule,
often
unstable
during
manufacturing,
transport,
storage.
Recently,
work
prebiotic
chemistry
discovered
borate
considerably
more
stable
than
itself.
However,
immediately
upon
consumption,
dissociates
from
lost
body
through
dilution
binding
other
species,
notably
carbohydrates
such
as
fructose
glucose.
The
left
behind
expected
behave
pharmacologically
ways
identical
This
review
provides
comprehensive
summary
(through
Q1
2023)
literature
makes
case
for
consumption
supplement.
It
then
summarizes
challenges
delivering
quality
consumers
using
standard
synthesis,
manufacture,
shipping,
storage
approaches.
concludes
by
outlining
advantages
these
processes.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Янв. 14, 2025
The
NF
concept
was
first
established
by
Regulation
(EC)
258/97
and
includes
any
food
that
has
not
been
used
to
a
significant
extent
for
human
consumption
in
the
EU
before
15
May
1997.
Synthetic
novel
foods
(SNF)
are
currently
undefined
group
of
without
universal
definition.
objectives
this
work
perform
an
analysis
those
authorized
EU,
identify
their
potential
adverse
effects
health
benefits,
claims.
For
that,
extensive
review
available
legislative
documents
scientific
literature
regarding
SNF
performed,
market
performed
commercial
availability.
This
considers
as
obtained
chemical
synthesis,
excluding
genetically
modified
foods.
A
total
29
were
identified
classified
into
9
categories,
risks
benefits
described.
All
considered
safe
different
studied
suggested
various
categories.
Currently,
22
on
market.
characterizes
previously
unexplored
expands
knowledge
new
promising
research
area
combining
toxicological
perspectives
with
legislation
more
optimal
risk
management
EU.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(2), С. 1291 - 1307
Опубликована: Фев. 1, 2024
Changes
in
intracellular
nicotinamide
adenine
dinucleotide
(NAD+)
levels
have
been
observed
various
disease
states.
A
decrease
NAD+
has
noted
following
spinal
cord
injury
(SCI).
Nicotinamide
riboside
(NR)
serves
as
the
precursor
of
NAD+.
Previous
research
demonstrated
anti-inflammatory
and
apoptosis-reducing
effects
NR
supplements.
However,
it
remains
unclear
whether
exerts
a
similar
role
mice
after
SCI.
The
objective
this
study
was
to
investigate
impact
on
these
changes
mouse
model
Four
groups
were
considered:
(1)
non-SCI
without
(Sham),
(2)
with
(Sham
+NR),
(3)
SCI
(SCI),
(4)
(SCI
+
NR).
Female
C57BL/6J
aged
6–8
weeks
intraperitoneally
administered
500
mg/kg/day
for
duration
one
week.
supplementation
resulted
significant
elevation
tissue
In
comparison
group,
exhibited
regulatory
chemotaxis/recruitment
leukocytes,
leading
reduced
inflammatory
factors
such
IL-1β,
TNF-α,
IL-22
injured
area.
Moreover,
notably
enhanced
survival
neurons
synapses
within
area,
ultimately
resulting
improved
motor
functions
Therefore,
our
findings
that
had
inhibitory
leukocyte
chemotaxis,
effects,
could
significantly
improve
immune
micro-environment
SCI,
thereby
promoting
neuronal
enhancing
recovery
showed
promise
potential
clinical
treatment
strategy
Nicotinamide
adenine
dinucleotide
(NAD+)
is
essential
in
the
proper
function
of
many
cellular
processes
human
body.
The
purpose
this
review
to
investigate
effect
nicotinamide
mononucleotide
(NMN),
a
NAD+
precursor,
on
physical
performance
and
evaluate
safety
profile
supplementation.
A
systematic
search
criteria
following
guidelines
from
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
(PRISMA)
was
performed
four
databases
randomized
controlled
trials
NMN
Study
variables
included
title,
author,
publication
date,
study
year,
number
patients,
dosage,
mean
age,
follow-up
time,
pre-
post-intervention
reported
outcomes,
rates
complications.
Ten
studies,
including
437
with
age
58.0
years
(35.1
81.1
years)
time
9.6
weeks
(4
12
weeks)
were
study.
dosages
ranged
150
1200
mg/day.
Mean
pre-intervention
grip
strength
(two
studies)
skeletal
mass
index
29.9
kilograms
(kg)
(range:
21.4-40.1
kg)
7.4
kg/m2
6.9-7.65
kg/m2),
respectively.
30.5
kg
21.7-41.9
(6.8-7.64
There
no
serious
adverse
effects
observed.
Moreover,
side
effects,
they
determined
be
independent
Therefore,
patients
taking
supplementation
demonstrated
non-significantly
improved
parameters.
well
tolerated