Chemical Constituents of Stinging Nettle (Urtica dioica L.): A Comprehensive Review on Phenolic and Polyphenolic Compounds and Their Bioactivity

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3430 - 3430

Опубликована: Март 18, 2024

Polyphenolic compounds are of great interest in today’s science. Naturally, they occur plants and other sources many different forms. Their wide range biological activity has attracted the attention scientific community. One phenolic is stinging nettle (Urtica dioica L.), a common plant almost all parts world. A long tradition utilization an interesting chemical profile make this fascinating extensive object study. The also allows to be used as food pigment source food, pharmaceutical, cosmetic industries. Previously conducted studies found acids polyphenolic root, stalk, leaves. Different extraction techniques were usually isolate them from Obtained extracts investigate further or formulate functional products. This study aimed collect available knowledge about plant, its composition, summarize with particular mechanisms their actions.

Язык: Английский

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Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Phytotherapy Research, Год журнала: 2023, Номер 37(11), С. 4999 - 5016

Опубликована: Июль 25, 2023

Abstract Numerous pharmacological effects of quercetin have been illustrated, including antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant activity has extensively reported, in particular, its impacts on glutathione, enzyme activity, signaling transduction pathways, reactive oxygen species (ROS). Quercetin also demonstrated to exert a striking antiinflammatory effect mainly by inhibiting production cytokines, reducing expression cyclooxygenase lipoxygenase, preserving integrity mast cells. By regulating oxidative stress inflammation, which are regarded as two critical processes involved defense regular physiological operation biological systems, validated be effective treating variety disorders. Symptoms these reactions linked degenerative metabolic disorders, syndrome, cardiovascular, neurodegeneration, cancer, nonalcoholic fatty liver disease. Despite that evidence demonstrates antioxidants employed prevent excessive inflammatory processes, there still concerns regarding expense, accessibility, side agents. Notably, natural products, especially those derived from plants, widely accessible, affordable, generally safe. this review, abilities active ingredient application stress‐related disorders outlined detail.

Язык: Английский

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Selected Flavonols Targeting Cell Death Pathways in Cancer Therapy: The Latest Achievements in Research on Apoptosis, Autophagy, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis

Nutrients, Год журнала: 2024, Номер 16(8), С. 1201 - 1201

Опубликована: Апрель 18, 2024

The complex and multi-stage processes of carcinogenesis are accompanied by a number phenomena related to the potential involvement various chemopreventive factors, which include, among others, compounds natural origin such as flavonols. use flavonols is not only promising but also recognized strategy for cancer treatment. impact on arises from their ability act antioxidants, impede proliferation, promote cell death, inhibit angiogenesis, regulate immune system through in diverse forms cellular death. So far, molecular mechanisms underlying regulation apoptosis, autophagy, necroptosis, pyroptosis, ferroptosis, cuproptosis occurring with participation have remained incompletely elucidated, results studies carried out so far ambiguous. For this reason, one therapeutic goals initiate death altered cells quercetin, kaempferol, myricetin, isorhamnetin, galangin, fisetin, morin. This article offers an extensive overview recent research these compounds, focusing particularly role combating elucidating governing cuproptosis. Assessment anticancer effects therapy targeting types pathways may prove useful developing new regimens counteracting resistance previously used treatments.

Язык: Английский

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Supplementation with Complex Phytonutrients Enhances Rumen Barrier Function and Growth Performance of Lambs by Regulating Rumen Microbiome and Metabolome

Animals, Год журнала: 2025, Номер 15(2), С. 228 - 228

Опубликована: Янв. 16, 2025

Complex phytonutrients (CPS) have attracted extensive interest due to their anti-inflammatory effects. This investigation focused on the impact of CPS rumen health in lambs high-concentrate diets, emphasizing growth performance, ruminal fermentation, epithelial barrier integrity, metabolism, and microbial communities. A total 54 lambs, 3 months old with a 30.42 ± 0.54 kg body weight, were randomly assigned three treatment groups, six replicates per replicate. The received basal diet (the ratio concentrate forage was 75:25) without supplementation (CON) or inclusion 2.5 g/kg (CPS2.5) 5.0 (CPS5.0) for 60 days. groups exhibited increased performance improved fermentation parameters. Mechanistically, enhanced function, thereby lowering inflammation inhibiting overactivation JNK/p38 MAPK signaling pathway, effect CPS5.0 better than that CPS2.5. Notably, could optimize composition microbiota increase levels Ursolic acid other metabolites. strong associations between bacteria health-related indicators differential metabolites further highlighted. Our findings suggest adding lambs’ diets has widespread positive impacts, including reduced mRNA relative expression apoptosis-related genes, beneficial changes microbiome metabolite profiles.

Язык: Английский

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A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12091 - 12091

Опубликована: Ноя. 11, 2024

The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize existing research quercetin's potential health benefits, therapeutic properties, effectiveness in disease prevention treatment. In addition evaluating for drug development with fewer side effects lower toxicity, type attempts collect scientific evidence addressing roles as an antioxidant, anti-inflammatory, antibacterial, anticancer agent. first part, we analyze various flavonoid compounds, focusing their chemical structure, classification, natural sources. We highlight most recent biological activities reported literature. Among these pay special attention quercetin, detailing its physicochemical process biosynthesis plants. also present sources emphasize such antioxidant anti-inflammatory effects. Additionally, discuss methods enhance bioavailability, analyzing latest effective delivery systems based quercetin.

Язык: Английский

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Evaluation of Polyphenolic Profile and Antioxidant Activity of Sea Buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) Leaf and Berry Extracts Obtained via Optimized Microwave-Assisted and Accelerated Solvent Extraction

Processes, Год журнала: 2024, Номер 12(1), С. 126 - 126

Опубликована: Янв. 3, 2024

The aim of this study was to optimize parameters microwave-assisted extraction (MAE) and accelerated solvent (ASE) in terms temperature time, microwave power cycle numbers on the phenolic content sea buckthorn leaves berries, using 70% ethanol (v/v) as an solvent. characterization composition leaf berry extracts obtained at optimal MAE ASE conditions performed with UPLC/ESI-MS2, while antioxidant activity determined ORAC method. for were 60 °C, 500 W 15 min 300 W, 10 berries. from both berries 120 min, 3 cycles. Total (TPC) similar TPC by conventional (60 °C/30 min); however, contributed higher extracts. flavonols kaempferol-3-rutinoside kaempferol most abundant phenols buckthorn. A found it correlated content. In general, favored all polyphenols leaves, more suitable suggesting that choice method is crucial regard target molecules future applications.

Язык: Английский

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Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

Phytotherapy Research, Год журнала: 2023, Номер 38(1), С. 280 - 304

Опубликована: Окт. 23, 2023

Abstract This review focuses on the potential ameliorative effects of polyphenolic compounds derived from human diet hepatic diseases. It discusses molecular mechanisms and recent advancements in clinical applications. Edible polyphenols have been found to play a therapeutic role, particularly liver injury, fibrosis, NAFLD/NASH, HCC. In regulation exhibit anti‐inflammatory antioxidant effects, primarily targeting TGF‐β, NF‐κB/TLR4, PI3K/AKT, Nrf2/HO‐1 signaling pathways. effectively reverse fibrotic process by inhibiting activation stellate cells (HSC). Furthermore, show efficacy against NAFLD/NASH lipid oxidation accumulation, mediated through AMPK, SIRT, PPARγ Moreover, several anti‐HCC activity suppressing tumor cell proliferation metastasis. inhibition involves blocking Akt Wnt signaling, as well epithelial‐mesenchymal transition (EMT). Additionally, trials nutritional evidence support notion that certain can improve disease associated metabolic disorders. However, further fundamental research are warranted validate dietary polyphenols.

Язык: Английский

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Advancement of Nanoengineered Flavonoids for Chronic Metabolic Diseases

Опубликована: Авг. 27, 2024

The increasing occurrence of chronic metabolic diseases (CMDs) presents a substantial public health challenge worldwide, necessitating the development pioneering therapeutic approaches. Flavonoids, which are naturally occurring compounds, exert broad spectrum biological activities, encompassing their anti-inflammatory, anti-diabetic, and antioxidant properties, among others. Though they have potential role in treating CMDs, face challenges extraction purification, poor gastrointestinal absorption, low solubility, rapid metabolism, impede clinical applicability. Nanotherapeutics has been receiving significant attention as it aids resolving these issues. Hence, purpose this chapter is to shed light on advances different nanoengineered formulations flavonoids. commences with an outline diseases, emphasizing prevalence pressing need for innovative therapeutics strategies address burden. Following this, flavonoids conditions discussed. Moreover, also elucidates nanoengineering accomplishing efficient flavonoid delivery, particular emphasis versatile nanoformulations, such liposomes, solid lipid nanoparticles, phytosomes. Next, we discuss optimization techniques, surface modification enhance targeting stability, controlled release approaches sustained effects, synergistic outcomes. enhancement bioavailability stability addressed, overcome barriers, targeted delivery site-specific action, methods prevent degradation. Subsequent sections elucidate managing focusing obesity, diabetes, cardiovascular disorders. mechanisms action impact systems efficacy highlighted, providing valuable insights. It highlights involved applicability discusses issues."

Язык: Английский

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Authenticity and Bioactive Markers Search in the Phenolic‐Rich Extracts of Asteraceae Medicinal Plants Through Integrative Computational Chemometrics

Food Science & Nutrition, Год журнала: 2025, Номер 13(1)

Опубликована: Янв. 1, 2025

The Asteraceae family has been of significant concern for ethnobotanical studies, thanks to its health-promoting properties linked a plethora bioactive compounds, among which phenolic compounds play critical role. In this work, workflow based on computational chemometrics was employed assess the authenticity and biomarker search five key species commonly in traditional medicine. UHPLC-DAD-ESI/MS-MS profile extracts combined with evaluation several vitro biological properties. Caffeoylquinic acids (CQAs), chicoric acids, flavonoid glycosides were reported as markers Achillea millefolium, Taraxacum officinale, Arnica montana, respectively. integration bioactivities provide insights identification trans 3,5-O-dicaffeoylquinic acid (3,5-O-diCQA) isorhamnetin major antioxidant agents extracts, whereas CQAs caffeoyl-deoxy-octulopyranosonic have responsible their cytotoxic anti-inflammatory activities. These results shed light authentication quality along characterization functional properties, leading application design novel plant-based foods.

Язык: Английский

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Phytochemical composition, antioxidant and antimicrobial activities of Enarthrocarpus clavatus Delile ex Godr flowers extracts

Natural Product Research, Год журнала: 2025, Номер unknown, С. 1 - 11

Опубликована: Янв. 25, 2025

The phytochemical profile of various plant species reveals that some compounds possess notable antioxidant and antimicrobial properties. In this study we investigated for the first time, activity (FRAP, DPPH TAC), total phenolic contents flavonoid Enarthrocarpus clavatus Delile ex Godr flowers extracts (n-hexane, ethyl acetate methanol) as well their activity. results obtained showed methanol extract contained highest content phenolics (346.7 mg GAE/g DE) flavonoids (339.9 QE/g) it exhibited strongest Furthermore, E. flower have been tested against gram-positive gram-negative bacteria an interesting was with (MICs = 31.25 µg.mL−1). chemical composition using a high-performance liquid chromatographic method coupled electrospray ionisation mass spectrometry (HPLC-ESI-MS). Therefore, 28 were detected among them 18 identified flavonoids, acids fatty acids.

Язык: Английский

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