Antioxidant, Anti-Inflammatory, Antimicrobial, and Anticancer Activities of Pomegranate Juice Concentrate

Nutrients, Год журнала: 2023, Номер 15(12), С. 2709 - 2709

Опубликована: Июнь 11, 2023

Pomegranate juice concentrate (PJC) is a rich source of polyphenols, which exhibit significant antioxidant activity and potential health benefits for disease prevention therapy. In this study, the polyphenolic profile PJC was investigated first time, it found that can inhibit oxidative damage to bovine serum albumin (BSA) deoxyribonucleic acid (DNA), as well acetylcholinesterase, α-amylase, tyrosinase activities. The primary polyphenols identified in were 4-Hydroxy-3-Methoxybenzoate, epicatechin, catechin, rutin, ferulic acid, P-coumaric cinnamic acid. Additionally, demonstrated potent antibacterial effects against human pathogens such Streptococcus mutans Aeromonas hydrophila dose-dependently reduced proliferation colorectal, breast, hepatic cancer cells via apoptosis. Furthermore, blocked B-cell lymphoma 2 (BCl-2) expression cyclin-dependent kinase inhibitor (P21) enhanced tumor protein (P53) expression, compared both untreated treated with fluoropyrimidine 5-fluorouracil (5-FU). As result, may be beneficial ingredient formulation emerging natural-compound-based chemotherapy functional foods could utilized by food, nutraceutical, pharmaceutical industries.

Язык: Английский

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Optimizing Physicochemical Properties, Antioxidant Potential, and Antibacterial Activity of Dry Ginger Extract Using Sonication Treatment

Heliyon, Год журнала: 2024, Номер 10(16), С. e36473 - e36473

Опубликована: Авг. 1, 2024

This research paper focused on enhancing the physico-chemical attributes, antioxidant capacity, and antibacterial effectiveness of dry ginger extract through sonication as an assistant extraction treatment. Ginger, resulting from rhizome

Язык: Английский

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Rutin Isolated from Acalypha indica L.: A Comprehensive Analysis of Its Antibacterial and Anticancer Activities

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер unknown, С. 151833 - 151833

Опубликована: Апрель 1, 2025

Язык: Английский

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Machine learning insights into the antioxidant and biomolecular shielding effects of polyphenol-rich 18 date palm pit extracts

Food Chemistry X, Год журнала: 2025, Номер unknown, С. 102480 - 102480

Опубликована: Апрель 1, 2025

Язык: Английский

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Moringa oleifera seed methanol extract with consolidated antimicrobial, antioxidant, anti‐inflammatory, and anticancer activities

Journal of Food Science, Год журнала: 2024, Номер 89(8), С. 5130 - 5149

Опубликована: Июль 2, 2024

The wide biological activity of the Moringa oleifera represents a potential opportunity for developing selective cancer treatment drugs. bioactive phytochemicals in seed extract (MSE) indicated large numbers (21 compounds) with dominant abundance cycloisolongifolene, 8,9-dehydro-9-vinyl, and chamazulene accounting 12.7% 12.19% total detected compounds. MSE showed potent anticancer effect toward Caco-2, MDA, HepG-2 cells half-maximal inhibitory concentration (IC

Язык: Английский

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Phoenix dactylifera L.: An Overview of Phytochemical Constituents and Impact on Women's Health

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(7)

Опубликована: Апрель 30, 2024

Phoenix dactylifera L. (date palm) is the most significant member of palm family (Arecaceae), particularly in Middle East and Arab World. It a valuable source both primary secondary metabolites including sugars, amino acids, phenolic flavonoids, proanthocyanidins, carotenoids, phytosterols, terpenes sphingolipids, besides vitamins minerals. Besides, it possesses wide array pharmacologic activities viz. immunomodulatory, antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, anti-mutagenic anti-cancer activities, addition to its positive effects on male female fertility. Further research still required deeply understand clinical implications, especially concerning women's health. Moreover, there are other species that need be investigated learn more about their undiscovered phytochemical components biological activities.

Язык: Английский

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Molecular Evidence of Breast Cancer Cell Proliferation Inhibition by a Combination of Selected Qatari Medicinal Plants Crude Extracts

Nutrients, Год журнала: 2023, Номер 15(19), С. 4276 - 4276

Опубликована: Окт. 7, 2023

Breast cancer (BC) is the most common malignancy, and conventional medicine has failed to establish efficient treatment modalities. Conventional due lack of knowledge mechanisms that underpin onset metastasis tumors, as well resistance regimen. However, Complementary Alternative (CAM) modalities are currently drawing attention both public health professionals. Our study examined effect a super-combination (SC) crude extracts, which were isolated from three selected Qatari medicinal plants, on proliferation, motility death BC cells. results revealed SC attenuated cell growth caused MDA-MB-231 cells when compared human normal neonatal fibroblast On other hand, functional assays showed reduced migration invasion, respectively. SC-inhibited cycle SC-regulated apoptosis was likely mediated by p53/p21 pathway p53-regulated Bax/BCL-2/Caspace-3 pathway. ongoing experiments aim validate these in vitro findings vivo using BC-Xenograft mouse model. These support our hypothesis inhibited proliferation induced apoptosis. lay foundation for further experiments, aiming an effective chemoprevention and/or chemotherapeutic strategy can ultimately pave way towards translational research/clinical trials eradication BC.

Язык: Английский

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Exploring ResNet-18 Estimation Design through Multiple Implementation Iterations and Techniques in Legacy Databases

Journal of Robotics and Control (JRC), Год журнала: 2023, Номер 4(5), С. 650 - 661

Опубликована: Сен. 21, 2023

In a rapidly evolving landscape where automated systems and database applications are increasingly crucial, there is pressing need for precise efficient object recognition methods. This study contributes to this burgeoning field by examining the ResNet-18 architecture, proven deep learning model, in context of fruit image classification. The research employs an elaborate experimental setup featuring diverse dataset that includes Rambutan, Mango, Santol, Mangosteen, Guava. efficacy single versus multiple models compared, shedding light on their relative classification accuracy. A unique aspect establishment 90% decision threshold, introduced mitigate risk incorrect Our statistical analysis reveals significant performance advantage over models, with average improvement margin 15%. finding substantiates study’s central hypothesis. implemented threshold determined play pivotal role augmenting system’s overall accuracy minimizing false positives. However, it’s worth noting increased computational complexity associated deploying necessitates further scrutiny. sum, provides nuanced evaluation realm classification, emphasizing utility practical, real-world applications. opens avenues future exploration refining these methodologies investigating applicability broader tasks.

Язык: Английский

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Cytotoxic Effect of Phoenix dactylifera (Iraqi Date) Leaves and Fruits Extracts against Breast Cancers Cell Lines

Asian Pacific Journal of Cancer Prevention, Год журнала: 2024, Номер 25(7), С. 2391 - 2396

Опубликована: Июль 1, 2024

Objective: Now a day's cancerous diseases are the most prevalent life threatening that spreading because of lifestyle. Its due to uncontrolled growth cell which can be cured if diagnosed in early stage. Treatment cancer depends on various internal and external factors causing cancer. The main objective this study is using herbal based medicine manage breast cancer, second common type world. Methods: In study, anticancer effect two Iraqi date palm part extracts (leaves fruits) against panel lines (AMJ13و MCF7, MDA-MB-231, CAL51) vitro evaluate their possible antitumor safety normal line (MEF). Results: Phoenix dactylifera (dray Zahdi) fresh leave extract showed highly cytotoxic effects all lines. leaves was concentration dependent cytotoxicity after 72 h exposure time. Leave effective AMJ13 line. concentrations both cells ranged from 2500-20000 μg/ ml with inhibition percentage (66.7, 70.6, 53, 54%). While MDA-MB, CAL51 were less significant only at (10000- 20000 ml) 64.3, 64.3% respectively 40, 50% 44.0, 52.0% CAL51. dray fruit has no cells. Both have fibroblast Conclusion: conclusion, shows promising properties while direct effect.

Язык: Английский

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Unveiling the Neuroprotective Potential of Date Palm (Phoenix dactylifera): A Systematic Review

Pharmaceuticals, Год журнала: 2024, Номер 17(9), С. 1221 - 1221

Опубликована: Сен. 17, 2024

Background: Neurodegenerative diseases primarily afflict the elderly and are characterized by a progressive loss of neurons. Oxidative stress is intricately linked to advancement these conditions. This study focuses on Phoenix dactylifera (P. dactylifera; Family: Arecaceae), commonly known as “Ajwa,” globally cultivated herbal plant renowned for its potent antioxidant properties reported neuroprotective effects in pharmacological studies. Method: comprehensive systematic review delves into extracts their phytochemical components, with particular emphasis P. potential benefits. Preferred reporting items systemic reviews meta-analysis (PRISMA) were employed articles. Results: The includes 269 articles published literature 17 selected after qualitative analysis. growing body research underscores critical role polyphenolic compounds found dactylifera, which significantly contribute through mechanisms. Despite emerging insights actions further investigation essential fully elucidate specific pathways it confers neuroprotection. Conclusions: Like many other plant-based supplements, dactylifera’s likely mediated synergistic interactions among diverse bioactive compounds, rather than any single constituent alone. Therefore, additional preclinical clinical studies necessary explore therapeutic comprehensively, especially terms targeted activities aimed at mitigating neurodegenerative processes. Such holds promise advancing our understanding potentially harnessing benefits

Язык: Английский

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