Frontiers in Physiology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 8, 2024
Introduction:
The
space
environment
astronauts
experience
during
missions
consists
of
multiple
environmental
challenges,
including
microgravity.
In
this
study,
we
assessed
the
behavioral
and
cognitive
performances
male
Fisher
rats
2
months
after
sham
irradiation
or
total
body
with
photons
in
absence
presence
simulated
We
analyzed
plasma
collected
9
for
distinct
alterations
metabolic
pathways
to
determine
whether
changes
measures
were
associated
specific
measures.
Methods:
A
344
Fischer
irradiated
(6
MeV;
3,
8,
10
Gy)
weightlessness
achieved
using
hindlimb
unloading
(HU).
To
identify
potential
biomarkers
photon
radiation
exposure
HU
condition
performance,
performed
regression
analyses.
Results:
effects
on
activity
levels
an
open
field,
anxiety
elevated
plus
maze,
anhedonia
M&M
consumption
test
more
pronounced
than
those
irradiation.
Phenylalanine,
tyrosine,
tryptophan
metabolism,
phenylalanine
metabolism
biosynthesis
showed
very
strong
pathway
changes,
following
animals
3
Gy.
Here,
29
out
101
metabolites
1
13
HU,
22
related
that
sham-irradiated
8
Gy,
one
metabolite
was
six
Discussion:
These
data
suggest
it
will
be
possible
develop
stable
challenges
like
exposure.
Brain Research Bulletin,
Год журнала:
2024,
Номер
208, С. 110903 - 110903
Опубликована: Фев. 15, 2024
Chronic
stress
is
a
pervasive
and
complex
issue
that
contributes
significantly
to
various
mental
physical
health
disorders.
Using
the
previously
established
chronic
unpredictable
(CUS)
model,
which
simulates
human
situations,
it
has
been
shown
induces
major
depressive
disorder
(MDD)
memory
deficiency.
However,
this
model
associated
with
several
drawbacks,
such
as
limited
research
reproducibility
inability
sustain
response.
To
resolve
these
issues,
we
developed
new
CUS
(CUS+C)
included
exogenous
corticosterone
exposure
induce
continuous
Thereafter,
evaluated
effect
of
on
brain
health.
Thus,
observed
use
CUS+C
decreased
body
weight
gain
induced
an
uncontrolled
coat
state
well
depressive-like
behavior
in
adult
mice.
It
also
impaired
learning
function
cognitive
abilities,
reduced
hippocampal
neurogenesis
number
astrocytes,
downregulated
glial
fibrillary
acidic
protein
expression
brains
These
findings
can
promote
utilization
validity
animal
provide
information
for
treatment
stress-induced
The
gut
microbiome
undergoes
primary
ecological
succession
over
the
course
of
early
life
before
achieving
ecosystem
stability
around
3
years
age.
These
maturational
patterns
have
been
well-characterized
for
bacteria,
but
limited
descriptions
exist
other
microbiota
members,
such
as
fungi.
Further,
our
current
understanding
prevalence
different
bacterial
and
fungal
maturation
how
inter-kingdom
dynamics
influence
early-life
establishment
is
limited.
Abstract
High
myopia
(HM)
is
a
leading
cause
of
blindness
worldwide
with
currently
no
effective
interventions
available.
A
major
hurdle
lies
in
its
often
isolated
perception
as
purely
ocular
morbidity,
disregarding
potential
systemic
implications.
Recent
evidence
suggests
the
existence
gut-eye
axis;
however,
role
gut
microbiota
pathogenesis
HM
remains
largely
unexplored.
Herein,
we
provide
crosstalk
among
HM’s
dysbiosis,
microbial
metabolites,
and
scleral
remodeling.
Utilizing
16S
rRNA
gene
sequencing,
observed
an
altered
profile
patients
significant
reduction
probiotic
abundance
compared
healthy
controls.
Subsequent
targeted
metabolic
profiling
revealed
notable
decrease
plasma
levels
microbiota-derived
metabolite
indole-3-acetic
acid
(3-IAA)
patients,
which
closely
associated
reduced
probiotics,
both
negatively
correlated
severity.
Genetic
analyses
determined
that
are
causally
risk.
Importantly,
when
mice
subjected
to
modeling
receive
fecal
transplantation
from
donors,
there
increase
3-IAA
simultaneous
retardation
progression
along
better
maintenance
collagen
type
I
alpha
1
(COL1A1)
expression
sclera.
Furthermore,
gavage
achieves
similar
effects.
Mechanistic
investigations
confirm
transcriptional
activation
COL1A1
by
via
promoting
enrichment
SP1
promoter.
Together,
our
findings
novel
insights
into
microbiota-eye
axis
propose
new
strategies
for
intervention
remodeling
indole
supplementation.
Microbiology Spectrum,
Год журнала:
2024,
Номер
12(5)
Опубликована: Март 18, 2024
Esophageal
squamous
cell
carcinoma
(ESCC)
is
one
of
the
most
predominant
subtypes
esophageal
cancer.
The
characteristics
gut
microbiome
and
its
metabolites
from
patients
with
ESCC
have
not
been
adequately
studied
discussed.
In
this
study,
40
fecal
samples
(20
20
healthy
controls)
were
analyzed
by
16S
rRNA
gene
sequencing
untargeted
metabolomics.
data
sets
individually
synthesized
using
various
bioinformatics
methods.
Alpha
beta
diversity
indicated
significant
differences
in
microbial
abundance
between
control
feces.
At
genus
level,
