The Effects of Mesenchymal Stem Cells-Derived Exosomes on Metabolic Reprogramming in Scar Formation and Wound Healing

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 9871 - 9887

Опубликована: Сен. 1, 2024

Pathological scarring results from aberrant cutaneous wound healing due to the overactivation of biological behaviors human skin fibroblasts, characterized by local inordinate inflammation, excessive extracellular matrix and collagen deposition. Yet, its underlying pathogenesis opinions vary, which could be caused increased mechanical tension, enhanced continuous gene mutation, as well cellular metabolic disorder, etc. Metabolic reprogramming is process pattern cells undergoes a systematic adjustment transformation adapt changes external environment meet needs their growth differentiation. Therefore, abnormality in within wounds scars attaches great importance scar formation. Mesenchymal stem cells-derived exosomes (MSC-Exo) are vesicles that play an important role tissue repair, cancer treatment immune regulation. However, there not work detail relevant studies. Herein, we gave comprehensive summary existing research on three main metabolisms, including glycometabolism, lipid metabolism amino acid metabolism, MSC-Exo regulating formation for further reference.

Язык: Английский

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Importance of Energy, Dietary Protein Sources and Amino Acids Composition in the Regulation of Metabolism: An Indissoluble Dynamic Combination for Life

Опубликована: Июнь 11, 2024

Purpose. This paper aims to present a unique perspective that emphasizes the intricate interplay between energy, dietary proteins, and amino acid composition, underscoring their mutual dependence for health-related considerations. Energy protein synthesis are fundamental biological processes, crucial sustenance of life growth organisms. Methods Results. We explore relationship energy metabolism, synthesis, regulatory mechanisms, sources, availability, autophagy, in order elucidate how these elements collectively maintain cellular homeostasis. underscore vital role this dynamic has preserving cell life. Conclusion. A deeper understanding link is essential comprehend processes. insight could have wide-ranging impact several medical fields, such as nutrition, disease management.

Язык: Английский

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Importance of Energy, Dietary Protein Sources, and Amino Acid Composition in the Regulation of Metabolism: An Indissoluble Dynamic Combination for Life

Nutrients, Год журнала: 2024, Номер 16(15), С. 2417 - 2417

Опубликована: Июль 25, 2024

This paper aims to present a unique perspective that emphasizes the intricate interplay between energy, dietary proteins, and amino acid composition, underscoring their mutual dependence for health-related considerations. Energy protein synthesis are fundamental biological processes, crucial sustenance of life growth organisms.

Язык: Английский

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Transcriptome analysis provides preliminary insights into the response of Sepia esculenta to high salinity stress

Agriculture Communications, Год журнала: 2024, Номер unknown, С. 100064 - 100064

Опубликована: Ноя. 1, 2024

Язык: Английский

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