Effects of a 12‐Week Mediterranean‐Type Time‐Restricted Feeding Protocol in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Randomised Controlled Trial—The ‘CHRONO‐NAFLD Project’

Alimentary Pharmacology & Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

ABSTRACT Background The Mediterranean diet (MD) is considered the best dietary approach for patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). Recently, time‐restricted feeding (TRF) has gained attention its lifestyle compatibility and health benefits. Aims This study aimed to compare effects of a hypocaloric MD 10‐h TRF protocol an unrestricted in MASLD overweight/obesity evaluate differences between early late TRF. Methods 12‐week randomised controlled trial consisted three groups, all following Mediterranean‐type diet. control group had no eating time restrictions. (eTRF) (lTRF) groups window, from 8 AM 6 PM 12 10 PM, respectively. Various parameters were measured. Compliance was tracked via food diaries, 8‐week follow‐up occurred post‐intervention. Results Fifty‐nine individuals (27 males; 52.9 years; body mass index 32.1 kg/m 2 ) completed (control, n = 19; eTRF, 20; lTRF, 20). All showed significant reductions weight, anthropometry blood pressure. Glycated haemoglobin A 1c insulin resistance, as measured by Matsuda index, homeostatic model assessment resistance fasting glucose‐to‐insulin ratio, improved eTRF at weeks. Conclusions corroborates efficacy ameliorating cardiometabolic risk factors such weight pressure patients. combination may improve glycaemic (NCT05866744). Trial Registration registered clinicaltrials.gov (NCT05866744)

Язык: Английский

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Effects of time-restricted eating with different eating duration on anthropometrics and cardiometabolic health: A systematic review and meta-analysis

World Journal of Cardiology, Год журнала: 2023, Номер 15(7), С. 354 - 374

Опубликована: Июль 25, 2023

Time-restricted eating (TRE) is a dietary approach that limits to set number of hours per day. Human studies on the effects TRE intervention cardiometabolic health have been contradictory. Heterogeneity in subjects and interventions led inconsistency results. Furthermore, impact duration eating/fasting has yet be fully explored.To analyze existing literature with different durations anthropometrics markers adults excessive weight obesity-related metabolic diseases.We reviewed series prominent scientific databases, including Medline, Scopus, Web Science, Academic Search Complete, Cochrane Library articles identify published clinical trials daily diseases. Randomized controlled were assessed for methodological rigor risk bias using version 2 risk-of-bias tool randomized (RoB-2). Outcomes interest include body weight, waist circumference, fat mass, lean fasting glucose, insulin, HbA1c, homeostasis model assessment insulin resistance (HOMA-IR), lipid profiles, C-reactive protein, blood pressure, heart rate.Fifteen included our systematic review. significantly reduces triglyceride. However, no significant changes observed HOMA-IR, total cholesterol, low-density lipoprotein high-density rate, systolic diastolic pressure. subgroup analyses based window revealed variation depending length window.TRE promising chrononutrition-based improving anthropometric health. further are needed determine optimal cardiovascular disease prevention.

Язык: Английский

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Chrononutrition in the Prevention and Management of Metabolic Disorders: A Literature Review

Nutrients, Год журнала: 2024, Номер 16(5), С. 722 - 722

Опубликована: Март 1, 2024

Background: The concept of time-restricted eating (TRE) or feeding (TRF) promotes daily periods and fasting to determine whole-body physiology. Chronic misalignment circadian rhythms chrono-disruption is related an increased risk diverse metabolic disorders. progression non-communicable diseases seems be affected by the timing meals. As a result, intermittent promising approach for their management. aim present literature review examine scrutinize TRE protocols in fields prevention management Methods: This thorough reported associations among rhythm, disorders, diabetes mellitus, obesity, TRE, TRF, dietary habits, disruption, cardiovascular diseases, atherosclerosis, non-alcoholic fatty liver find already existing clinical studies from last decade (2014–2024) most precise scientific online databases, using relevant specific keywords. Several inclusion exclusion criteria were applied only longitudinal, cross-sectional, descriptive, prospective human studies. Results: currently available findings remain scarce suggest that chrononutrition behaviors such as TRF may promote several benefits, mainly body weight control fat loss. Improvements glucose levels lipid profiles are quite controversial since some show little no effect. far concerned, efficacy stronger disease due decline Conclusions: Even if there has been gradual increase few years, providing perspectives, currently, conclusive evidence role Future should well-designed with longer duration larger sample sizes. Moreover, it important best window its feasibility.

Язык: Английский

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Intermittent fasting with ketogenic diet: A combination approach for management of chronic diseases

Clinical Nutrition ESPEN, Год журнала: 2023, Номер 54, С. 166 - 174

Опубликована: Янв. 28, 2023

Язык: Английский

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Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2023, Номер 25(2), С. 325 - 337

Опубликована: Ноя. 22, 2023

Abstract Daily rhythms of metabolic function are supported by molecular circadian clock systems that strongly regulated feeding and fasting. Intermittent fasting diets have been associated with weight loss improved metabolism. However, the effects time-restricted eating (TRE) on glycemic parameters still under debate. In this review, we aim to systematically analyze TRE parameters. We searched PubMed, EMBASE, Cochrane Library for controlled studies in which subjects followed at least 4 weeks. 20 were included qualitative systematic 18 (n = 1169 subjects) meta-analysis. Overall, had no significant effect glucose (Hedges’s g -0.08; 95% CI:-0.31,0.16; p 0.52), but it did reduce HbA1c levels -0.27; CI: -0.47, -0.06; 0.01). significantly reduced insulin -0.40; -0.73,-0.08; 0.01) showed a tendency decrease HOMA-IR -0.32; CI:-0.66,0.02; 0.06). Interestingly, cumulative analysis beneficial regarding less apparent as later windows (lTRE) being included. Indeed, subgroup early (eTRE) revealed was eTRE -0.38; CI:-0.62, -0.14; < Our meta-analysis suggests can levels, timing food intake is crucial factor benefit TRE, only capable reducing overweight or obesity. PROSPERO registration number CRD42023405946.

Язык: Английский

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The Effect of Observing Religious or Faith-based Fasting on Cardiovascular Disease Risk Factors: A Systematic Review and Meta-analysis

Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2024, Номер 34(5), С. 1097 - 1109

Опубликована: Фев. 16, 2024

Cardiovascular diseases (CVD) are the leading cause of death worldwide. Fasting is common in many religions and associated with health benefits. This systematic review to compares impact different religious fasting practices, on risk cardiometabolic diseases.

Язык: Английский

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Therapeutic Potential of Various Intermittent Fasting Regimens in Alleviating Type 2 Diabetes Mellitus and Prediabetes: A Narrative Review

Nutrients, Год журнала: 2024, Номер 16(16), С. 2692 - 2692

Опубликована: Авг. 14, 2024

Intermittent fasting has drawn significant interest in the clinical research community due to its potential address metabolic complications such as obesity and type 2 diabetes mellitus. Various intermittent regimens include alternate-day (24 h of followed by 24 eating), time-restricted (fasting for 14 eating within a 10 window), 5:2 diet two days normally other five days). is associated with reduced risk mellitus-related can slow their progression. The increasing global prevalence mellitus highlights importance early management. Since prediabetes precursor mellitus, understanding progression essential. However, long-term effects on are not yet well understood. Therefore, this review aims comprehensively compile existing knowledge therapeutic managing prediabetes.

Язык: Английский

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Ramadan fasting and glycemic control in patients with type 2 diabetes: A real-world data analysis

Primary care diabetes, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Body Weight Changes During Ramadan Intermittent Fasting: A Cross‐Sectional Study of Healthy Adults in Turkey

Journal of Nutrition and Metabolism, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Introduction: This study explores the impact of observing Ramadan intermittent fasting (RIF) on body weight in Turkish residents, marking it as first conducted Turkey to investigate interplay religious with dietary changes amid COVID‐19 pandemic. We hypothesized that would result loss attributable changes, while decreased physical activity correlate gain during this period. Methods: A cross‐sectional survey was among Muslims aged 18+ who fasted at least two days 2021. Data were collected via Google Forms, 1669 participants recruited through social media. Descriptive statistics summarized participant characteristics, and Pearson’s Chi‐square tests assessed change differences. Binary logistic regression identified predictors gain, adjusting for factors such sex, age, activity, water consumption, diet. Results: Of respondents (53.6% female), 49.4% perceived their normal, 47.0% classified themselves overweight or obese. Logistic indicated (AOR = 1.618, p 0.001) increased fat intake 1.9, 95% CI 1.2–2.9) significant gain. Conclusion: Our findings emphasize importance promoting healthy eating regular Ramadan.

Язык: Английский

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Relationships Between Body Image and Body Parameters in Men Under Long-Term Fasting Conditions

Nutrients, Год журнала: 2025, Номер 17(6), С. 1023 - 1023

Опубликована: Март 14, 2025

Background/Objectives: Fasting and physical exertion positively affect body mass composition. This study aimed to examine the effects of changes induced by eight days water-only fasting a test their influence on satisfaction image parameters in middle-aged men. Methods: Fifteen participants were assessed for (height, mass, composition) psychological (body satisfaction, evaluation parts, determinants) aspects before after intervention, both at rest post-exercise. Correlation concordance coefficients calculated analyzed variables. Results: It was found that intervention led reduction favorable shift composition, while also increasing with one’s its specific parts. impacted volunteers’ self-assessment health status. Selected remained an average level male population did not change following fasting. Attitudes toward weight control methods perceived effectiveness either. Participants favored reducing food intake eliminating high-calorie products from diet, rejecting use pathological typically associated eating disorders. A few associations between corporeality observed, whereas significant correlations parts positive confirmed. Conclusions: The above suggest conditions resulting lead components but do alter image.

Язык: Английский

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