Probiotics’ Effects in the Treatment of Anxiety and Depression: A Comprehensive Review of 2014–2023 Clinical Trials

Microorganisms, Год журнала: 2024, Номер 12(2), С. 411 - 411

Опубликована: Фев. 19, 2024

Changes in the gut microbiome can affect cognitive and psychological functions via microbiota-gut-brain (MGB) axis. Probiotic supplements are thought to have largely positive effects on mental health when taken sufficient amounts; however, despite extensive research having been conducted, there is a lack of consistent findings probiotics anxiety depression associated alterations. The aim our study systematically review most recent literature last 10 years order clarify whether could actually improve symptoms. Our results indicate that majority suggests beneficial role treatment anxiety, existence substantial number less findings. Given probiotics' potential offer novel, personalized options for mood disorders, further, better targeted psychiatric populations needed address concerns about exact mechanisms probiotics, dosing, timing treatment, possible differences outcomes depending severity depression.

Язык: Английский

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Probiotic Functions in Fermented Foods: Anti-Viral, Immunomodulatory, and Anti-Cancer Benefits

Foods, Год журнала: 2024, Номер 13(15), С. 2386 - 2386

Опубликована: Июль 28, 2024

Fermented foods can provide many benefits to our health. These are created by the action of microorganisms and help support digestive health immune system. include yogurt,

Язык: Английский

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Metabolic Status Influences Probiotic Efficacy for Depression—PRO-DEMET Randomized Clinical Trial Results

Nutrients, Год журнала: 2024, Номер 16(9), С. 1389 - 1389

Опубликована: Май 3, 2024

Probiotics may represent a safe and easy-to-use treatment option for depression or its metabolic comorbidities. However, it is not known whether features can influence the efficacy of probiotics treatments depression. This trial involved parallel-group, prospective, randomized, double-blind, controlled design. In total, 116 participants with received probiotic preparation containing Lactobacillus helveticus Rosell®-52 Bifidobacterium longum Rosell®-175 placebo over 60 days. The psychometric data were assessed longitudinally at five time-points. Data blood pressure, body weight, waist circumference, complete count, serum levels C-reactive protein, cholesterol, triglycerides, fasting glucose measured beginning intervention period. There was no advantage usage in score overall (PRO vs. PLC: F(1.92) = 0.58; p 0.45). we found higher rate minimum clinically important differences patients supplemented than those allocated to generally (74.5 53.5%; X2(1,n 94) 4.53; 0.03; NNT 4.03), as well antidepressant-treated subgroup. Moreover, that more advanced pre-intervention abnormalities (such overweight, excessive central adipose tissue, liver steatosis), lower improvements scores. A baseline stress level correlated better improvements. current formulations only be used complementary depressive disorders. Metabolic require complex treatments. ClinicalTrials.gov identifier: NCT04756544.

Язык: Английский

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Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy

Microbial Biotechnology, Год журнала: 2025, Номер 18(1)

Опубликована: Янв. 1, 2025

ABSTRACT Advancing microbiome–gut–brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of gut microbiome as a tractable therapeutic target for gastrointestinal, mental brain health. Current research is still marked by many open questions that undermine widespread application humans. For example, lack mechanistic understanding probiotic effects means it remains unclear why even apparently closely related strains exhibit different in vivo. live microbial psychobiotics, consensus on their adjunct treatments conventional neuromodulators, use unmedicated populations or at‐risk cohorts with sub‐clinical symptomatology warranted. This missing information both sides equation when treating central nervous system (CNS) conditions makes psychobiotic challenging, especially compared other pharmaceutical functional food approaches. Expediting transition from positive preclinical data proven benefits humans includes interpreting promises pitfalls animal behavioural assays, well navigating mechanism‐informed decision making select right microbe(s) job. In this review, we consider how these decisions can be supported light accrued range clinical studies across healthy, pathological study populations, where specific have been evaluated context gastrointestinal physiology, function behaviour. Examples successful, partial unsuccessful translation bench bedside are considered. We also discuss developments silico analyses enhanced our moved towards pinpointing host–microbe interactions most important optimal gut–brain function. Combining assays vitro ex vivo domains incorporating model organisms prime discovery pipelines promising rationally selected candidates.

Язык: Английский

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Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms

Journal of Personalized Medicine, Год журнала: 2025, Номер 15(1), С. 33 - 33

Опубликована: Янв. 17, 2025

A significant proportion of patients who sustain a concussion/mild traumatic brain injury endorse persisting, lingering symptoms. The symptoms associated with concussion are nonspecific, and many other medical conditions present similar Medical that overlap symptomatically include anxiety, depression, insomnia, chronic pain, fatigue, fibromyalgia, cervical strain injuries. One the factors may account for these similarities is all disturbances in optimal functioning autonomic nervous system its intricate interactions endocrine immune system—the three primary regulatory systems body. When clinicians working presenting persisting after concussion, evidence-based treatment options drawn from literature limited. We framework assessment following based on available evidence (treatment trials), neuroanatomical principles (research into physiology concussion), clinical judgment. review research supporting premise behavioral interventions designed to stabilize optimize body have potential reduce improve patients. Foundational rehabilitation strategies areas sleep stabilization, fatigue management, physical exercise, nutrition, relaxation protocols, activation outlined along practical implementing intervention modules

Язык: Английский

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Antibiotic-induced gut microbe dysbiosis alters neurobehavior in mice through modulation of BDNF and gut integrity

Physiology & Behavior, Год журнала: 2024, Номер 283, С. 114621 - 114621

Опубликована: Июнь 24, 2024

Язык: Английский

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Crime and Nourishment: A Narrative Review Examining Ultra-Processed Foods, Brain, and Behavior

Dietetics, Год журнала: 2024, Номер 3(3), С. 318 - 345

Опубликована: Авг. 28, 2024

Recently, there has been increased scientific and clinical interest in the potential harms associated with ultra-processed foods, including poor mental health, aggression, antisocial behavior. Research spanning epidemiology, mechanistic pre-clinical work, addiction science, microbiome exposome human intervention trials underscored that nutrition is of relevance along criminal justice continuum. As such, emerging dietetics research salient to thousands international psychologists allied health professionals are engaged forensics, prevention, intervention. In addition, relationships between behavior relate “food crime”, an emergent area unifying researchers psychology, public other interdisciplinary sectors. Food crime scrutinizes vast harms, non-communicable diseases adverse behavioral outcomes, as influenced by distribution addictive food products. Here, we examine research, biophysiological mechanisms, evidence indicating dietary patterns/components intersect psychosocial vulnerabilities linked risks involvement. Viewed through a prevention lens, study aggressive should be prioritized, especially if outcomes emerge externalities global consumption food. context behavior, need for forensic examination how industry influence power structures can undermine matters justice.

Язык: Английский

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Evaluating the scientific evidence to support mental health and well-being claims made on probiotic products

Nutrition and Health, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Background Increasing interest in probiotics for mental health has led to products marketed consumers claiming psychological benefits. This study aimed identify claims on probiotic supplements and provide a narrative review of the scientific evidence support these claims. Methods Probiotic with product label were identified. A search literature was performed using Google Scholar, PubMed Cochrane Central Register Controlled Trials. Studies included if primary outcome or biomarker health, they investigated exact strain combination strains as present product, trial conducted either humans animals. Included studies assessed risk bias. Results Fourteen identified containing five different combinations. Eighteen relevant investigating outcomes met inclusion criteria. Ten same provided made. Statistically significant results not universally all products. Conclusion The amount quality benefits made is variable. need grading system facilitate informed consumer decision-making when choosing supplement health.

Язык: Английский

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Can We Modulate Our Second Brain and Its Metabolites to Change Our Mood? A Systematic Review on Efficacy, Mechanisms, and Future Directions of “Psychobiotics”

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1972 - 1972

Опубликована: Фев. 25, 2025

Psychobiotics, live microorganisms that provide mental health by interacting with the gut microbiota, are emerging as a promising therapeutic option for psychiatric and neurodevelopmental disorders. Their effectiveness in addressing conditions such depression, anxiety, insomnia, stress, autism spectrum disorder (ASD), eating disorders were examined through comprehensive analysis of existing studies up to first half 2024, based on data from reliable electronic databases. We found psychobiotics can significantly reduce symptoms various influencing neurotransmitter levels, regulating hypothalamic-pituitary-adrenal (HPA) axis, improving barrier function short-chain fatty acids (SCFAs) other metabolites. However, several limitations identified, including inconsistent study methodologies, small sample sizes, lack long-term safety. Addressing these rigorous research is essential establishing standardized protocols fully confirming potential psychobiotics. In conclusion, show great promise complementary treatments conditions, but continued necessary refine their application integrate them into clinical practice effectively.

Язык: Английский

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Low mental health literacy is associated with depression and anxiety among adults: a population-based survey of 16,715 adults in China

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 6, 2024

Mental health literacy is a predictor of outcomes in psychological distress. However, limited research has explored whether low mental associated with recent depression and anxiety. We used data from the Guangdong Health Survey, provincial representative population-based survey multistage stratified cluster random sampling method. included adults aged 18 above living communities September to December 2021 Guangdong, China. Eligible participants were those who completed questionnaire assessments for anxiety symptoms. assessed proportion individuals by categories symptoms was depressive general population subgroups. A total 16,715 included. found that more severe had greater literacy- it went 89.4% without or 96.2% people co-occurred (x2 = 21.457, P < 0.001). After controlling confounders, (adjusted Odds Ratio, aOR [95%CI]:2.74 [1.92–4.04]) (2.27 [1.49–3.64]) sample, when compared adequate literacy. This study positive association between presence Tackling inadequate may be key strategy promote well-being across lifespan, especially young adults.

Язык: Английский

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