Circulation Research, Год журнала: 2023, Номер 132(12), С. 1567 - 1569
Опубликована: Июнь 8, 2023
Язык: Английский
Circulation, Год журнала: 2023, Номер 148(20), С. 1636 - 1664
Опубликована: Окт. 9, 2023
A growing appreciation of the pathophysiological interrelatedness metabolic risk factors such as obesity and diabetes, chronic kidney disease, cardiovascular disease has led to conceptualization cardiovascular-kidney-metabolic syndrome. The confluence within syndrome is strongly linked for adverse outcomes. In addition, there are unique management considerations individuals with established coexisting factors, or both. An extensive body literature supports our scientific understanding of, approach to, prevention However, critical gaps in knowledge related terms mechanisms development, heterogeneity clinical phenotypes, interplay between social determinants health biological accurate assessments incidence context competing risks. There also key limitations data supporting care syndrome, particularly early-life prevention, screening interdisciplinary models, optimal strategies lifestyle modification weight loss, targeting emerging cardioprotective kidney-protective therapies, patients both impact systematically assessing addressing health. This statement uses a crosswalk major guidelines, addition review literature, summarize evidence fundamental science, screening,
Язык: Английский
Процитировано
226
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Март 4, 2024
Abstract In the era of precision medicine, it has been increasingly recognized that individuals with a certain disease are complex and different from each other. Due to underestimation significant heterogeneity across participants in traditional “one-size-fits-all” trials, patient-centered trials could provide optimal therapy customization specific biomarkers were developed including basket, umbrella, platform trial designs under master protocol framework. recent years, successive FDA approval indications based on biomarker-guided demonstrated these new clinical ushering tremendous opportunities. Despite rapid increase number current research understanding designs, as compared remains limited. The majority focuses methodologies, there is lack in-depth insight concerning underlying biological logic designs. Therefore, we this comprehensive review discovery development their perspective medicine. Meanwhile, discuss future directions potential design view “Precision Pro”, “Dynamic Precision”, “Intelligent Precision”. This would assist trial-related researchers enhance innovation feasibility by expounding logic, which be essential accelerate progression
Язык: Английский
Процитировано
49
Journal of the American Heart Association, Год журнала: 2024, Номер 13(16)
Опубликована: Авг. 13, 2024
Poor cardiovascular-kidney-metabolic (CKM) health is associated with premature mortality and excess morbidity in the United States. Adverse social conditions have a prominent impact on cardiometabolic diseases during life course. We aim to examine association between risk profile (SRP) CKM multimorbidity among US adults.
Язык: Английский
Процитировано
10
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1870(6), С. 167247 - 167247
Опубликована: Май 16, 2024
Язык: Английский
Процитировано
9
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Март 7, 2025
Redox signaling acts as a critical mediator in the dynamic interactions between organisms and their external environment, profoundly influencing both onset progression of various diseases. Under physiological conditions, oxidative free radicals generated by mitochondrial respiratory chain, endoplasmic reticulum, NADPH oxidases can be effectively neutralized NRF2-mediated antioxidant responses. These responses elevate synthesis superoxide dismutase (SOD), catalase, well key molecules like nicotinamide adenine dinucleotide phosphate (NADPH) glutathione (GSH), thereby maintaining cellular redox homeostasis. Disruption this finely tuned equilibrium is closely linked to pathogenesis wide range Recent advances have broadened our understanding molecular mechanisms underpinning dysregulation, highlighting pivotal roles genomic instability, epigenetic modifications, protein degradation, metabolic reprogramming. findings provide foundation for exploring regulation mechanistic basis improving therapeutic strategies. While antioxidant-based therapies shown early promise conditions where stress plays primary pathological role, efficacy diseases characterized complex, multifactorial etiologies remains controversial. A deeper, context-specific signaling, particularly redox-sensitive proteins, designing targeted aimed at re-establishing balance. Emerging small molecule inhibitors that target specific cysteine residues proteins demonstrated promising preclinical outcomes, setting stage forthcoming clinical trials. In review, we summarize current intricate relationship disease also discuss how these insights leveraged optimize strategies practice.
Язык: Английский
Процитировано
1
Cell Metabolism, Год журнала: 2024, Номер 36(2), С. 263 - 277
Опубликована: Янв. 3, 2024
Язык: Английский
Процитировано
6
Nature Medicine, Год журнала: 2024, Номер 30(7), С. 1865 - 1873
Опубликована: Июль 1, 2024
Язык: Английский
Процитировано
6
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
American Journal of Lifestyle Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Provider lifestyle counseling is important for improving lifestyles and cardiometabolic disease (CMD) prognosis. However, an examination of the relationship between sociodemographic characteristics, modification provider receipt among adults with CMD scarce. The study examined prevalence associations characteristics diagnosis. We used cross-sectional data from 2017-2020 National Health Nutrition Examination Survey (N = 4847). (i.e., advice to control/lose weight, exercise, reduce salt, fat/calories), (yes or no) were assessed. Adjusted odds ratios evaluated using logistic regression models. Among sample CMD, 44.6% received lose 56.1% 36.1% 43.9% fat/calories. Adults who made modifications had higher receiving weight (OR: 1.81), exercise 1.95), salt 2.23) calories 2.66). Age, sex, race/ethnicity, educational attainment, insurance associated counseling. generally suboptimal U.S. lifetime diagnosis differ by modification. control should involve training providers increase
Язык: Английский
Процитировано
0
Preventive Medicine Reports, Год журнала: 2025, Номер 51, С. 102997 - 102997
Опубликована: Фев. 7, 2025
This study aimed to estimate and compare cardiometabolic disease (CMD) mortality in U.S. Black White men during the transition from early adulthood middle age. Using 2022 National Vital Statistics System data standard period life table methods, we estimated risk of CMD death hypothetical cohorts age 25 45 years. We cumulative risk, excess mortality, years lost (YLL), proportion deaths due CMD, stratifying by metabolic cardiovascular disease. Of 325,134 aged initial cohort, before was one 63 individuals or 1.58 %. For men, risks were markedly lower. 1,185,384 158 0.63 The also found that 5141 expected 3090 60.10 % relative cohort. Additionally, all among 19.15 rising 6.02 at 38.00 45, compared with 11.10 increasing 4.57 19.79 45. YLL for averaged 6.72 months per person while 2.94 months. investigation shows profound racial disparities mid-adulthood.
Язык: Английский
Процитировано
0