Foods, Год журнала: 2024, Номер 13(22), С. 3529 - 3529
Опубликована: Ноя. 5, 2024
Obesity is a pandemic currently affecting the world's population that decreases quality of life and promotes development chronic non-communicable diseases.
Язык: Английский
Contraception, Год журнала: 2025, Номер unknown, С. 110829 - 110829
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Diabetes Obesity and Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Abstract Aims Obesity is a global public health challenge, and the traditional WHO‐proposed diagnostic criteria based on body mass index (BMI) often fail to fully assess related risks. The European Association for Study of (EASO) has proposed new that combine BMI, waist‐to‐height ratio (WtHR) complications more accurately evaluate obesity‐related Materials Methods This study utilized data from National Health Nutrition Examination Survey database, covering years 1999–2018. validated EASO diagnosing obesity, defined as BMI ≥25 kg/m 2 , WtHR ≥0.5 presence 12 complications. associations between obesity mortality were assessed using Kaplan–Meier survival curves Cox proportional hazards regression analyses. Mediation analysis was conducted explore potential mechanisms by which impacts patient prognosis. Results A total 39 066 participants included, with mean age 43.6 years; 51.3% male. Over median follow‐up period 141 months, 3708 deaths recorded. prevalence 63.04% according criteria. rate ≥30 only 35.55%. achieved C‐index 0.5549, surpasses predictive accuracy criterion, 0.5265. indicated when criterion diagnose it associated all‐cause cardiovascular disease (CVD)‐related mortality, but did not predict cancer‐related mortality. diagnosed significantly an increased risk (hazard [HR] 95% confidence interval [CI]: 1.13 [1.02, 1.24]), CVD (HR CI: 1.48 [1.20, 1.83]) cancer 1.26 [1.03, 1.54]). When simplified any top five (diabetes mellitus, hypertension, CVD, metabolic syndrome ageing) criteria, had highest (0.612), remained independent prognostic factor poor overall CI mortality: 1.41 [1.26, 1.58], HR 2.08 [1.61, 2.68] 1.32 [1.06, 1.65]). Conclusions confirms value EASO, suggesting these offer accurate assessment
Язык: Английский
Процитировано
1
Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity, Год журнала: 2024, Номер 29(1)
Опубликована: Янв. 2, 2024
Abstract Obesity is a complex, chronic disease requiring multidisciplinary approach to its management. In clinical practice, body mass index and waist-related measurements can be used for obesity screening. The estimated prevalence of among adults worldwide 12%. With the expected further increase in overall prevalence, clinicians will increasingly managing patients with obesity. Energy balance regulated by complex neurohumoral system that involves central nervous circulating mediators, which leptin most studied. functioning these systems influenced both genetic environmental factors. generally occurs when genetically predisposed individual lives an obesogenic environment long period. Cardiologists are deeply involved evaluating Cardiovascular risk profile one important items quantified understand health due benefit single patient obtain weight loss. At level, appropriate involvement, detection potential causes, tools improve outcomes. near future, we probably have new pharmacological at our disposal facilitate achieving maintaining However, treatment alone cannot cure such disease. aim this paper summarize some key points field, as definition measurement tools, epidemiology, main mechanisms underlying energy homeostasis, consequences focus on cardiovascular diseases paradox. Level evidence V: report expert committees.
Язык: Английский
Процитировано
6
Journal of Hazardous Materials, Год журнала: 2024, Номер 466, С. 133500 - 133500
Опубликована: Янв. 11, 2024
Язык: Английский
Процитировано
6
RMD Open, Год журнала: 2024, Номер 10(2), С. e004227 - e004227
Опубликована: Апрель 1, 2024
Objective This report from the NORD-STAR (Nordic Rheumatic Diseases Strategy Trials and Registries) trial aimed to determine if obesity is associated with response conventional biological antirheumatic treatment in early rheumatoid arthritis (RA). Methods included 793 participants untreated RA randomised, longitudinal trial, all of whom had their body mass index (BMI) assessed at baseline. Obesity was defined as BMI ≥30 kg/m 2 . All were randomised 1:1:1:1 one four arms: active treatment, certolizumab-pegol, abatacept tocilizumab. Clinical laboratory measurements performed baseline 8, 12, 24 48-week follow-up. The primary endpoint for this based on Disease Activity Index (CDAI) Simple (SDAI) remission Score 28 joints using C-reactive protein (DAS28-CRP) <2.6 stratified by BMI. Results Out people present report, 161 (20%) During follow-up, higher disease activity compared those lower BMI, despite having similar In survival analyses, a likelihood achieving during follow-up up 48 weeks (CDAI remission, HR 0.84, 95% CI 0.67 1.05; SDAI, 0.77, 0.62 0.97; DAS28-CRP <2.6, 0.78, 0.64 0.95). effect not influenced arms. Conclusion followed weeks, good response, irrespective type received. Trial registration number NCT01491815
Язык: Английский
Процитировано
6
Nature Reviews Endocrinology, Год журнала: 2024, Номер 20(10), С. 615 - 626
Опубликована: Июль 15, 2024
Язык: Английский
Процитировано
6
Archives of Osteoporosis, Год журнала: 2024, Номер 19(1)
Опубликована: Июль 22, 2024
Язык: Английский
Процитировано
6
Medicine, Год журнала: 2024, Номер 103(25), С. e38610 - e38610
Опубликована: Июнь 21, 2024
Maintaining a balanced bile acids (BAs) metabolism is essential for lipid and cholesterol metabolism, as well fat intake absorption. The development of obesity may be intricately linked to BAs their conjugated compounds. Our study aims assess how influence the indicators by Mendelian randomization (MR) analysis. Instrumental variables 5 were obtained from public genome-wide association databases, 8 studies related used outcomes. Causal inference analysis utilized inverse-variance weighted (IVW), median, MR-Egger methods. Sensitivity involved MR-PRESSO leave-one-out techniques detect pleiotropy outliers. Horizontal heterogeneity assessed using intercept Cochran Q statistic, respectively. IVW revealed an odds ratio 0.94 (95% confidence interval: 0.88, 1.00; P = .05) between glycolithocholate (GLCA) obesity, indicating marginal negative causal association. Consistent direction estimates median methods was observed in GLCA obesity. Furthermore, demonstrated suggestive trunk percentage, with beta value -0.014 -0.027, -0.0004; .04). findings suggest potential relationship both although no survived corrections multiple comparisons. These results indicate trend towards possible emphasizing need future studies.
Язык: Английский
Процитировано
5
Nutrients, Год журнала: 2024, Номер 16(13), С. 2160 - 2160
Опубликована: Июль 7, 2024
Obesity constitutes a public health problem worldwide and causes non-alcoholic fatty liver disease (MALFD), the leading cause of in developed countries, which progresses to cirrhosis cancer. MAFLD is associated with obesity can be evaluated by validated formulas assess risk using different parameters such as body mass index (BMI) waist circumference (WC). However, these do not accurately measure fat. As strongly obesity, we hypothesize that measuring visceral fat electrical bioimpedance an efficient method predict MAFLD. The objective our work was demonstrate more than BMI or WC elevated A cross-sectional, descriptive study involving 8590 Spanish workers Balearic Islands carried out. study's sample employees drawn from those who underwent occupational medicine examinations between January 2019 December 2020. Five scales were determined for evaluating very high levels determination performed bioimpedanciometry. Student's t-test employed ascertain mean standard deviation quantitative data. chi-square test used find prevalences qualitative variables, while ROC curves define cut-off points calculations included area under curve (AUC), along their Youden index, sensitivity, specificity. Correlation concordance various Pearson's correlation Cohen's kappa, respectively. both total increase, increases statistically significant result (p < 0.001), presenting higher men. areas (AUC) five overweight determine occurrence values high, most them exceeding 0.9. These AUC circumference. FLD-high presented best results men women at around 0.97, fat, all cases (women = 0.830, 0.892; 0.780, 0.881). In study, show good association assessing are BMI. Both better scales.
Язык: Английский
Процитировано
5
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Июль 22, 2024
Many studies define obesity based on body mass index (BMI) and explore its relationship with adult asthma. However, BMI only considers height weight, ignoring other factors such as fat, which may have a greater impact health. We investigated the between fat distribution asthma using both cross-sectional study bidirectional Mendelian randomization (MR) analysis.
Язык: Английский
Процитировано
5