HLA-DQ2/8 and COVID-19 in Celiac Disease: Boon or Bane DOI Creative Commons
Aaron Lerner, Carina Benzvi, Aristo Vojdani

и другие.

Microorganisms, Год журнала: 2023, Номер 11(12), С. 2977 - 2977

Опубликована: Дек. 13, 2023

The SARS-CoV-2 pandemic continues to pose a global threat. While its virulence has subsided, it persisted due the continual emergence of new mutations. Although many high-risk conditions related COVID-19 have been identified, understanding protective factors remains limited. Intriguingly, epidemiological evidence suggests low incidence COVID-19-infected CD patients. present study explores whether their genetic background, namely, associated HLA-DQs, offers protection against severe outcomes. We hypothesize that HLA-DQ2/8 alleles may shield patients from and subsequent effects, possibly memory CD4 T cells primed by previous exposure human-associated common cold coronaviruses (CCC) higher affinity those allele's groove. In this context, we examined potential cross-reactivity between epitopes CCC assessed binding (BA) these HLA-DQ2/8. Using computational methods, analyzed sequence similarity four distinct CCC. Of 924 unique immunodominant 15-mer with at least 67% identity, 37 exhibited significant BA HLA-DQ2/8, suggesting effect. various mechanisms might explain role in COVID-19-afflicted If substantiated, insights could enhance our gene-environment enigma viral-host relationship, guiding therapeutic innovations ongoing pandemic.

Язык: Английский

Predictive factors of health related quality of life in children and adolescents with celiac disease: An Italian multicenter study on behalf of the SIGENP DOI
Marco Crocco, Federica Malerba, Angela Calvi

и другие.

Digestive and Liver Disease, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
No COVID‐19 pandemic impact on incidence and clinical presentation of celiac disease in Italian children DOI Creative Commons
Pietro Guacci,

Claudia Ballabio,

Alice Folegatti

и другие.

Acta Paediatrica, Год журнала: 2024, Номер unknown

Опубликована: Май 27, 2024

Abstract Aim We aimed to evaluate the impact of Coronavirus Disease‐19 (COVID‐19) pandemic on incidence and clinical presentation celiac disease (CD) in children. Methods The diagnoses CD were compared between COVID‐19 (from April 2020 March 2022) pre‐pandemic period 2018 2020) three Italian Paediatric Gastroenterology centres (Varese, Como, Catanzaro). Electronic patient records reviewed additional information collected through parental interview. diagnosis was made according ESPGHAN criteria. SARS‐CoV‐2 infection diagnosed based pre‐vaccination positive serum antibodies or nasopharyngeal swabs. Z test chi‐square used for statistical analysis. Results overall number paediatric did not differ two years periods (177 172 cases) participating centres. Clinical also similar throughout study periods. has been documented 10.6% children but only 5.8% these occurred before diagnosis. Conclusion Different what reported other autoimmune diseases, presenting symptoms our population change during previous 2 years.

Язык: Английский

Процитировано

4
Hub-and-Spoke regional system supported by telehealth for managing coeliac disease in Liguria: a mixed-methods survey followed by an observational pilot study DOI Creative Commons

Marco Crocco,

Federica Malerba, Paolo Gandullia

и другие.

BMC Health Services Research, Год журнала: 2025, Номер 25(1)

Опубликована: Март 18, 2025

Due to the need reorganize care network for national screening mandated by law, a new healthcare model was required management of coeliac disease. The hub-and-spoke is organizational system, here we describe its application (supported telehealth), in pediatric disease (CD) Liguria. results pilot phase are presented and system's strengths weaknesses discussed. A mixed-methods survey followed an observational study performed. multiphase approach used including preparation setting, operative planning application. involves single primary center. reduction families' expenditure environmental impact assessed using Viamichelin calculator. regional meeting (specifically developed this study) needs analysis highlighted priority have efficient, up date homogeneous assistance throughout network. diagnostic therapeutic pathway (PDTC) working group. project involved 986 Ligurian families allowed 90% distance traveled residing within center's catchment area, saving €177 113 kg CO2 on average per family year. Gaslini Diffuso system managing CD Liguria exemplifies commitment enhancing efficiency patient care, reducing cost both system.

Язык: Английский

Процитировано

0
Risk of celiac disease, type 1 diabetes, and thyroid disease autoimmunity during the SARS-CoV-2 pandemic in South of Sweden: insights from the TRIAD study DOI Creative Commons
A. R. Lind,

Maria Naredi Scherman,

Samia Hamdan

и другие.

Autoimmunity, Год журнала: 2025, Номер 58(1)

Опубликована: Апрель 15, 2025

Recent studies have implied an increased incidence of autoimmune diseases following the SARS-CoV-2 pandemic. The objective was to determine if infections were associated with celiac disease (CD), type 1 diabetes (T1D), and thyroid (AITD) autoantibodies in a population-based screening when pandemic hit South Sweden during 2021 2022. Between August June 2022 self-obtained capillary plasma samples collected from 1088 children at 6-9 years age 1185 adolescents 13-16 age, who randomly invited general population for CD, T1D, AITD, antibodies. Among screened T1D infection rate tissue transglutaminase autoantibody (tTGA) positive (13/17; 76.5%) compared tTGA negative (492/1168; 42.1%) 13-16-year-old individuals (p = 0.0057). There no association between AITD- or autoantibodies. Our findings indicate potential prior screening-detected CD autoimmunity aged years. Further research is needed elucidate whether ongoing increases susceptibility may act as trigger genetically environmentally predisposed individuals.

Язык: Английский

Процитировано

0
Health‐related quality of life in children with coeliac disease and in their families: A long‐term follow‐up study DOI

Marco Crocco,

Federica Malerba, Angela Calvi

и другие.

Journal of Pediatric Gastroenterology and Nutrition, Год журнала: 2023, Номер 78(1), С. 105 - 112

Опубликована: Дек. 11, 2023

Abstract Objectives The aim of the study was to assess long‐term health‐related quality life (HRQoL) in children and adolescents with coeliac disease (CD), their parents. Methods We re‐evaluated prospectively HRQoL clinical characteristics 80 families, assessed 5 years earlier, using a disease‐specific questionnaire, CD Dutch Questionnaire (CDDUX), generic Paediatric Quality Life Inventory (PedsQL). Results After 10‐year follow‐up, there no significant change total CDDUX PedsQL scores parents when compared evaluation conducted earlier. score reflected neutral QoL, while for good‐very good. only decrease after subdomain Emotional functioning . Patients who admitted voluntarily eating gluten reported lower Diet Lower “ Physical functioning” (PedsQL) were patients positivity TTG or associated diseases. Conclusions indicated consistently stable QoL perception among caregivers, even postdiagnosis, suggesting minimal fluctuations impact on health domains over time. Furthermore, good could be reflection resilience families coping this chronic condition. Gluten‐free diet compliance confirmed determinant long term. confirms importance extending surveillance these patients, possibly different questionnaires, from perspectives.

Язык: Английский

Процитировано

8
The risk for celiac disease after Covid-19 infection DOI Creative Commons
Jesper Lexner, Ylva Lindroth, Klas Sjöberg

и другие.

BMC Gastroenterology, Год журнала: 2023, Номер 23(1)

Опубликована: Май 22, 2023

Celiac disease (CD) is an autoimmune leading to gastrointestinal symptoms and mineral deficiencies. The pathogenetic mechanisms, besides the clear HLA association, are elusive. Among environmental factors infections have been proposed. Covid-19 infection results in a systemic inflammatory response that often also involves tract. aim of present study was investigate whether could increase risk for CD.All patients, both children adults, county Skåne (1.4 million citizens) southern Sweden with newly diagnosed biopsy- or serology-verified CD positive tissue transglutaminase antibody test (tTG-ab) during 2016-2021 were identified from registries at Departments Pathology Immunology, respectively. Patients PCR antigen 2020 2021 Public Health Agency Sweden.During pandemic (March - December 2021), there 201 050 cases 568 patients first-time tTG-ab tests, which 35 had infected before CD. incidence verified positivity lower comparison (May 2018 February 2020; 22.5 vs. 25.5 per 100 000 person-years, respectively, rate difference (IRD) -3.0, 95% CI -5.7 -0.3, p = 0.028). without prior 21.1 22.4 respectively (IRD 1.3, -8.5-5.9, 0.75).Our indicate not factor development. While seem be important part pathogenesis, respiratory probably less relevance.

Язык: Английский

Процитировано

6
Coronavirus disease 2019 and gastrointestinal disorders in children DOI Creative Commons
Anna Röckert Tjernberg, Petter Malmborg, Karl Mårild

и другие.

Therapeutic Advances in Gastroenterology, Год журнала: 2023, Номер 16

Опубликована: Янв. 1, 2023

During the past 3 years, coronavirus disease 2019 (COVID-19) pandemic has had a great impact on people all over world. However, it become evident that manifestations and severity differ across age groups. Most children have milder course than adults but possibly more pronounced gastrointestinal (GI) symptoms. Given child’s developing immune system, of COVID-19 development may compared to adults. This study reviews potential bi-directional relationship between GI diseases in children, focusing common pediatric conditions such as functional disorders (FGID), celiac (CeD), inflammatory bowel (IBD). Children with diseases, general, CeD IBD, particular, do not seem an increased risk severe COVID-19, including risks hospitalization, critical care need, death. While infections are considered candidate environmental factors both IBD pathogenesis, specific infectious agents known triggers for FGID, there is still sufficient evidence implicate either these diseases. given scarcity data possible latency period development, future investigations this field warranted.

Язык: Английский

Процитировано

5
HLA-DQ2/8 and COVID-19 in celiac disease: Boon or Bane DOI Open Access
Aaron Lerner, Carina Benzvi, Aristo Vojdani

и другие.

Опубликована: Ноя. 17, 2023

The SARS-CoV-2 pandemic continues to pose a global threat. While its virulence has subsided, it persisted due the continual emergence of new mutations. Although many high-risk conditions related COVID-19 have been identified, understanding protective factors remains limited. Intriguingly, epidemiological evidence suggests low incidence COVID-19-infected CD patients. present study explores whether their genetic background, namely associated HLA-DQs, offers protection against severe outcomes. We hypothesize that HLA-DQ 2/8 alleles may shield patients from and subsequent effects, possibly memory CD4 T cells primed by previous exposure human-associated common cold coronaviruses (CCC) higher affinity those allele's groove. In this context, we examined potential cross-reactivity between epitopes CCC assessed binding (BA) these 2/8. Using computational methods, analyzed sequence similarity four distinct CCC. Of 924 unique immunodominant 15-mer with at least 67% identity, 37 exhibited significant BA 2/8, suggesting effect. various mechanisms might explain role HLA-DQ2/8 in COVID-19-afflicted If substantiated, insights could enhance our gene-environment enigma viral-host relationship, guiding therapeutic innovations ongoing pandemic.

Язык: Английский

Процитировано

2
Celiac Disease on the Bed-Side: Embedding Case Finding and Screening in Hospitalized Children DOI Open Access
Angela Pepe, Claudia Mandato,

Tiziana Di Leo

и другие.

Nutrients, Год журнала: 2023, Номер 15(23), С. 4899 - 4899

Опубликована: Ноя. 23, 2023

Background: Strategies for diagnosing celiac disease (CD) include case-finding and population-screening programs. Case finding consists of testing individuals at increased risk the due to symptoms or associated conditions. Screening programs are widespread campaigns, which definitely perform better in terms unveiling CD diagnoses but nowadays still debatable. The global prevalence is around 1% it almost doubles when considering screening among school children. Within this framework, we aimed estimate hospitalized children Pediatric Department a Southern Italy University Hospital period from January 2018 through December 2021. In addition, attempted explore, time diagnosis, leading clinical alerts malabsorption/malnutrition such as anemia failure thrive systemic inflammation/immune dysfunction hypertransaminasemia thyroid dysfunction. Methods: Data records pediatric patients admitted inpatients tested by anti-transglutaminase IgA antibodies (TGA-IgA) were retrospectively analyzed. was diagnosed according either 2012 2020 ESPGHAN guidelines, depending on year diagnosis. autoimmunity (CDA) wider group defined within our protocol if had elevated TGA-IgA least one occasion, regardless anti-endomysial (EMA-IgA) without biopsy confirmation. Results: During observation period, 3608 1320 screened (median age 5 years, IQR 2–9 years; test rate: 36.6% out all admissions). available newly 1.59% (21 diagnosed) CDA 3.86% (51 subjects). Among patients, underweight/malnourished accounted 28.6% (6 21). Conclusions: estimated setting comparable most recent even higher. A hospital-admission during routine blood draws might be non-invasive, cost-effective valuable approach reduce discrepancy between

Язык: Английский

Процитировано

2
Cutaneous Disorders Masking Celiac Disease: Case Report and Mini Review with Proposal for a Practical Clinical Approach DOI Open Access
Silvana Ancona,

Silvia Bianchin,

Noemi Zampatti

и другие.

Nutrients, Год журнала: 2023, Номер 16(1), С. 83 - 83

Опубликована: Дек. 26, 2023

Celiac disease (CD) is an immune-mediated systemic gluten-related disorder characterized by a wide spectrum of intestinal and extra-intestinal manifestations, including damage to cutaneous connective tissue. We report rare case chronic severe dermatitis involving tissue vascular vessels as the main clinical presentation undiagnosed seronegative gluten disorder. A gluten-free diet dramatically improved in patient. Pitfalls steps differential diagnosis are described. also review literature regarding studies CD diseases extend knowledge these associations. propose practical diagnostic approach suspected autoimmune disorders.

Язык: Английский

Процитировано

2