Synthetic and Systems Biotechnology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Antioxidants, Год журнала: 2023, Номер 12(9), С. 1653 - 1653
Опубликована: Авг. 22, 2023
The liver is an organ that particularly exposed to reactive oxygen species (ROS), which not only arise during metabolic functions but also the biotransformation of xenobiotics. disruption redox balance causes oxidative stress, affects function, modulates inflammatory pathways and contributes disease. Thus, stress implicated in acute injury pathogenesis prevalent infectious or chronic diseases such as viral hepatitis B C, alcoholic fatty disease, non-alcoholic disease (NAFLD) steatohepatitis (NASH). Moreover, plays a crucial role progression fibrosis, cirrhosis hepatocellular carcinoma (HCC). Herein, we provide overview on effects pathophysiology mechanisms by promotes
Язык: Английский
Процитировано
138
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(1), С. 587 - 587
Опубликована: Янв. 2, 2024
Ovarian cancer is one of the most dangerous gynecologic cancers worldwide and has a high fatality rate due to diagnosis at an advanced stage disease as well recurrence occurrence chemotherapy resistance. In fact, chemoresistance weakens therapeutic effects, worsening outcome this pathology. Solute Carrier Family 7 Member 11 (SLC7A11, also known xCT) functional subunit Xc− system, anionic L-cystine/L-glutamate antiporter expressed on cell surface. SLC7A11 expression significantly upregulated in several types which it can inhibit ferroptosis favor proliferation, invasion chemoresistance. increased ovarian tissues, suggesting possible role protein target. review, we provide overview current literature regarding new insights modulation evaluate potential
Язык: Английский
Процитировано
55
Cancers, Год журнала: 2023, Номер 15(11), С. 3037 - 3037
Опубликована: Июнь 2, 2023
Prostate cancer is the second most common in men worldwide. can be treated by surgery or active surveillance when early diagnosed but, at an advanced metastatic stage, radiation therapy androgen-deprivation needed to reduce progression. However, both of these therapies cause prostate resistance treatment. Several studies demonstrated that oxidative stress involved occurrence, development, progression and treatment resistance. The nuclear factor erythroid 2-related 2 (NRF2)/KEAP1 (Kelch-Like ECH-Associated Protein 1) pathway plays important role protecting cells against damage. Reactive oxygen species (ROS) levels NRF2 activation determine cell fate. In particular, toxic ROS lead physiological death tumor suppression, while lower are associated with carcinogenesis On contrary, a high level promotes survival related activating adaptive antioxidant response. this review, we analyzed current literature regarding natural synthetic compounds modulating NRF2/KEAP1 signaling cancer.
Язык: Английский
Процитировано
42
Cancers, Год журнала: 2024, Номер 16(5), С. 901 - 901
Опубликована: Фев. 23, 2024
Liver cancer, predominantly hepatocellular carcinoma (HCC), globally ranks sixth in incidence and third cancer-related deaths. HCC risk factors include non-viral hepatitis, alcohol abuse, environmental exposures, genetic factors. No specific alterations are unequivocally linked to tumorigenesis. Current standard therapies surgical options, systemic chemotherapy, kinase inhibitors, like sorafenib regorafenib. Immunotherapy, targeting immune checkpoints, represents a promising avenue. FDA-approved checkpoint such as atezolizumab pembrolizumab, show efficacy, combination enhance clinical responses. Despite this, the treatment of (HCC) remains challenge, complex tumor ecosystem immunosuppressive microenvironment associated with it hamper efficacy available therapeutic approaches. This review explores current advanced approaches treat HCC, considering both known new potential targets, especially derived from proteomic analysis, which is today considered most approach. Exploring novel strategies, this discusses antibody drug conjugates (ADCs), chimeric antigen receptor T-cell therapy (CAR-T), engineered antibodies. It then reports systematic analysis main ligand/receptor pairs molecular pathways reported be overexpressed cells, highlighting their limitations. Finally, TGFβ, one targets microenvironment.
Язык: Английский
Процитировано
18
Frontiers in Bioscience-Landmark, Год журнала: 2023, Номер 28(7)
Опубликована: Июль 21, 2023
Prostate cancer is the second most common malignancy in men worldwide. can be treated by surgery, radiotherapy and hormone therapy. The latter, form of androgen-deprivation therapy needed to reduce prostate progression at an advanced stage. Several studies demonstrated that oxidative stress involved occurrence, development Nuclear factor erythroid 2-related 2 (NRF2)/Kelch Like ECH Associated Protein 1 (KEAP1) pathway affected reactive oxygen species (ROS). Furthermore, NRF2/KEAP1 signaling has been investigated several related anti-androgen therapy, biochemical recurrence radiotherapy. In this review we analysed current literature regarding indirect modulators regulation their role as possible therapeutic targets cells.
Язык: Английский
Процитировано
38
Cancers, Год журнала: 2023, Номер 15(12), С. 3207 - 3207
Опубликована: Июнь 16, 2023
Renal cell carcinoma (RCC) belongs to a heterogenous cancer group arising from renal tubular epithelial cells. Among RCC subtypes, clear (ccRCC) is the most common variant, characterized by high aggressiveness, invasiveness and metastatic potential, features that lead poor prognosis mortality rate. In addition, diagnosis of kidney incidental in majority cases, this results late diagnosis, when stage disease advanced tumor has already metastasized. Furthermore, ccRCC treatment complicated its strong resistance chemo- radiotherapy. Therefore, there active ongoing research focused on identifying novel biomarkers which could be useful for assessing better prognosis, as well new molecules used targeted therapy. light, several therapies have been shown effective prolonging overall survival patients. Thus, aim review analyze actual state-of-the-art therapeutic options, while also reporting recent advances biomarker discoveries, exploited or
Язык: Английский
Процитировано
35
Aging Cell, Год журнала: 2023, Номер 23(1)
Опубликована: Июль 9, 2023
Abstract The geroscience hypothesis proposes that addressing the biology of aging could directly prevent onset or mitigate severity multiple chronic diseases. Understanding interplay between key aspects biological hallmarks is essential in delivering promises hypothesis. Notably, nucleotide nicotinamide adenine dinucleotide (NAD) interfaces with several aging, including cellular senescence, and changes NAD metabolism have been shown to be involved process. relationship senescence appears complex. On one hand, accumulation DNA damage mitochondrial dysfunction induced by low + can promote development senescence. other state occurs during may inhibit SASP as this secretory phenotype are both highly metabolically demanding. However, date, impact on progression has not fully characterized. Therefore, explore implications replacement therapies, it consider their interactions We propose a comprehensive understanding boosting strategies senolytic agents necessary advance field.
Язык: Английский
Процитировано
34
Antioxidants, Год журнала: 2023, Номер 12(7), С. 1425 - 1425
Опубликована: Июль 14, 2023
Ethanol consumption triggers oxidative stress by generating reactive oxygen species (ROS) through its metabolites. This process leads to steatosis and liver inflammation, which are critical for the development of alcoholic disease (ALD). Autophagy is a regulated dynamic that sequesters damaged excess cytoplasmic organelles lysosomal degradation may counteract harmful effects ROS-induced stress. These include hepatotoxicity, mitochondrial damage, steatosis, endoplasmic reticulum stress, iron overload. In diseases, particularly ALD, macroautophagy has been implicated as protective mechanism in hepatocytes, although it does not appear play same role stellate cells. Beyond liver, autophagy also mitigate alcohol on other organs, thereby providing an additional layer protection against ALD. potential further supported studies showing drugs interact with autophagy, such rapamycin, can prevent ALD animal models. systematic review presents comprehensive analysis literature, focusing regulation, involvement organ-organ crosstalk relevant autophagy-targeting therapeutic strategies.
Язык: Английский
Процитировано
32
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14964 - 14964
Опубликована: Окт. 6, 2023
Epigenetics play a crucial role in gene regulation and cellular processes. Most importantly, its dysregulation can contribute to the development of tumors. Epigenetic modifications, such as DNA methylation histone acetylation, are reversible processes that be utilized targets for therapeutic intervention. inhibitors disrupt patterns by inhibiting methyltransferases. Such restore normal expression patterns, they effective against various forms cancer. Histone deacetylase increase acetylation levels, leading altered expressions. Like inhibitors, methyltransferase target molecules involved methylation. Bromodomain extra-terminal domain proteins expression. They oncogene inducing anti-proliferative effects seen Understanding epigenetic modifications utilizing will offer new possibilities cancer research.
Язык: Английский
Процитировано
23
Antioxidants, Год журнала: 2024, Номер 13(10), С. 1270 - 1270
Опубликована: Окт. 18, 2024
Periodontitis affects up to 40% of adults over 60 years old and is a consequence gingivitis. characterized by chronic inflammation, periodontal damage, alveolar bone resorption. The nuclear factor erythroid 2-related 2 (NFE2L2 or NRF2)/Kelch-like ECH-Associated Protein 1 (KEAP1) (NRF2/KEAP1) signaling pathway plays key role in periodontitis modulating redox balance inflammation the periodontium. However, NRF2 expression decreased gingival tissues patients with while oxidative stress significantly increased this pathology. Oxidative lipopolysaccharide (LPS) produced gram-negative bacteria favor production inflammatory causing favoring bone. In review, we analyzed current literature regarding natural synthetic compounds NRF2/KEAP1 vitro vivo models order evaluate new potential treatments that can improve outcome disease.
Язык: Английский
Процитировано
15