International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(9), С. 4878 - 4878
Опубликована: Апрель 30, 2024
The
olive
oil
sector
is
a
fundamental
food
in
the
Mediterranean
diet.
It
has
been
demonstrated
that
consumption
of
extra
virgin
(EVOO)
with
high
content
phenolic
compounds
beneficial
prevention
and/or
treatment
many
diseases.
main
objective
this
work
was
to
study
relationship
between
and
vitro
neuroprotective
anti-inflammatory
activity
EVOOs
from
two
PDOs
province
Granada.
To
purpose,
amounts
were
determined
by
liquid
chromatography
coupled
mass
spectrometry
(HPLC–MS)
inhibitory
acetylcholinesterase
(AChE)
cyclooxygenase-2
(COX-2)
enzymes
spectrophotometric
fluorimetric
assays.
families
identified
alcohols,
secoiridoids,
lignans,
flavonoids,
acids.
EVOO
samples
highest
total
concentration
belonged
Picual
Manzanillo
varieties.
Statistical
analysis
showed
positive
correlation
AChE
COX-2
activity,
except
for
lignans.
These
results
confirm
EVOO’s
possess
potential.
Molecules,
Год журнала:
2023,
Номер
28(14), С. 5415 - 5415
Опубликована: Июль 14, 2023
The
increase
in
people’s
longevity
has,
consequently,
led
to
more
brain
involvement
and
neurodegenerative
diseases,
which
can
become
complicated
lead
chronic
degenerative
thereby
presenting
greater
public
health
problems.
Medicinal
plants
have
been
used
since
ancient
times
contain
high
concentrations
of
molecules,
including
polyphenols.
It
has
proven
that
polyphenols,
are
present
various
natural
sources
provide
curative
effects
against
diseases
disorders
through
neuroprotective
effects.
These
mainly
attributed
their
ability
cross
the
blood–brain
barrier,
eliminate
reactive
oxygen
species,
cause
chelation
metal
ions.
Polyphenols
concentration
neurotrophic
factors
bind
directly
membrane
receptors
these
factors,
modulate
activate
signaling
cascades
allow
plasticity,
survival,
proliferation,
growth
neuronal
cells,
allowing
for
better
learning,
memory,
cognition.
Moreover,
polyphenols
no
serious
adverse
side
resulting
from
consumption.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(6), С. 692 - 692
Опубликована: Май 27, 2024
There
are
a
wide
variety
of
phytochemicals
collectively
known
as
polyphenols.
Their
structural
diversity
results
in
broad
range
characteristics
and
biological
effects.
Polyphenols
can
be
found
foods
drinks,
including
fruits,
cereals,
tea,
coffee.
Studies
both
vitro
vivo,
well
clinical
trials,
have
shown
that
they
possess
potent
antioxidant
activities,
numerous
therapeutic
effects,
health
advantages.
Dietary
polyphenols
demonstrated
the
potential
to
prevent
many
problems,
obesity,
atherosclerosis,
high
blood
sugar,
diabetes,
hypertension,
cancer,
neurological
diseases.
In
this
paper,
protective
effects
mechanisms
behind
them
investigated
detail,
citing
most
recent
available
literature.
This
review
aims
provide
comprehensive
overview
current
knowledge
on
role
preventing
managing
chronic
The
cited
publications
derived
from
vitro,
human-based
studies
trials.
A
more
complete
understanding
these
naturally
occurring
metabolites
will
pave
way
for
development
novel
polyphenol-rich
diet
drug
programs.
This,
turn,
provides
further
evidence
their
benefits.
Marine Drugs,
Год журнала:
2023,
Номер
21(6), С. 323 - 323
Опубликована: Май 26, 2023
Polyphenols
are
compounds
found
in
various
plants
and
foods,
known
for
their
antioxidant
anti-inflammatory
properties.
Recently,
researchers
have
been
exploring
the
therapeutic
potential
of
marine
polyphenols
other
minor
nutrients
that
algae,
fish
crustaceans.
These
unique
chemical
structures
exhibit
diverse
biological
properties,
including
anti-inflammatory,
antioxidant,
antimicrobial
antitumor
action.
Due
to
these
being
investigated
as
possible
agents
treatment
a
wide
variety
conditions,
such
cardiovascular
disease,
diabetes,
neurodegenerative
diseases
cancer.
This
review
focuses
on
applications
human
health,
also,
phenolic
classes,
extraction
methods,
purification
techniques
future
compounds.
Current Research in Biotechnology,
Год журнала:
2024,
Номер
8, С. 100235 - 100235
Опубликована: Янв. 1, 2024
Neuropharmacology
faces
challenges
due
to
the
intricate
nervous
system,
diverse
neurological
disorders,
and
existence
of
blood–brain
barrier
(BBB),
which
hinder
development
effective
treatments.
Although
primary
function
BBB
is
expel
toxins
pathogens,
this
structure
also
prevents
optimal
drug
delivery.
Natural
products,
with
their
chemical
diversity
sustainability,
have
long
been
recognized
as
potential
neuroprotective
compounds,
making
permeability
studies
mandatory.
Over
last
ten
years,
biotechnological
advances
in
two-dimensional
vitro
models
(monoculture
co-culture),
vivo
imaging
techniques,
pharmacokinetic
modeling
contributed
expanding
our
current
knowledge.
In
study,
we
reviewed
crossing
natural
products
such
different
terpenoids,
polyphenolic
alkaloids.
The
findings,
obtained
through
vitro,
vivo,
silico
methods,
revealed
moderate
high
for
many
these
products.
However,
other
compounds
showed
not
be
able
reach
brain.
To
better
understand
behavior
humans
improve
ability
pass
across
blood-brainier,
new
three-dimensional
dynamic
BBB,
nanosystems
complexes
encapsulation
or
in-depth
transport
mechanism
are
future
lines
research.
Plants,
Год журнала:
2025,
Номер
14(2), С. 289 - 289
Опубликована: Янв. 20, 2025
The
search
for
neuroprotective
compounds
in
lavender
is
driven
by
its
traditional
use
brain
health,
with
antioxidant
activity
serving
as
a
key
mechanism
reducing
oxidative
stress
and
supporting
cognitive
function.
Lavender’s
potential
to
protect
neurons
based
on
calming,
anti-stress
properties,
which
increase
the
brain’s
resistance
neurodegeneration.
Although
not
medicinal
plant
Ukraine,
it
increasingly
recognised
properties
widely
cultivated
country.
Lavender
Ukraine
influenced
both
global
herbal
practices
local
medical
traditions.
aim
of
this
study
was
optimise
preparation
herb
extracts,
perform
chemical
profiling
evaluate
their
activities.
focused
Lavandula
angustifolia
Lviv,
Ukraine.
Modern
analytical
methods
were
used,
including
HPLC,
spectrophotometry,
molecular
docking,
lyophilisation
pharmacological
testing.
selection
optimal
conditions
obtaining
extracts
determined
basis
results
total
yield
phenolic
each
extract,
where
found
that
raw
material–solvent
ratio
(1:10)
water
50%
ethanol
gave
highest
substances;
preferred
extraction
time
20
min,
temperature
60–70
°C,
especially
extraction.
Further
HPLC
analysis
identified
marker
rosmarinic
acid
(28.31
mg/g),
chlorogenic
(1.64
mg/g)
luteolin
(0.23
lyophilised
previously
markers
docking.
extract
showed
higher
(total
50.85
activity,
probably
due
synergistic
interactions
among
components.
Behavioural
tests
further
demonstrated
herb.
These
demonstrate
open
new
possibilities
treatment
various
neurodegenerative
diseases.
