Melatonin regulates mitochondrial function to alleviate ferroptosis through the MT2/Akt signaling pathway in swine testicular cells

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 2, 2024

Abstract Increasing evidence has shown that many environmental and toxic factors can cause testicular damage, leading to ferroptosis subsequent male reproductive disorders. Melatonin is a major hormone plays an vital role in regulating reproduction. However, there lack of research on whether Mel alleviate cell its specific mechanism. In this study, the results indicated could enhance viability swine testis cells undergoing ferroptosis, reduce LDH enzyme release, increase mitochondrial membrane potential, affect expression biomarkers. Furthermore, we found melatonin depended receptor 1B exert these functions. Detection MMP biomarker protein confirmed MT2 acted through downstream Akt signaling pathway. Moreover, inhibition pathway eliminate protective effect inhibit AMPK phosphorylation, gated channel (VDAC2/3), DNA transcription ATP content. These suggest exerts beneficial function mitigate MT2/Akt ST cells.

Язык: Английский

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Sulforaphane substantially impedes testicular ferroptosis in adult rats exposed to di-2-ethylhexyl phthalate through activation of NRF-2/SLC7A11/GPX-4 trajectory

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Curcumin strengthens a spontaneous self-protective mechanism-SP1/PRDX6 pathway, against di-n-butyl phthalate-induced testicular ferroptosis damage

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(58), С. 122165 - 122181

Опубликована: Ноя. 15, 2023

Язык: Английский

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Role of trace minerals in bull reproductive physiology and semen quality

Clinical Theriogenology, Год журнала: 2024, Номер 16

Опубликована: Май 20, 2024

Testicular dysfunction is often associated with an imbalance in antioxidant/oxidant homeostasis, leading to negative effects of oxidative stress on germ cell proliferation, steroidogenesis, and sperm function. Trace minerals (TM) are involved basic homeostatic enzymatic processes like free radical detoxification, cellular respiration, carbohydrates, lipids, nucleic acids, synthesis metabolism proteins, stabilization membranes DNA. Dietary source TM necessary support these processes. Supplementing cattle nowadays a common practice help growth, reproduction, immunity. This review provides information roles bulls testicular functions, mineral supplementation bull reproductive parameters.

Язык: Английский

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High Concentration of Iron Ions Contributes to Ferroptosis-Mediated Testis Injury

Biological Trace Element Research, Год журнала: 2024, Номер unknown

Опубликована: Май 21, 2024

Язык: Английский

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