Food Bioscience, Год журнала: 2024, Номер unknown, С. 105635 - 105635
Опубликована: Дек. 1, 2024
Язык: Английский
BMC Cancer, Год журнала: 2024, Номер 24(1)
Опубликована: Апрель 4, 2024
Abstract Background Through research on the gut microbiota (GM), increasing evidence has indicated that GM is associated with esophageal cancer (ESCA). However, specific cause-and-effect relationship remains unclear. In this study, Mendelian randomization (MR) analysis was applied to investigate causal between and ESCA, including its subtypes. Methods We collected information 211 GMs acquired data ESCA subtypes through genome-wide association studies (GWASs). The primarily assessed using inverse variance weighted (IVW) method. Additionally, we median estimator (WME) method, MR–Egger mode, simple mode provide further assistance. Subsequent these analyses, sensitivity conducted intercept test, MR-PRESSO global leave-one-out Result Following our assessment five methods analysis, identified seven potential relationships At genus level, Veillonella Coprobacter were positively correlated whereas Prevotella9 , Eubacterium oxidoreducens group Turicibacter negatively ESCA. case of adenocarcinoma (EAC), Flavonifractor exhibited a positive correlation, while Actinomyces negative correlation. Conclusion Our study revealed subtypes, offering novel insights for advancement diagnosis treatment.
Язык: Английский
Процитировано
7
Journal of Cellular and Molecular Medicine, Год журнала: 2024, Номер 28(8)
Опубликована: Март 25, 2024
Abstract The causal relationship between gut microbiota (GM) and pancreatic cancer (PC) remains unclear. This study aimed to investigate the potential genes underlying this mechanism. GM Genome‐wide association (GWAS) summary data were from MiBioGen consortium. PC GWAS National Human Genome Research Institute‐European Bioinformatics Institute (NHGRI‐EBI) Catalogue. To detect PC, we implemented three complementary Mendelian randomization (MR) methods: Inverse Variance Weighting (IVW), MR‐Egger Weighted Median, followed by sensitivity analyses. Furthermore, integrated with blood cis‐expression quantitative trait loci (eQTLs) cis‐DNA methylation QTL (mQTLs) using Summary data‐based Randomization (SMR) methods. integration prioritize GM‐affecting through SMR analysis of two molecular traits. cis‐eQTLs cis‐mQTLs summarized Cancer Atlas (TCGA) data. Through colocalization cis‐QTLs data, identified common that influence both PC. Our found a including four protective five risk‐associated [Inverse p < 0.05]. No significant heterogeneity instrumental variables (IVs) or horizontal pleiotropy was found. gene SVBP as traits (FDR<0.05, P_HEIDI>0.05). Additionally, genes, MCM6 RPS26, implicated in interaction based on (PPH4>0.5). In summary, provides evidence for future research at developing suitable therapeutic interventions disease prevention.
Язык: Английский
Процитировано
6
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Март 18, 2024
Colorectal cancer (CRC) is one of the most common malignant tumors primarily affecting individuals over age 50 years. Recent studies have suggested that dysbiosis gut microbiota, a community microorganisms in human gut, closely associated with occurrence and development CRC. Additionally, inflammatory factors (IFs) also been reported to play significant role However, causal relationships between IFs, CRC remain unclear. In this study, we performed Mendelian randomization (MR) analysis using publicly available genome-wide association study (GWAS) data explore relationship The microbiota GWAS were obtained from MiBioGen while IFs derived comprehensive three independent cohorts. Causal was conducted appropriate instrumental variables (IVs) statistical models. MR revealed negative correlation Lachnospiraceae species risk, positive observed Porphyromonadaceae species, UCG010 genus, Lachnospira Sellimonas genus risk. IL-10 These findings suggest might be an increased risk specific bacterial groups may crucial Using analysis, as well CRC, provide important clues for potential roles regulation factor control prevention treatment
Язык: Английский
Процитировано
5
International Journal of Environmental Health Research, Год журнала: 2025, Номер unknown, С. 1 - 11
Опубликована: Янв. 10, 2025
Previous research yields inconsistent findings on the association between air pollution and breast cancer risk, with no definitive causal relationship established. To address this, we conducted a two-sample Mendelian randomization study data from IEU open GWAS databases Breast Cancer Association Consortium to explore potential link (including PM2.5, PM2.5 absorbance, PM2.5–10, PM10, NO2, NOx) risk. We found that PM10 (odds ratio (OR) = 1.39, 95% CI: 1.07–1.80, p 0.013) NOx (OR 1.67, 1.16–2.41, 0.006) were significantly associated elevated Furthermore, 2.10, 1.09–4.03, 0.027) 3.08, 1.24–7.64, 0.015) an risk of luminal B/HER2-negative-like cancer. Results stable in sensitivity analyses. This suggested controlling could potentially reduce
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Май 13, 2024
Background Multiple studies have suggested a possible connection between the gut microbiota and development of lymphoma, though exact nature this relationship remains unclear. This study aimed to explore whether causal association exists lymphoma. Methods A bidirectional two-sample Mendelian randomization (MR) approach was conducted investigate potential effects various lymphoma subtypes. The primary method employed for MR analysis inverse variance weighted (IVW), supplemented by additional methods including MR-Egger, median, mode approaches. Cochrane Q test, MR-PRESSO global test MR-Egger intercept were performed assess pleiotropy heterogeneity. Furthermore, reverse effect. Results identified 36 relationships genetic liabilities in different Neither nor regression detected any pleiotropy, Cochran’s indicated no significant Conclusions Our revealed substantial associations offering new insights into prevention management microbiota.
Язык: Английский
Процитировано
4
Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 14
Опубликована: Янв. 7, 2025
Prior studies have established correlations between gut microbiota (GM) dysbiosis, circulating metabolite alterations, and gastric cancer (GC) risk. However, the causal nature of these associations remains uncertain. We utilized summary data from genome-wide association (GWAS) on GM (European, n=8,956), blood metabolites n=120,241; East Asian, n=4,435), GC n=476,116; n=167,122) to perform a bidirectional Mendelian randomization (MR) analysis, investigating effects Additionally, we conducted mediation analysis (two-step MR) identify potential mediators in GM-GC relationship. identified twelve negative seven positive specific taxa For metabolites, traits were found be significantly associated with reduced risk European population, findings subsequently validated Asian cohort. Three showed five metabolic traits: Bacteroidia class Bacteroidales order positively correlated (all P < 0.013), while Bacteroides OTU97_27 exhibited correlation one (P = 0.007). Two-step MR indicated that total lipids intermediate-density lipoprotein (IDL), IDL particle concentration, phospholipids medium low-density (LDL), small LDL, free cholesterol LDL indirectly influenced class/Bacteroidales GC, proportions 1.71% 0.048), 1.69% 2.05% 0.045), 1.85% 1.99% respectively. The present study provides suggestive evidence relationship GM, risk, potentially offering new insights into etiology.
Язык: Английский
Процитировано
0
Orphanet Journal of Rare Diseases, Год журнала: 2025, Номер 20(1)
Опубликована: Янв. 18, 2025
Lynch syndrome (LS)-associated colorectal cancer (CRC) always ascribes to pathogenic germline mutations in mismatch repair (MMR) genes. However, the penetrance of CRC varies among those with same MMR gene mutation. Thus, we hypothesized that gut microbiota is also involved development LS families. This prospective, observational study was performed from December 2020 March 2023. We enrolled 72 individuals 9 families across six provinces China and employed 16S rRNA amplicon sequencing analyze fecal components LS-related patients (AS group), their spouses (BS mutation carriers without (CS non-mutation (DS group) using alpha beta diversity indices. There were no apparent differences age or gender four groups. Alpha indices exhibited significant between AS BS groups, verifying role occurrence Beta analysis CS revealing importance for A greater difference (both indices) shown DS demonstrating combined impact genetic on Compared identified ten microbial genera enriched group, one genus (Bacteroides) decreased group. Among elevated Agathobacter, Coprococcus Prevotellaceae_NK3B31_group butyrate-producing genera. found can be attributed effects as well provided novel insights into prevention treatment
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 20, 2025
The composition of the gut microbiome patients with advanced non-small cell lung cancer is currently considered a factor influencing effectiveness treatment immune checkpoint inhibitors. We aimed to evaluate baseline in before receiving first-line immunotherapy alone or combined chemoimmunotherapy. performed 16S rRNA sequencing based on hypervariable regions. Stool samples were collected from 52 NSCLC treated chemoimmunotherapy treatment. found that Ruminococcaceae family, species Alistipes sp. genus Eubacterium ventriosum group and Marvinbryantia may be intestinal, microbiological predictors response Genus Akkermansia [Clostridum] leptum predicted length PFS (progression-free survival). Longer OS (overall survival) associated bacteria family genera [Eubacterium] group, Marvinbryantia, Colidextribacter leptum. Bacteria have an adverse effect (shortening OS) using inhibitors are Rothia genus, Streptococus salivarius, Streptococus, Family XIII AD3011 s. uncultured bacterium. intestinal flora can predictive for patients. Specific positively negatively treatment, progression-free survival, overall survival. They potentially used as markers immunotherapy.
Язык: Английский
Процитировано
0
Preventive Medicine, Год журнала: 2024, Номер 189, С. 108147 - 108147
Опубликована: Окт. 3, 2024
Язык: Английский
Процитировано
3
Frontiers in Microbiology, Год журнала: 2023, Номер 14
Опубликована: Дек. 12, 2023
Background Previous observational studies have indicated that an imbalance in gut microbiota may contribute to non-alcoholic fatty liver disease (NAFLD). However, given the inevitable bias and unmeasured confounders studies, causal relationship between NAFLD cannot be deduced. Therefore, we employed a two-sample Mendelian randomization (TSMR) study assess causality NAFLD. Methods The microbiota-related genome-wide association (GWAS) data of 18,340 individuals were collected from International MiBioGen consortium. GWAS summary for Anstee cohort (1,483 cases 17,781 controls) FinnGen consortium (894 217,898 utilized discovery verification phases, respectively. inverse variance weighted (IVW) method was used as principal our (MR) study, with sensitivity analyses using MR-Egger, median, simple mode, mode methods. MR-Egger intercept test, Cochran’s Q leave-one-out analysis conducted identify heterogeneity pleiotropy. Moreover, fixed-effect meta-analysis verify robustness results. Results gene prediction results showed at genus level, four causally associated by et al. relative abundance Intestinimonas (OR: 0.694, 95%CI: 0.533–0.903, p = 0.006, IVW), Lachnoclostridium 0.420, 0.245–0.719, 0.002, Senegalimassilia 0.596, 0.363–0.978, 0.041, IVW) negatively Ruminococcus1 1.852, 1.179–2.908, 0.007, positively correlated Among them, validated 0.53, 0.304–0.928, 0.026, IVW). also significantly risk meta-analyses 0.470, 0.319–0.692, 0.0001, No or pleiotropy observed. Conclusion This provided new evidence NAFLD, suggesting augmentation through oral administration probiotics fecal transplantation could effective way reduce
Язык: Английский
Процитировано
7