A New Heteroleptic Zn(II) Complex with Schiff Bases Sensitizes Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel DOI Creative Commons
R. Z. Machado, Raoni Pais Siqueira, Fernanda Cardoso da Silva

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(12), С. 1610 - 1610

Опубликована: Дек. 18, 2024

Background/Objectives: Triple-negative breast cancer (TNBC) is the most challenging molecular subtype of (BC) in clinical practice, associated with a worse prognosis due to limited treatment strategies and its insensitivity conventional drugs. Zinc an important trace element for homeostasis, Schiff base metal complexes have shown promise treating advanced tumors. In this study, four new heteroleptic Zn(II) (1–4) bases were synthesized, characterized, evaluated their activity BC cells. Methods: Compounds crystal structures determined. Biological was assessed using MTT, clonogenic, scratch wound healing, caspase 3 8 activity, qPCR, chemosensitization assays. Results: The exhibited cytotoxicity against MCF-7 (luminal BC), MDA-MB-453 (HER2-positive MDA-MB-231 cell lines, IC50 values ranging from 0.01 20 µM. Complex 4 showed reduced toward non-tumor lines. This, complexation increased ligands, trend not observed 1–3. Due favorable profile, complex selected further assays, which it inhibited colony formation migration TNBC cells dose-dependent manner. Furthermore, compound induced death independently caspases, decreasing 8. Interestingly, sensitized TBNC doxorubicin paclitaxel, possibly modulating epithelial–mesenchymal transition mechanism, as evidenced by CDH1 expression. Conclusions: Results suggest potential sensitizing aggressive chemotherapy, proving be promising alternative cases therapeutic failure.

Язык: Английский

Ferroptosis as a promising targeted therapy for triple negative breast cancer DOI

Kasra Mokhtarpour,

Sepideh Razi,

Nima Rezaei

и другие.

Breast Cancer Research and Treatment, Год журнала: 2024, Номер 207(3), С. 497 - 513

Опубликована: Июнь 14, 2024

Язык: Английский

Процитировано

7
Micronutrient Status and Breast Cancer: A Narrative Review DOI Open Access
Alicja Forma, Arkadiusz Grunwald, Patryk Zembala

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(9), С. 4968 - 4968

Опубликована: Май 2, 2024

Breast cancer is one of the most common cancers worldwide, at same time being prevalent causes women’s death. Many factors such as alcohol, weight fluctuations, or hormonal replacement therapy can potentially contribute to breast development and progression. Another important factor in onset includes micronutrient status. In this narrative review, we analyzed 23 micronutrients their possible influence on Further, aim study was investigate impact status prevention its various therapeutic pathways. We researched meta-analyses, systemic reviews, retrospective studies, well original studies human animal models. The results these indicate a correlation between different levels decreased risk better survival rate. However, further are necessary establish adequate doses supplementation chosen exact mechanisms therapy.

Язык: Английский

Процитировано

6
Systematic characterization of zinc in a series of breast cancer cell lines reveals significant changes in zinc homeostasis DOI Open Access

Mena Woyciehowsky,

P S Larson,

A Stephan

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

An optimal amount of labile zinc (Zn 2+ ) is essential for proliferation human cells, where Zn levels that are too high or low cause cell cycle exit. Tumors the breast have been characterized by total . Given role in cells and elevation cancer tumors, we examined concentration across a panel 5 lines, compared to normal MCF10A line. We found three lines (MDA-MB-231, MDA-MB-157, SK-Br-3) showed elevated cytosol, while T-47D significantly lower , MCF7 no change cells. There was as measured ICP-MS, but did observe difference ability accumulate when media elevated. Therefore, how each line affected increases decreases media. striking differences, MCF7) robust at concentrations killed MCF10A, T-47D, SK-Br-3 also discovered 4 demonstrate compromised increased death suggesting these may be addicted Overall, our study suggests significant differences homeostasis regulation different types with consequences both viability.

Язык: Английский

Процитировано

0
Updates on Triple-Negative Breast Cancer in Type 2 Diabetes Mellitus Patients: From Risk Factors to Diagnosis, Biomarkers and Therapy DOI Creative Commons
Sabine Matou‐Nasri, M Sarawatense Aldawood,

Fatimah Alanazi

и другие.

Diagnostics, Год журнала: 2023, Номер 13(14), С. 2390 - 2390

Опубликована: Июль 17, 2023

Triple-negative breast cancer (TNBC) is usually the most malignant and aggressive mammary epithelial tumor characterized by lack of expression for estrogen receptors progesterone receptors, absence epidermal growth factor receptor (HER)2 amplification. Corresponding to 15–20% all cancers well-known its poor clinical outcome, this negative deprives TNBC from targeted therapy makes management therapeutically challenging. Type 2 diabetes mellitus (T2DM) common ageing metabolic disorder due insulin deficiency or resistance resulting in hyperglycemia, hyperinsulinemia, hyperlipidemia. Due hormonal imbalances, there are many interplays between both chronic disorders leading increased risk cancer, especially TNBC, diagnosed T2DM patients. The purpose review provide up-to-date information related epidemiology clinicopathological features, factors, diagnosis, biomarkers, current therapy/clinical trials patients with compared non-diabetic counterparts. Thus, in-depth investigation diabetic complications on onset, development, progression discovery biomarkers would improve through early tailoring a better outcome TNBC.

Язык: Английский

Процитировано

11
Study of Toxic and Essential Elemental Imbalances at More Advance Stage of Breast Carcinoma Patients DOI
Muhammad Abdul Qayyum, Sajid Mahmood,

Ali Bahadur

и другие.

Pathology - Research and Practice, Год журнала: 2025, Номер 269, С. 155866 - 155866

Опубликована: Фев. 27, 2025

Язык: Английский

Процитировано

0
Integrating iron metabolism-related gene signature to evaluate prognosis and immune infiltration in nasopharyngeal carcinoma DOI Creative Commons
Jiaming Su,

Guanlin Zhong,

Weiling Qin

и другие.

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Апрель 11, 2024

Abstract Background Dysregulation of iron metabolism has been shown to have significant implications for cancer development. We aimed investigate the prognostic and immunological significance metabolism-related genes (IMRGs) in nasopharyngeal carcinoma (NPC). Methods Multiple Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) datasets were analyzed identify key IMRGs associated with prognosis. Additionally, was explored. Results A novel risk model established using LASSO regression algorithm, incorporating three (TFRC, SLC39A14, ATP6V0D1).This categorized patients into low high-risk groups, Kaplan–Meier analysis revealed significantly shorter progression-free survival group ( P < 0.0001). model’s accuracy additionally confirmed by employing time-dependent Receiver Operating Characteristic (ROC) curves conducting Decision Curve Analysis (DCA). High-risk found correlate advanced clinical stages, specific tumor microenvironment subtypes, distinct morphologies. ESTIMATE demonstrated a inverse relationship between increased immune, stromal, scores lowered score. Immune indicated negative correlation score abundance most tumor-infiltrating immune cells, including dendritic CD8 + T CD4 B cells. This extended checkpoint such as PDCD1, CTLA4, TIGIT, LAG3, BTLA. protein expression patterns selected NPC samples validated through immunohistochemistry. Conclusion study presents utilizing NPC, which could assist assessing patient prognosis provide insights new therapeutic targets NPC.

Язык: Английский

Процитировано

3
A zinc metabolism-related gene signature for predicting prognosis and characteristics of breast cancer DOI Creative Commons

Jinghui Hong,

Mengxin Li, Yi‐Chang Chen

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Янв. 8, 2024

Background Breast cancer is one of the most serious and prevalent malignancies. Zinc commonly known to play a crucial role in development progression breast cancer; however, detailed mechanisms underlying this are not well understood. This study aimed develop zinc metabolism-related gene (ZMRG) signature based on multi-database predict patient prognosis investigate relationship between drug therapy response immune enrichment. Methods Data for samples from The Cancer Genome Atlas Gene Expression Omnibus databases were screened genes using Molecular Signature Database. Cox Least Absolute Shrinkage Selection Operator regressions performed construct ZMRG signature. To assess predictive performance signature, Kaplan–Meier analysis receiver operating characteristic curves used. Additionally, we utilised single-sample set enrichment analysis, Tumour Immune Estimation Resource, Genomics Drug Sensitivity database, Therapeutics Response Portal association tumour microenvironment sensitivity. Quantitative PCR was used expression each cell lines samples. Results Five ZMRGs identified (ATP7B, BGLAP, P2RX4, SLC39A11, TH) risk profile constructed each. Two groups, high- low-risk, way, high-risk score subgroups found have worse prognosis. validated GSE42568 dataset. sensitivity analyses showed that these five significantly associated with response. group substantial infiltration pathways, patients more sensitive drugs cancer. Conclusion represents new prognostic predictor cancer, may also provide insights into individualised treatment

Язык: Английский

Процитировано

2
Assessment of the Impact of Trace Essential Metals on Cancer Development DOI Open Access
Aleksandra Górska,

Agnieszka Markiewicz-Gospodarek,

Mateusz Trubalski

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 6842 - 6842

Опубликована: Июнь 21, 2024

This study examines the impact of zinc, copper, cobalt, iron, and manganese on cancer development, considering their dual roles as potential promoters or inhibitors within tumorigenesis. A comprehensive analysis existing literature experimental data is conducted to elucidate intricate relationship between these trace elements progression. The findings highlight multifaceted effects various aspects including cell proliferation, angiogenesis, metastasis. Understanding nuanced interactions could offer crucial insights into tumorigenesis mechanisms facilitate identification novel biomarkers therapeutic targets for prevention treatment strategies. research underscores importance essential in biology may ultimately contribute advancements precision medicine approaches combating cancer.

Язык: Английский

Процитировано

1
Dextran-Graft-Polyacrylamide/Zinc Oxide Nanoparticles Inhibit of Cancer Cells in vitro and in vivo DOI Creative Commons
Petro Virych, Pavlo Virych, Volodymyr Prokopіuk

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 11719 - 11743

Опубликована: Ноя. 1, 2024

Tumor drug resistance and systemic toxicity are major challenges of modern anticancer therapy. Nanotechnology makes it possible to create new materials with the required properties for

Язык: Английский

Процитировано

1
Synthesis of Zinc Oxide-Doped Carbon Dots for Treatment of Triple-Negative Breast Cancer DOI Creative Commons
Mengqi Wang, Shuting Lan,

Mingjun Song

и другие.

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 13949 - 13971

Опубликована: Дек. 1, 2024

The anti-cancer properties of zinc oxide-doped carbon dots (CDs/ZnO) in inhibiting triple-negative breast cancer (TNBC) progression merit more investigation.

Язык: Английский

Процитировано

0